ENSGALG00000011992


Gallus gallus

Features
Gene ID: ENSGALG00000011992
  
Biological name :EP300
  
Synonyms : E1A binding protein p300 / EP300
  
Possible biological names infered from orthology : B2RWS6 / Histone acetyltransferase p300 / Q09472
  
Species: Gallus gallus
  
Chr. number: 1
Strand: -1
Band:
Gene start: 49814540
Gene end: 49870572
  
Corresponding Affymetrix probe sets: Gga.18534.1.S1_s_at (Chicken Array)   Gga.2794.1.S1_at (Chicken Array)   Gga.9883.1.A1_at (Chicken Array)   GgaAffx.23725.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000019537
Ensembl peptide - ENSGALP00000044932
NCBI entrez gene - 418000     See in Manteia.
RefSeq - XM_004937710
swissprot - A0A1D5NX39
swissprot - E1BSS0
Ensembl - ENSGALG00000011992
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ep300aENSDARG00000100666Danio rerio
 ep300bENSDARG00000061108Danio rerio
 EP300ENSG00000100393Homo sapiens
 Ep300ENSMUSG00000055024Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CREBBP / CREB binding protein / Q92793*ENSGALG0000000776262
BAZ2B / bromodomain adjacent to zinc finger domain protein 2B / Q9UIF8* / bromodomain adjacent to zinc finger domain 2B*ENSGALG000000125798
BRD3 / bromodomain containing 3 / Q15059* / Q8K2F0* / Bromodomain-containing protein 3 *ENSGALG000000026827
BRD2 / bromodomain-containing protein 2 / P25440* / Q7JJ13* / bromodomain containing 2*ENSGALG000000001567
BAZ2A / bromodomain adjacent to zinc finger domain 2A / Q9UIF9*ENSGALG000000295886
BRDT / bromodomain testis associated / Q58F21* / Q91Y44* / Bromodomain testis-specific protein *ENSGALG000000060316
BAZ1A* / O88379* / Q9NRL2* / bromodomain adjacent to zinc finger domain 1A* / Bromodomain adjacent to zinc finger domain protein 1A *ENSGALG000000100304
BAZ1B / bromodomain adjacent to zinc finger domain 1B / Q9UIG0* / Q9Z277* / Tyrosine-protein kinase BAZ1B *ENSGALG000000294084
BAZ1A* / O88379* / Q9NRL2* / bromodomain adjacent to zinc finger domain 1A* / Bromodomain adjacent to zinc finger domain protein 1A *ENSGALG000000315881
BAZ1A* / O88379* / Q9NRL2* / bromodomain adjacent to zinc finger domain 1A* / Bromodomain adjacent to zinc finger domain protein 1A *ENSGALG000000336470


Protein motifs (from Interpro)
Interpro ID Name
 IPR000197  Zinc finger, TAZ-type
 IPR000433  Zinc finger, ZZ-type
 IPR001487  Bromodomain
 IPR003101  Coactivator CBP, KIX domain
 IPR009110  Nuclear receptor coactivator, interlocking
 IPR010303  CREB-binding protein/p300, atypical RING domain
 IPR013178  Histone acetyltransferase Rtt109/CBP
 IPR014744  Nuclear receptor coactivator, CREB-bp-like, interlocking
 IPR018359  Bromodomain, conserved site
 IPR031162  CBP/p300-type histone acetyltransferase domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001756 somitogenesis IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006473 protein acetylation IEA
 biological_processGO:0006475 internal protein amino acid acetylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007519 skeletal muscle tissue development IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010742 macrophage derived foam cell differentiation IEA
 biological_processGO:0016573 histone acetylation IEA
 biological_processGO:0018076 N-terminal peptidyl-lysine acetylation IEA
 biological_processGO:0018393 internal peptidyl-lysine acetylation IEA
 biological_processGO:0018394 peptidyl-lysine acetylation IEA
 biological_processGO:0030183 B cell differentiation IEA
 biological_processGO:0030220 platelet formation IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0032460 negative regulation of protein oligomerization IEA
 biological_processGO:0034644 cellular response to UV IEA
 biological_processGO:0035855 megakaryocyte development IEA
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0043923 positive regulation by host of viral transcription IEA
 biological_processGO:0043967 histone H4 acetylation IEA
 biological_processGO:0043969 histone H2B acetylation IEA
 biological_processGO:0045444 fat cell differentiation IEA
 biological_processGO:0045815 positive regulation of gene expression, epigenetic IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0060765 regulation of androgen receptor signaling pathway IEA
 biological_processGO:0061921 peptidyl-lysine propionylation IEA
 biological_processGO:0090043 regulation of tubulin deacetylation IEA
 biological_processGO:0140066 peptidyl-lysine crotonylation IEA
 biological_processGO:0140067 peptidyl-lysine butyrylation IEA
 cellular_componentGO:0000123 histone acetyltransferase complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001047 core promoter binding IEA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0003712 transcription coregulator activity IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0004402 histone acetyltransferase activity IEA
 molecular_functionGO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor IEA
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016407 acetyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0031490 chromatin DNA binding IEA
 molecular_functionGO:0033613 activating transcription factor binding IEA
 molecular_functionGO:0035257 nuclear hormone receptor binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050681 androgen receptor binding IEA
 molecular_functionGO:0061920 protein propionyltransferase activity IEA
 molecular_functionGO:0097157 pre-mRNA intronic binding IEA
 molecular_functionGO:0097677 STAT family protein binding IEA
 molecular_functionGO:0140065 peptide butyryltransferase activity IEA
 molecular_functionGO:0140068 histone crotonyltransferase activity IEA
 molecular_functionGO:0140069 histone butyryltransferase activity IEA


Pathways (from Reactome)
Pathway description
Regulation of gene expression by Hypoxia-inducible Factor
Formation of the beta-catenin:TCF transactivating complex
Attenuation phase
SUMOylation of transcription cofactors
B-WICH complex positively regulates rRNA expression
CD209 (DC-SIGN) signaling
Formation of TC-NER Pre-Incision Complex
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Activation of the TFAP2 (AP-2) family of transcription factors
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
RUNX3 regulates NOTCH signaling
Regulation of RUNX3 expression and activity
RUNX3 regulates p14-ARF
Estrogen-dependent gene expression
TRAF6 mediated IRF7 activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000678 CITED4 / Q9I8K7 / Cbp/p300-interacting transactivator 3 / Q96RK1* / Q9WUL8* / Cbp/p300-interacting transactivator 4 * / Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-termin...  / complex / reaction
 ENSGALG00000003369 KAT2A / lysine acetyltransferase 2A / Q92830* / Q9JHD2* / K(lysine) acetyltransferase 2A*  / complex
 ENSGALG00000008883 TCF7L2 / transcription factor 7 like 2 / Q924A0* / Q9NQB0* / transcription factor 7 like 2, T cell specific, HMG box*  / complex / reaction
 ENSGALG00000008435 SUMO1 / Q8QGH2 / Small ubiquitin-related modifier 1 / P63166* / P63165* / small ubiquitin-like modifier 1*  / reaction / complex
 ENSGALG00000006428 UBE2I / P63283 / SUMO-conjugating enzyme UBC9 / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSGALG00000016617 NCOA1 / nuclear receptor coactivator 1 / P70365* / Q15788*  / reaction / complex
 ENSGALG00000010005 EPAS1 / endothelial PAS domain protein 1 / P97481* / Q99814* / Endothelial PAS domain-containing protein 1 *  / complex
 ENSGALG00000016022 RUNX1 / runt related transcription factor 1 / Q01196*  / complex / reaction
 ENSGALG00000013818 CITED2 / Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 / O35740* / Q99967* / Cbp/p300-interacting transactivator 2 *  / complex / reaction
 ENSGALG00000007690 TFAP2C / transcription factor AP-2 gamma / Q61312* / Q92754*  / reaction / complex
 ENSGALG00000000156 BRD2 / bromodomain-containing protein 2 / P25440* / Q7JJ13* / bromodomain containing 2*  / reaction / complex
 ENSGALG00000032713 FOXA1 / forkhead box A1 / P35582* / P55317* / Hepatocyte nuclear factor 3-alpha *  / reaction / complex
 ENSGALG00000029270 GATA3 / P23825 / GATA-binding factor 3 / P23771* / P23772* / GATA binding protein 3* / Mus musculus GATA binding protein 3 (Gata3), transcript variant 3, mRNA.*  / complex / reaction
 ENSGALG00000043062 P84229 / HIST2H3D / Histone H3.2 / Q71DI3* / histone cluster 2 H3 family member d*  / reaction
 ENSGALG00000011171 TBP / TATA-box-binding protein / P20226* / P29037*  / reaction / complex
 ENSGALG00000010576 GTF2A1 / general transcription factor IIA subunit 1 / P52655* / Q99PM3* / Transcription initiation factor IIA subunit 1 Transcription initiation factor IIA alpha chain Transcription initiat...  / reaction / complex
 ENSGALG00000003793 GTF2A2 / general transcription factor IIA subunit 2 / P52657* / Q80ZM7* / Transcription initiation factor IIA subunit 2 *  / complex / reaction
 ENSGALG00000020078 H3F3C / histone H3.2 / H3.Y* / H3F3B* / H3F3A* / Q6NXT2* / P84243* / P84244* / Histone H3.3 * / H3 histone family member 3B* / H3 histone family member 3A* / H3 histone family member 3C* /...  / reaction
 ENSGALG00000004570 NCOA3 / nuclear receptor coactivator 3 / Q9Y6Q9*  / reaction / complex
 ENSGALG00000042491 P62801 / Histone H4   / reaction
 ENSGALG00000012304 NFKB1 / Q04861 / Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit / P19838* / P25799* / nuclear factor kappa B subunit 1*  / reaction / complex
 ENSGALG00000031960 LEF1 / lymphoid enhancer binding factor 1 / P27782* / Q9UJU2*  / complex / reaction






 

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