ENSMUSG00000028163


Mus musculus

Features
Gene ID: ENSMUSG00000028163
  
Biological name :Nfkb1
  
Synonyms : Nfkb1 / Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit / P25799
  
Possible biological names infered from orthology : nuclear factor kappa B subunit 1 / P19838
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: G3
Gene start: 135584655
Gene end: 135691547
  
Corresponding Affymetrix probe sets: 10502299 (MoGene1.0st)   1427705_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114798
Ensembl peptide - ENSMUSP00000139044
Ensembl peptide - ENSMUSP00000143601
Ensembl peptide - ENSMUSP00000029812
Ensembl peptide - ENSMUSP00000128345
NCBI entrez gene - 18033     See in Manteia.
MGI - MGI:97312
RefSeq - XM_006501107
RefSeq - NM_008689
RefSeq - XM_006501106
RefSeq Peptide - NP_032715
swissprot - P25799
swissprot - V9GX90
swissprot - F6Z9G5
swissprot - A0A0G2JGK6
Ensembl - ENSMUSG00000028163
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nfkb1ENSDARG00000105261Danio rerio
 NFKB1ENSGALG00000012304Gallus gallus
 NFKB1ENSG00000109320Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nfkb2 / Q9WTK5 / nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 / Q00653* / nuclear factor kappa B subunit 2*ENSMUSG0000002522541
Rel / reticuloendotheliosis oncogene / Q04864* / REL proto-oncogene, NF-kB subunit*ENSMUSG0000002027518
Relb / Q04863 / avian reticuloendotheliosis viral (v-rel) oncogene related B / Q01201* / RELB proto-oncogene, NF-kB subunit*ENSMUSG0000000298317
Rela / Q04207 / v-rel reticuloendotheliosis viral oncogene homolog A (avian) / Q04206* / RELA proto-oncogene, NF-kB subunit*ENSMUSG0000002492717


Protein motifs (from Interpro)
Interpro ID Name
 IPR000451  NF-kappa-B/Dorsal
 IPR000488  Death domain
 IPR002110  Ankyrin repeat
 IPR002909  IPT domain
 IPR008967  p53-like transcription factor, DNA-binding
 IPR011029  Death-like domain superfamily
 IPR011539  Rel homology domain (RHD), DNA-binding domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR020683  Ankyrin repeat-containing domain
 IPR030492  Rel homology domain, conserved site
 IPR030503  Nuclear factor NF-kappa-B, p105 subunit
 IPR032397  Rel homology dimerisation domain
 IPR033926  NFkappaB IPT domain
 IPR036770  Ankyrin repeat-containing domain superfamily
 IPR037059  Rel homology domain (RHD), DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IBA
 biological_processGO:0001818 negative regulation of cytokine production IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IBA
 biological_processGO:0010629 negative regulation of gene expression ISO
 biological_processGO:0010956 negative regulation of calcidiol 1-monooxygenase activity ISO
 biological_processGO:0034097 response to cytokine IBA
 biological_processGO:0035994 response to muscle stretch IDA
 biological_processGO:0038061 NIK/NF-kappaB signaling IBA
 biological_processGO:0045083 negative regulation of interleukin-12 biosynthetic process IDA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048535 lymph node development TAS
 biological_processGO:0050728 negative regulation of inflammatory response IMP
 biological_processGO:0071222 cellular response to lipopolysaccharide ISO
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071316 cellular response to nicotine ISO
 biological_processGO:0071345 cellular response to cytokine stimulus ISO
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0071354 cellular response to interleukin-6 ISO
 biological_processGO:0071356 cellular response to tumor necrosis factor IDA
 biological_processGO:0071359 cellular response to dsRNA IMP
 biological_processGO:0071407 cellular response to organic cyclic compound ISO
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway ISO
 biological_processGO:1900127 positive regulation of hyaluronan biosynthetic process ISO
 biological_processGO:1904385 cellular response to angiotensin ISO
 biological_processGO:2000630 positive regulation of miRNA metabolic process ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0033256 I-kappaB/NF-kappaB complex IBA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding ISO
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding ISO
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0042805 actinin binding ISO
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding ISS
 molecular_functionGO:0046982 protein heterodimerization activity ISO


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
RIP-mediated NFkB activation via ZBP1
Regulated proteolysis of p75NTR
Downstream TCR signaling
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
PKMTs methylate histone lysines
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Interleukin-1 processing
CLEC7A (Dectin-1) signaling
CD209 (DC-SIGN) signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Neutrophil degranulation
Interleukin-1 signaling
TRAF6 mediated NF-kB activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000065 abnormal bone marrow cavities "absence or abnormal size or shape of the medullary cavities of the bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Adora2a-cre)2MDkde/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0000067 osteopetrosis "excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Adora2a-cre)2MDkde/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0000121 failure of tooth eruption "inability of the teeth to grow into the oral cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Nfkb1tm1Brv/Nfkb1tm1Brv,Nfkb2tm1Brv/Nfkb2tm1Brv
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Myo5atm1a(KOMP)Wtsi/Myo5atm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Myo5atm1a(KOMP)Wtsi/Wtsi

Allelic Composition: Nfkb1tm1a(KOMP)Wtsi/Nfkb1tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nanos2tm1Ysa/Nanos2tm3Ysa
Genetic Background: involves: 129 * C57BL/6 * CBA * ICR

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+,Tg(Adora2a-cre)2MDkde/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Relatm1Bal/Rela+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0000688 lymphoid hyperplasia "increased cell number in lymphatic tissues" [J:62478]
Show

Allelic Composition: Nfkb1tm1a(KOMP)Wtsi/Nfkb1tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nanos2tm1Ysa/Nanos2tm3Ysa
Genetic Background: involves: 129 * C57BL/6 * CBA * ICR

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nanos2tm1Ysa/Nanos2tm3Ysa
Genetic Background: involves: 129 * C57BL/6 * CBA * ICR

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myo5atm1a(KOMP)Wtsi/Myo5atm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Myo5atm1a(KOMP)Wtsi/Wtsi

 MP:0001218 thin epidermis "reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Vhltm1Bjg/Vhltm1Bjg
Genetic Background: Not Specified

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Myo5atm1a(KOMP)Wtsi/Myo5atm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Myo5atm1a(KOMP)Wtsi/Wtsi

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Myo5atm1a(KOMP)Wtsi/Myo5atm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Myo5atm1a(KOMP)Wtsi/Wtsi

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nanos2tm1Ysa/Nanos2tm3Ysa
Genetic Background: involves: 129 * C57BL/6 * CBA * ICR

Allelic Composition: Nfkb1tm1Brv/Nfkb1tm1Brv,Nfkb2tm1Brv/Nfkb2tm1Brv
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal
Genetic Background: B6.129S-Reltm1Grd Relatm1Bal

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Nanos2tm1Ysa/Nanos2tm3Ysa
Genetic Background: involves: 129 * C57BL/6 * CBA * ICR

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nfkb1M3Btlr/Nfkb1M3Btlr
Genetic Background: C57BL/6J-Nfkb1M3Btlr

Allelic Composition: Nfkb1M3Btlr/Nfkb1+
Genetic Background: C57BL/6J-Nfkb1M3Btlr

Allelic Composition: Nfkb1m2Btlr/Nfkb1m2Btlr
Genetic Background: C57BL/6J-Nfkb1m2Btlr

Allelic Composition: Nfkb1m2Btlr/Nfkb1+
Genetic Background: C57BL/6J-Nfkb1m2Btlr

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Inpp5dm2Btlr/Inpp5dm2Btlr
Genetic Background: C57BL/6J-Inpp5dm2Btlr

Allelic Composition: Nfkb1M1Btlr/Nfkb1+
Genetic Background: C57BL/6J-Nfkb1M1Btlr

Allelic Composition: Nfkb1M3Btlr/Nfkb1M3Btlr
Genetic Background: C57BL/6J-Nfkb1M3Btlr

Allelic Composition: Nfkb1M3Btlr/Nfkb1+
Genetic Background: C57BL/6J-Nfkb1M3Btlr

Allelic Composition: Nfkb1m2Btlr/Nfkb1m2Btlr
Genetic Background: C57BL/6J-Nfkb1m2Btlr

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nfkb1m2Btlr/Nfkb1m2Btlr
Genetic Background: C57BL/6J-Nfkb1m2Btlr

Allelic Composition: Nfkb1m2Btlr/Nfkb1+
Genetic Background: C57BL/6J-Nfkb1m2Btlr

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nfkb1tm1a(KOMP)Wtsi/Nfkb1tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Nanos2tm1Ysa/Nanos2tm3Ysa
Genetic Background: involves: 129 * C57BL/6 * CBA * ICR

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Nanos2tm1Ysa/Nanos2tm3Ysa
Genetic Background: involves: 129 * C57BL/6 * CBA * ICR

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Nanos2tm1Ysa/Nanos2tm3Ysa
Genetic Background: involves: 129 * C57BL/6 * CBA * ICR

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
Show

Allelic Composition: Myo5atm1a(KOMP)Wtsi/Myo5atm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Myo5atm1a(KOMP)Wtsi/Wtsi

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nanos2tm1Ysa/Nanos2tm3Ysa
Genetic Background: involves: 129 * C57BL/6 * CBA * ICR

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hprtb-m3/Y,Impdh1tm1Bmi/Impdh1tm1Bmi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002221 abnormal lymph organ size "change in the normal size of lymphatic tissues" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nanos2tm1Ysa/Nanos2tm3Ysa
Genetic Background: involves: 129 * C57BL/6 * CBA * ICR

 MP:0002353 abnormal inguinal lymph node morphology "anomalous structure, development, or number of the lymph nodes located in the groin area" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hesx1tm1Icar/Hesx1tm3Jpmb
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB/N

 MP:0002371 abnormal thymus cortex morphology "anomalous structure or development of the outer area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0002375 abnormal thymus medulla morphology "anomalous structure or development of the inner area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Fbxo11Jf/Fbxo11Mutt
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0002389 abnormal Peyer s patch follicle morphology "anomaly of the structure, development, or size of the Peyer s patch normally occupied by B cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002391 abnormal Peyer s patch germinal center morphology "anomalous structure or differentiation of the area of the Peyer s patch where B cells proliferate and differentiate into plasma cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002392 abnormal Peyer s patch T cell area "anomalous structure or development of the Peyer s patch normally occupied by T lymphcytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nanos2tm1Ysa/Nanos2tm3Ysa
Genetic Background: involves: 129 * C57BL/6 * CBA * ICR

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nanos2tm1Ysa/Nanos2tm3Ysa
Genetic Background: involves: 129 * C57BL/6 * CBA * ICR

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Relatm1Bal/Rela+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Nfkb1tm1a(KOMP)Wtsi/Nfkb1tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fbxo11Jf/Fbxo11Mutt
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0002452 abnormal antigen presenting cell physiology "impairment or abnormality of the function of cells involved in making antigen recognizable by lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fbxo11Jf/Fbxo11Mutt
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tg(Tnfsf13b)1Fma/?,Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: B6.Cg-Tnfrsf13btm1Rjb Tg(Tnfsf13b)1Fma

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nanos2tm1Ysa/Nanos2tm3Ysa
Genetic Background: involves: 129 * C57BL/6 * CBA * ICR

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nfkb1M3Btlr/Nfkb1M3Btlr
Genetic Background: C57BL/6J-Nfkb1M3Btlr

Allelic Composition: Nfkb1M3Btlr/Nfkb1+
Genetic Background: C57BL/6J-Nfkb1M3Btlr

Allelic Composition: Nfkb1m2Btlr/Nfkb1m2Btlr
Genetic Background: C57BL/6J-Nfkb1m2Btlr

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nanos2tm1Ysa/Nanos2tm3Ysa
Genetic Background: involves: 129 * C57BL/6 * CBA * ICR

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fbxo11Jf/Fbxo11Mutt
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nanos2tm1Ysa/Nanos2tm3Ysa
Genetic Background: involves: 129 * C57BL/6 * CBA * ICR

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Myo5atm1a(KOMP)Wtsi/Myo5atm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Myo5atm1a(KOMP)Wtsi/Wtsi

