ENSDARG00000038030


Danio rerio

Features
Gene ID: ENSDARG00000038030
  
Biological name :rbx1
  
Synonyms : rbx1 / ring-box 1, E3 ubiquitin protein ligase
  
Possible biological names infered from orthology : E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877 / P62878 / ring-box 1
  
Species: Danio rerio
  
Chr. number: 3
Strand: -1
Band:
Gene start: 25101960
Gene end: 25107802
  
Corresponding Affymetrix probe sets: Dr.667.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000055431
Ensembl peptide - ENSDARP00000114244
NCBI entrez gene - 449846     See in Manteia.
RefSeq - NM_001083544
RefSeq Peptide - NP_001077013
swissprot - E9QBL1
swissprot - A4FUL3
ZFIN ID - ZDB-GENE-041008-106
Ensembl - ENSDARG00000038030
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RBX1ENSGALG00000011993Gallus gallus
 RBX1ENSG00000100387Homo sapiens
 Rbx1ENSMUSG00000022400Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rnf7 / ring finger protein 7 / Q9WTZ1* / Gm7075* / Q9UBF6* / RING-box protein 2 *ENSDARG0000005552446


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR024766  Zinc finger, RING-H2-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0045116 protein neddylation IBA
 cellular_componentGO:0031462 Cul2-RING ubiquitin ligase complex IBA
 cellular_componentGO:0031463 Cul3-RING ubiquitin ligase complex IBA
 cellular_componentGO:0031467 Cul7-RING ubiquitin ligase complex IBA
 cellular_componentGO:0043224 nuclear SCF ubiquitin ligase complex IBA
 cellular_componentGO:0080008 Cul4-RING E3 ubiquitin ligase complex IBA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0019788 NEDD8 transferase activity IBA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA
 molecular_functionGO:0097602 cullin family protein binding IBA


