ENSG00000072803


Homo sapiens

Features
Gene ID: ENSG00000072803
  
Biological name :FBXW11
  
Synonyms : F-box and WD repeat domain containing 11 / FBXW11 / Q9UKB1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q35.1
Gene start: 171861549
Gene end: 172006873
  
Corresponding Affymetrix probe sets: 209455_at (Human Genome U133 Plus 2.0 Array)   209456_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000428753
Ensembl peptide - ENSP00000427777
Ensembl peptide - ENSP00000429818
Ensembl peptide - ENSP00000431100
Ensembl peptide - ENSP00000430104
Ensembl peptide - ENSP00000265094
Ensembl peptide - ENSP00000296933
Ensembl peptide - ENSP00000377391
NCBI entrez gene - 23291     See in Manteia.
OMIM - 605651
RefSeq - XM_017009281
RefSeq - NM_033645
RefSeq - XM_005265855
RefSeq - XM_005265856
RefSeq - XM_005265857
RefSeq - XM_005265858
RefSeq - XM_017009279
RefSeq - XM_017009280
RefSeq - NM_012300
RefSeq - NM_033644
RefSeq Peptide - NP_387449
RefSeq Peptide - NP_036432
RefSeq Peptide - NP_387448
swissprot - E5RG78
swissprot - Q9UKB1
swissprot - E5RGC1
swissprot - E5RH92
Ensembl - ENSG00000072803
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fbxw11aENSDARG00000104806Danio rerio
 fbxw11bENSDARG00000017230Danio rerio
 FBXW11ENSGALG00000002229Gallus gallus
 Fbxw11ENSMUSG00000020271Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BTRC / Q9Y297 / beta-transducin repeat containing E3 ubiquitin protein ligaseENSG0000016616784
FBXW7 / Q969H0 / F-box and WD repeat domain containing 7ENSG0000010967026
Q9H2Y7 / ZNF106 / zinc finger protein 106ENSG0000010399421
TRAF7 / Q6Q0C0 / TNF receptor associated factor 7ENSG0000013165320
FBXW10 / Q5XX13 / F-box and WD repeat domain containing 10ENSG0000017193118
CDRT1 / O95170 / CMT1A duplicated region transcript 1ENSG0000024132217
FBXW2 / Q9UKT8 / F-box and WD repeat domain containing 2ENSG0000011940217
WDR86 / Q86TI4 / WD repeat domain 86ENSG0000018726015


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR001810  F-box domain
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR021977  D domain of beta-TrCP
 IPR036047  F-box-like domain superfamily
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle TAS
 biological_processGO:0000209 protein polyubiquitination IDA
 biological_processGO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
 biological_processGO:0006470 protein dephosphorylation ISS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016567 protein ubiquitination NAS
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0031648 protein destabilization IMP
 biological_processGO:0038061 NIK/NF-kappaB signaling TAS
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0042753 positive regulation of circadian rhythm ISS
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0045862 positive regulation of proteolysis IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0050852 T cell receptor signaling pathway TAS
 biological_processGO:0051403 stress-activated MAPK cascade TAS
 biological_processGO:0070498 interleukin-1-mediated signaling pathway TAS
 cellular_componentGO:0000151 ubiquitin ligase complex NAS
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Downstream TCR signaling
Regulation of PLK1 Activity at G2/M Transition
FCERI mediated NF-kB activation
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000077150 NFKB2 / Q00653 / nuclear factor kappa B subunit 2  / reaction / complex
 ENSG00000109320 NFKB1 / P19838 / nuclear factor kappa B subunit 1  / complex / reaction
 ENSG00000104856 RELB / Q01201 / RELB proto-oncogene, NF-kB subunit  / reaction / complex
 ENSG00000107968 MAP3K8 / P41279 / mitogen-activated protein kinase kinase kinase 8  / reaction / complex
 ENSG00000136122 BORA / Q6PGQ7 / bora, aurora kinase A activator  / reaction / complex
 ENSG00000173039 RELA / Q04206 / RELA proto-oncogene, NF-kB subunit  / reaction / complex
 ENSG00000162924 REL / Q04864 / REL proto-oncogene, NF-kB subunit  / reaction / complex
 ENSG00000055130 CUL1 / Q13616 / cullin 1  / complex
 ENSG00000104825 NFKBIB / Q15653 / NFKB inhibitor beta  / reaction / complex
 ENSG00000100906 NFKBIA / P25963 / NFKB inhibitor alpha  / reaction / complex
 ENSG00000146232 NFKBIE / O00221 / NFKB inhibitor epsilon  / reaction / complex
 ENSG00000113558 SKP1 / P63208 / S-phase kinase associated protein 1  / complex
 ENSG00000168884 TNIP2 / Q8NFZ5 / TNFAIP3 interacting protein 2  / reaction / complex
 ENSG00000006062 Q99558 / MAP3K14 / mitogen-activated protein kinase kinase kinase 14  / complex / reaction
 ENSG00000213341 CHUK / O15111 / conserved helix-loop-helix ubiquitous kinase  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr