ENSMUSG00000029238


Mus musculus

Features
Gene ID: ENSMUSG00000029238
  
Biological name :Clock
  
Synonyms : Circadian locomoter output cycles protein kaput / Clock / O08785
  
Possible biological names infered from orthology : clock circadian regulator / O15516
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: C3.3
Gene start: 76209868
Gene end: 76304792
  
Corresponding Affymetrix probe sets: 10530733 (MoGene1.0st)   1418659_at (Mouse Genome 430 2.0 Array)   1418660_at (Mouse Genome 430 2.0 Array)   1435775_at (Mouse Genome 430 2.0 Array)   1439314_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000074656
Ensembl peptide - ENSMUSP00000143939
Ensembl peptide - ENSMUSP00000144022
NCBI entrez gene - 12753     See in Manteia.
MGI - MGI:99698
RefSeq - XM_017320651
RefSeq - NM_001289826
RefSeq - NM_001305222
RefSeq - NM_007715
RefSeq - XM_011249402
RefSeq - XM_017320648
RefSeq - XM_017320649
RefSeq - XM_017320650
RefSeq Peptide - NP_001276755
RefSeq Peptide - NP_001292151
RefSeq Peptide - NP_031741
swissprot - A0A0J9YU61
swissprot - O08785
Ensembl - ENSMUSG00000029238
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 clockaENSDARG00000011703Danio rerio
 clockbENSDARG00000003631Danio rerio
 CLOCKENSGALG00000013793Gallus gallus
 CLOCKENSG00000134852Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Npas2 / neuronal PAS domain protein 2 / Q99743*ENSMUSG0000002607746
Arnt / P53762 / Aryl hydrocarbon receptor nuclear translocator / P27540*ENSMUSG0000001552218
Arnt2 / Q61324 / Aryl hydrocarbon receptor nuclear translocator 2 / Q9HBZ2*ENSMUSG0000001570916
Hif1a / Q61221 / Hypoxia-inducible factor 1-alpha / Q16665* / hypoxia inducible factor 1 alpha subunit*ENSMUSG0000002110915
Arntl / Q9WTL8 / Mus musculus aryl hydrocarbon receptor nuclear translocator-like (Arntl), transcript variant 3, mRNA. / O00327* / aryl hydrocarbon receptor nuclear translocator like*ENSMUSG0000005511615
Epas1 / P97481 / Endothelial PAS domain-containing protein 1 / Q99814* / endothelial PAS domain protein 1*ENSMUSG0000002414015
Arntl2 / Q2VPD4 / Aryl hydrocarbon receptor nuclear translocator-like protein 2 / Q8WYA1* / aryl hydrocarbon receptor nuclear translocator like 2*ENSMUSG0000004018714
Hif3a / Q0VBL6 / Hypoxia-inducible factor 3-alpha / Q9Y2N7* / hypoxia inducible factor 3 alpha subunit*ENSMUSG0000000432813
Sim2 / Q61079 / Single-minded homolog 2 / Q14190* / single-minded family bHLH transcription factor 2*ENSMUSG0000006271313
Sim1 / Q61045 / Single-minded homolog 1 / P81133* / single-minded family bHLH transcription factor 1*ENSMUSG0000001991312
Npas3 / neuronal PAS domain protein 3 / Q8IXF0*ENSMUSG0000002101012
Npas1 / P97459 / Neuronal PAS domain-containing protein 1 / Q99742* / neuronal PAS domain protein 1*ENSMUSG0000000198810


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR001067  Nuclear translocator
 IPR001610  PAC motif
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013767  PAS fold
 IPR035965  PAS domain superfamily
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000077 DNA damage checkpoint ISO
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006473 protein acetylation IDA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0007623 circadian rhythm TAS
 biological_processGO:0016573 histone acetylation IEA
 biological_processGO:0032922 circadian regulation of gene expression ISO
 biological_processGO:0042634 regulation of hair cycle ISO
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0050729 positive regulation of inflammatory response IMP
 biological_processGO:0050796 regulation of insulin secretion IMP
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0051775 response to redox state ISS
 biological_processGO:0071479 cellular response to ionizing radiation ISO
 biological_processGO:2000074 regulation of type B pancreatic cell development IMP
 biological_processGO:2000323 negative regulation of glucocorticoid receptor signaling pathway IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005694 chromosome ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0033391 chromatoid body IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001047 core promoter binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IC
 molecular_functionGO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0004402 histone acetyltransferase activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008134 transcription factor binding ISA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0031490 chromatin DNA binding IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070888 E-box binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000427 abnormal hair cycle "aberrant growth or asynchronous timing of the hair growth " [J:65302]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

Allelic Composition: Clockm1Jt/Clockm1Jt,Lepob/Lepob
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6 * Jcl:ICR

