ENSDARG00000039754


Danio rerio

Features
Gene ID: ENSDARG00000039754
  
Biological name :xpc
  
Synonyms : xeroderma pigmentosum, complementation group C / xpc
  
Possible biological names infered from orthology : P51612 / Q01831 / XPC complex subunit, DNA damage recognition and repair factor
  
Species: Danio rerio
  
Chr. number: 8
Strand: 1
Band:
Gene start: 26007308
Gene end: 26032245
  
Corresponding Affymetrix probe sets: Dr.19728.1.A1_at (Zebrafish Array)   Dr.4069.1.A1_at (Zebrafish Array)   NM_001045210_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000058099
Ensembl peptide - ENSDARP00000148614
Ensembl peptide - ENSDARP00000148705
NCBI entrez gene - 541386     See in Manteia.
RefSeq - NM_001045210
RefSeq Peptide - NP_001038675
swissprot - Q1LVE4
swissprot - Q5BLD2
ZFIN ID - ZDB-GENE-030131-8461
Ensembl - ENSDARG00000039754
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 XPCENSGALG00000006357Gallus gallus
 XPCENSG00000154767Homo sapiens
 XpcENSMUSG00000030094Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004583  DNA repair protein Rad4
 IPR018325  Rad4/PNGase transglutaminase-like fold
 IPR018326  Rad4 beta-hairpin domain 1
 IPR018327  Rad4 beta-hairpin domain 2
 IPR018328  Rad4 beta-hairpin domain 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006289 nucleotide-excision repair IEA
 biological_processGO:0006298 mismatch repair IBA
 cellular_componentGO:0000111 nucleotide-excision repair factor 2 complex IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0071942 XPC complex IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IBA


Pathways (from Reactome)
Pathway description
SUMOylation of DNA damage response and repair proteins
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000019529 parp1 / poly (ADP-ribose) polymerase 1 / P09874* / poly (ADP-ribose) polymerase family, member 1*  / complex / reaction
 ENSDARG00000028119 Q6NV25 / sumo3a / small ubiquitin-like modifier 3a / SUMO3* / Q9Z172* / P55854* / small ubiquitin-like modifier 3*  / complex
 ENSDARG00000035993 sumo3b / small ubiquitin-like modifier 3b / SUMO3* / P55854* / small ubiquitin-like modifier 3*  / complex
 ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *  / complex / reaction
 ENSDARG00000060510 cul4b / cullin 4B / A2A432* / Q13620*  / complex / reaction
 ENSDARG00000007438 ube2ib / Q9W6H5 / ubiquitin-conjugating enzyme E2Ib / UBE2I* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000101510 cetn2 / centrin, EF-hand protein, 2 / CETN1* / Q9R1K9* / P41209* / Q12798* / P41208* / centrin 2* / centrin 1*  / reaction / complex
 ENSDARG00000052649 Q9DDJ0 / ube2ia / ubiquitin-conjugating enzyme E2Ia / UBE2I* / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSDARG00000021550 rad23b / RAD23 homolog B, nucleotide excision repair protein / P54727*  / reaction / complex
 ENSDARG00000038030 rbx1 / ring-box 1, E3 ubiquitin protein ligase / P62878* / P62877* / ring-box 1* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / complex / reaction
 ENSDARG00000041140 ddb2 / Q2YDS1 / damage-specific DNA binding protein 2 / Q92466* / Q99J79* / DNA damage-binding protein 2 *  / complex / reaction
 ENSDARG00000096578 cul4a / cullin 4A / Q13619* / Q3TCH7*  / complex / reaction
 ENSDARG00000102741 sumo2b / Q6DHL4 / small ubiquitin-like modifier 2b / SUMO4* / SUMO2* / Q6EEV6* / P61956* / P61957* / small ubiquitin-like modifier 4* / small ubiquitin-like modifier 2*  / complex






 

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