ENSDARG00000086173


Danio rerio

Features
Gene ID: ENSDARG00000086173
  
Biological name :relb
  
Synonyms : relb / v-rel avian reticuloendotheliosis viral oncogene homolog B
  
Possible biological names infered from orthology : avian reticuloendotheliosis viral (v-rel) oncogene related B / Q01201 / Q04863 / RELB proto-oncogene, NF-kB subunit
  
Species: Danio rerio
  
Chr. number: 15
Strand: 1
Band:
Gene start: 17100412
Gene end: 17125217
  
Corresponding Affymetrix probe sets: Dr.9524.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000128656
Ensembl peptide - ENSDARP00000107495
Ensembl peptide - ENSDARP00000157347
NCBI entrez gene - 795414     See in Manteia.
RefSeq - XM_021466348
RefSeq - XM_001335557
RefSeq - XM_021472925
swissprot - X1WEK5
swissprot - E7F394
ZFIN ID - ZDB-GENE-030131-9531
Ensembl - ENSDARG00000086173
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RELBENSG00000104856Homo sapiens
 RelbENSMUSG00000002983Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rel / v-rel avian reticuloendotheliosis viral oncogene homolog / Q04864* / reticuloendotheliosis oncogene* / REL proto-oncogene, NF-kB subunit*ENSDARG0000005527627
rela / v-rel avian reticuloendotheliosis viral oncogene homolog A / Q04206* / RELA proto-oncogene, NF-kB subunit*ENSDARG0000009869624
nfkb1 / nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 / P25799* / P19838* / nuclear factor kappa B subunit 1* / Nuclear factor NF-kappa-B p105 subunit Nuclear factor ...ENSDARG0000010526123
nfkb2 / nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) / Q00653* / Q9WTK5* / nuclear factor kappa B subunit 2*ENSDARG0000003868723


Protein motifs (from Interpro)
Interpro ID Name
 IPR000451  NF-kappa-B/Dorsal
 IPR002909  IPT domain
 IPR008967  p53-like transcription factor, DNA-binding
 IPR011539  Rel homology domain (RHD), DNA-binding domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR030492  Rel homology domain, conserved site
 IPR030496  Transcription factor RelB
 IPR032397  Rel homology dimerisation domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IBA
 biological_processGO:0034097 response to cytokine IBA
 biological_processGO:0038061 NIK/NF-kappaB signaling IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0033256 I-kappaB/NF-kappaB complex IBA
 cellular_componentGO:0071159 NF-kappaB complex IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IBA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA


Pathways (from Reactome)
Pathway description
Dectin-1 mediated noncanonical NF-kB signaling
CD209 (DC-SIGN) signaling
NIK-->noncanonical NF-kB signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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