ENSMUSG00000020271


Mus musculus

Features
Gene ID: ENSMUSG00000020271
  
Biological name :Fbxw11
  
Synonyms : F-box/WD repeat-containing protein 11 / Fbxw11 / Q5SRY7
  
Possible biological names infered from orthology : F-box and WD repeat domain containing 11 / Q9UKB1
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: A4
Gene start: 32642724
Gene end: 32746816
  
Corresponding Affymetrix probe sets: 10375103 (MoGene1.0st)   1425461_at (Mouse Genome 430 2.0 Array)   1425462_at (Mouse Genome 430 2.0 Array)   1437468_x_at (Mouse Genome 430 2.0 Array)   1438336_at (Mouse Genome 430 2.0 Array)   1447294_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000075721
Ensembl peptide - ENSMUSP00000090893
Ensembl peptide - ENSMUSP00000104991
Ensembl peptide - ENSMUSP00000116834
NCBI entrez gene - 103583     See in Manteia.
MGI - MGI:2144023
RefSeq - XM_006514436
RefSeq - NM_001271347
RefSeq - NM_001271348
RefSeq - NM_001271349
RefSeq - NM_134015
RefSeq - XM_006514433
RefSeq - XM_006514434
RefSeq - XM_006514435
RefSeq Peptide - NP_598776
RefSeq Peptide - NP_001258276
RefSeq Peptide - NP_001258277
RefSeq Peptide - NP_001258278
swissprot - Q5SRY7
swissprot - F7BGU3
Ensembl - ENSMUSG00000020271
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fbxw11aENSDARG00000104806Danio rerio
 fbxw11bENSDARG00000017230Danio rerio
 FBXW11ENSGALG00000002229Gallus gallus
 FBXW11ENSG00000072803Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Btrc / Q3ULA2 / F-box/WD repeat-containing protein 1A / Q9Y297* / beta-transducin repeat containing E3 ubiquitin protein ligase*ENSMUSG0000002521783
Fbxw7 / Q8VBV4 / F-box/WD repeat-containing protein 7 / Q969H0* / F-box and WD repeat domain containing 7*ENSMUSG0000002808626
Zfp106 / zinc finger protein 106 / Q9H2Y7* / ZNF106*ENSMUSG0000002728822
Traf7 / TNF receptor-associated factor 7 / Q6Q0C0*ENSMUSG0000005275220
Q5SUS0 / Fbxw10 / F-box/WD repeat-containing protein 10 / CDRT1* / O95170* / Q5XX13* / CMT1A duplicated region transcript 1* / F-box and WD repeat domain containing 10*ENSMUSG0000009017318
Wdr86 / WD repeat domain 86 / Q86TI4*ENSMUSG0000005523516
Fbxw2 / F-box and WD repeat domain containing 2 / Q9UKT8*ENSMUSG0000003594916


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR001810  F-box domain
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR021977  D domain of beta-TrCP
 IPR036047  F-box-like domain superfamily
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IEA
 biological_processGO:0006470 protein dephosphorylation IDA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0042752 regulation of circadian rhythm ISS
 biological_processGO:0042753 positive regulation of circadian rhythm IMP
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0045862 positive regulation of proteolysis IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0048511 rhythmic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IDA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
Downstream TCR signaling
Regulation of PLK1 Activity at G2/M Transition
FCERI mediated NF-kB activation
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000479 abnormal intestinal cell "anomalous structure or development of the cells comprising the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Setd1atm1.2Afst/Setd1atm1.2Afst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Btrctm1Paga/Btrc+,Fbxw11tm1Ybn/Fbxw11tm1Ybn,Tg(Vil-cre/ERT2)23Syr/?
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Btrctm1Paga/Btrc+,Fbxw11tm1Ybn/Fbxw11tm1Ybn,Tg(Vil-cre/ERT2)23Syr/?
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Setd1atm1.2Afst/Setd1atm1.2Afst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0000511 abnormal intestinal mucosa morphology "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Setd1atm1.2Afst/Setd1atm1.2Afst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Btrctm1Paga/Btrc+,Fbxw11tm1Ybn/Fbxw11tm1Ybn,Tg(Vil-cre/ERT2)23Syr/?
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0001858 intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Setd1atm1.2Afst/Setd1atm1.2Afst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Setd1atm1.2Afst/Setd1atm1.2Afst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0003293 rectal hemorrhage "bleeding in the rectum" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Setd1atm1.2Afst/Setd1atm1.2Afst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Setd1atm1.2Afst/Setd1atm1.2Afst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0004842 abnormal large intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Btrctm1Paga/Btrctm1Paga,Fbxw11tm1Ybn/Fbxw11tm1Ybn,Tg(Vil-cre/ERT2)23Syr/?
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Setd1atm1.2Afst/Setd1atm1.2Afst
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0008641 increased circulating interleukin-1 beta level "increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Btrctm1Paga/Btrctm1Paga,Fbxw11tm1Ybn/Fbxw11tm1Ybn,Tg(Vil-cre/ERT2)23Syr/?
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
Show

Allelic Composition: Btrctm1Paga/Btrctm1Paga,Fbxw11tm1Ybn/Fbxw11tm1Ybn,Tg(Vil-cre/ERT2)23Syr/?
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0009760 abnormal mitotic spindle "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during mitosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]
Show

Allelic Composition: Btrctm1Paga/Btrctm1Paga,Fbxw11tm1Ybn/Fbxw11tm1Ybn,Tg(Vil-cre/ERT2)23Syr/?
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025199 Chuk / conserved helix-loop-helix ubiquitous kinase / O15111*  / complex / reaction
 ENSMUSG00000020941 Q9WUL6 / Map3k14 / Mitogen-activated protein kinase kinase kinase 14 / Q99558*  / reaction / complex
 ENSMUSG00000023947 Nfkbie / O54910 / NF-kappa-B inhibitor epsilon / O00221* / NFKB inhibitor epsilon*  / complex / reaction
 ENSMUSG00000024927 Rela / Q04207 / v-rel reticuloendotheliosis viral oncogene homolog A (avian) / Q04206* / RELA proto-oncogene, NF-kB subunit*  / complex / reaction
 ENSMUSG00000024235 Map3k8 / Q07174 / mitogen-activated protein kinase kinase kinase 8 / P41279*  / complex / reaction
 ENSMUSG00000022070 Bora / Q8BS90 / Protein aurora borealis / Q6PGQ7* / bora, aurora kinase A activator*  / complex / reaction
 ENSMUSG00000021025 Nfkbia / Q9Z1E3 / NF-kappa-B inhibitor alpha / P25963* / NFKB inhibitor alpha*  / reaction / complex
 ENSMUSG00000029686 Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*  / complex
 ENSMUSG00000059866 Tnip2 / Q99JG7 / TNFAIP3 interacting protein 2 / Q8NFZ5*  / complex / reaction
 ENSMUSG00000036309 Skp1a / Q9WTX5 / S-phase kinase-associated protein 1A / SKP1* / P63208* / AC104109.3* / S-phase kinase associated protein 1*  / complex
 ENSMUSG00000030595 Nfkbib / Q60778 / NF-kappa-B inhibitor beta / Q15653* / NFKB inhibitor beta*  / complex / reaction
 ENSMUSG00000028163 Nfkb1 / P25799 / Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit / P19838* / nuclear factor kappa B subunit 1*  / reaction / complex
 ENSMUSG00000002983 Relb / Q04863 / avian reticuloendotheliosis viral (v-rel) oncogene related B / Q01201* / RELB proto-oncogene, NF-kB subunit*  / reaction / complex
 ENSMUSG00000025225 Nfkb2 / Q9WTK5 / nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 / Q00653* / nuclear factor kappa B subunit 2*  / complex / reaction
 ENSMUSG00000020275 Rel / reticuloendotheliosis oncogene / Q04864* / REL proto-oncogene, NF-kB subunit*  / complex / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr