ENSMUSG00000024002


Mus musculus

Features
Gene ID: ENSMUSG00000024002
  
Biological name :Brd4
  
Synonyms : Brd4 / Bromodomain-containing protein 4 / Q9ESU6
  
Possible biological names infered from orthology : bromodomain containing 4 / O60885
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: B1
Gene start: 32196274
Gene end: 32284722
  
Corresponding Affymetrix probe sets: 10449815 (MoGene1.0st)   1424922_a_at (Mouse Genome 430 2.0 Array)   1450711_at (Mouse Genome 430 2.0 Array)   1451870_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113070
Ensembl peptide - ENSMUSP00000112474
Ensembl peptide - ENSMUSP00000115163
Ensembl peptide - ENSMUSP00000155477
Ensembl peptide - ENSMUSP00000115277
Ensembl peptide - ENSMUSP00000003726
NCBI entrez gene - 57261     See in Manteia.
MGI - MGI:1888520
RefSeq - XM_017317588
RefSeq - XM_006524686
RefSeq - XM_006524687
RefSeq - XM_006524688
RefSeq - XM_006524689
RefSeq - XM_006524690
RefSeq - XM_006524691
RefSeq - XM_006524693
RefSeq - XM_006524695
RefSeq - XM_011246543
RefSeq - NM_001286630
RefSeq - NM_020508
RefSeq - NM_198094
RefSeq - XM_006524683
RefSeq - XM_006524684
RefSeq - XM_006524685
RefSeq Peptide - NP_001273559
RefSeq Peptide - NP_065254
RefSeq Peptide - NP_932762
swissprot - Q3UH70
swissprot - D6RGP2
swissprot - B0V2V6
swissprot - Q9ESU6
swissprot - B2RSE4
swissprot - B0V2V8
Ensembl - ENSMUSG00000024002
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 brd4ENSDARG00000078904Danio rerio
 BRD4ENSG00000141867Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Brd3 / Q8K2F0 / Bromodomain-containing protein 3 / Q15059* / bromodomain containing 3*ENSMUSG0000002691831
Brd2 / Q7JJ13 / Bromodomain-containing protein 2 / P25440* / bromodomain containing 2*ENSMUSG0000002433530
Brdt / Q91Y44 / Bromodomain testis-specific protein / Q58F21* / bromodomain testis associated*ENSMUSG0000002927929
Crebbp / CREB binding protein / Q92793*ENSMUSG0000002252119
Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*ENSMUSG0000005502419
Baz2a / bromodomain adjacent to zinc finger domain 2A / Q9UIF9*ENSMUSG0000004005411
Baz2b / bromodomain adjacent to zinc finger domain, 2B / Q9UIF8*ENSMUSG0000002698710
Baz1a / O88379 / Bromodomain adjacent to zinc finger domain protein 1A / Q9NRL2* / bromodomain adjacent to zinc finger domain 1A*ENSMUSG000000350219
Baz1b / Q9Z277 / Tyrosine-protein kinase BAZ1B / Q9UIG0* / bromodomain adjacent to zinc finger domain 1B*ENSMUSG000000027488


Protein motifs (from Interpro)
Interpro ID Name
 IPR001487  Bromodomain
 IPR018359  Bromodomain, conserved site
 IPR027353  NET domain
 IPR031354  Bromodomain protein 4, C-terminal
 IPR036427  Bromodomain-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle ISO
 biological_processGO:0001833 inner cell mass cell proliferation IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IPI
 biological_processGO:0007059 chromosome segregation IMP
 biological_processGO:0010971 positive regulation of G2/M transition of mitotic cell cycle ISO
 biological_processGO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter ISO
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling ISS
 biological_processGO:0043388 positive regulation of DNA binding IDA
 biological_processGO:0043983 histone H4-K12 acetylation IMP
 biological_processGO:0044154 histone H3-K14 acetylation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0050727 regulation of inflammatory response ISS
 biological_processGO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain ISS
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0000794 condensed nuclear chromosome ISO
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005665 DNA-directed RNA polymerase II, core complex IDA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0008024 cyclin/CDK positive transcription elongation factor complex IDA
 molecular_functionGO:0000993 RNA polymerase II core binding ISO
 molecular_functionGO:0002039 p53 binding ISS
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0008353 RNA polymerase II carboxy-terminal domain kinase activity IMP
 molecular_functionGO:0034211 GTP-dependent protein kinase activity IDA
 molecular_functionGO:0070577 lysine-acetylated histone binding ISS
 molecular_functionGO:1990269 RNA polymerase II C-terminal domain phosphoserine binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000091 short premaxilla "reduced length of the anterior and interior portion of the maxilla" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001246 mixed cellular infiltration to dermis "gradual accumulation of mixed cell types in the dermis that are not normally found there" [J:65416]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002116 abnormal craniofacial bone morphology "abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002769 abnormal vas deferens morphology "malformation of the secretory duct of the testicle that carries spermatozoa, running from the epididymis, of which it is the continuation, to the prostatic urethra where it terminates to form ejaculatory duct" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004471 short nasal bone "reduced length of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004933 abnormal epididymis epithelium morphology "any structural anomaly of the layer of secretory cells which lines the epididymis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004965 inner cell mass degeneration 
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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