ENSDARG00000061108


Danio rerio

Features
Gene ID: ENSDARG00000061108
  
Biological name :ep300b
  
Synonyms : E1A binding protein p300 b / ep300b
  
Possible biological names infered from orthology : B2RWS6 / E1A binding protein p300 / EP300 / Histone acetyltransferase p300 / Q09472
  
Species: Danio rerio
  
Chr. number: 3
Strand: -1
Band:
Gene start: 24996930
Gene end: 25055795
  
Corresponding Affymetrix probe sets: Dr.13506.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000129212
Ensembl peptide - ENSDARP00000081202
NCBI entrez gene - 565612     See in Manteia.
RefSeq - XM_009299413
RefSeq - XM_009299414
swissprot - X1WG57
swissprot - F1R259
ZFIN ID - ZDB-GENE-080403-15
Ensembl - ENSDARG00000061108
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EP300ENSGALG00000011992Gallus gallus
 EP300ENSG00000100393Homo sapiens
 Ep300ENSMUSG00000055024Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ep300a / E1A binding protein p300 a / EP300* / Q09472* / B2RWS6* / E1A binding protein p300* / Histone acetyltransferase p300 *ENSDARG0000010066665
crebbpb / CREB binding protein b / CREBBP* / Q92793* / CREB binding protein*ENSDARG0000011245250
crebbpa / CREB binding protein a / CREBBP* / Q92793* / CREB binding protein*ENSDARG0000010460949
brd4 / F1R5H6 / bromodomain containing 4 / O60885* / Q9ESU6* / Bromodomain-containing protein 4 *ENSDARG000000789049
baz2a / bromodomain adjacent to zinc finger domain, 2A / Q9UIF9*ENSDARG000001029747
brdt / bromodomain, testis-specific / Q91Y44* / Q58F21* / bromodomain testis associated* / Bromodomain testis-specific protein *ENSDARG000001028026
brd2a / bromodomain containing 2a / BRD2* / Q7JJ13* / P25440* / bromodomain containing 2* / Bromodomain-containing protein 2 *ENSDARG000000222806
baz2ba / bromodomain adjacent to zinc finger domain, 2Ba / BAZ2B* / Q9UIF8* / bromodomain adjacent to zinc finger domain 2B*ENSDARG000000577826
brd3a / bromodomain containing 3a / BRD3* / Q8K2F0* / Q15059* / bromodomain containing 3* / Bromodomain-containing protein 3 *ENSDARG000000065275
brd3b / bromodomain containing 3b / BRD3* / Q8K2F0* / Q15059* / bromodomain containing 3* / Bromodomain-containing protein 3 *ENSDARG000001001295
baz1a / bromodomain adjacent to zinc finger domain, 1A / O88379* / Q9NRL2* / Bromodomain adjacent to zinc finger domain protein 1A *ENSDARG000000997454
baz1b / bromodomain adjacent to zinc finger domain, 1B / Q9UIG0* / Q9Z277* / Tyrosine-protein kinase BAZ1B *ENSDARG000001028324
brd2b / bromodomain containing 2bENSDARG000000460871
baz1a / bromodomain adjacent to zinc finger domain, 1A / O88379* / Q9NRL2* / Bromodomain adjacent to zinc finger domain protein 1A *ENSDARG000000632331


Protein motifs (from Interpro)
Interpro ID Name
 IPR000197  Zinc finger, TAZ-type
 IPR000433  Zinc finger, ZZ-type
 IPR001487  Bromodomain
 IPR003101  Coactivator CBP, KIX domain
 IPR009110  Nuclear receptor coactivator, interlocking
 IPR010303  CREB-binding protein/p300, atypical RING domain
 IPR013178  Histone acetyltransferase Rtt109/CBP
 IPR014744  Nuclear receptor coactivator, CREB-bp-like, interlocking
 IPR018359  Bromodomain, conserved site
 IPR031162  CBP/p300-type histone acetyltransferase domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0016573 histone acetylation IEA
 cellular_componentGO:0000123 histone acetyltransferase complex IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003712 transcription coregulator activity IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0004402 histone acetyltransferase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of gene expression by Hypoxia-inducible Factor
Formation of the beta-catenin:TCF transactivating complex
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
Attenuation phase
SUMOylation of transcription cofactors
B-WICH complex positively regulates rRNA expression
CD209 (DC-SIGN) signaling
Formation of TC-NER Pre-Incision Complex
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Regulation of TP53 Activity through Acetylation
Regulation of TP53 Activity through Methylation
PI5P Regulates TP53 Acetylation
Activation of the TFAP2 (AP-2) family of transcription factors
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
RUNX3 regulates NOTCH signaling
Regulation of RUNX3 expression and activity
RUNX3 regulates p14-ARF
Estrogen-dependent gene expression
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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