Manteia

ENSDARG00000011703

Danio rerio

Features

Gene ID:	ENSDARG00000011703

Biological name :	clocka

Synonyms :	clocka / clock circadian regulator a

Possible biological names infered from orthology :	Circadian locomoter output cycles protein kaput / CLOCK / clock circadian regulator / O08785 / O15516

Species:	Danio rerio

Chr. number:	20
Strand:	1
Band:
Gene start:	22067337
Gene end:	22176003

Corresponding Affymetrix probe sets:	Dr.8089.1.S1_at (Zebrafish Array) NM_130957_at (Zebrafish Genome Array with custom cdf files)

Cross references:	Ensembl peptide - ENSDARP00000014377 Ensembl peptide - ENSDARP00000126787 NCBI entrez gene - 30140 See in Manteia. RefSeq - NM_130957 RefSeq Peptide - NP_571032 swissprot - Q5RIV1 ZFIN ID - ZDB-GENE-990630-14 Ensembl - ENSDARG00000011703

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
CLOCK	ENSGALG00000013793	Gallus gallus
CLOCK	ENSG00000134852	Homo sapiens
Clock	ENSMUSG00000029238	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
clockb / clock circadian regulator b / CLOCK* / O15516* / O08785* / clock circadian regulator* / Circadian locomoter output cycles protein kaput *	ENSDARG00000003631	63
npas2 / neuronal PAS domain protein 2 / Q99743*	ENSDARG00000016536	42
arnt2 / aryl-hydrocarbon receptor nuclear translocator 2 / Q61324* / Q9HBZ2*	ENSDARG00000103697	16
arntl2 / aryl hydrocarbon receptor nuclear translocator-like 2 / Q2VPD4* / Q8WYA1* / Aryl hydrocarbon receptor nuclear translocator-like protein 2 *	ENSDARG00000041381	15
arntl1b / aryl hydrocarbon receptor nuclear translocator-like 1b / ARNTL* / O00327* / Q9WTL8* / aryl hydrocarbon receptor nuclear translocator like* / Mus musculus aryl hydrocarbon receptor...	ENSDARG00000035732	14
arntl1a / aryl hydrocarbon receptor nuclear translocator-like 1a / ARNTL* / O00327* / Q9WTL8* / aryl hydrocarbon receptor nuclear translocator like* / Mus musculus aryl hydrocarbon receptor...	ENSDARG00000006791	14
arnt / aryl hydrocarbon receptor nuclear translocator / P27540* / P53762*	ENSDARG00000021855	14
epas1a / endothelial PAS domain protein 1a / EPAS1* / Q99814* / P97481* / endothelial PAS domain protein 1* / Endothelial PAS domain-containing protein 1 *	ENSDARG00000008697	14
epas1b / endothelial PAS domain protein 1b / EPAS1* / Q99814* / P97481* / endothelial PAS domain protein 1* / Endothelial PAS domain-containing protein 1 *	ENSDARG00000057671	13
hif1ab / hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b / HIF1A* / Q61221* / Q16665* / Hypoxia-inducible factor 1-alpha * / hypoxia inducible fact...	ENSDARG00000034293	13
hif1al / hypoxia-inducible factor 1, alpha subunit, like / HIF3A* / Q9Y2N7* / Q0VBL6* / Hypoxia-inducible factor 3-alpha * / hypoxia inducible factor 3 alpha subunit*	ENSDARG00000100826	11
NPAS3 / neuronal PAS domain protein 3 / Q8IXF0*	ENSDARG00000109820	11
sim1a / single-minded family bHLH transcription factor 1a / SIM1* / Q61045* / P81133* / Single-minded homolog 1 * / single-minded family bHLH transcription factor 1*	ENSDARG00000023316	11
hif1aa / hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) a / HIF1A* / Q61221* / Q16665* / Hypoxia-inducible factor 1-alpha * / hypoxia inducible fact...	ENSDARG00000006181	11
hif1al2 / hypoxia-inducible factor 1, alpha subunit, like 2	ENSDARG00000044550	10
sim1b / single-minded family bHLH transcription factor 1b / SIM1* / Q61045* / P81133* / Single-minded homolog 1 * / single-minded family bHLH transcription factor 1*	ENSDARG00000013789	10
npas1 / neuronal PAS domain protein 1 / P97459* / Q99742* / Neuronal PAS domain-containing protein 1 *	ENSDARG00000015876	9
CABZ01064671.1	ENSDARG00000039935	8

Protein motifs (from Interpro)

Interpro ID	Name
IPR000014	PAS domain
IPR001067	Nuclear translocator
IPR001610	PAC motif
IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
IPR013767	PAS fold

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0007623	circadian rhythm	IMP
biological_process	GO:0009266	response to temperature stimulus	IDA
biological_process	GO:0009416	response to light stimulus	IGI
biological_process	GO:0009648	photoperiodism	IEP
biological_process	GO:0010468	regulation of gene expression	IGI
biological_process	GO:0010628	positive regulation of gene expression	IGI
biological_process	GO:0032922	circadian regulation of gene expression	IMP
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	IMP
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005667	transcription factor complex	IEA
cellular_component	GO:0005737	cytoplasm	IEA
molecular_function	GO:0003677	DNA binding	IDA
molecular_function	GO:0003700	DNA-binding transcription factor activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0046982	protein heterodimerization activity	NAS
molecular_function	GO:0046983	protein dimerization activity	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
ZFA:0000037	anatomical structure	anatomical structure increased amount , abnormal anatomical structure decreased amount , abnormal	Show
ZFA:0000054	pericardium	pericardium edematous , abnormal	Show
ZFA:0000071	shield	shield decreased amount , abnormal	Show
ZFA:0000083	ventral mesoderm	ventral mesoderm decreased amount , abnormal	Show
ZFA:0001069	ventral fin fold	ventral fin fold aplastic , abnormal	Show
ZFA:0001094	whole organism	whole organism increased amount , abnormal whole organism decreased length , abnormal whole organism decreased amount , abnormal	Show
ZFA:0001204	axial mesoderm	axial mesoderm decreased amount , abnormal	Show
ZFA:0001377	presumptive mesoderm	presumptive mesoderm decreased amount , abnormal	Show
ZFA:0009256	nucleate erythrocyte	nucleate erythrocyte decreased amount , abnormal	Show
ZFA:0009258	angioblastic mesenchymal cell	angioblastic mesenchymal cell decreased amount , abnormal	Show

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr