ENSMUSG00000022521


Mus musculus

Features
Gene ID: ENSMUSG00000022521
  
Biological name :Crebbp
  
Synonyms : CREB binding protein / Crebbp
  
Possible biological names infered from orthology : Q92793
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: A1
Gene start: 4081328
Gene end: 4213997
  
Corresponding Affymetrix probe sets: 10437330 (MoGene1.0st)   10437332 (MoGene1.0st)   1434633_at (Mouse Genome 430 2.0 Array)   1435224_at (Mouse Genome 430 2.0 Array)   1436983_at (Mouse Genome 430 2.0 Array)   1459804_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023165
Ensembl peptide - ENSMUSP00000146330
Ensembl peptide - ENSMUSP00000146076
Ensembl peptide - ENSMUSP00000146029
Ensembl peptide - ENSMUSP00000145825
Ensembl peptide - ENSMUSP00000145798
NCBI entrez gene - 12914     See in Manteia.
MGI - MGI:1098280
RefSeq - XM_006521754
RefSeq - NM_001025432
RefSeq - XM_006521751
RefSeq - XM_006521752
RefSeq - XM_006521753
RefSeq Peptide - NP_001020603
swissprot - A0A0U1RQB6
swissprot - A0A0U1RPQ3
swissprot - A0A0U1RP46
swissprot - A0A0U1RP23
swissprot - F8VPR5
swissprot - A0A0U1RPL2
Ensembl - ENSMUSG00000022521
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 crebbpaENSDARG00000104609Danio rerio
 crebbpbENSDARG00000112452Danio rerio
 CREBBPENSGALG00000007762Gallus gallus
 CREBBPENSG00000005339Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*ENSMUSG0000005502460
Brd4 / Q9ESU6 / Bromodomain-containing protein 4 / O60885* / bromodomain containing 4*ENSMUSG0000002400211
Brdt / Q91Y44 / Bromodomain testis-specific protein / Q58F21* / bromodomain testis associated*ENSMUSG000000292798
Baz2a / bromodomain adjacent to zinc finger domain 2A / Q9UIF9*ENSMUSG000000400548
Baz2b / bromodomain adjacent to zinc finger domain, 2B / Q9UIF8*ENSMUSG000000269878
Brd2 / Q7JJ13 / Bromodomain-containing protein 2 / P25440* / bromodomain containing 2*ENSMUSG000000243358
Brd3 / Q8K2F0 / Bromodomain-containing protein 3 / Q15059* / bromodomain containing 3*ENSMUSG000000269187
Baz1a / O88379 / Bromodomain adjacent to zinc finger domain protein 1A / Q9NRL2* / bromodomain adjacent to zinc finger domain 1A*ENSMUSG000000350215
Baz1b / Q9Z277 / Tyrosine-protein kinase BAZ1B / Q9UIG0* / bromodomain adjacent to zinc finger domain 1B*ENSMUSG000000027484


Protein motifs (from Interpro)
Interpro ID Name
 IPR000197  Zinc finger, TAZ-type
 IPR000433  Zinc finger, ZZ-type
 IPR001487  Bromodomain
 IPR003101  Coactivator CBP, KIX domain
 IPR009110  Nuclear receptor coactivator, interlocking
 IPR010303  CREB-binding protein/p300, atypical RING domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013178  Histone acetyltransferase Rtt109/CBP
 IPR014744  Nuclear receptor coactivator, CREB-bp-like, interlocking
 IPR018359  Bromodomain, conserved site
 IPR031162  CBP/p300-type histone acetyltransferase domain
 IPR035898  TAZ domain superfamily
 IPR036427  Bromodomain-like superfamily
 IPR036529  Coactivator CBP, KIX domain superfamily
 IPR037073  Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006473 protein acetylation IEA
 biological_processGO:0016573 histone acetylation IEA
 biological_processGO:0018076 N-terminal peptidyl-lysine acetylation IEA
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0034644 cellular response to UV IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 cellular_componentGO:0000123 histone acetyltransferase complex IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016604 nuclear body IEA
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0003712 transcription coregulator activity IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0004402 histone acetyltransferase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016407 acetyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0043426 MRF binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of gene expression by Hypoxia-inducible Factor
Formation of the beta-catenin:TCF transactivating complex
NOTCH1 Intracellular Domain Regulates Transcription
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
Attenuation phase
Notch-HLH transcription pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
CD209 (DC-SIGN) signaling
Activation of the TFAP2 (AP-2) family of transcription factors
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
RUNX3 regulates NOTCH signaling
Estrogen-dependent gene expression
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