Pathways (from Reactome)
Pathway description
Recognition of DNA damage by PCNA-containing replication complex
Prolactin receptor signaling
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Degradation of beta-catenin by the destruction complex
Degradation of DVL
Degradation of GLI1 by the proteasome
Hedgehog on state
Regulation of RAS by GAPs
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Orc1 removal from chromatin
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Regulation of RUNX2 expression and activity
Neddylation
Interleukin-1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000003151 skp1 / S-phase kinase-associated protein 1 / Skp1a* / P63208* / Q9WTX5* / AC104109.3* / S-phase kinase-associated protein 1A*  / complex / reaction
 ENSDARG00000019529 parp1 / poly (ADP-ribose) polymerase 1 / P09874* / poly (ADP-ribose) polymerase family, member 1*  / reaction / complex
 ENSDARG00000008697 epas1a / endothelial PAS domain protein 1a / EPAS1* / Q99814* / P97481* / endothelial PAS domain protein 1* / Endothelial PAS domain-containing protein 1 *  / reaction / complex
 ENSDARG00000034293 hif1ab / hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b / HIF1A* / Q61221* / Q16665* / Hypoxia-inducible factor 1-alpha * / hypoxia inducible fact...  / complex / reaction
 ENSDARG00000007989 nedd8 / neural precursor cell expressed, developmentally down-regulated 8 / P29595* / Q15843*  / complex / reaction
 ENSDARG00000005481 nfkbiaa / nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a / Q9Z1E3* / NFKBIA* / P25963* / NFKB inhibitor alpha* / NF-kappa-B inhibitor alpha *  / complex / reaction
 ENSDARG00000007693 nfkbiab / nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b / Q9Z1E3* / NFKBIA* / P25963* / NFKB inhibitor alpha* / NF-kappa-B inhibitor alpha *  / complex / reaction
 ENSDARG00000023002 dtl / Q5RHI5 / denticleless E3 ubiquitin protein ligase homolog (Drosophila) / Q9NZJ0* / Q3TLR7* / Denticleless protein homolog * / denticleless E3 ubiquitin protein ligase homolog*  / complex
 ENSDARG00000003938 rpa1 / Q6NY74 / replication protein A1 / Q8VEE4* / P27694* / Replication protein A 70 kDa DNA-binding subunit *  / complex / reaction
 ENSDARG00000038576 ube2d1b / ubiquitin-conjugating enzyme E2D 1b / UBE2D1* / P51668* / P61080* / ubiquitin conjugating enzyme E2 D1*  / reaction
 ENSDARG00000006181 hif1aa / hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) a / HIF1A* / Q61221* / Q16665* / Hypoxia-inducible factor 1-alpha * / hypoxia inducible fact...  / complex / reaction
 ENSDARG00000060510 cul4b / cullin 4B / A2A432* / Q13620*  / complex
 ENSDARG00000027689 pold1 / polymerase (DNA directed), delta 1, catalytic subunit / P28340* / P52431* / DNA polymerase delta 1, catalytic subunit*  / reaction / complex
 ENSDARG00000043484 ube2d2 / ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) / P62838* / P62837* / Ube2d2a* / ubiquitin conjugating enzyme E2 D2* / ubiquitin-conjugating enzyme E2D 2A*  / reaction
 ENSDARG00000037188 rpa2 / replication protein A2 / RPA4* / Q13156* / P15927* / replication protein A4*  / complex / reaction
 ENSDARG00000038967 cul3a / cullin 3a / CUL3* / Q13618* / Q9JLV5* / cullin 3*  / complex
 ENSDARG00000037980 elob / elongin B / Elobl* / P62869* / Q15370*  / complex
 ENSDARG00000062251 fbxl7 / A1A5X2 / F-box and leucine-rich repeat protein 7 / Q9UJT9* / Q5BJ29* / F-box/LRR-repeat protein 7 *  / reaction / complex
 ENSDARG00000057671 epas1b / endothelial PAS domain protein 1b / EPAS1* / Q99814* / P97481* / endothelial PAS domain protein 1* / Endothelial PAS domain-containing protein 1 *  / complex / reaction
 ENSDARG00000011493 dcun1d3 / defective in cullin neddylation 1 domain containing 3 / Q8IWE4* / Q8K0V2* / DCN1-like protein 3 *  / reaction / complex
 ENSDARG00000104808 jak2a / Janus kinase 2a / JAK2* / O60674* / Janus kinase 2*  / reaction / complex
 ENSDARG00000038996 egln1a / egl-9 family hypoxia-inducible factor 1a / EGLN1* / Q91YE3* / Q9GZT9* / Egl nine homolog 1 * / egl-9 family hypoxia inducible factor 1*  / complex
 ENSDARG00000004632 egln1b / egl-9 family hypoxia-inducible factor 1b / EGLN1* / Q91YE3* / Q9GZT9* / Egl nine homolog 1 * / egl-9 family hypoxia inducible factor 1*  / complex
 ENSDARG00000100826 hif1al / hypoxia-inducible factor 1, alpha subunit, like / HIF3A* / Q9Y2N7* / Q0VBL6* / Hypoxia-inducible factor 3-alpha * / hypoxia inducible factor 3 alpha subunit*  / reaction / complex