Allelic Composition: Nfkb1tm1a(KOMP)Wtsi/Nfkb1tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fbxo11Jf/Fbxo11Mutt
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Nfkb1tm1Brv/Nfkb1tm1Brv
Genetic Background: involves: 129S1/Sv

Allelic Composition: Nfkb1tm1Brv/Nfkb1tm1Brv,Nfkb2tm1Brv/Nfkb2tm1Brv
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Nfkb1tm1Brv/Nfkb1tm1Brv,Nfkb2tm1Brv/Nfkb2tm1Brv
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003303 peritoneal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the membrane that lines the abdominal cavity and covers most of the viscera" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Relatm1Bal/Rela+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0003304 large intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the large intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Relatm1Bal/Rela+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfkb1tm1Brv/Nfkb1tm1Brv,Nfkb2tm1Brv/Nfkb2tm1Brv
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Nfkb1tm1Brv/Nfkb1tm1Brv
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfkb1tm1Brv/Nfkb1tm1Brv
Genetic Background: involves: 129S1/Sv

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Myo5atm1a(KOMP)Wtsi/Myo5atm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Myo5atm1a(KOMP)Wtsi/Wtsi

 MP:0003998 decreased thermal nociceptive threshold "a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Myo5atm1a(KOMP)Wtsi/Myo5atm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Myo5atm1a(KOMP)Wtsi/Wtsi

 MP:0004231 abnormal calcium ion homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fbxo11Jf/Fbxo11Mutt
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0004393 abnormal cochlear inner hair cell morphology "any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there is a single row of flask-shaped inner hair cells tightly surrounded by supporting interphalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a more or less linear (or shallow) U-shaped pattern extend from the cell s surface through the cuticular plate into the endolymphic space inferior to the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fbxo11Jf/Fbxo11Mutt
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0004417 decreased cochlear nerve compound action potential "reduction of the combined potentials resulting from activation of the auditory division of the eighth cranial nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fbxo11Jf/Fbxo11Mutt
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0004597 increased susceptibility to noise-induced hearing loss "greater than normal reduction in hearing sensitivity following exposure to acute noise that is injurious to the cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fbxo11Jf/Fbxo11Mutt
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0004748 increased susceptibility to age-related hearing loss "greater than normal loss of hearing associated with advancing age, manifest as reduced ability to perceive or discriminate sounds; the pattern and age of onset vary" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fbxo11Jf/Fbxo11Mutt
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fbxo11Jf/Fbxo11Mutt
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Tg(Tnfsf13b)1Fma/?
Genetic Background: B6.Cg-Nfkb1tm1Bal Tg(Tnfsf13b)1Fma

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkb1tm1Sley/Nfkb1tm1Sley
Genetic Background: involves: 129S4/SvJae * 129S8/SvEv

Allelic Composition: Nfkb1tm1Sley/Nfkb1tm1Sley
Genetic Background: involves: 129S4/SvJae * 129S8/SvEv * C57BL/6

Allelic Composition: Nfkb1tm1a(KOMP)Wtsi/Nfkb1tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkb1tm1Brv/Nfkb1tm1Brv,Nfkb2tm1Brv/Nfkb2tm1Brv
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nfkb1tm1Brv/Nfkb1tm1Brv
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nfkb1tm1Brv/Nfkb1tm1Brv,Nfkb2tm1Brv/Nfkb2+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Relatm1Bal/Rela+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005046 failure of spleen white pulp formation "lack of development of the lymphoid area of the spleen" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Nanos2tm1Ysa/Nanos2tm3Ysa
Genetic Background: involves: 129 * C57BL/6 * CBA * ICR

Allelic Composition: Nfkb1tm1Sley/Nfkb1tm1Sley
Genetic Background: involves: 129S4/SvJae * 129S8/SvEv

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nanos2tm1Ysa/Nanos2tm3Ysa
Genetic Background: involves: 129 * C57BL/6 * CBA * ICR

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nanos2tm1Ysa/Nanos2tm3Ysa
Genetic Background: involves: 129 * C57BL/6 * CBA * ICR

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
Show

Allelic Composition: Nfkb1tm1Brv/Nfkb1tm1Brv,Nfkb2tm1Brv/Nfkb2tm1Brv
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fbxo11Jf/Fbxo11Mutt
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0005634 decreased circulating sodium level "less than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Myo5atm1a(KOMP)Wtsi/Myo5atm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Myo5atm1a(KOMP)Wtsi/Wtsi

 MP:0005642 decreased mean corpuscular hemoglobin concentration "less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
Show

Allelic Composition: Myo5atm1a(KOMP)Wtsi/Myo5atm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Myo5atm1a(KOMP)Wtsi/Wtsi

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fbxo11Jf/Fbxo11Mutt
Genetic Background: involves: BALB/c * C3H/HeN

 MP:0008024 absent lymph nodes "absence of the oval or bean shaped bodies located along the lymphatic system that consist of densely packed lymphocytes, lymph fluid and connective tissue; these are the sites where acquired immune responses are launched" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
Show

Allelic Composition: Nfkb1tm1Sley/Nfkb1tm1Sley
Genetic Background: involves: 129S4/SvJae * 129S8/SvEv * C57BL/6

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Nfkb1tm1a(KOMP)Wtsi/Nfkb1tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0008050 decreased memory T cell number "reduced number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkb1tm1Sley/Nfkb1tm1Sley
Genetic Background: involves: 129S4/SvJae * 129S8/SvEv

Allelic Composition: Nfkb1tm1Sley/Nfkb1tm1Sley
Genetic Background: involves: 129S4/SvJae * 129S8/SvEv * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkb1tm1Brv/Nfkb1tm1Brv
Genetic Background: involves: 129S1/Sv

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0008115 abnormal dendritic cell differentiation "atypical production of or inability to produce a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal
Genetic Background: B6.129S-Reltm1Grd Relatm1Bal

 MP:0008122 decreased myeloid dendritic cell number "reduction in the number of phagocytic cells of the myeloid lineage that capture antigens in the periphery and then migrate to the lymphoid organs and secrete cytokines to initiate immune responses" [PMID:10449155, PMID:9521319]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008127 decreased dendritic cell number "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal
Genetic Background: B6.129S-Reltm1Grd Relatm1Bal

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0008133 decreased Peyer s patch number "reduction in the number of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008135 small Peyer s patches "reduced size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
Show

Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal
Genetic Background: B6.129S-Reltm1Grd Relatm1Bal

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Tg(Tnfsf13b)1Fma/?
Genetic Background: B6.Cg-Nfkb1tm1Bal Tg(Tnfsf13b)1Fma

 MP:0008189 increased transitional stage B cell number "greater number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Tg(Tnfsf13b)1Fma/?
Genetic Background: B6.Cg-Nfkb1tm1Bal Tg(Tnfsf13b)1Fma

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Tg(Tnfsf13b)1Fma/?
Genetic Background: B6.Cg-Nfkb1tm1Bal Tg(Tnfsf13b)1Fma

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkb1tm1Brv/Nfkb1tm1Brv,Nfkb2tm1Brv/Nfkb2tm1Brv
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nfkb1tm1Brv/Nfkb1tm1Brv,Nfkb2tm1Brv/Nfkb2+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Nfkb2tm1Sbn/Nfkb2tm1Sbn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nfkb1tm1a(KOMP)Wtsi/Nfkb1tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkb1tm1Brv/Nfkb1tm1Brv
Genetic Background: involves: 129S1/Sv

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkb1tm1Brv/Nfkb1tm1Brv
Genetic Background: involves: 129S1/Sv

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkb1M3Btlr/Nfkb1M3Btlr
Genetic Background: C57BL/6J-Nfkb1M3Btlr

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Nfkb1tm1Brv/Nfkb1tm1Brv
Genetic Background: involves: 129S1/Sv

Allelic Composition: Map3k8tm1Sley/Map3k8tm1Sley,Nfkb1tm1Sley/Nfkb1tm1Sley
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Map3k8tm1Pnt/Map3k8tm1Pnt,Nfkb1tm1Sley/Nfkb1tm1Sley
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

Allelic Composition: Nfkb1tm1Sley/Nfkb1tm1Sley
Genetic Background: involves: 129S4/SvJae

 MP:0008600 decreased circulating interleukin-2 level "reduction in the amount in the blood of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Nfkb1tm1Sley/Nfkb1tm1Sley
Genetic Background: involves: 129S4/SvJae * 129S8/SvEv

