ENSMUSG00000024335


Mus musculus

Features
Gene ID: ENSMUSG00000024335
  
Biological name :Brd2
  
Synonyms : Brd2 / Bromodomain-containing protein 2 / Q7JJ13
  
Possible biological names infered from orthology : bromodomain containing 2 / P25440
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: B1
Gene start: 34112023
Gene end: 34122634
  
Corresponding Affymetrix probe sets: 10450126 (MoGene1.0st)   1423502_at (Mouse Genome 430 2.0 Array)   1437210_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138431
Ensembl peptide - ENSMUSP00000128835
Ensembl peptide - ENSMUSP00000134608
Ensembl peptide - ENSMUSP00000025193
Ensembl peptide - ENSMUSP00000092990
Ensembl peptide - ENSMUSP00000109880
Ensembl peptide - ENSMUSP00000117359
NCBI entrez gene - 14312     See in Manteia.
MGI - MGI:99495
RefSeq - XM_017317255
RefSeq - XM_017317246
RefSeq - XM_017317247
RefSeq - XM_017317248
RefSeq - XM_017317249
RefSeq - XM_017317250
RefSeq - XM_017317251
RefSeq - XM_017317252
RefSeq - XM_017317253
RefSeq - XM_017317254
RefSeq - NM_001204973
RefSeq - NM_010238
RefSeq - XM_017317245
RefSeq Peptide - NP_034368
RefSeq Peptide - NP_001191902
swissprot - U3KLT0
swissprot - B2RS09
swissprot - Q3TH63
swissprot - Q7JJ13
swissprot - I7HPW1
swissprot - S4R1Z1
swissprot - G3UZR9
Ensembl - ENSMUSG00000024335
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 brd2aENSDARG00000022280Danio rerio
 BRD2ENSGALG00000000156Gallus gallus
 BRD2ENSG00000204256Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Brd3 / Q8K2F0 / Bromodomain-containing protein 3 / Q15059* / bromodomain containing 3*ENSMUSG0000002691858
Brd4 / Q9ESU6 / Bromodomain-containing protein 4 / O60885* / bromodomain containing 4*ENSMUSG0000002400252
Brdt / Q91Y44 / Bromodomain testis-specific protein / Q58F21* / bromodomain testis associated*ENSMUSG0000002927946
Crebbp / CREB binding protein / Q92793*ENSMUSG0000002252124
Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*ENSMUSG0000005502424
Baz2b / bromodomain adjacent to zinc finger domain, 2B / Q9UIF8*ENSMUSG0000002698716
Baz2a / bromodomain adjacent to zinc finger domain 2A / Q9UIF9*ENSMUSG0000004005413
Baz1a / O88379 / Bromodomain adjacent to zinc finger domain protein 1A / Q9NRL2* / bromodomain adjacent to zinc finger domain 1A*ENSMUSG0000003502112
Baz1b / Q9Z277 / Tyrosine-protein kinase BAZ1B / Q9UIG0* / bromodomain adjacent to zinc finger domain 1B*ENSMUSG0000000274810


Protein motifs (from Interpro)
Interpro ID Name
 IPR001487  Bromodomain
 IPR018359  Bromodomain, conserved site
 IPR027353  NET domain
 IPR036427  Bromodomain-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006334 nucleosome assembly ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II ISS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0016607 nuclear speck ISO
 molecular_functionGO:0003682 chromatin binding ISS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0070577 lysine-acetylated histone binding ISS


Pathways (from Reactome)
Pathway description
RUNX3 regulates p14-ARF


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000003 abnormal adipose tissue morphology "structural anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Brd2Gt(RRE050)Byg/Brd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pou4f3tm1.1(HBEGF)Jsto/Pou4f3+
Genetic Background: either: (involves: 129S4/SvJaeSor * C57BL/6) or (involves: 129S4/SvJaeSor * CBA/J)

