ENSDARG00000060994


Danio rerio

Features
Gene ID: ENSDARG00000060994
  
Biological name :fbxw7
  
Synonyms : F-box and WD repeat domain containing 7 / fbxw7
  
Possible biological names infered from orthology : F-box/WD repeat-containing protein 7 / Q8VBV4 / Q969H0
  
Species: Danio rerio
  
Chr. number: 1
Strand: -1
Band:
Gene start: 24870661
Gene end: 25144439
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000112746
Ensembl peptide - ENSDARP00000121723
NCBI entrez gene - 564991     See in Manteia.
swissprot - B7ZDC8
swissprot - B8A474
ZFIN ID - ZDB-GENE-090313-79
Ensembl - ENSDARG00000060994
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FBXW7ENSGALG00000010103Gallus gallus
 FBXW7ENSG00000109670Homo sapiens
 Fbxw7ENSMUSG00000028086Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
fbxw11a / F-box and WD repeat domain containing 11a / FBXW11* / Q9UKB1* / F-box and WD repeat domain containing 11*ENSDARG0000010480626
fbxw11b / F-box and WD repeat domain containing 11b / Q9UKB1* / FBXW11* / Q5SRY7* / F-box/WD repeat-containing protein 11 * / F-box and WD repeat domain containing 11*ENSDARG0000001723025
znf106a / zinc finger protein 106a / Q9H2Y7* / Zfp106* / ZNF106* / zinc finger protein 106*ENSDARG0000001665119
traf7 / TNF receptor-associated factor 7 / Q6Q0C0*ENSDARG0000006020719
fbxw2 / F-box and WD repeat domain containing 2 / Q9UKT8*ENSDARG0000000974518
fbxw10 / F-box and WD repeat domain containing 10 / CDRT1* / Q5XX13* / O95170* / Q5SUS0* / CMT1A duplicated region transcript 1* / F-box/WD repeat-containing protein 10 *ENSDARG0000008648414
znf106b / zinc finger protein 106bENSDARG0000009194712


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR001810  F-box domain
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0031641 regulation of myelination IGI
 biological_processGO:0031642 negative regulation of myelination IMP
 biological_processGO:0032006 regulation of TOR signaling IGI
 biological_processGO:0045746 negative regulation of Notch signaling pathway IMP


Pathways (from Reactome)
Pathway description
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000075 spinal cord spinal cord dorsal region has extra parts of type glioblast (sensu Vertebrata) , abnormal
spinal cord has number of oligodendrocyte , ameliorated
spinal cord has extra parts of type oligodendrocyte , abnormal
spinal cord medial region mislocalised , abnormal
spinal cord central nervous system myelination increased occurrence , abnormal
spinal cord oligodendrocyte increased amount , abnormal
spinal cord myelin sheath increased amount , abnormal
spinal cord myelin sheath increased thickness , abnormal
spinal cord oligodendrocyte amount , ameliorated
spinal cord oligodendrocyte decreased amount , abnormal
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 ZFA:0001094 whole organism whole organism lacks all parts of type dorsal longitudinal anastomotic vessel , abnormal
whole organism viability , abnormal
whole organism amount , ameliorated
whole organism increased amount , abnormal
whole organism cholesterol biosynthetic process increased occurrence , abnormal
whole organism decreased amount , abnormal
whole organism TOR signaling increased occurrence , abnormal
whole organism TOR signaling decreased occurrence , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel morphology , abnormal
intersegmental vessel decreased length , abnormal
intersegmental vessel endothelial cell decreased amount , abnormal
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 ZFA:0009076 oligodendrocyte oligodendrocyte increased amount , abnormal
oligodendrocyte mislocalised medially , abnormal
oligodendrocyte TOR signaling increased occurrence , abnormal
oligodendrocyte TOR signaling decreased occurrence , abnormal
Show

 ZFA:0009168 neuroblast (sensu Vertebrata) neuroblast (sensu Vertebrata) increased amount , abnormal
Show

 ZFA:0009169 glioblast (sensu Vertebrata) glioblast (sensu Vertebrata) increased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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