 MP:0008648 decreased circulating interleukin-12b level "reduction in the amount in the blood of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
Show

Allelic Composition: Map3k8tm1Pnt/Map3k8tm1Pnt,Nfkb1tm1Sley/Nfkb1tm1Sley
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

 MP:0008664 decreased interleukin-12 secretion "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
Show

Allelic Composition: Reltm1Grd/Reltm1Grd,Relatm1Bal/Relatm1Bal
Genetic Background: B6.129S-Reltm1Grd Relatm1Bal

 MP:0008670 decreased interleukin-12b secretion "reduction in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
Show

Allelic Composition: Map3k8tm1Pnt/Map3k8tm1Pnt,Nfkb1tm1Sley/Nfkb1tm1Sley
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Nfkb1tm1Brv/Nfkb1tm1Brv
Genetic Background: involves: 129S1/Sv

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Nfkb1tm1Brv/Nfkb1tm1Brv
Genetic Background: involves: 129S1/Sv

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nfkb1tm1Brv/Nfkb1tm1Brv,Nfkb2tm1Brv/Nfkb2tm1Brv
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008805 decreased circulating amylase level "reduction in the concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D08.811.277.450.066, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo5atm1a(KOMP)Wtsi/Myo5atm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Myo5atm1a(KOMP)Wtsi/Wtsi

 MP:0009481 cecum inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the cecum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal,Relatm1Bal/Rela+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0009622 absent inguinal lymph nodes "absence of the lymph nodes normally located in the groin area" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkb1tm1Sley/Nfkb1tm1Sley
Genetic Background: involves: 129S4/SvJae * 129S8/SvEv

 MP:0009624 small inguinal lymph nodes "reduced size of the lymph nodes located in the groin area" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkb1tm1Sley/Nfkb1tm1Sley
Genetic Background: involves: 129S4/SvJae * 129S8/SvEv

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009790 decreased susceptibility to viral infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkb1tm1Bal/Nfkb1tm1Bal
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010179 rough coat "coat does not have the usual smooth appearance" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkb1tm1Brv/Nfkb1tm1Brv
Genetic Background: involves: 129S1/Sv

 MP:0010373 myeloid hyperplasia "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkb1tm1Brv/Nfkb1tm1Brv
Genetic Background: involves: 129S1/Sv

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkb1tm1a(KOMP)Wtsi/Nfkb1tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0010842 decreased central memory CD4-positive, alpha-beta T cell number "reduced number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000904, GO_REF:0000031, GOC:add, GOC:pam]
Show

Allelic Composition: Nfkb1m2Btlr/Nfkb1m2Btlr
Genetic Background: C57BL/6J-Nfkb1m2Btlr

Allelic Composition: Nfkb1m2Btlr/Nfkb1+
Genetic Background: C57BL/6J-Nfkb1m2Btlr

 MP:0010845 decreased effector memory CD4-positive, alpha-beta T cell number "reduced number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000905, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm]
Show

Allelic Composition: Nfkb1m2Btlr/Nfkb1m2Btlr
Genetic Background: C57BL/6J-Nfkb1m2Btlr

Allelic Composition: Nfkb1m2Btlr/Nfkb1+
Genetic Background: C57BL/6J-Nfkb1m2Btlr

 MP:0010847 increased central memory CD8 positive, alpha-beta T cell number "increased number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000907, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:20146720]
Show

Allelic Composition: Nfkb1M3Btlr/Nfkb1M3Btlr
Genetic Background: C57BL/6J-Nfkb1M3Btlr

Allelic Composition: Nfkb1M3Btlr/Nfkb1+
Genetic Background: C57BL/6J-Nfkb1M3Btlr

Allelic Composition: Nfkb1m2Btlr/Nfkb1m2Btlr
Genetic Background: C57BL/6J-Nfkb1m2Btlr

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ncantm3Ref/Ncantm3Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Vhltm1Bjg/Vhltm1Bjg
Genetic Background: Not Specified

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Vhltm1Bjg/Vhltm1Bjg
Genetic Background: Not Specified