 MP:0001413 abnormal response to new environment "altered investigative behavior from controls in reactions associated with placing an animal in a new location" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Rac2tm1Mddw/Rac2tm1Mddw,Tg(TcrAND)53Hed/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
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Allelic Composition: Wnt9bclf1/Wnt9bclf1,clf2/clf2
Genetic Background: AEJ.A/Jur

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: Wnt9bclf1/Wnt9bclf1,clf2/clf2
Genetic Background: AEJ.A/Jur

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6 * Jcl:ICR

 MP:0001501 abnormal sleep pattern "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Wnt9bclf1/Wnt9bclf1,clf2/clf2
Genetic Background: AEJ.A/Jur

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6 * Jcl:ICR

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

Allelic Composition: Clockm1Jt/Clockm1Jt,Lepob/Lepob
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Clockm1Jt/Clockm1Jt,Lepob/Lepob
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ros1tm1.1Char/Ros1tm1.1Char
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0001666 abnormal nutrient absorption "anomalous ability of the body to take in constituents of food necessary for normal physiologic function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

 MP:0001669 abnormal glucose absorption "anomalous ability of the body to take in this major monosaccharide, a 6-carbon sugar" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rac2tm1Mddw/Rac2tm1Mddw,Tg(TcrAND)53Hed/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Clockm1Jt/Clockm1Jt,Lepob/Lepob
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rac2tm1Mddw/Rac2tm1Mddw,Tg(TcrAND)53Hed/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rock1tm1.1Itl/Rock1tm1.1Itl
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nlgn3tm1.1Htz/Nlgn3tm1.1Htz
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Wnt9bclf1/Wnt9bclf1,clf2/clf2
Genetic Background: AEJ.A/Jur

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6 * Jcl:ICR

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0002665 decreased circulating corticosterone level "less than the normal blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0002693 abnormal pancreas physiology "abberrant function of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ros1tm1.1Char/Ros1tm1.1Char
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Clockm1Jt/Clockm1Jt,Lepob/Lepob
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

 MP:0002773 decreased circulating luteinizing hormone level "lower than normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35132, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6J

 MP:0002907 abnormal parturition "defect in the process of labor and delivery in female animals " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6J

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6

 MP:0003463 abnormal single cell response "altered values from controls obtained upon extra- or intracellular recordings from single cells" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6

 MP:0003969 abnormal lutenizing hormone level 
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6

 MP:0004080 abnormal nucleus accumbens morphology "malformation in the group of neurons located at the head of the caudate nucleus and anterior to the putamen; these neurons normally are involved in sensations of pleasure and reactions to addictive substances " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Nlgn3tm1.1Htz/Nlgn3tm1.1Htz
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0004890 decreased energy expenditure "decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wnt9bclf1/Wnt9bclf1,clf2/clf2
Genetic Background: AEJ.A/Jur

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Arntltm2Bra/Arntltm2Bra,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

Allelic Composition: Clockm1Jt/Clockm1Jt,Lepob/Lepob
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

 MP:0005181 decreased circulating estradiol level "less than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6

 MP:0005182 increased circulating estradiol level "greater than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6

 MP:0005185 decreased circulating progesterone level "less than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6

 MP:0005186 increased circulating progesterone level "greater than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ros1tm1.1Char/Ros1tm1.1Char
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ros1tm1.1Char/Ros1tm1.1Char
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ros1tm1.1Char/Ros1tm1.1Char
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0005342 abnormal lipid absorption "anomalous ability of the body to take in fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Arntltm2Bra/Arntltm2Bra,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

Allelic Composition: Clockm1Jt/Clockm1Jt,Lepob/Lepob
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Clockm1Jt/Clockm1Jt,Lepob/Lepob
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0006094 adipocyte hypertrophy "increase in the size of fat cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:90802]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

Allelic Composition: Clockm1Jt/Clockm1Jt,Lepob/Lepob
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

 MP:0008462 abnormal medium spiny neuron morphology "any structural anomaly of the inhibitory projection neurons located in the striatum that integrate glutamatergic signals arising from the cerebral cortex and thalamus" [PMID:15504319]
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Allelic Composition: Nlgn3tm1.1Htz/Nlgn3tm1.1Htz
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0008858 abnormal hair cycle anagen phase "anomaly in the growth phase of the hair cycle" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

 MP:0008882 abnormal enterocyte physiology "any functional anomaly of the epithelial cells that have an apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen" [CL:0000584, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

 MP:0008961 abnormal basal metabolism "any anomaly in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [MESH:E01.370.374.750.100]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0009006 prolonged estrous cycle "increase in the length of the sexual cycle of female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6

 MP:0009015 short proestrus "decrease in the length of the proestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6

 MP:0009017 prolonged estrus "increase in the length of the estrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6J

 MP:0009661 abnormal pregnancy "any anomaly in the process of maintaining a developing embryo or fetus within the female body from conception to birth" [ISBN:0198542771 "Rugh, Roberts, The Mouse: Its Reproduction and Development", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6

 MP:0009754 enhanced behavioral response to cocaine "increased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6

 MP:0010080 abnormal hepatocyte physiology "any functional anomaly of the main structural specialized epithelial cells which normally organize into interconnected plates called lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0011020 abnormal circadian temperature homeostasis "any anomaly in the process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours" [GO:0060086]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6 * Jcl:ICR

 MP:0011021 abnormal circadian regulation of heart rate "anomaly in the process in which an organism modulates its heart rate at different values with a regularity of approximately 24 hours" [GO:0003053]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0011022 abnormal circadian regulation of systemic arterial blood pressure "any anomaly in the process in which an organism modulates its blood pressure at different values with a regularity of approximately 24 hours" [GO:0003052]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0014121 increased pancreatic islet cell apoptosis "increase in the number of pancreatic islet cells undergoing programmed cell death" [MGI:Anna]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6J

 MP:0020467 abnormal circadian behavior "any anomaly in the specific behavior of an organism that recurs with a regularity of approximately 24 hours" [GO:0048512]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6 * Jcl:ICR

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6 * C57BL/6J * Jcl:ICR

 MP:0020468 abnormal circadian behavior period "any change in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
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Allelic Composition: Usf1Gt(W233A07)Wrst/Usf1Gt(W233A07)Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Clockm1Jt/Clock+,Per2tm1Jt/Per2+,Usf1soc/?
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6J

 MP:0020469 prolonged circadian behavior period "increase in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
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Allelic Composition: Wnt9bclf1/Wnt9bclf1,clf2/clf2
Genetic Background: AEJ.A/Jur

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/cJ * C57BL/6

Allelic Composition: Clockm1Jt/Clock+,Usf1soc/Usf1+
Genetic Background: (BALB/cJ x C57BL/6J)F1

Allelic Composition: Clockm1Jt/Clock+
Genetic Background: B6(C)-Clockm1Jt

 MP:0020471 abnormal circadian behavior persistence "anomaly in the ability for an animal to retain a circadian behavior when time cues are removed" [MGI:smb]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0020472 arrhythmic circadian behavior persistence "loss of a behavioral rhythmic pattern upon removal of time cues" [MGI:smb]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0020473 abnormal circadian behavior phase "anomaly in the phase relationship between a temporal synchronizing event (such as light cycle) and a behavioral phase reference point of an animal (such as activity onset)" [MGI:smb]
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Allelic Composition: Wnt9bclf1/Wnt9bclf1,clf2/clf2
Genetic Background: AEJ.A/Jur

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

Allelic Composition: Clocktm1.1Rep/Clocktm1.1Rep
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6 * C57BL/6J * Jcl:ICR

 MP:0020474 advanced circadian behavior phase "increase in the phase relationship between a temporal synchronizing event (such as light cycle) and a behavioral phase reference point of an animal (such as activity onset)" [MGI:smb]
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Allelic Composition: Clocktm1.1Rep/Clocktm1.1Rep
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0020477 abnormal locomotor circadian rhythm "any anomaly in the rhythm of the locomotor activity of an organism during its 24 hour activity cycle" [GO:0045475]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

 MP:0020478 abnormal circadian sleep/wake cycle "any anomaly in the cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm" [GO:0042745]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: C57BL/6-Clockm1Jt

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: C57BL/6 * Jcl:ICR

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025162 Csnk1d / Q9DC28 / casein kinase 1, delta / P48730*  / reaction / complex
 ENSMUSG00000020038 Cry1 / P97784 / Cryptochrome-1 / Q16526* / cryptochrome circadian regulator 1*  / complex / reaction
 ENSMUSG00000020893 Per1 / O35973 / Period circadian protein homolog 1 / O15534* / period circadian regulator 1*  / reaction / complex
 ENSMUSG00000055116 Arntl / Q9WTL8 / Mus musculus aryl hydrocarbon receptor nuclear translocator-like (Arntl), transcript variant 3, mRNA. / O00327* / aryl hydrocarbon receptor nuclear translocator like*  / complex / reaction
 ENSMUSG00000068742 Cry2 / Q9R194 / Cryptochrome-2 / Q49AN0* / cryptochrome circadian regulator 2*  / reaction / complex
 ENSMUSG00000022433 Csnk1e / Q9JMK2 / Casein kinase I isoform epsilon / P49674* / Z98749.3* / casein kinase 1 epsilon*  / complex / reaction






 

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