ENSDARG00000022280


Danio rerio

Features
Gene ID: ENSDARG00000022280
  
Biological name :brd2a
  
Synonyms : brd2a / bromodomain containing 2a
  
Possible biological names infered from orthology : BRD2 / bromodomain containing 2 / Bromodomain-containing protein 2 / P25440 / Q7JJ13
  
Species: Danio rerio
  
Chr. number: 19
Strand: 1
Band:
Gene start: 7152966
Gene end: 7170674
  
Corresponding Affymetrix probe sets: Dr.10549.1.S1_at (Zebrafish Array)   Dr.10549.1.S2_at (Zebrafish Array)   Dr.26333.1.A1_at (Zebrafish Array)   Dr.6983.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000139243
Ensembl peptide - ENSDARP00000038787
Ensembl peptide - ENSDARP00000125986
NCBI entrez gene - 30445     See in Manteia.
RefSeq - NM_001270571
RefSeq - NM_131200
RefSeq Peptide - NP_001257500
RefSeq Peptide - NP_571275
swissprot - A8CYR1
swissprot - Q1LWX7
swissprot - I3ISU1
ZFIN ID - ZDB-GENE-990415-248
Ensembl - ENSDARG00000022280
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BRD2ENSGALG00000000156Gallus gallus
 BRD2ENSG00000204256Homo sapiens
 Brd2ENSMUSG00000024335Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
brd3a / bromodomain containing 3a / BRD3* / Q8K2F0* / Q15059* / bromodomain containing 3* / Bromodomain-containing protein 3 *ENSDARG0000000652747
brd3b / bromodomain containing 3b / BRD3* / Q8K2F0* / Q15059* / bromodomain containing 3* / Bromodomain-containing protein 3 *ENSDARG0000010012947
brd4 / F1R5H6 / bromodomain containing 4 / O60885* / Q9ESU6* / Bromodomain-containing protein 4 *ENSDARG0000007890444
brdt / bromodomain, testis-specific / Q91Y44* / Q58F21* / bromodomain testis associated* / Bromodomain testis-specific protein *ENSDARG0000010280242
brd2b / bromodomain containing 2bENSDARG0000004608723
ep300a / E1A binding protein p300 a / EP300* / Q09472* / B2RWS6* / E1A binding protein p300* / Histone acetyltransferase p300 *ENSDARG0000010066621
crebbpb / CREB binding protein b / CREBBP* / Q92793* / CREB binding protein*ENSDARG0000011245221
ep300b / E1A binding protein p300 b / EP300* / Q09472* / B2RWS6* / E1A binding protein p300* / Histone acetyltransferase p300 *ENSDARG0000006110820
crebbpa / CREB binding protein a / CREBBP* / Q92793* / CREB binding protein*ENSDARG0000010460919
baz2a / bromodomain adjacent to zinc finger domain, 2A / Q9UIF9*ENSDARG0000010297412
baz2ba / bromodomain adjacent to zinc finger domain, 2Ba / BAZ2B* / Q9UIF8* / bromodomain adjacent to zinc finger domain 2B*ENSDARG0000005778212
baz1a / bromodomain adjacent to zinc finger domain, 1A / O88379* / Q9NRL2* / Bromodomain adjacent to zinc finger domain protein 1A *ENSDARG000000997459
baz1b / bromodomain adjacent to zinc finger domain, 1B / Q9UIG0* / Q9Z277* / Tyrosine-protein kinase BAZ1B *ENSDARG000001028328
baz1a / bromodomain adjacent to zinc finger domain, 1A / O88379* / Q9NRL2* / Bromodomain adjacent to zinc finger domain protein 1A *ENSDARG000000632331


Protein motifs (from Interpro)
Interpro ID Name
 IPR001487  Bromodomain
 IPR018359  Bromodomain, conserved site
 IPR027353  NET domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002574 thrombocyte differentiation IMP
 biological_processGO:0021510 spinal cord development IMP
 biological_processGO:0030902 hindbrain development IMP
 biological_processGO:0030917 midbrain-hindbrain boundary development IMP
 biological_processGO:0042981 regulation of apoptotic process IMP
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
RUNX3 regulates p14-ARF


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain structure , abnormal
brain decreased size , abnormal
brain decreased distribution , abnormal
brain apoptotic process occurrence , ameliorated
brain apoptotic process increased occurrence , abnormal
brain cell death increased occurrence , abnormal
Show

 ZFA:0000012 central nervous system central nervous system apoptotic process increased occurrence , abnormal
central nervous system cell death increased occurrence , abnormal
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 ZFA:0000041 mesoderm mesoderm disorganized , abnormal
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 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary morphology , abnormal
midbrain hindbrain boundary posterior region decreased distribution , abnormal
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 ZFA:0000110 fourth ventricle fourth ventricle collapsed , abnormal
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 ZFA:0000112 gut gut decreased distribution , abnormal
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 ZFA:0000135 notochord notochord morphology , abnormal
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 ZFA:0000151 pronephros pronephros decreased distribution , abnormal
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 ZFA:0000155 somite somite condensed , abnormal
somite decreased distribution , abnormal
somite irregularly shaped , abnormal
Show

 ZFA:0000778 spinal cord interneuron spinal cord interneuron spatial pattern , abnormal
spinal cord interneuron mislocalised , abnormal
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 ZFA:0000948 rhombomere 3 rhombomere 3 decreased distribution , abnormal
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 ZFA:0001094 whole organism whole organism decreased amount , abnormal
whole organism apoptotic process decreased occurrence , abnormal
Show

 ZFA:0001117 post-vent region post-vent region morphology , abnormal
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 ZFA:0005209 hindbrain interneuron hindbrain interneuron spatial pattern , abnormal
hindbrain interneuron mislocalised , abnormal
Show

 ZFA:0007042 spinal cord neural tube spinal cord neural tube decreased distribution , abnormal
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 ZFA:0009310 retinal ganglion cell retinal ganglion cell decreased distribution , abnormal
Show

 ZFA:0009323 thrombocyte thrombocyte decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000098349 hdac4 / histone deacetylase 4 / P56524* / Q6NZM9*  / complex / reaction
 ENSDARG00000101637 ccnd1 / Q90459 / cyclin D1 / P24385* / P25322* / G1/S-specific cyclin-D1 *  / reaction / complex
 ENSDARG00000022280 brd2a / bromodomain containing 2a / BRD2* / Q7JJ13* / P25440* / bromodomain containing 2* / Bromodomain-containing protein 2 *  / complex
 ENSDARG00000052826 runx3 / runt-related transcription factor 3 / Q13761* / Q64131*  / complex / reaction






 

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