ENSDARG00000055276


Danio rerio

Features
Gene ID: ENSDARG00000055276
  
Biological name :rel
  
Synonyms : rel / v-rel avian reticuloendotheliosis viral oncogene homolog
  
Possible biological names infered from orthology : Q04864 / REL proto-oncogene, NF-kB subunit / reticuloendotheliosis oncogene
  
Species: Danio rerio
  
Chr. number: 13
Strand: -1
Band:
Gene start: 25795511
Gene end: 25819825
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000072078
NCBI entrez gene - 415101     See in Manteia.
RefSeq - NM_001001841
RefSeq Peptide - NP_001001841
swissprot - Q6DGE6
ZFIN ID - ZDB-GENE-040718-255
Ensembl - ENSDARG00000055276
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RELENSGALG00000007845Gallus gallus
 RELENSG00000162924Homo sapiens
 RelENSMUSG00000020275Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rela / v-rel avian reticuloendotheliosis viral oncogene homolog A / Q04206* / RELA proto-oncogene, NF-kB subunit*ENSDARG0000009869632
nfkb2 / nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) / Q00653* / Q9WTK5* / nuclear factor kappa B subunit 2*ENSDARG0000003868727
relb / v-rel avian reticuloendotheliosis viral oncogene homolog B / Q04863* / Q01201* / RELB proto-oncogene, NF-kB subunit* / avian reticuloendotheliosis viral (v-rel) oncogene related B*ENSDARG0000008617326
nfkb1 / nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 / P25799* / P19838* / nuclear factor kappa B subunit 1* / Nuclear factor NF-kappa-B p105 subunit Nuclear factor ...ENSDARG0000010526124


Protein motifs (from Interpro)
Interpro ID Name
 IPR000451  NF-kappa-B/Dorsal
 IPR002909  IPT domain
 IPR008967  p53-like transcription factor, DNA-binding
 IPR011539  Rel homology domain (RHD), DNA-binding domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR030492  Rel homology domain, conserved site
 IPR032397  Rel homology dimerisation domain
 IPR033926  NFkappaB IPT domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0007420 brain development IMP
 biological_processGO:0034097 response to cytokine IBA
 biological_processGO:0038061 NIK/NF-kappaB signaling IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0033256 I-kappaB/NF-kappaB complex IBA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IBA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001114 head head morphology , abnormal
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 ZFA:0001115 trunk trunk morphology , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000017037 ikbkg / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma / Q9Y6K9* / O88522* / NF-kappa-B essential modulator * / inhibitor of nuclear factor kappa B kinase subunit gamma*  / reaction
 ENSDARG00000005481 nfkbiaa / nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a / Q9Z1E3* / NFKBIA* / P25963* / NFKB inhibitor alpha* / NF-kappa-B inhibitor alpha *  / complex
 ENSDARG00000007693 nfkbiab / nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b / Q9Z1E3* / NFKBIA* / P25963* / NFKB inhibitor alpha* / NF-kappa-B inhibitor alpha *  / complex
 ENSDARG00000030087 nfkbib / nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta / Q15653* / Q60778* / NFKB inhibitor beta* / NF-kappa-B inhibitor beta *  / complex
 ENSDARG00000017230 fbxw11b / F-box and WD repeat domain containing 11b / Q9UKB1* / FBXW11* / Q5SRY7* / F-box/WD repeat-containing protein 11 * / F-box and WD repeat domain containing 11*  / reaction / complex
 ENSDARG00000104806 fbxw11a / F-box and WD repeat domain containing 11a / FBXW11* / Q9UKB1* / F-box and WD repeat domain containing 11*  / complex / reaction
 ENSDARG00000003151 skp1 / S-phase kinase-associated protein 1 / Skp1a* / P63208* / Q9WTX5* / AC104109.3* / S-phase kinase-associated protein 1A*  / reaction / complex
 ENSDARG00000019239 cul1a / cullin 1a / CUL1* / Q13616* / Q9WTX6* / cullin 1* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*  / reaction / complex
 ENSDARG00000105261 nfkb1 / nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 / P25799* / P19838* / nuclear factor kappa B subunit 1* / Nuclear factor NF-kappa-B p105 subunit Nuclear factor ...  / complex
 ENSDARG00000079123 ikbkb / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta / O14920* / inhibitor of kappaB kinase beta* / inhibitor of nuclear factor kappa B kinase subunit beta*  / reaction






 

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