 MP:0000786 abnormal neuroepithelial layer differentiation "malformation or arrest of differentiation or patterning of the epithelial layer of the brain" [J:45302]
Show

Allelic Composition: Pou4f3tm1.1(HBEGF)Jsto/Pou4f3+
Genetic Background: either: (involves: 129S4/SvJaeSor * C57BL/6) or (involves: 129S4/SvJaeSor * CBA/J)

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
Show

Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Brd2Gt(RRE050)Byg/Brd2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pou4f3tm1.1(HBEGF)Jsto/Pou4f3+
Genetic Background: either: (involves: 129S4/SvJaeSor * C57BL/6) or (involves: 129S4/SvJaeSor * CBA/J)

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: H2-Oa/Brd2Tg(otx2-lacZ)F5pImat/H2-Oa/Brd2Tg(otx2-lacZ)F5pImat
Genetic Background: involves: CD-1

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0002712 increased circulating glucagon level "greater than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: H2-Oa/Brd2Tg(otx2-lacZ)F5pImat/H2-Oa/Brd2Tg(otx2-lacZ)F5pImat
Genetic Background: involves: CD-1

 MP:0003645 increased number of pancreatic beta cells "greater than normal number of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
Show

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0003949 abnormal circulating lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: H2-Oa/Brd2Tg(otx2-lacZ)F5pImat/H2-Oa/Brd2Tg(otx2-lacZ)F5pImat
Genetic Background: involves: CD-1

 MP:0004129 abnormal respiratory quotient "anomaly in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism" [J:94416]
Show

Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: H2-Oa/Brd2Tg(otx2-lacZ)F5pImat/H2-Oa/Brd2Tg(otx2-lacZ)F5pImat
Genetic Background: involves: CD-1

 MP:0004892 increased adiponectin level "greater level of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0005491 islet cell hyperplasia "increased numbers cells within the structures that are scattered throughout the pancreas and comprise its endocrine portion" [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0006094 adipocyte hypertrophy "increase in the size of fat cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:90802]
Show

Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0008641 increased circulating interleukin-1 beta level "increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0008965 increased basal metabolism "increase in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [MESH:E01.370.374.750.100]
Show

Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0009167 increased pancreatic islet number "increase in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
Show

Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0009288 increased epididymal fat pad weight 
Show

Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0009294 increased interscapular fat pad weight 
Show

Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: H2-Oa/Brd2Tg(otx2-lacZ)F5pImat/H2-Oa/Brd2Tg(otx2-lacZ)F5pImat
Genetic Background: involves: CD-1

 MP:0012701 increased embryonic neuroepithelium apoptosis "increase in the number of cells of the embryonic neuroepithelium undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: H2-Oa/Brd2Tg(otx2-lacZ)F5pImat/H2-Oa/Brd2Tg(otx2-lacZ)F5pImat
Genetic Background: involves: CD-1

 MP:0012702 increased embryonic neuroepithelium thickness "increased width of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [MGI:anna]
Show

Allelic Composition: H2-Oa/Brd2Tg(otx2-lacZ)F5pImat/H2-Oa/Brd2Tg(otx2-lacZ)F5pImat
Genetic Background: involves: CD-1

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Lig4tm1Fwa/Lig4tm1Fwa
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026313 Hdac4 / Q6NZM9 / Histone deacetylase 4 / P56524*  / reaction / complex
 ENSMUSG00000070348 Ccnd1 / P25322 / G1/S-specific cyclin-D1 / P24385* / cyclin D1*  / reaction / complex
 ENSMUSG00000024335 Brd2 / Q7JJ13 / Bromodomain-containing protein 2 / P25440* / bromodomain containing 2*  / complex
 ENSMUSG00000070691 Runx3 / Q64131 / Runt-related transcription factor 3 / Q13761*  / complex / reaction
 ENSMUSG00000031885 Cbfb / Q08024 / Core-binding factor subunit beta / Q13951* / core-binding factor beta subunit*  / complex / reaction
 ENSMUSG00000055024 Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr