Manteia - Molecule gene

ENSMUSG00000035021

Mus musculus

Features

Gene ID:	ENSMUSG00000035021

Biological name :	Baz1a

Synonyms :	Baz1a / Bromodomain adjacent to zinc finger domain protein 1A / O88379

Possible biological names infered from orthology :	bromodomain adjacent to zinc finger domain 1A / Q9NRL2

Species:	Mus musculus

Chr. number:	12
Strand:	-1
Band:	C1
Gene start:	54892989
Gene end:	55014348

Corresponding Affymetrix probe sets:	10400357 (MoGene1.0st) 1433599_at (Mouse Genome 430 2.0 Array) 1447930_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000134445 Ensembl peptide - ENSMUSP00000039757 Ensembl peptide - ENSMUSP00000133324 Ensembl peptide - ENSMUSP00000133478 Ensembl peptide - ENSMUSP00000133796 Ensembl peptide - ENSMUSP00000134207 Ensembl peptide - ENSMUSP00000134384 NCBI entrez gene - 217578 See in Manteia. MGI - MGI:1309478 RefSeq - XM_011244058 RefSeq - NM_013815 RefSeq - XM_006515670 RefSeq - XM_006515671 RefSeq - XM_006515672 RefSeq Peptide - NP_038843 swissprot - G3UWK3 swissprot - O88379 swissprot - G3UXR5 swissprot - G3UYS9 swissprot - G3UZ82 swissprot - G3UWZ0 swissprot - G3UZD1 Ensembl - ENSMUSG00000035021

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
baz1a	ENSDARG00000099745	Danio rerio
baz1a	ENSDARG00000063233	Danio rerio
	ENSGALG00000010030	Gallus gallus
	ENSGALG00000031588	Gallus gallus
	ENSGALG00000033647	Gallus gallus
BAZ1A	ENSG00000198604	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Baz2b / bromodomain adjacent to zinc finger domain, 2B / Q9UIF8*	ENSMUSG00000026987	19
Baz2a / bromodomain adjacent to zinc finger domain 2A / Q9UIF9*	ENSMUSG00000040054	19
Baz1b / Q9Z277 / Tyrosine-protein kinase BAZ1B / Q9UIG0* / bromodomain adjacent to zinc finger domain 1B*	ENSMUSG00000002748	17
Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*	ENSMUSG00000055024	9
Brd4 / Q9ESU6 / Bromodomain-containing protein 4 / O60885* / bromodomain containing 4*	ENSMUSG00000024002	8
Crebbp / CREB binding protein / Q92793*	ENSMUSG00000022521	8
Brdt / Q91Y44 / Bromodomain testis-specific protein / Q58F21* / bromodomain testis associated*	ENSMUSG00000029279	7
Brd2 / Q7JJ13 / Bromodomain-containing protein 2 / P25440* / bromodomain containing 2*	ENSMUSG00000024335	6
Brd3 / Q8K2F0 / Bromodomain-containing protein 3 / Q15059* / bromodomain containing 3*	ENSMUSG00000026918	6

Protein motifs (from Interpro)

Interpro ID	Name
IPR001487	Bromodomain
IPR001965	Zinc finger, PHD-type
IPR011011	Zinc finger, FYVE/PHD-type
IPR013083	Zinc finger, RING/FYVE/PHD-type
IPR013136	WSTF/Acf1/Cbp146
IPR018359	Bromodomain, conserved site
IPR018501	DDT domain
IPR019786	Zinc finger, PHD-type, conserved site
IPR019787	Zinc finger, PHD-finger
IPR028941	WHIM2 domain
IPR028942	WHIM1 domain
IPR036427	Bromodomain-like superfamily
IPR037325	Bromodomain adjacent to zinc finger domain protein 1A, bromodomain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006261	DNA-dependent DNA replication	ISO
biological_process	GO:0006338	chromatin remodeling	TAS
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
cellular_component	GO:0000228	nuclear chromosome	IDA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0008623	CHRAC	ISO
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001156	abnormal spermatogenesis	"incomplete maturation or aberrant formation of the male gametes" [J:58959]	Show Allelic Composition: Kmt2d^tm1.1Kaig/Kmt2d^tm1.1Kaig,Tg(Tnnt2-cre)5Blh/0 Genetic Background: B6.Cg-Kmt2d^tm1.1Kaig Tg(Tnnt2-cre)5Blh
MP:0001258	decreased body length	"decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Barx2^{tm1b(EUCOMM)Hmgu}/Barx2^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Barx2^{tm1b(EUCOMM)Hmgu}/H
MP:0001402	hypoactivity	"reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]	Show Allelic Composition: Barx2^{tm1b(EUCOMM)Hmgu}/Barx2^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Barx2^{tm1b(EUCOMM)Hmgu}/H
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Barx2^{tm1b(EUCOMM)Hmgu}/Barx2^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Barx2^{tm1b(EUCOMM)Hmgu}/H Allelic Composition: Baz1a^tm1.1Sky/Baz1a^tm1.1Sky Genetic Background: involves: C57BL/6J * FVB/NJ
MP:0001932	abnormal spermiogenesis	"failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kmt2d^tm1.1Kaig/Kmt2d^tm1.1Kaig,Tg(Tnnt2-cre)5Blh/0 Genetic Background: B6.Cg-Kmt2d^tm1.1Kaig Tg(Tnnt2-cre)5Blh
MP:0002599	increased mean platelet volume	"increased content of platelet cells over the norm" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]	Show Allelic Composition: Barx2^{tm1b(EUCOMM)Hmgu}/Barx2^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Barx2^{tm1b(EUCOMM)Hmgu}/H
MP:0002660	abnormal caput	"anomalous structure of the head of the epididymis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Baz1a^tm1.1Sky/Baz1a^tm1.1Sky Genetic Background: involves: C57BL/6J * FVB/NJ
MP:0002662	abnormal cauda	"anomalous structure of the tail of the epididymis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Baz1a^tm1.1Sky/Baz1a^tm1.1Sky Genetic Background: involves: C57BL/6J * FVB/NJ
MP:0002675	asthenozoospermia	"loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Baz1a^tm1.1Sky/Baz1a^tm1.1Sky Genetic Background: involves: C57BL/6J * FVB/NJ
MP:0002687	oligozoospermia	"reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]	Show Allelic Composition: Baz1a^tm1.1Sky/Baz1a^tm1.1Sky Genetic Background: involves: C57BL/6J * FVB/NJ
MP:0003961	decreased lean body mass	"less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]	Show Allelic Composition: Barx2^{tm1b(EUCOMM)Hmgu}/Barx2^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Barx2^{tm1b(EUCOMM)Hmgu}/H
MP:0004182	abnormal spermiation	"failure of mature spermatozoa to release from supporting Sertoli cells into the lumen of seminiferous tubules" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Baz1a^tm1.1Sky/Baz1a^tm1.1Sky Genetic Background: involves: C57BL/6J * FVB/NJ
MP:0004543	abnormal sperm physiology	"anomaly in the normal function of spermatozoa" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Baz1a^tm1.1Sky/Baz1a^tm1.1Sky Genetic Background: involves: C57BL/6J * FVB/NJ
MP:0005565	increased blood urea nitrogen level	"high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Barx2^{tm1b(EUCOMM)Hmgu}/Barx2^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Barx2^{tm1b(EUCOMM)Hmgu}/H
MP:0005578	teratozoospermia	"presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]	Show Allelic Composition: Baz1a^tm1.1Sky/Baz1a^tm1.1Sky Genetic Background: involves: C57BL/6J * FVB/NJ
MP:0006380	abnormal spermatid morphology	"anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Baz1a^tm1.1Sky/Baz1a^tm1.1Sky Genetic Background: involves: C57BL/6J * FVB/NJ
MP:0008892	abnormal sperm flagellum	"any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]	Show Allelic Composition: Baz1a^tm1.1Sky/Baz1a^tm1.1Sky Genetic Background: involves: C57BL/6J * FVB/NJ
MP:0009230	abnormal sperm head morphology	"any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Baz1a^tm1.1Sky/Baz1a^tm1.1Sky Genetic Background: involves: C57BL/6J * FVB/NJ
MP:0009238	coiled sperm flagellum	"abnormal twisting of the sperm flagellum into coils or spirals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Baz1a^tm1.1Sky/Baz1a^tm1.1Sky Genetic Background: involves: C57BL/6J * FVB/NJ
MP:0009831	abnormal sperm midpiece morphology	"any structural abnormality of the highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece" [PMID:14581499]	Show Allelic Composition: Baz1a^tm1.1Sky/Baz1a^tm1.1Sky Genetic Background: involves: C57BL/6J * FVB/NJ
MP:0009834	abnormal sperm annulus morphology	"any structural anomaly of the ring-like, filamentous structure located at the distal end of the midpiece of the sperm flagellum; the annulus is thought to form a diffusion barrier between the midpiece and the principal piece and serve as a stabilizing structure for tail rigidity" [PMID:14581499]	Show Allelic Composition: Baz1a^tm1.1Sky/Baz1a^tm1.1Sky Genetic Background: involves: C57BL/6J * FVB/NJ
MP:0009839	multiflagellated sperm	"presence of more than one sperm flagellum, displaying either one common origin from the sperm head or multiple origins from the same sperm head" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Baz1a^tm1.1Sky/Baz1a^tm1.1Sky Genetic Background: involves: C57BL/6J * FVB/NJ
MP:0010025	decreased total body fat amount	"less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Barx2^{tm1b(EUCOMM)Hmgu}/Barx2^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Barx2^{tm1b(EUCOMM)Hmgu}/H
MP:0013601	increased testis apoptosis	"increase in the number of cells of the male reproductive glands undergoing programmed cell death" [MGI:Anna]	Show Allelic Composition: Baz1a^tm1.1Sky/Baz1a^tm1.1Sky Genetic Background: involves: C57BL/6J * FVB/NJ
MP:0020550	multinucleated giant male germ cells	"presence of large cells containing multiple nuclei formed abnormal opening of the cytoplasmic bridges that are part of normal germ cell division" [PMID:16272280, url:https://ntp.niehs.nih.gov/nnl/male_reproductive/testis/setubmgcel/index.htm]	Show Allelic Composition: Baz1a^tm1.1Sky/Baz1a^tm1.1Sky Genetic Background: involves: C57BL/6J * FVB/NJ

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr