ENSG00000109670


Homo sapiens

Features
Gene ID: ENSG00000109670
  
Biological name :FBXW7
  
Synonyms : F-box and WD repeat domain containing 7 / FBXW7 / Q969H0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q31.3
Gene start: 152320544
Gene end: 152536063
  
Corresponding Affymetrix probe sets: 218751_s_at (Human Genome U133 Plus 2.0 Array)   222729_at (Human Genome U133 Plus 2.0 Array)   229419_at (Human Genome U133 Plus 2.0 Array)   239494_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000495753
Ensembl peptide - ENSP00000495702
Ensembl peptide - ENSP00000495905
Ensembl peptide - ENSP00000263981
Ensembl peptide - ENSP00000281708
Ensembl peptide - ENSP00000296555
Ensembl peptide - ENSP00000377528
Ensembl peptide - ENSP00000474538
Ensembl peptide - ENSP00000474725
Ensembl peptide - ENSP00000474751
Ensembl peptide - ENSP00000474971
NCBI entrez gene - 55294     See in Manteia.
OMIM - 606278
RefSeq - XM_017008362
RefSeq - NM_001257069
RefSeq - NM_001349798
RefSeq - NM_018315
RefSeq - NM_033632
RefSeq - XM_011532083
RefSeq - XM_011532084
RefSeq - XM_011532085
RefSeq - XM_011532086
RefSeq - XM_011532087
RefSeq - XM_011532088
RefSeq - NM_001013415
RefSeq Peptide - NP_361014
RefSeq Peptide - NP_001013433
RefSeq Peptide - NP_001243998
RefSeq Peptide - NP_001336727
RefSeq Peptide - NP_060785
swissprot - B7Z2C8
swissprot - Q969H0
swissprot - S4R3N3
swissprot - S4R3U4
swissprot - G0Z2K0
Ensembl - ENSG00000109670
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fbxw7ENSDARG00000060994Danio rerio
 FBXW7ENSGALG00000010103Gallus gallus
 Fbxw7ENSMUSG00000028086Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9H2Y7 / ZNF106 / zinc finger protein 106ENSG0000010399423
BTRC / Q9Y297 / beta-transducin repeat containing E3 ubiquitin protein ligaseENSG0000016616721
FBXW11 / Q9UKB1 / F-box and WD repeat domain containing 11ENSG0000007280320
TRAF7 / Q6Q0C0 / TNF receptor associated factor 7ENSG0000013165317
FBXW10 / Q5XX13 / F-box and WD repeat domain containing 10ENSG0000017193116
FBXW2 / Q9UKT8 / F-box and WD repeat domain containing 2ENSG0000011940214
CDRT1 / O95170 / CMT1A duplicated region transcript 1ENSG0000024132214
WDR86 / Q86TI4 / WD repeat domain 86ENSG0000018726012


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR001810  F-box domain
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR036047  F-box-like domain superfamily
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination TAS
 biological_processGO:0001944 vasculature development TAS
 biological_processGO:0007062 sister chromatid cohesion IMP
 biological_processGO:0010868 negative regulation of triglyceride biosynthetic process ISS
 biological_processGO:0010883 regulation of lipid storage ISS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016567 protein ubiquitination IDA
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0031398 positive regulation of protein ubiquitination IDA
 biological_processGO:0032876 negative regulation of DNA endoreduplication IMP
 biological_processGO:0032880 regulation of protein localization ISS
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0045741 positive regulation of epidermal growth factor-activated receptor activity IDA
 biological_processGO:0045746 negative regulation of Notch signaling pathway ISS
 biological_processGO:0050821 protein stabilization IDA
 biological_processGO:0051443 positive regulation of ubiquitin-protein transferase activity IDA
 biological_processGO:0055088 lipid homeostasis ISS
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:1901800 positive regulation of proteasomal protein catabolic process IDA
 biological_processGO:1902806 regulation of cell cycle G1/S phase transition TAS
 biological_processGO:1903146 regulation of autophagy of mitochondrion IMP
 biological_processGO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IDA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IMP
 biological_processGO:2000060 positive regulation of ubiquitin-dependent protein catabolic process IDA
 biological_processGO:2000346 negative regulation of hepatocyte proliferation ISS
 biological_processGO:2000639 negative regulation of SREBP signaling pathway ISS
 biological_processGO:2001205 negative regulation of osteoclast development IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IDA
 cellular_componentGO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex IPI
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030332 cyclin binding IPI
 molecular_functionGO:0030674 protein binding, bridging IDA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0050816 phosphothreonine residue binding IDA
 molecular_functionGO:0097027 ubiquitin-protein transferase activator activity IDA


Pathways (from Reactome)
Pathway description
Association of TriC/CCT with target proteins during biosynthesis
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000082701 GSK3B / P49841 / glycogen synthase kinase 3 beta  / reaction / complex
 ENSG00000055130 CUL1 / Q13616 / cullin 1  / complex
 ENSG00000148400 NOTCH1 / P46531  / complex / reaction
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / complex
 ENSG00000113558 SKP1 / P63208 / S-phase kinase associated protein 1  / complex
 ENSG00000124813 RUNX2 / Q13950 / runt related transcription factor 2  / complex / reaction






 

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