Allelic Composition: Crebbptm1Sis/Crebbp+
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)

 MP:0000085 large anterior fontanelle "enlarged diamond-shaped membranous interval at the junction of the coronal, sagittal and metopic sutures of the cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

Allelic Composition: Crebbptm1Sis/Crebbp+
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)

 MP:0000091 short premaxilla "reduced length of the anterior and interior portion of the maxilla" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0000097 short maxilla "reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0000103 nasal bone hypoplasia "reduced cell number in the bone which forms the nasal bridge" [J:53370]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Crebbptm1Sis/Crebbptm1Sis
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Crebbptm1Sis/Crebbptm1Sis
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)

 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
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Allelic Composition: Crebbptm1Sis/Crebbptm1Sis
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)

 MP:0000161 scoliosis "lateral and rotational curvature of the spine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53770, J:66943]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

Allelic Composition: Crebbptm1Sis/Crebbp+
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)

 MP:0000238 deficiency of pre-B cells "lack of progenitor cells that form the B cell component of the immune system" [J:60630, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Crebbptm1Dli/Crebbptm1Dli
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Crebbptm1Dli/Crebbp+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0000263 absent organized vascular network "formation of vasculature, but failure to differentiate into stereotypic organized pattern" [J:53370]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0000264 failure of vascular branching "failure of vasculature to form divisions (offshoots)" [J:53370]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Crebbptm1Reck/Crebbp+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000286 abnormal mitral valve morphology "malformation of the valve between the left atrium and the left ventricle of the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0000321 increased bone marrow cell number "increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Crebbptm1Dli/Crebbp+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Crebbptm1Dli/Crebbp+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Crebbptm1Dli/Crebbptm1Dli
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129-Crebbptm2Pkb x 129-Crebbptm2Pkb)F1

Allelic Composition: Crebbptm2Pkb/Crebbp+,Ep300tm3Pkb/Ep300+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0000447 flattened snout 
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Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129P2-Crebbptm2Pkb/Pkb x 129S2.129P2(B6)-Crebbptm2Pkb/Pkb)F1

 MP:0000449 broad nasal bridge "wider than normal upper part of the ridge of the nose" [J:53370]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0000457 maxilla hypoplasia "arrested growth or atrophy of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0000565 oligodactyly "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Crebbptm1Dli/Crebbp+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Crebbptm1Jvd/Crebbptm1Jvd,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Crebbptm1Jvd/Crebbptm1Jvd,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Crebbptm1Sis/Crebbptm1Sis
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Crebbptm1Dli/Crebbp+,Ep300tm1Dli/Ep300+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Crebbptm1Sis/Crebbptm1Sis
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
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Allelic Composition: Crebbptm1Sis/Crebbptm1Sis
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

Allelic Composition: Crebbptm1Dli/Crebbptm1Dli
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Crebbptm1Dli/Crebbp+,Ep300tm1Dli/Ep300+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Crebbptm1Sis/Crebbptm1Sis
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Crebbptm1Sis/Crebbptm1Sis
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

Allelic Composition: Crebbptm1Dli/Crebbp+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam17tm1Imx/Adam17tm1Imx,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Crebbptm2Pkb/Crebbp+,Ep300tm3Pkb/Ep300+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129P2-Crebbptm2Pkb/Pkb x 129S2.129P2(B6)-Crebbptm2Pkb/Pkb)F1

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fermt3tm1.1Efp/Fermt3tm1.1Efp
Genetic Background: involves: C57BL/6

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Fermt3tm1.1Efp/Fermt3tm1.1Efp
Genetic Background: involves: C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129P2-Crebbptm2Pkb/Pkb x 129S2.129P2(B6)-Crebbptm2Pkb/Pkb)F1

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129P2-Crebbptm2Pkb/Pkb x 129S2.129P2(B6)-Crebbptm2Pkb/Pkb)F1

 MP:0001409 increased stereotypic behavior "more frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, MGI:CLS, J:57125]
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Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129P2-Crebbptm2Pkb/Pkb x 129S2.129P2(B6)-Crebbptm2Pkb/Pkb)F1

 MP:0001441 increased grooming behavior "increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129P2-Crebbptm2Pkb/Pkb x 129S2.129P2(B6)-Crebbptm2Pkb/Pkb)F1

 MP:0001447 abnormal nest building behavior "deviation from the usual behavior of mice to build sleeping nests out of any available materials; also of female mice to bulid nests to protect offspring" [J:42758, What s wrong with my mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Fermt3tm1.1Efp/Fermt3tm1.1Efp
Genetic Background: involves: C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

Allelic Composition: Crebbptm1Sis/Crebbptm1Sis
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

Allelic Composition: Crebbptm1Sis/Crebbptm1Sis
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0001622 abnormal vasculogenesis "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

Allelic Composition: Crebbptm1Sis/Crebbptm1Sis
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

Allelic Composition: Crebbptm1Dli/Crebbp+,Ep300tm1Dli/Ep300+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Crebbptm1Sis/Crebbptm1Sis
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

Allelic Composition: Crebbptm1Sis/Crebbptm1Sis
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Crebbptm1Dli/Crebbp+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Crebbptm1Sis/Crebbp+
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)

Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129-Crebbptm2Pkb x 129-Crebbptm2Pkb)F1

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Crebbptm1Sis/Crebbptm1Sis
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
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Allelic Composition: Crebbptm1Dli/Crebbptm1Dli
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002019 abnormal tumor incidence "deviation from the expected number of abnormal growths of a specific tissue in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Crebbptm2Pkb/Crebbp+,Ep300tm3Pkb/Ep300tm3Pkb
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Crebbptm1Jvd/Crebbptm1Jvd
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cdkn1btm1Mlf/Cdkn1b+,Crebbptm1Jvd/Crebbptm1Jvd,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

Allelic Composition: Crebbptm1Jvd/Crebbptm1Jvd,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Crebbptm1Dli/Crebbp+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: B6.129S4-Col18a1tm1Hms

Allelic Composition: Crebbptm1Few/Crebbp+
Genetic Background: Not Specified

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

Allelic Composition: Crebbptm1Few/Crebbptm1Few
Genetic Background: Not Specified

Allelic Composition: Crebbptm1Few/Crebbp+
Genetic Background: Not Specified

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam17tm1Imx/Adam17tm1Imx,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

Allelic Composition: Crebbptm1Reck/Crebbp+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam17tm1Imx/Adam17tm1Imx,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Crebbptm1.1Ltz/Crebbp+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N * CD-1

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

Allelic Composition: Crebbptm1Sis/Crebbptm1Sis
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0002088 abnormal embryonic growth/weight/body size "limited or accelerated growth or development apparent before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Crebbptm1Sis/Crebbptm1Sis
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Crebbptm1Dli/Crebbp+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Crebbptm1Sis/Crebbptm1Sis
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam17tm1Imx/Adam17tm1Imx,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Crebbptm1Jvd/Crebbptm1Jvd
Genetic Background: involves: 129 * C57BL/6

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lattm1Bpay/Lattm1Bpay
Genetic Background: involves: 129S2/SvPas

 MP:0002276 abnormal lung interstitium morphology "any structural anomaly of the lung tissue, but not including the conducting airways (bronchi, bronchioles, alveoli) " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Lattm1Bpay/Lattm1Bpay
Genetic Background: involves: 129S2/SvPas

 MP:0002417 abnormal megakaryocyte morphology/development "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Crebbptm1Dli/Crebbp+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002441 abnormal granulocyte morphology/development "anomalous structure, differentiation, or number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Crebbptm1Dli/Crebbp+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129P2-Crebbptm2Pkb/Pkb x 129S2.129P2(B6)-Crebbptm2Pkb/Pkb)F1

 MP:0002696 decreased circulating glucagon level "lower than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Crebbptm1Few/Crebbptm1Few
Genetic Background: Not Specified

Allelic Composition: Crebbptm1Few/Crebbp+
Genetic Background: Not Specified

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0002801 abnormal long-term recognition memory "defects in long-term memory for objects that is consolidated over hours and days after training." [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

Allelic Composition: Crebbptm1.2Ltz/Crebbptm1.2Ltz,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL * C57BL/6J

Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129P2-Crebbptm2Pkb/Pkb x 129S2.129P2(B6)-Crebbptm2Pkb/Pkb)F1

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0002923 increased post-tetanic potential "increase in the size or duration of potentials that persist after tetanic stimulation of central synapses" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129P2-Crebbptm2Pkb/Pkb x 129S2.129P2(B6)-Crebbptm2Pkb/Pkb)F1

 MP:0002932 abnormal joint "defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Crebbptm1Sis/Crebbp+
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)

 MP:0003542 abnormal vascular endothelial cell development "malformation or aberrant differentiation of the cells that line the vasculature" [J:95387, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam17tm1Imx/Adam17tm1Imx,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
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Allelic Composition: Lattm1Bpay/Lattm1Bpay
Genetic Background: involves: 129S2/SvPas

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

Allelic Composition: Crebbptm1Sis/Crebbptm1Sis
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0003862 decreased aggression towards males "when compared to controls, subjects exhibit less than normal level of domineering, assaultive posture and/or hostile physical action towards male mice " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129P2-Crebbptm2Pkb/Pkb x 129S2.129P2(B6)-Crebbptm2Pkb/Pkb)F1

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Crebbptm1Sis/Crebbptm1Sis
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0004033 supernumerary teeth "occurrence of more than the usual number of teeth" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129P2-Crebbptm2Pkb/Pkb x 129S2.129P2(B6)-Crebbptm2Pkb/Pkb)F1

 MP:0004057 thin myocardial compact layer "reduced thickness of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Crebbptm1Reck/Crebbp+
Genetic Background: involves: 129P2/OlaHsd

 MP:0004379 wide frontal bone "increased width of the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0004471 short nasal bone "reduced length of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129P2-Crebbptm2Pkb/Pkb x 129S2.129P2(B6)-Crebbptm2Pkb/Pkb)F1

 MP:0004678 split xiphoid process "the appearance of an abnormal division of the posterior tip of the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129P2-Crebbptm2Pkb/Pkb x 129S2.129P2(B6)-Crebbptm2Pkb/Pkb)F1

 MP:0004679 xiphoid process foramen "the appearance of a hole or holes in the posterior tip of the sternum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Crebbptm1Sis/Crebbp+
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Crebbptm1Dli/Crebbp+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004892 increased adiponectin level "greater level of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Crebbptm1.2Ltz/Crebbptm1.2Ltz,Tg(Camk2a-cre)T29-1Stl/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL * C57BL/6J

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Crebbptm1Dli/Crebbp+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Crebbptm1Dli/Crebbp+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Crebbptm1Jvd/Crebbptm1Jvd,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ep300tm2Pkb/Ep300tm2Pkb,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Crebbptm1Jvd/Crebbptm1Jvd,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ep300tm2Pkb/Ep300tm2Pkb,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Crebbptm1Jvd/Crebbptm1Jvd,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: 129 * C57BL/6 * FVB

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Crebbptm1Few/Crebbptm1Few
Genetic Background: Not Specified

Allelic Composition: Crebbptm1Few/Crebbp+
Genetic Background: Not Specified

 MP:0005269 abnormal occipital bone morphology "anomalous structure of the bone at the lower, posterior part of the skull" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129P2-Crebbptm2Pkb/Pkb x 129S2.129P2(B6)-Crebbptm2Pkb/Pkb)F1

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Crebbptm1Few/Crebbptm1Few
Genetic Background: Not Specified

Allelic Composition: Crebbptm1Few/Crebbp+
Genetic Background: Not Specified

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Crebbptm1Few/Crebbp+
Genetic Background: Not Specified

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Crebbptm1Few/Crebbptm1Few
Genetic Background: Not Specified

Allelic Composition: Crebbptm1Few/Crebbp+
Genetic Background: Not Specified

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

Allelic Composition: Crebbptm1Sis/Crebbptm1Sis
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0006057 decreased vascular endothelial cell number "less than normal number of cells lining the vasculature" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0006207 embryonic lethality during organogenesis "death anytime after embryo turning but before the completion of organogenesis (E9 to less than E14)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Crebbptm2Pkb/Crebbp+,Ep300tm3Pkb/Ep300+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0006387 abnormal T cell number "deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ep300tm2Pkb/Ep300tm2Pkb,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Crebbptm1Dli/Crebbp+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Crebbptm1Jvd/Crebbptm1Jvd,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Crebbptm1Jvd/Crebbptm1Jvd,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: 129 * C57BL/6 * FVB

 MP:0008246 abnormal leukocyte morphology "any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]
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Allelic Composition: Crebbptm1Dli/Crebbp+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008254 increased megakaryocyte cell number "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
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Allelic Composition: Crebbptm1Dli/Crebbp+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Crebbptm1Dli/Crebbp+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009269 decreased fat cell size "reduction in the size of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0009321 histiocytic sarcoma 
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Allelic Composition: Crebbptm1Dli/Crebbp+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: Lattm1Bpay/Lattm1Bpay
Genetic Background: involves: 129S2/SvPas

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129P2-Crebbptm2Pkb/Pkb x 129S2.129P2(B6)-Crebbptm2Pkb/Pkb)F1

 MP:0010296 increased hemolymphoid system tumor incidence "greater than the expected number of tumors originating in the hemolymphoid system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Crebbptm1Dli/Crebbp+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0010400 increased liver glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Crebbptm1Few/Crebbptm1Few
Genetic Background: Not Specified

Allelic Composition: Crebbptm1Few/Crebbp+
Genetic Background: Not Specified

 MP:0010403 atrial septal defect "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0010418 perimembraneous ventricular septal defect "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Crebbptm1Reck/Crebbp+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Crebbptm1Pkb/Crebbptm1Pkb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Lattm1Bpay/Lattm1Bpay
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Crebbptm2Pkb/Crebbptm2Pkb
Genetic Background: (B6.129-Crebbptm2Pkb x 129-Crebbptm2Pkb)F1

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Crebbptm1Dli/Crebbp+,Ep300tm1Dli/Ep300+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Crebbptm1Dli/Crebbptm1Dli
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Crebbptm1Sis/Crebbptm1Sis
Genetic Background: either: (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA)

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

Allelic Composition: Crebbptm1Sis/Crebbptm1Sis
Genetic Background: involves: BALB/c * C57BL/6 * CBA

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Apaf1Gt(IRESBetageo)XIX18Pgr/Apaf1Gt(IRESBetageo)XIX18Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Crebbptm1Reck/Crebbp+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Crebbptm2Pkb/Crebbp+,Ep300tm3Pkb/Ep300tm3Pkb
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Crebbptm1Reck/Crebbp+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Ep300tm3Pkb/Ep300tm3Pkb
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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