ENSMUSG00000022124


Mus musculus

Features
Gene ID: ENSMUSG00000022124
  
Biological name :Fbxl3
  
Synonyms : F-box/LRR-repeat protein 3 / Fbxl3 / Q8C4V4
  
Possible biological names infered from orthology : F-box and leucine rich repeat protein 3 / Q9UKT7
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: E2.3
Gene start: 103080239
Gene end: 103099566
  
Corresponding Affymetrix probe sets: 10422067 (MoGene1.0st)   1427471_at (Mouse Genome 430 2.0 Array)   1441561_at (Mouse Genome 430 2.0 Array)   1454635_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022720
Ensembl peptide - ENSMUSP00000116044
Ensembl peptide - ENSMUSP00000117701
Ensembl peptide - ENSMUSP00000120691
Ensembl peptide - ENSMUSP00000115843
NCBI entrez gene - 50789     See in Manteia.
MGI - MGI:1354702
RefSeq - XM_017316078
RefSeq - NM_015822
RefSeq - XM_006519239
RefSeq - XM_006519240
RefSeq - XM_006519241
RefSeq - XM_006519242
RefSeq - XM_006519243
RefSeq Peptide - NP_001334529
RefSeq Peptide - NP_001334530
RefSeq Peptide - NP_056637
swissprot - Q8C4V4
swissprot - Q5PRF6
swissprot - D3Z388
swissprot - D3YWZ0
Ensembl - ENSMUSG00000022124
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fbxl3aENSDARG00000103505Danio rerio
 fbxl3bENSDARG00000021882Danio rerio
 FBXL3ENSGALG00000045204Gallus gallus
 FBXL3ENSG00000005812Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fbxl21 / Q8BFZ4 / Mus musculus F-box and leucine-rich repeat protein 21 (Fbxl21), transcript variant 2, mRNA.ENSMUSG0000003550974


Protein motifs (from Interpro)
Interpro ID Name
 IPR001810  F-box domain
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036047  F-box-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007623 circadian rhythm TAS
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
 biological_processGO:0031648 protein destabilization IMP
 biological_processGO:0042752 regulation of circadian rhythm IMP
 biological_processGO:0043153 entrainment of circadian clock by photoperiod IMP
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0048511 rhythmic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016604 nuclear body ISO
 cellular_componentGO:0019005 SCF ubiquitin ligase complex ISO
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IDA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005645 abnormal hypothalamus physiology "anomalous function of the ventral and medial region of the diencephalon forming the walls of the ventral half of the third ventricle, which is normally involved in the functions of the autonomic (visceral motor) nervous system and, through its vascular link with the anterior lobe of the pituitary gland, in endocrine mechanisms" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Elovl4tm1Wked/Elovl4+
Genetic Background: involves: 129S/SvEv * 129S1/Sv

Allelic Composition: Fbxl3Afh/Fbxl3+
Genetic Background: involves: BALB/c * C3H/HeH

 MP:0020467 abnormal circadian behavior "any anomaly in the specific behavior of an organism that recurs with a regularity of approximately 24 hours" [GO:0048512]
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Allelic Composition: Fbxl3tm1Kei/Fbxl3tm1Kei
Genetic Background: B6.Cg-Fbxl3tm1Kei

 MP:0020468 abnormal circadian behavior period "any change in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
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Allelic Composition: Fbxl3tm1.1Ljp/Fbxl3tm1.1Ljp
Genetic Background: Not Specified

Allelic Composition: Cry1tm1Asn/Cry1tm1Asn,Fbxl3tm1.1Ljp/Fbxl3tm1.1Ljp
Genetic Background: involves: 129P2/OlaHsd

 MP:0020469 prolonged circadian behavior period "increase in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
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Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Fbxl3Ovtm/Fbxl3+
Genetic Background: BTBR T+ Itpr3tf/Itpr3tf-Fbxl3Ovtm/Nwu

Allelic Composition: Fbxl3Afh/Fbxl3+
Genetic Background: involves: BALB/cOlaHsd * C3H/HeH

Allelic Composition: Fbxl3Afh/Fbxl3Afh
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Fbxl3Afh/Fbxl3+
Genetic Background: involves: BALB/c * C3H/HeH

Allelic Composition: Fbxl3Ovtm/Fbxl3Ovtm
Genetic Background: involves: BTBR/J * C3H/HeJ * C57BL/6J

Allelic Composition: Fbxl3Gt(FHCRC-GT-S13-12G1)Sor/Fbxl3Ovtm
Genetic Background: involves: BTBR/J * C3H/HeJ * C57BL/6J

Allelic Composition: Fbxl3Ovtm/Fbxl3Ovtm
Genetic Background: involves: BTBR * C57BL/6J

Allelic Composition: Fbxl3tm1.1Ljp/Fbxl3tm1.1Ljp
Genetic Background: Not Specified

Allelic Composition: Cry2tm1Asn/Cry2tm1Asn,Fbxl3tm1.1Ljp/Fbxl3tm1.1Ljp
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Fbxl3tm1Kei/Fbxl3tm1Kei
Genetic Background: B6.Cg-Fbxl3tm1Kei

Allelic Composition: Fbxl3M1Jt/Fbxl3M1Jt
Genetic Background: C57BL/6J-Fbxl3M1Jt

Allelic Composition: Fbxl3Mgbe/Fbxl3Mgbe
Genetic Background: C57BL/6J-Fbxl3Mgbe

Allelic Composition: Fbxl3Mgbe/Fbxl3+
Genetic Background: C57BL/6J-Fbxl3Mgbe

 MP:0020476 abnormal circardian behavior entrainment "anomaly in the synchronization of a circadian behavior to environmental time cues such as light" [GO:0009649]
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Allelic Composition: Fbxl3tm1Kei/Fbxl3tm1Kei
Genetic Background: B6.Cg-Fbxl3tm1Kei

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020038 Cry1 / P97784 / Cryptochrome-1 / Q16526* / cryptochrome circadian regulator 1*  / reaction / complex
 ENSMUSG00000068742 Cry2 / Q9R194 / Cryptochrome-2 / Q49AN0* / cryptochrome circadian regulator 2*  / reaction / complex






 

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