ENSDARG00000008697


Danio rerio

Features
Gene ID: ENSDARG00000008697
  
Biological name :epas1a
  
Synonyms : endothelial PAS domain protein 1a / epas1a
  
Possible biological names infered from orthology : Endothelial PAS domain-containing protein 1 / endothelial PAS domain protein 1 / EPAS1 / P97481 / Q99814
  
Species: Danio rerio
  
Chr. number: 12
Strand: 1
Band:
Gene start: 25775734
Gene end: 25830268
  
Corresponding Affymetrix probe sets: Dr.12182.1.A1_at (Zebrafish Array)   Dr.16214.1.S1_at (Zebrafish Array)   Dr.25865.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000021260
Ensembl peptide - ENSDARP00000124584
NCBI entrez gene - 566886     See in Manteia.
swissprot - E7FAJ1
swissprot - F8W2W5
ZFIN ID - ZDB-GENE-030131-4490
Ensembl - ENSDARG00000008697
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EPAS1ENSGALG00000010005Gallus gallus
 EPAS1ENSG00000116016Homo sapiens
 Epas1ENSMUSG00000024140Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
epas1b / endothelial PAS domain protein 1b / EPAS1* / Q99814* / P97481* / endothelial PAS domain protein 1* / Endothelial PAS domain-containing protein 1 *ENSDARG0000005767158
hif1ab / hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b / HIF1A* / Q61221* / Q16665* / Hypoxia-inducible factor 1-alpha * / hypoxia inducible fact...ENSDARG0000003429341
hif1aa / hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) a / HIF1A* / Q61221* / Q16665* / Hypoxia-inducible factor 1-alpha * / hypoxia inducible fact...ENSDARG0000000618135
hif1al / hypoxia-inducible factor 1, alpha subunit, like / HIF3A* / Q9Y2N7* / Q0VBL6* / Hypoxia-inducible factor 3-alpha * / hypoxia inducible factor 3 alpha subunit*ENSDARG0000010082630
hif1al2 / hypoxia-inducible factor 1, alpha subunit, like 2ENSDARG0000004455023
NPAS3 / neuronal PAS domain protein 3 / Q8IXF0*ENSDARG0000010982022
sim1a / single-minded family bHLH transcription factor 1a / SIM1* / Q61045* / P81133* / Single-minded homolog 1 * / single-minded family bHLH transcription factor 1*ENSDARG0000002331620
npas1 / neuronal PAS domain protein 1 / P97459* / Q99742* / Neuronal PAS domain-containing protein 1 *ENSDARG0000001587619
sim1b / single-minded family bHLH transcription factor 1b / SIM1* / Q61045* / P81133* / Single-minded homolog 1 * / single-minded family bHLH transcription factor 1*ENSDARG0000001378919
arnt2 / aryl-hydrocarbon receptor nuclear translocator 2 / Q61324* / Q9HBZ2*ENSDARG0000010369716
clocka / clock circadian regulator a / CLOCK* / O15516* / O08785* / clock circadian regulator* / Circadian locomoter output cycles protein kaput *ENSDARG0000001170314
npas2 / neuronal PAS domain protein 2 / Q99743*ENSDARG0000001653614
clockb / clock circadian regulator b / CLOCK* / O15516* / O08785* / clock circadian regulator* / Circadian locomoter output cycles protein kaput *ENSDARG0000000363114
arnt / aryl hydrocarbon receptor nuclear translocator / P27540* / P53762*ENSDARG0000002185513
arntl2 / aryl hydrocarbon receptor nuclear translocator-like 2 / Q2VPD4* / Q8WYA1* / Aryl hydrocarbon receptor nuclear translocator-like protein 2 *ENSDARG0000004138113
arntl1b / aryl hydrocarbon receptor nuclear translocator-like 1b / ARNTL* / O00327* / Q9WTL8* / aryl hydrocarbon receptor nuclear translocator like* / Mus musculus aryl hydrocarbon receptor...ENSDARG0000003573212
arntl1a / aryl hydrocarbon receptor nuclear translocator-like 1a / ARNTL* / O00327* / Q9WTL8* / aryl hydrocarbon receptor nuclear translocator like* / Mus musculus aryl hydrocarbon receptor...ENSDARG0000000679112
CABZ01064671.1ENSDARG0000003993511


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR001067  Nuclear translocator
 IPR001610  PAC motif
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR013655  PAS fold-3
 IPR013767  PAS fold
 IPR014887  HIF-1 alpha, transactivation domain, C-terminal
 IPR021537  Hypoxia-inducible factor, alpha subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Regulation of gene expression by Hypoxia-inducible Factor
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000004632 egln1b / egl-9 family hypoxia-inducible factor 1b / EGLN1* / Q91YE3* / Q9GZT9* / Egl nine homolog 1 * / egl-9 family hypoxia inducible factor 1*  / reaction / complex
 ENSDARG00000112452 crebbpb / CREB binding protein b / CREBBP* / Q92793* / CREB binding protein*  / complex
 ENSDARG00000038030 rbx1 / ring-box 1, E3 ubiquitin protein ligase / P62878* / P62877* / ring-box 1* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / reaction / complex
 ENSDARG00000038576 ube2d1b / ubiquitin-conjugating enzyme E2D 1b / UBE2D1* / P51668* / P61080* / ubiquitin conjugating enzyme E2 D1*  / reaction
 ENSDARG00000037980 elob / elongin B / Elobl* / P62869* / Q15370*  / complex / reaction
 ENSDARG00000045359 elocb / elongin C paralog b / ELOC* / P83940* / Q15369* / elongin C*  / reaction / complex
 ENSDARG00000038996 egln1a / egl-9 family hypoxia-inducible factor 1a / EGLN1* / Q91YE3* / Q9GZT9* / Egl nine homolog 1 * / egl-9 family hypoxia inducible factor 1*  / complex / reaction
 ENSDARG00000104609 crebbpa / CREB binding protein a / CREBBP* / Q92793* / CREB binding protein*  / complex
 ENSDARG00000013965 cul2 / cullin 2 / Q13617* / Q9D4H8*  / complex / reaction
 ENSDARG00000043484 ube2d2 / ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) / P62838* / P62837* / Ube2d2a* / ubiquitin conjugating enzyme E2 D2* / ubiquitin-conjugating enzyme E2D 2A*  / reaction
 ENSDARG00000021855 arnt / aryl hydrocarbon receptor nuclear translocator / P27540* / P53762*  / reaction / complex
 ENSDARG00000031915 hif1an / P59723 / hypoxia inducible factor 1, alpha subunit inhibitor / Q8BLR9* / Q9NWT6* / Hypoxia-inducible factor 1-alpha inhibitor *  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr