ENSG00000104856


Homo sapiens

Features
Gene ID: ENSG00000104856
  
Biological name :RELB
  
Synonyms : Q01201 / RELB / RELB proto-oncogene, NF-kB subunit
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.32
Gene start: 45001430
Gene end: 45038198
  
Corresponding Affymetrix probe sets: 205205_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000423287
Ensembl peptide - ENSP00000485826
Ensembl peptide - ENSP00000468460
Ensembl peptide - ENSP00000427348
Ensembl peptide - ENSP00000221452
NCBI entrez gene - 5971     See in Manteia.
OMIM - 604758
RefSeq - XM_005259128
RefSeq - NM_006509
RefSeq - XM_005259127
RefSeq Peptide - NP_006500
swissprot - D6RIV7
swissprot - Q01201
swissprot - D6R992
swissprot - K7ERX9
Ensembl - ENSG00000104856
  
Related genetic diseases (OMIM): 617585 - ?Immunodeficiency 53, 617585

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 relbENSDARG00000086173Danio rerio
 RelbENSMUSG00000002983Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RELA / Q04206 / RELA proto-oncogene, NF-kB subunitENSG0000017303931
NFKB1 / P19838 / nuclear factor kappa B subunit 1ENSG0000010932030
REL / Q04864 / REL proto-oncogene, NF-kB subunitENSG0000016292430
NFKB2 / Q00653 / nuclear factor kappa B subunit 2ENSG0000007715027


Protein motifs (from Interpro)
Interpro ID Name
 IPR000451  NF-kappa-B/Dorsal
 IPR002909  IPT domain
 IPR008967  p53-like transcription factor, DNA-binding
 IPR011539  Rel homology domain (RHD), DNA-binding domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR030492  Rel homology domain, conserved site
 IPR030496  Transcription factor RelB
 IPR032397  Rel homology dimerisation domain
 IPR032399  RelB leucine zipper
 IPR032400  RelB transactivation domain
 IPR033926  NFkappaB IPT domain
 IPR037059  Rel homology domain (RHD), DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IBA
 biological_processGO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IBA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0019882 antigen processing and presentation IEA
 biological_processGO:0030098 lymphocyte differentiation IMP
 biological_processGO:0032688 negative regulation of interferon-beta production IMP
 biological_processGO:0032922 circadian regulation of gene expression ISS
 biological_processGO:0034097 response to cytokine IBA
 biological_processGO:0038061 NIK/NF-kappaB signaling IBA
 biological_processGO:0042088 T-helper 1 type immune response IEA
 biological_processGO:0043011 myeloid dendritic cell differentiation IEA
 biological_processGO:0045063 T-helper 1 cell differentiation IEA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0071470 cellular response to osmotic stress IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0033256 I-kappaB/NF-kappaB complex IBA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0001047 core promoter binding ISS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IBA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0003714 transcription corepressor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Dectin-1 mediated noncanonical NF-kB signaling
CD209 (DC-SIGN) signaling
NIK-->noncanonical NF-kB signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000077150 NFKB2 / Q00653 / nuclear factor kappa B subunit 2  / complex
 ENSG00000055130 CUL1 / Q13616 / cullin 1  / complex / reaction
 ENSG00000113558 SKP1 / P63208 / S-phase kinase associated protein 1  / reaction / complex
 ENSG00000006062 Q99558 / MAP3K14 / mitogen-activated protein kinase kinase kinase 14  / reaction / complex
 ENSG00000213341 CHUK / O15111 / conserved helix-loop-helix ubiquitous kinase  / reaction / complex
 ENSG00000072803 FBXW11 / Q9UKB1 / F-box and WD repeat domain containing 11  / complex / reaction
 ENSG00000173039 RELA / Q04206 / RELA proto-oncogene, NF-kB subunit  / complex / reaction
 ENSG00000166167 BTRC / Q9Y297 / beta-transducin repeat containing E3 ubiquitin protein ligase  / reaction / complex






 

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