 ENSDARG00000038095 socs1a / suppressor of cytokine signaling 1a / SOCS1* / O35716* / O15524* / suppressor of cytokine signaling 1*  / complex
 ENSDARG00000039754 xpc / xeroderma pigmentosum, complementation group C / P51612* / Q01831* / XPC complex subunit, DNA damage recognition and repair factor*  / complex / reaction
 ENSDARG00000045359 elocb / elongin C paralog b / ELOC* / P83940* / Q15369* / elongin C*  / complex
 ENSDARG00000018882 jak2b / Janus kinase 2b / JAK2* / O60674* / Janus kinase 2*  / reaction / complex
 ENSDARG00000026611 socs3b / suppressor of cytokine signaling 3b / SOCS3* / O35718* / O14543* / suppressor of cytokine signaling 3*  / complex
 ENSDARG00000025428 socs3a / suppressor of cytokine signaling 3a / SOCS3* / O14543* / suppressor of cytokine signaling 3*  / complex
 ENSDARG00000096306 si:ch1073-342h5.2 / LRRC41* / Q15345* / Q8K1C9* / leucine rich repeat containing 41* / Leucine-rich repeat-containing protein 41 *  / complex
 ENSDARG00000041140 ddb2 / Q2YDS1 / damage-specific DNA binding protein 2 / Q92466* / Q99J79* / DNA damage-binding protein 2 *  / complex
 ENSDARG00000098696 rela / v-rel avian reticuloendotheliosis viral oncogene homolog A / Q04206* / RELA proto-oncogene, NF-kB subunit*  / complex / reaction
 ENSDARG00000101510 cetn2 / centrin, EF-hand protein, 2 / CETN1* / Q9R1K9* / P41209* / Q12798* / P41208* / centrin 2* / centrin 1*  / complex / reaction
 ENSDARG00000019239 cul1a / cullin 1a / CUL1* / Q13616* / Q9WTX6* / cullin 1* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*  / reaction / complex
 ENSDARG00000038030 rbx1 / ring-box 1, E3 ubiquitin protein ligase / P62878* / P62877* / ring-box 1* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / complex
 ENSDARG00000031203 commd1 / copper metabolism (Murr1) domain containing 1 / Q8K4M5* / Q8N668* / Gm28048* / COMM domain-containing protein 1 * / copper metabolism domain containing 1*  / complex / reaction
 ENSDARG00000038185 gh1 / growth hormone 1 / Gh* / GH2* / CSH2* / CSH1* / CSHL1* / P01242* / Q14406* / P0DML3* / P0DML2* / P01241* / P06880* / Somatotropin * / growth hormone 2* / chorionic somatomammotropin h...  / complex / reaction
 ENSDARG00000021550 rad23b / RAD23 homolog B, nucleotide excision repair protein / P54727*  / reaction / complex
 ENSDARG00000075612 ercc6 / excision repair cross-complementation group 6 / P0DP91* / Q03468* / Q8N328* / ERCC excision repair 6, chromatin remodeling factor*  / reaction / complex
 ENSDARG00000105261 nfkb1 / nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 / P25799* / P19838* / nuclear factor kappa B subunit 1* / Nuclear factor NF-kappa-B p105 subunit Nuclear factor ...  / reaction / complex
 ENSDARG00000054155 pcna / Q9PTP1 / proliferating cell nuclear antigen / P17918* / P12004* / Pcna-ps2*  / complex / reaction
 ENSDARG00000057624 cops5 / Q6PC30 / COP9 signalosome subunit 5 / O35864* / Q92905* / COP9 signalosome complex subunit 5 *  / reaction
 ENSDARG00000069742 cul5a / cullin 5a / CUL5* / Q93034* / cullin 5*  / complex
 ENSDARG00000040261 runx2a / runt-related transcription factor 2a / RUNX2* / Q08775* / Q13950* / runt related transcription factor 2*  / complex / reaction
 ENSDARG00000004937 skp2 / S-phase kinase-associated protein 2, E3 ubiquitin protein ligase / Q9Z0Z3* / Q13309* / S-phase kinase associated protein 2* / S-phase kinase-associated protein 2 (p45)*  / complex
 ENSDARG00000078001 kbtbd7 / kelch repeat and BTB (POZ) domain containing 7 / Q86V97* / KBTBD6* / Q8WVZ9* / uncharacterized protein LOC432879 * / kelch repeat and BTB domain containing 7* / kelch repeat and BT...  / complex
 ENSDARG00000004260 cul5b / cullin 5b / CUL5* / Q93034* / cullin 5*  / complex
 ENSDARG00000013965 cul2 / cullin 2 / Q13617* / Q9D4H8*  / complex
 ENSDARG00000079632 si:dkey-28b4.7 / POLD4* / Q9CWP8* / Q9HCU8* / AP003419.1* / polymerase (DNA-directed), delta 4* / DNA polymerase delta 4, accessory subunit*  / complex / reaction
 ENSDARG00000096578 cul4a / cullin 4A / Q13619* / Q3TCH7*  / complex
 ENSDARG00000100108 cul3b / cullin 3b / CUL3* / Q13618* / Q9JLV5* / cullin 3*  / complex
 ENSDARG00000100519 spop / Q7T330 / speckle-type POZ protein / Gm5773* / Gm9117* / Gm9125* / O43791* / P0DMR5* / P0DMR6* / Tdpoz5* / Gm4778* / Gm4858* / Gm5286* / Q6YCH2* / Q6ZWS8* / Q717B2* / Q717B4* / Tdpoz1...  / complex






 

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