ENSMUSG00000028086


Mus musculus

Features
Gene ID: ENSMUSG00000028086
  
Biological name :Fbxw7
  
Synonyms : F-box/WD repeat-containing protein 7 / Fbxw7 / Q8VBV4
  
Possible biological names infered from orthology : F-box and WD repeat domain containing 7 / Q969H0
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F1
Gene start: 84815268
Gene end: 84979198
  
Corresponding Affymetrix probe sets: 10492826 (MoGene1.0st)   1424986_s_at (Mouse Genome 430 2.0 Array)   1451558_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000103306
Ensembl peptide - ENSMUSP00000029727
Ensembl peptide - ENSMUSP00000103302
Ensembl peptide - ENSMUSP00000103305
NCBI entrez gene - 50754     See in Manteia.
MGI - MGI:1354695
RefSeq - XM_006501658
RefSeq - NM_001177773
RefSeq - NM_001177774
RefSeq - NM_080428
RefSeq - XM_006501656
RefSeq - XM_006501657
RefSeq Peptide - NP_001171245
RefSeq Peptide - NP_536353
RefSeq Peptide - NP_001171244
swissprot - D3YUA8
swissprot - Q8VBV4
swissprot - D3YUA5
Ensembl - ENSMUSG00000028086
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fbxw7ENSDARG00000060994Danio rerio
 FBXW7ENSGALG00000010103Gallus gallus
 FBXW7ENSG00000109670Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Zfp106 / zinc finger protein 106 / Q9H2Y7* / ZNF106*ENSMUSG0000002728822
Btrc / Q3ULA2 / F-box/WD repeat-containing protein 1A / Q9Y297* / beta-transducin repeat containing E3 ubiquitin protein ligase*ENSMUSG0000002521721
Fbxw11 / Q5SRY7 / F-box/WD repeat-containing protein 11 / Q9UKB1* / F-box and WD repeat domain containing 11*ENSMUSG0000002027120
Traf7 / TNF receptor-associated factor 7 / Q6Q0C0*ENSMUSG0000005275216
Q5SUS0 / Fbxw10 / F-box/WD repeat-containing protein 10 / CDRT1* / O95170* / Q5XX13* / CMT1A duplicated region transcript 1* / F-box and WD repeat domain containing 10*ENSMUSG0000009017316
Wdr86 / WD repeat domain 86 / Q86TI4*ENSMUSG0000005523514
Fbxw2 / F-box and WD repeat domain containing 2 / Q9UKT8*ENSMUSG0000003594913


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR001810  F-box domain
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR036047  F-box-like domain superfamily
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISS
 biological_processGO:0007062 sister chromatid cohesion ISS
 biological_processGO:0007219 Notch signaling pathway IDA
 biological_processGO:0016567 protein ubiquitination ISO
 biological_processGO:0030324 lung development IMP
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
 biological_processGO:0031398 positive regulation of protein ubiquitination ISS
 biological_processGO:0031648 protein destabilization IDA
 biological_processGO:0032876 negative regulation of DNA endoreduplication ISS
 biological_processGO:0034644 cellular response to UV ISS
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process ISO
 biological_processGO:0045741 positive regulation of epidermal growth factor-activated receptor activity ISS
 biological_processGO:0050821 protein stabilization ISS
 biological_processGO:0051443 positive regulation of ubiquitin-protein transferase activity ISS
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade ISS
 biological_processGO:0090049 regulation of cell migration involved in sprouting angiogenesis IMP
 biological_processGO:1901800 positive regulation of proteasomal protein catabolic process IMP
 biological_processGO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding IDA
 biological_processGO:1903146 regulation of autophagy of mitochondrion ISO
 biological_processGO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IMP
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion ISO
 biological_processGO:2000060 positive regulation of ubiquitin-dependent protein catabolic process ISS
 biological_processGO:2001205 negative regulation of osteoclast development IMP
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0016021 integral component of membrane NAS
 cellular_componentGO:0019005 SCF ubiquitin ligase complex ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex ISO
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030332 cyclin binding ISS
 molecular_functionGO:0030674 protein binding, bridging ISS
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISS
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0050816 phosphothreonine residue binding ISO
 molecular_functionGO:0061630 ubiquitin protein ligase activity TAS
 molecular_functionGO:0097027 ubiquitin-protein transferase activator activity ISS


Pathways (from Reactome)
Pathway description
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Adora1tm1Bbf/Adora1tm1Bbf
Genetic Background: B6.129P2-Adora1tm1Bbf

Allelic Composition: Fbxw7tm1.1Iken/Fbxw7+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
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Allelic Composition: Sim1tm1Fan/Sim1+,Sim2tm1Fan/Sim2+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Fbxw7tm1.1Kei/Fbxw7tm1.1Kei
Genetic Background: involves: C57BL/6

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Uchl1gad/Uchl1gad
Genetic Background: Not Specified

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Fbxw7tm1Iaai/Fbxw7tm1Iaai,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
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Allelic Composition: Fbxw7tm1.1Kei/Fbxw7tm1.1Kei
Genetic Background: involves: C57BL/6

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Tyrc/Tyrc-26DVT
Genetic Background: involves: 101/Rl * C3H/Rl * T-stock

Allelic Composition: Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe,Juntm4Wag/Juntm4Wag,Tg(En2-cre)22Alj/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe,Juntm2.1Wag/Juntm4Wag,Tg(En2-cre)22Alj/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0000857 abnormal cerebellar foliation "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]
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Allelic Composition: Tyrc/Tyrc-26DVT
Genetic Background: involves: 101/Rl * C3H/Rl * T-stock

 MP:0000866 vermis hypoplasia "reduced cell number in the vermis" [J:61509]
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Allelic Composition: Tyrc/Tyrc-26DVT
Genetic Background: involves: 101/Rl * C3H/Rl * T-stock

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Tyrc/Tyrc-26DVT
Genetic Background: involves: 101/Rl * C3H/Rl * T-stock

Allelic Composition: Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe,Juntm4Wag/Juntm4Wag,Tg(En2-cre)22Alj/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe,Juntm2.1Wag/Juntm4Wag,Tg(En2-cre)22Alj/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0000880 decreased Purkinje cell number "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Tyrc/Tyrc-26DVT
Genetic Background: involves: 101/Rl * C3H/Rl * T-stock

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Uchl1gad/Uchl1gad
Genetic Background: Not Specified

Allelic Composition: Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Uchl1gad/Uchl1gad
Genetic Background: Not Specified

 MP:0001179 thicker alveolar septa 
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Allelic Composition: Fbxw7tm1.1Iken/Fbxw7+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Adora1tm1Bbf/Adora1tm1Bbf
Genetic Background: B6.129P2-Adora1tm1Bbf

Allelic Composition: Fbxw7tm1.1Iken/Fbxw7+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001586 abnormal erythrocyte count "altered number of red blood cells per volume in the bloodstream" [J:53370]
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Allelic Composition: Uchl1gad/Uchl1gad
Genetic Background: Not Specified

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Uchl1gad/Uchl1gad
Genetic Background: Not Specified

 MP:0001622 abnormal vasculogenesis "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sim1tm1Fan/Sim1+,Sim2tm1Fan/Sim2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sim1tm1Fan/Sim1+,Sim2tm1Fan/Sim2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Uchl1gad/Uchl1gad
Genetic Background: Not Specified

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Uchl1gad/Uchl1gad
Genetic Background: Not Specified

 MP:0001723 disorganized vascular plexus 
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Allelic Composition: Uchl1gad/Uchl1gad
Genetic Background: Not Specified

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: Sim1tm1Fan/Sim1+,Sim2tm1Fan/Sim2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Fbxw7tm1Iaai/Fbxw7tm1Iaai,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fbxw7tm1.1Kei/Fbxw7tm1.1Kei
Genetic Background: involves: C57BL/6

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Fbxw7tm1.1Kei/Fbxw7tm1.1Kei
Genetic Background: involves: C57BL/6

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sim1tm1Fan/Sim1+,Sim2tm1Fan/Sim2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Fbxw7tm1.1Iken/Fbxw7+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fbxw7tm1Kei/Fbxw7tm1Kei,Trp53tm1Tyj/Trp53tm1Tyj,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Fbxw7tm1Iaai/Fbxw7tm1Iaai,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Otx1tm1Sia/Otx1tm1Sia,Otx2tm8.2Sia/Otx2tm8.2Sia
Genetic Background: involves: C57BL/6 * CBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fbxw7tm1.1Kei/Fbxw7tm1.1Kei
Genetic Background: involves: C57BL/6

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fbxw7tm1.1Iken/Fbxw7+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fbxw7tm1Iaai/Fbxw7tm1Iaai,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Fbxw7tm1Iaai/Fbxw7tm1Iaai,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tlr4lps-Btlr/Tlr4lps-Btlr
Genetic Background: C57BL/6J-Tlr4lps-Btlr

 MP:0003202 abnormal neuron apoptosis "change in the timing or the number of neurons undergoing programmed cell death" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0003253 bile duct dilation "abnormal distention of the bile ducts due to accumulation of fluid or bile" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Fbxw7tm1.1Iken/Fbxw7+
Genetic Background: involves: C57BL/6 * C57BL/6N

Allelic Composition: Fbxw7tm1Iken/Fbxw7+,Krastm4Tyj/Kras+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sim1tm1Fan/Sim1+,Sim2tm1Fan/Sim2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
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Allelic Composition: Sim1tm1Fan/Sim1+,Sim2tm1Fan/Sim2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sim1tm1Fan/Sim1+,Sim2tm1Fan/Sim2+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Fbxw7tm1Sje/Fbxw7tm1Sje
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sim1tm1Fan/Sim1+,Sim2tm1Fan/Sim2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004274 abnormal embryonic/fetal subventricular zone morphology "any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fbxw7tm1Iaai/Fbxw7tm1Iaai,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Fbxw7tm1Iaai/Fbxw7tm1Iaai,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0004839 bile duct hyperplasia "overdevelopment or increased size of the bile ducts, usually due to an increase in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fbxw7tm1.1Iken/Fbxw7+
Genetic Background: involves: C57BL/6 * C57BL/6N

Allelic Composition: Fbxw7tm1Iken/Fbxw7+,Krastm4Tyj/Kras+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sim1tm1Fan/Sim1+,Sim2tm1Fan/Sim2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004981 decreased neuronal precursor cell number "reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Fbxw7tm1Iaai/Fbxw7tm1Iaai,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Fbxw7tm1.1Kei/Fbxw7tm1.1Kei
Genetic Background: involves: C57BL/6

Allelic Composition: Fbxw7tm1Kei/Fbxw7tm1Kei,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Fbxw7tm1Kei/Fbxw7tm1Kei,Rbpjtm1Hon/Rbpjtm1Hon,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Sim1tm1Fan/Sim1+,Sim2tm1Fan/Sim2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0006027 impaired alveologenesis "a block or reduction in the generation of alveoli" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]
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Allelic Composition: Adora1tm1Bbf/Adora1tm1Bbf
Genetic Background: B6.129P2-Adora1tm1Bbf

 MP:0006104 abnormal tectum morphology "any structural alterations or malfunction of the rostral part of the midbrain roof" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator, J:65762]
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Allelic Composition: Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe,Juntm4Wag/Jun+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fbxw7tm1.1Kei/Fbxw7tm1.1Kei
Genetic Background: involves: C57BL/6

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fbxw7tm1.1Kei/Fbxw7tm1.1Kei
Genetic Background: involves: C57BL/6

 MP:0008439 abnormal cortical plate morphology "any strucutral anomaly of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236]
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Allelic Composition: Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0008457 abnormal cortical intermediate zone morphology "any structural anomaly of the region of the developing mammalian cortex that extends between the ventricular zone and the cortical plate (CP); normally, the IZ is a region of tangential migration of cells, and at midgestation, the lower part of the IZ develops into the subventricular zone" [PMID:10632599]
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Allelic Composition: Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0009267 abnormal cerebellum fissure morphology "any structural anomaly of the deep furrows which divide the lobules of the cerebellum, including the postcentral, primary and secondary furrows" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tyrc/Tyrc-26DVT
Genetic Background: involves: 101/Rl * C3H/Rl * T-stock

Allelic Composition: Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe,Juntm4Wag/Juntm4Wag,Tg(En2-cre)22Alj/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe,Notch1tm1Agt/Notch1+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

Allelic Composition: Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe,Tg(En2-cre)22Alj/0
Genetic Background: Not Specified

 MP:0010308 decreased tumor latency "earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fbxw7tm1Iaai/Fbxw7tm1Iaai,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0010315 increased cholangiocarcinoma incidence "greater than the expected number of malignant adenocarcimomas arising in the intrahepatic bile duct epithelium, in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fbxw7tm1Iken/Fbxw7+,Krastm4Tyj/Kras+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA

 MP:0010763 abnormal hematopoietic stem cell physiology "any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fbxw7tm1Iaai/Fbxw7tm1Iaai,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0010903 abnormal pulmonary alveolus wall morphology 
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Allelic Composition: Adora1tm1Bbf/Adora1tm1Bbf
Genetic Background: B6.129P2-Adora1tm1Bbf

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Adora1tm1Bbf/Adora1tm1Bbf
Genetic Background: B6.129P2-Adora1tm1Bbf

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Fbxw7tm1.1Iken/Fbxw7+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Fbxw7tm1.1Kei/Fbxw7tm1.1Kei
Genetic Background: involves: C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Tyrc/Tyrc-26DVT
Genetic Background: involves: 101/Rl * C3H/Rl * T-stock

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Sim1tm1Fan/Sim1+,Sim2tm1Fan/Sim2+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Fbxw7tm1Sje/Fbxw7tm1Sje
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011400 complete lethality "all individuals of a given genotype in a population die before the end of the normal lifespan but time(s) of death are unspecified" [MGI:llw2]
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Allelic Composition: Rag2m1Btlr/Rag2m1Btlr
Genetic Background: C57BL/6J-Rag2m1Btlr

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Fbxw7tm1.1Kei/Fbxw7tm1.1Kei
Genetic Background: involves: C57BL/6

Allelic Composition: Fbxw7tm1Kei/Fbxw7tm1Kei,Trp53tm1Tyj/Trp53tm1Tyj,Tg(Lck-cre)1Cwi/?
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0012728 abnormal somite border morphology "any structural anomaly of the anatomical surface separating somites; somite formation requires the physical separation of somitic tissue from the initially continuous presomitic mesoderm (PSM), coalescence of cells in the forming somite, and the establishment of a stable border between the somite and the PSM; when a somite forms in the anterior end of the PSM, an intersomitic boundary (also called a fissure, gap, or cleft) emerges, and it is rapidly followed by a mesenchymal-to-epithelial transition of cells that face a forming gap" [MGI:anna]
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Allelic Composition: Sim1tm1Fan/Sim1+,Sim2tm1Fan/Sim2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0020528 thalamus hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the thalamus" [MGI:smb]
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Allelic Composition: Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022812 Gsk3b / Q9WV60 / glycogen synthase kinase 3 beta / P49841*  / complex / reaction
 ENSMUSG00000039153 Runx2 / Q08775 / runt related transcription factor 2 / Q13950*  / reaction / complex
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / complex
 ENSMUSG00000036309 Skp1a / Q9WTX5 / S-phase kinase-associated protein 1A / SKP1* / P63208* / AC104109.3* / S-phase kinase associated protein 1*  / complex
 ENSMUSG00000029686 Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*  / complex






 

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