ENSG00000005812


Homo sapiens

Features
Gene ID: ENSG00000005812
  
Biological name :FBXL3
  
Synonyms : F-box and leucine rich repeat protein 3 / FBXL3 / Q9UKT7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: -1
Band: q22.3
Gene start: 76992598
Gene end: 77027195
  
Corresponding Affymetrix probe sets: 225132_at (Human Genome U133 Plus 2.0 Array)   235608_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000412183
Ensembl peptide - ENSP00000347834
NCBI entrez gene - 26224     See in Manteia.
OMIM - 605653
RefSeq - XM_017020538
RefSeq - NM_012158
RefSeq - XM_005266336
RefSeq - XM_005266337
RefSeq Peptide - NP_036290
swissprot - C9J0Y7
swissprot - Q9UKT7
Ensembl - ENSG00000005812
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fbxl3aENSDARG00000103505Danio rerio
 fbxl3bENSDARG00000021882Danio rerio
 FBXL3ENSGALG00000045204Gallus gallus
 Fbxl3ENSMUSG00000022124Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001810  F-box domain
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036047  F-box-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination TAS
 biological_processGO:0016567 protein ubiquitination NAS
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0042752 regulation of circadian rhythm IEA
 biological_processGO:0043153 entrainment of circadian clock by photoperiod IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0048511 rhythmic process IEA
 cellular_componentGO:0000151 ubiquitin ligase complex NAS
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Association of TriC/CCT with target proteins during biosynthesis
Circadian Clock
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000008405 CRY1 / Q16526 / cryptochrome circadian regulator 1  / complex / reaction
 ENSG00000121671 CRY2 / Q49AN0 / cryptochrome circadian regulator 2  / reaction / complex






 

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