ENSGALG00000012304


Gallus gallus

Features
Gene ID: ENSGALG00000012304
  
Biological name :NFKB1
  
Synonyms : NFKB1 / Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit / Q04861
  
Possible biological names infered from orthology : nuclear factor kappa B subunit 1 / P19838 / P25799
  
Species: Gallus gallus
  
Chr. number: 4
Strand: 1
Band:
Gene start: 61175391
Gene end: 61232967
  
Corresponding Affymetrix probe sets: Gga.4408.2.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000060090
Ensembl peptide - ENSGALP00000036814
NCBI entrez gene - 396033     See in Manteia.
RefSeq - XM_015285418
RefSeq - NM_205134
RefSeq - XM_015285415
RefSeq - XM_015285416
RefSeq - XM_015285417
RefSeq Peptide - NP_990465
swissprot - Q04861
swissprot - A0A1L1RMU1
Ensembl - ENSGALG00000012304
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nfkb1ENSDARG00000105261Danio rerio
 NFKB1ENSG00000109320Homo sapiens
 Nfkb1ENSMUSG00000028163Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NFKB2 / nuclear factor NF-kappa-B p100 subunit / Q00653* / Q9WTK5* / nuclear factor kappa B subunit 2* / nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100*ENSGALG0000000565338
REL / REL proto-oncogene, NF-kB subunit / Q04864* / reticuloendotheliosis oncogene*ENSGALG0000000784517


Protein motifs (from Interpro)
Interpro ID Name
 IPR000451  NF-kappa-B/Dorsal
 IPR000488  Death domain
 IPR002110  Ankyrin repeat
 IPR002909  IPT domain
 IPR008967  p53-like transcription factor, DNA-binding
 IPR011029  Death-like domain superfamily
 IPR011539  Rel homology domain (RHD), DNA-binding domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR020683  Ankyrin repeat-containing domain
 IPR030492  Rel homology domain, conserved site
 IPR030503  Nuclear factor NF-kappa-B, p105 subunit
 IPR032397  Rel homology dimerisation domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IBA
 biological_processGO:0001818 negative regulation of cytokine production IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IBA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010956 negative regulation of calcidiol 1-monooxygenase activity IEA
 biological_processGO:0034097 response to cytokine IBA
 biological_processGO:0035994 response to muscle stretch IEA
 biological_processGO:0038061 NIK/NF-kappaB signaling IBA
 biological_processGO:0045083 negative regulation of interleukin-12 biosynthetic process IEA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071316 cellular response to nicotine IEA
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0071354 cellular response to interleukin-6 IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071359 cellular response to dsRNA IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 biological_processGO:1900127 positive regulation of hyaluronan biosynthetic process IEA
 biological_processGO:1904385 cellular response to angiotensin IEA
 biological_processGO:2000630 positive regulation of miRNA metabolic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0033256 I-kappaB/NF-kappaB complex IBA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IBA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0042805 actinin binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0051059 NF-kappaB binding IDA


Pathways (from Reactome)
Pathway description
Activation of NF-kappaB in B cells
TRAF6 mediated NF-kB activation
RIP-mediated NFkB activation via ZBP1
Regulated proteolysis of p75NTR
Downstream TCR signaling
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
PKMTs methylate histone lysines
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
NFkB activation mediated by RIP1 complexed with activated TLR3
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Interleukin-1 processing
CLEC7A (Dectin-1) signaling
CD209 (DC-SIGN) signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Neutrophil degranulation
Interleukin-1 signaling
TRAF6 mediated NF-kB activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000002247 SETD6 / SET domain containing 6 / Q8TBK2* / Q9CWY3* / N-lysine methyltransferase SETD6 *  / reaction
 ENSGALG00000002229 FBXW11 / F-box and WD repeat domain containing 11 / Q5SRY7* / Q9UKB1* / F-box/WD repeat-containing protein 11 *  / complex / reaction
 ENSGALG00000006474 SKP1 / Q5ZKF5 / S-phase kinase-associated protein 1 / Skp1a* / Q9WTX5* / P63208* / AC104109.3* / S-phase kinase-associated protein 1A*  / complex / reaction
 ENSGALG00000007356 MAP3K8 / mitogen-activated protein kinase kinase kinase 8 / P41279* / Q07174*  / complex / reaction
 ENSGALG00000044525 NFKBIE / NFKB inhibitor epsilon / O00221* / O54910* / NF-kappa-B inhibitor epsilon *  / complex
 ENSGALG00000011993 RBX1 / ring-box 1 / P62877* / P62878* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction / complex
 ENSGALG00000012304 NFKB1 / Q04861 / Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit / P19838* / P25799* / nuclear factor kappa B subunit 1*  / complex
 ENSGALG00000015666 TNIP2 / TNFAIP3 interacting protein 2 / Q8NFZ5* / Q99JG7*  / reaction / complex
 ENSGALG00000035950 NGFR / P18519 / Tumor necrosis factor receptor superfamily member 16 / P08138* / nerve growth factor receptor*  / reaction / complex
 ENSGALG00000029691 NFKBIB / NFKB inhibitor beta / Q15653* / Q60778* / NF-kappa-B inhibitor beta *  / complex
 ENSGALG00000011992 EP300 / E1A binding protein p300 / B2RWS6* / Q09472* / Histone acetyltransferase p300 *  / complex / reaction
 ENSGALG00000007845 REL / REL proto-oncogene, NF-kB subunit / Q04864* / reticuloendotheliosis oncogene*  / complex
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / complex / reaction
 ENSGALG00000007932 TRAF6 / TNF receptor associated factor 6 / P70196* / Q9Y4K3*  / reaction / complex
 ENSGALG00000036941 CUL1 / cullin 1 / Q13616* / Q9WTX6* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*  / reaction / complex
 ENSGALG00000030580 Q5F3L1 / RPS6KA5 / Ribosomal protein S6 kinase alpha-5 / Q8C050* / O75582* / ribosomal protein S6 kinase A5* / ribosomal protein S6 kinase, polypeptide 5*  / reaction






 

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