ENSDARG00000105261


Danio rerio

Features
Gene ID: ENSDARG00000105261
  
Biological name :nfkb1
  
Synonyms : nfkb1 / nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
  
Possible biological names infered from orthology : nuclear factor kappa B subunit 1 / Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit / P19838 / P25799
  
Species: Danio rerio
  
Chr. number: 14
Strand: -1
Band:
Gene start: 49811926
Gene end: 49859823
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000131701
Ensembl peptide - ENSDARP00000135800
NCBI entrez gene - 565756     See in Manteia.
RefSeq - NM_001353873
RefSeq - XM_021481269
RefSeq Peptide - NP_001340802
swissprot - A0A0R4IN79
swissprot - A0A0R4ICP8
ZFIN ID - ZDB-GENE-121204-3
Ensembl - ENSDARG00000105261
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NFKB1ENSGALG00000012304Gallus gallus
 NFKB1ENSG00000109320Homo sapiens
 Nfkb1ENSMUSG00000028163Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nfkb2 / nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) / Q00653* / Q9WTK5* / nuclear factor kappa B subunit 2*ENSDARG0000003868744
rel / v-rel avian reticuloendotheliosis viral oncogene homolog / Q04864* / reticuloendotheliosis oncogene* / REL proto-oncogene, NF-kB subunit*ENSDARG0000005527626
rela / v-rel avian reticuloendotheliosis viral oncogene homolog A / Q04206* / RELA proto-oncogene, NF-kB subunit*ENSDARG0000009869626
relb / v-rel avian reticuloendotheliosis viral oncogene homolog B / Q04863* / Q01201* / RELB proto-oncogene, NF-kB subunit* / avian reticuloendotheliosis viral (v-rel) oncogene related B*ENSDARG0000008617324


Protein motifs (from Interpro)
Interpro ID Name
 IPR000451  NF-kappa-B/Dorsal
 IPR002909  IPT domain
 IPR008967  p53-like transcription factor, DNA-binding
 IPR011539  Rel homology domain (RHD), DNA-binding domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR030492  Rel homology domain, conserved site
 IPR030503  Nuclear factor NF-kappa-B, p105 subunit
 IPR032397  Rel homology dimerisation domain
 IPR033926  NFkappaB IPT domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
RIP-mediated NFkB activation via ZBP1
Regulated proteolysis of p75NTR
Downstream TCR signaling
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
PKMTs methylate histone lysines
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Interleukin-1 processing
CLEC7A (Dectin-1) signaling
CD209 (DC-SIGN) signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Neutrophil degranulation
Interleukin-1 signaling
TRAF6 mediated NF-kB activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000017037 ikbkg / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma / Q9Y6K9* / O88522* / NF-kappa-B essential modulator * / inhibitor of nuclear factor kappa B kinase subunit gamma*  / reaction
 ENSDARG00000003151 skp1 / S-phase kinase-associated protein 1 / Skp1a* / P63208* / Q9WTX5* / AC104109.3* / S-phase kinase-associated protein 1A*  / reaction / complex
 ENSDARG00000005481 nfkbiaa / nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a / Q9Z1E3* / NFKBIA* / P25963* / NFKB inhibitor alpha* / NF-kappa-B inhibitor alpha *  / complex
 ENSDARG00000007693 nfkbiab / nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b / Q9Z1E3* / NFKBIA* / P25963* / NFKB inhibitor alpha* / NF-kappa-B inhibitor alpha *  / complex
 ENSDARG00000030087 nfkbib / nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta / Q15653* / Q60778* / NFKB inhibitor beta* / NF-kappa-B inhibitor beta *  / complex
 ENSDARG00000028058 traf6 / Q6IWL4 / TNF receptor-associated factor 6 / P70196* / Q9Y4K3*  / complex / reaction
 ENSDARG00000061710 map3k8 / mitogen-activated protein kinase kinase kinase 8 / P41279* / Q07174*  / reaction / complex
 ENSDARG00000059125 prkacbb / protein kinase, cAMP-dependent, catalytic, beta b / P22694* / PRKACB* / protein kinase cAMP-activated catalytic subunit beta*  / reaction
 ENSDARG00000060551 rps6ka5 / ribosomal protein S6 kinase, polypeptide 5 / O75582* / Q8C050* / ribosomal protein S6 kinase A5*  / reaction
 ENSDARG00000055276 rel / v-rel avian reticuloendotheliosis viral oncogene homolog / Q04864* / reticuloendotheliosis oncogene* / REL proto-oncogene, NF-kB subunit*  / complex
 ENSDARG00000038030 rbx1 / ring-box 1, E3 ubiquitin protein ligase / P62878* / P62877* / ring-box 1* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / reaction / complex
 ENSDARG00000079123 ikbkb / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta / O14920* / inhibitor of kappaB kinase beta* / inhibitor of nuclear factor kappa B kinase subunit beta*  / reaction
 ENSDARG00000019239 cul1a / cullin 1a / CUL1* / Q13616* / Q9WTX6* / cullin 1* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*  / reaction / complex
 ENSDARG00000104609 crebbpa / CREB binding protein a / CREBBP* / Q92793* / CREB binding protein*  / reaction / complex
 ENSDARG00000098696 rela / v-rel avian reticuloendotheliosis viral oncogene homolog A / Q04206* / RELA proto-oncogene, NF-kB subunit*  / complex
 ENSDARG00000089223 ngfrb / nerve growth factor receptor b / NGFR* / P08138* / nerve growth factor receptor*  / complex / reaction
 ENSDARG00000105261 nfkb1 / nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 / P25799* / P19838* / nuclear factor kappa B subunit 1* / Nuclear factor NF-kappa-B p105 subunit Nuclear factor ...  / complex
 ENSDARG00000017230 fbxw11b / F-box and WD repeat domain containing 11b / Q9UKB1* / FBXW11* / Q5SRY7* / F-box/WD repeat-containing protein 11 * / F-box and WD repeat domain containing 11*  / complex / reaction
 ENSDARG00000112452 crebbpb / CREB binding protein b / CREBBP* / Q92793* / CREB binding protein*  / complex / reaction
 ENSDARG00000104806 fbxw11a / F-box and WD repeat domain containing 11a / FBXW11* / Q9UKB1* / F-box and WD repeat domain containing 11*  / complex / reaction
 ENSDARG00000074501 tnip2 / TNFAIP3 interacting protein 2 / Q8NFZ5* / Q99JG7*  / complex / reaction
 ENSDARG00000088708 ngfra / nerve growth factor receptor a (TNFR superfamily, member 16) / NGFR* / P08138* / nerve growth factor receptor*  / complex / reaction






 

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