ENSG00000119402


Homo sapiens

Features
Gene ID: ENSG00000119402
  
Biological name :FBXW2
  
Synonyms : F-box and WD repeat domain containing 2 / FBXW2 / Q9UKT8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: q33.2
Gene start: 120751978
Gene end: 120793412
  
Corresponding Affymetrix probe sets: 1560752_at (Human Genome U133 Plus 2.0 Array)   209630_s_at (Human Genome U133 Plus 2.0 Array)   218941_at (Human Genome U133 Plus 2.0 Array)   235195_at (Human Genome U133 Plus 2.0 Array)   241736_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000398662
Ensembl peptide - ENSP00000476369
NCBI entrez gene - 26190     See in Manteia.
OMIM - 609071
RefSeq - XM_017014617
RefSeq - NM_012164
RefSeq - XM_011518518
RefSeq - XM_017014615
RefSeq - XM_017014616
RefSeq - XM_005251910
RefSeq - XM_005251913
RefSeq - XM_006717049
RefSeq - XM_006717051
RefSeq Peptide - NP_036296
swissprot - Q4VXH1
swissprot - Q9UKT8
Ensembl - ENSG00000119402
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fbxw2ENSDARG00000009745Danio rerio
 FBXW2ENSGALG00000000864Gallus gallus
 Fbxw2ENSMUSG00000035949Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FBXW10 / Q5XX13 / F-box and WD repeat domain containing 10ENSG0000017193124
CDRT1 / O95170 / CMT1A duplicated region transcript 1ENSG0000024132222
FBXW7 / Q969H0 / F-box and WD repeat domain containing 7ENSG0000010967021
BTRC / Q9Y297 / beta-transducin repeat containing E3 ubiquitin protein ligaseENSG0000016616720
FBXW11 / Q9UKB1 / F-box and WD repeat domain containing 11ENSG0000007280320
Q9H2Y7 / ZNF106 / zinc finger protein 106ENSG0000010399418
WDR86 / Q86TI4 / WD repeat domain 86ENSG0000018726017
TRAF7 / Q6Q0C0 / TNF receptor associated factor 7ENSG0000013165317


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR001810  F-box domain
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR036047  F-box-like domain superfamily
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination TAS
 biological_processGO:0006464 cellular protein modification process TAS
 biological_processGO:0006508 proteolysis TAS
 biological_processGO:0043687 post-translational protein modification TAS
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0004842 ubiquitin-protein transferase activity EXP
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Association of TriC/CCT with target proteins during biosynthesis
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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