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Nfkb1tm1Brv/Nfkb1tm1Brv
Genetic Background: involves: 129S1/Sv

 MP:0013435 decreased CD8-positive, naive alpha-beta T cell number "reduction in the number of the naïve regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions with a CD44-low CD62L+ phenotype" [IMPC:Saran]
Show

Allelic Composition: Nfkb1m2Btlr/Nfkb1m2Btlr
Genetic Background: C57BL/6J-Nfkb1m2Btlr

 MP:0020154 impaired humoral immune response "impaired response of the immune system that mediates secreted antibodies produced in B cells" [GOC:NV]
Show

Allelic Composition: Inpp5dm2Btlr/Inpp5dm2Btlr
Genetic Background: C57BL/6J-Inpp5dm2Btlr

Allelic Composition: Nfkb1M1Btlr/Nfkb1+
Genetic Background: C57BL/6J-Nfkb1M1Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000120 Ngfr / nerve growth factor receptor / P08138*  / reaction / complex
 ENSMUSG00000005469 P05132 / Prkaca / protein kinase, cAMP dependent, catalytic, alpha / P17612* / protein kinase cAMP-activated catalytic subunit alpha*  / reaction
 ENSMUSG00000005034 P68181 / Prkacb / protein kinase, cAMP dependent, catalytic, beta / P22694* / protein kinase cAMP-activated catalytic subunit beta*  / reaction
 ENSMUSG00000004221 Ikbkg / O88522 / NF-kappa-B essential modulator / Q9Y6K9* / inhibitor of nuclear factor kappa B kinase subunit gamma*  / reaction
 ENSMUSG00000025199 Chuk / conserved helix-loop-helix ubiquitous kinase / O15111*  / reaction
 ENSMUSG00000023947 Nfkbie / O54910 / NF-kappa-B inhibitor epsilon / O00221* / NFKB inhibitor epsilon*  / complex
 ENSMUSG00000024927 Rela / Q04207 / v-rel reticuloendotheliosis viral oncogene homolog A (avian) / Q04206* / RELA proto-oncogene, NF-kB subunit*  / complex
 ENSMUSG00000024235 Map3k8 / Q07174 / mitogen-activated protein kinase kinase kinase 8 / P41279*  / reaction / complex
 ENSMUSG00000021025 Nfkbia / Q9Z1E3 / NF-kappa-B inhibitor alpha / P25963* / NFKB inhibitor alpha*  / complex
 ENSMUSG00000031671 Setd6 / Q9CWY3 / N-lysine methyltransferase SETD6 / Q8TBK2* / SET domain containing 6*  / reaction
 ENSMUSG00000021180 Q8C050 / Rps6ka5 / ribosomal protein S6 kinase, polypeptide 5 / O75582* / ribosomal protein S6 kinase A5*  / reaction
 ENSMUSG00000030595 Nfkbib / Q60778 / NF-kappa-B inhibitor beta / Q15653* / NFKB inhibitor beta*  / complex
 ENSMUSG00000020271 Fbxw11 / Q5SRY7 / F-box/WD repeat-containing protein 11 / Q9UKB1* / F-box and WD repeat domain containing 11*  / complex / reaction
 ENSMUSG00000036309 Skp1a / Q9WTX5 / S-phase kinase-associated protein 1A / SKP1* / P63208* / AC104109.3* / S-phase kinase associated protein 1*  / reaction / complex
 ENSMUSG00000020275 Rel / reticuloendotheliosis oncogene / Q04864* / REL proto-oncogene, NF-kB subunit*  / complex
 ENSMUSG00000029686 Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*  / complex / reaction
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / reaction / complex
 ENSMUSG00000025217 Btrc / Q3ULA2 / F-box/WD repeat-containing protein 1A / Q9Y297* / beta-transducin repeat containing E3 ubiquitin protein ligase*  / complex / reaction
 ENSMUSG00000059866 Tnip2 / Q99JG7 / TNFAIP3 interacting protein 2 / Q8NFZ5*  / complex / reaction
 ENSMUSG00000028163 Nfkb1 / P25799 / Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit / P19838* / nuclear factor kappa B subunit 1*  / complex
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / reaction / complex
 ENSMUSG00000055024 Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr