ENSMUSG00000022433


Mus musculus

Features
Gene ID: ENSMUSG00000022433
  
Biological name :Csnk1e
  
Synonyms : Casein kinase I isoform epsilon / Csnk1e / Q9JMK2
  
Possible biological names infered from orthology : casein kinase 1 epsilon / P49674 / Z98749.3
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: E1
Gene start: 79417856
Gene end: 79455566
  
Corresponding Affymetrix probe sets: 10430519 (MoGene1.0st)   1417175_at (Mouse Genome 430 2.0 Array)   1417176_at (Mouse Genome 430 2.0 Array)   1435373_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000155186
Ensembl peptide - ENSMUSP00000122135
Ensembl peptide - ENSMUSP00000155317
Ensembl peptide - ENSMUSP00000155731
Ensembl peptide - ENSMUSP00000113096
Ensembl peptide - ENSMUSP00000113341
Ensembl peptide - ENSMUSP00000113975
Ensembl peptide - ENSMUSP00000115637
Ensembl peptide - ENSMUSP00000116593
NCBI entrez gene - 27373     See in Manteia.
MGI - MGI:1351660
RefSeq - XM_017316660
RefSeq - XM_011245650
RefSeq - XM_011245651
RefSeq - XM_011245652
RefSeq - XM_011245653
RefSeq - XM_011245654
RefSeq - XM_017316657
RefSeq - XM_017316658
RefSeq - XM_017316659
RefSeq - NM_001289898
RefSeq - NM_001289899
RefSeq - NM_013767
RefSeq - XM_006521043
RefSeq - XM_011245649
RefSeq Peptide - NP_001276827
RefSeq Peptide - NP_001276828
RefSeq Peptide - NP_038795
swissprot - Q9JMK2
swissprot - A9J9D8
swissprot - A8Y2Z5
swissprot - A8Y2Z9
swissprot - Q3TYE1
Ensembl - ENSMUSG00000022433
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 csnk1eENSDARG00000045150Danio rerio
 CSNK1EENSGALG00000032257Gallus gallus
 CSNK1EENSG00000213923Homo sapiens
 Z98749.3ENSG00000283900Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Csnk1d / Q9DC28 / casein kinase 1, delta / P48730*ENSMUSG0000002516284
Q8BK63 / Csnk1a1 / casein kinase 1, alpha 1 / P48729*ENSMUSG0000002457655
Ttbk2 / Q3UVR3 / tau tubulin kinase 2 / Q6IQ55*ENSMUSG0000009010030
Ttbk1 / Q6PCN3 / tau tubulin kinase 1 / Q5TCY1*ENSMUSG0000001559930


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006897 endocytosis IBA
 biological_processGO:0007623 circadian rhythm TAS
 biological_processGO:0008360 regulation of cell shape IBA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IGI
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IGI
 biological_processGO:0032091 negative regulation of protein binding ISO
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0032922 circadian regulation of gene expression IMP
 biological_processGO:0034613 cellular protein localization IDA
 biological_processGO:0042752 regulation of circadian rhythm IMP
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0048512 circadian behavior IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IGI
 biological_processGO:1902004 positive regulation of amyloid-beta formation IEA
 biological_processGO:1903827 regulation of cellular protein localization ISO
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IEA
 biological_processGO:2000052 positive regulation of non-canonical Wnt signaling pathway IGI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
WNT mediated activation of DVL
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Akt1Gt1Pnt/Akt1Gt1Pnt,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Csnk1etm1Asil/Csnk1etm1Asil
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0020469 prolonged circadian behavior period "increase in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
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Allelic Composition: Csnk1etm1Asil/Csnk1etm1.1Asil
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Csnk1etm1.1Drw/Csnk1etm1.1Drw
Genetic Background: B6.129S4-Csnk1etm1.1Drw

 MP:0020470 shortened circadian behavior period "decrease in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
Show

Allelic Composition: Akt1Gt1Pnt/Akt1Gt1Pnt,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Csnk1etm1Asil/Csnk1etm1Asil
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Csnk1etm1Asil/Csnk1etm1.1Asil
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025162 Csnk1d / Q9DC28 / casein kinase 1, delta / P48730*  / reaction
 ENSMUSG00000020038 Cry1 / P97784 / Cryptochrome-1 / Q16526* / cryptochrome circadian regulator 1*  / complex / reaction
 ENSMUSG00000020893 Per1 / O35973 / Period circadian protein homolog 1 / O15534* / period circadian regulator 1*  / complex / reaction
 ENSMUSG00000068742 Cry2 / Q9R194 / Cryptochrome-2 / Q49AN0* / cryptochrome circadian regulator 2*  / complex / reaction
 ENSMUSG00000020888 Dvl2 / Q60838 / Segment polarity DVL-2 / O14641* / dishevelled segment polarity protein 2*  / reaction
 ENSMUSG00000029071 Dvl1 / P51141 / Segment polarity DVL-1 / O14640* / dishevelled segment polarity protein 1*  / reaction
 ENSMUSG00000022433 Csnk1e / Q9JMK2 / Casein kinase I isoform epsilon / P49674* / Z98749.3* / casein kinase 1 epsilon*  / reaction
 ENSMUSG00000029238 Clock / O08785 / Circadian locomoter output cycles protein kaput / O15516* / clock circadian regulator*  / complex / reaction
 ENSMUSG00000003233 Dvl3 / Q61062 / Segment polarity DVL-3 / Q92997* / dishevelled segment polarity protein 3*  / reaction
 ENSMUSG00000055116 Arntl / Q9WTL8 / Mus musculus aryl hydrocarbon receptor nuclear translocator-like (Arntl), transcript variant 3, mRNA. / O00327* / aryl hydrocarbon receptor nuclear translocator like*  / reaction / complex






 

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