ENSDARG00000023316


Danio rerio

Features
Gene ID: ENSDARG00000023316
  
Biological name :sim1a
  
Synonyms : sim1a / single-minded family bHLH transcription factor 1a
  
Possible biological names infered from orthology : P81133 / Q61045 / SIM1 / single-minded family bHLH transcription factor 1 / Single-minded homolog 1
  
Species: Danio rerio
  
Chr. number: 16
Strand: -1
Band:
Gene start: 1465624
Gene end: 1503023
  
Corresponding Affymetrix probe sets: Dr.25265.1.S1_at (Zebrafish Array)   NM_178222_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000033085
Ensembl peptide - ENSDARP00000151913
NCBI entrez gene - 260351     See in Manteia.
RefSeq - NM_178222
RefSeq Peptide - NP_835740
swissprot - F1QMF7
ZFIN ID - ZDB-GENE-020829-1
Ensembl - ENSDARG00000023316
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SIM1ENSGALG00000015466Gallus gallus
 SIM1ENSG00000112246Homo sapiens
 Sim1ENSMUSG00000019913Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
sim1b / single-minded family bHLH transcription factor 1b / SIM1* / Q61045* / P81133* / Single-minded homolog 1 * / single-minded family bHLH transcription factor 1*ENSDARG0000001378954
NPAS3 / neuronal PAS domain protein 3 / Q8IXF0*ENSDARG0000010982027
npas1 / neuronal PAS domain protein 1 / P97459* / Q99742* / Neuronal PAS domain-containing protein 1 *ENSDARG0000001587625
hif1ab / hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b / HIF1A* / Q61221* / Q16665* / Hypoxia-inducible factor 1-alpha * / hypoxia inducible fact...ENSDARG0000003429324
epas1b / endothelial PAS domain protein 1b / EPAS1* / Q99814* / P97481* / endothelial PAS domain protein 1* / Endothelial PAS domain-containing protein 1 *ENSDARG0000005767123
epas1a / endothelial PAS domain protein 1a / EPAS1* / Q99814* / P97481* / endothelial PAS domain protein 1* / Endothelial PAS domain-containing protein 1 *ENSDARG0000000869722
hif1aa / hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) a / HIF1A* / Q61221* / Q16665* / Hypoxia-inducible factor 1-alpha * / hypoxia inducible fact...ENSDARG0000000618121
hif1al / hypoxia-inducible factor 1, alpha subunit, like / HIF3A* / Q9Y2N7* / Q0VBL6* / Hypoxia-inducible factor 3-alpha * / hypoxia inducible factor 3 alpha subunit*ENSDARG0000010082619
CABZ01064671.1ENSDARG0000003993517
hif1al2 / hypoxia-inducible factor 1, alpha subunit, like 2ENSDARG0000004455017
arnt2 / aryl-hydrocarbon receptor nuclear translocator 2 / Q61324* / Q9HBZ2*ENSDARG0000010369716
arntl2 / aryl hydrocarbon receptor nuclear translocator-like 2 / Q2VPD4* / Q8WYA1* / Aryl hydrocarbon receptor nuclear translocator-like protein 2 *ENSDARG0000004138115
arnt / aryl hydrocarbon receptor nuclear translocator / P27540* / P53762*ENSDARG0000002185514
arntl1a / aryl hydrocarbon receptor nuclear translocator-like 1a / ARNTL* / O00327* / Q9WTL8* / aryl hydrocarbon receptor nuclear translocator like* / Mus musculus aryl hydrocarbon receptor...ENSDARG0000000679114
arntl1b / aryl hydrocarbon receptor nuclear translocator-like 1b / ARNTL* / O00327* / Q9WTL8* / aryl hydrocarbon receptor nuclear translocator like* / Mus musculus aryl hydrocarbon receptor...ENSDARG0000003573214
clocka / clock circadian regulator a / CLOCK* / O15516* / O08785* / clock circadian regulator* / Circadian locomoter output cycles protein kaput *ENSDARG0000001170313
clockb / clock circadian regulator b / CLOCK* / O15516* / O08785* / clock circadian regulator* / Circadian locomoter output cycles protein kaput *ENSDARG0000000363113
npas2 / neuronal PAS domain protein 2 / Q99743*ENSDARG0000001653612


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR001610  PAC motif
 IPR010578  Single-minded, C-terminal
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR013655  PAS fold-3
 IPR013767  PAS fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000032 hypothalamus hypothalamus dopaminergic neuron decreased amount , abnormal
hypothalamus neurosecretory neuron decreased amount , abnormal
Show

 ZFA:0000101 diencephalon diencephalon neurosecretory neuron mislocalised , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000114 heart heart edematous , abnormal
Show

 ZFA:0000151 pronephros pronephros lacks all parts of type corpuscles of Stannius , abnormal
pronephros lacks all parts of type pronephric proximal straight tubule , abnormal
Show

 ZFA:0000470 preoptic area preoptic area morphology , abnormal
preoptic area decreased amount , abnormal
preoptic area neurosecretory neuron decreased amount , abnormal
Show

 ZFA:0000633 caudal tuberculum caudal tuberculum dopaminergic neuron decreased amount , abnormal
caudal tuberculum neurosecretory neuron decreased amount , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
head apoptotic , abnormal
Show

 ZFA:0001200 corpuscles of Stannius corpuscles of Stannius absent , abnormal
Show

 ZFA:0001620 pronephric proximal convoluted tubule pronephric proximal convoluted tubule mislocalised , abnormal
pronephric proximal convoluted tubule distended , abnormal
pronephric proximal convoluted tubule increased distribution , abnormal
pronephric proximal convoluted tubule mislocalised posteriorly , abnormal
pronephric proximal convoluted tubule straight , abnormal
Show

 ZFA:0001621 pronephric proximal straight tubule pronephric proximal straight tubule absent , abnormal
pronephric proximal straight tubule decreased size , abnormal
Show

 ZFA:0001622 pronephric distal early tubule pronephric distal early tubule increased length , abnormal
pronephric distal early tubule mislocalised anteriorly , abnormal
pronephric distal early tubule mislocalised posteriorly , abnormal
pronephric distal early tubule spatial pattern , ameliorated
Show

 ZFA:0001624 pronephric distal late tubule pronephric distal late tubule increased length , abnormal
pronephric distal late tubule decreased length , abnormal
pronephric distal late tubule decreased distribution , abnormal
Show

 ZFA:0001659 diencephalic nucleus diencephalic nucleus axon displaced to hindbrain medial region, abnormal
Show

 ZFA:0009098 neuroendocrine cell neuroendocrine cell decreased amount , abnormal
Show

 ZFA:0009301 dopaminergic neuron dopaminergic neuron decreased amount , abnormal
dopaminergic neuron axon displaced to hindbrain medial region, abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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