ENSMUSG00000029279


Mus musculus

Features
Gene ID: ENSMUSG00000029279
  
Biological name :Brdt
  
Synonyms : Brdt / Bromodomain testis-specific protein / Q91Y44
  
Possible biological names infered from orthology : bromodomain testis associated / Q58F21
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: E5
Gene start: 107331159
Gene end: 107387058
  
Corresponding Affymetrix probe sets: 10523822 (MoGene1.0st)   1435502_a_at (Mouse Genome 430 2.0 Array)   1444667_at (Mouse Genome 430 2.0 Array)   1450178_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031215
Ensembl peptide - ENSMUSP00000108297
NCBI entrez gene - 114642     See in Manteia.
MGI - MGI:1891374
RefSeq - XM_017320608
RefSeq - NM_001079873
RefSeq - NM_054054
RefSeq - XM_011249398
RefSeq - XM_011249399
RefSeq - XM_017320607
RefSeq - XM_006534728
RefSeq - XM_006534729
RefSeq - XM_006534730
RefSeq Peptide - NP_473395
RefSeq Peptide - NP_001073342
swissprot - Q91Y44
Ensembl - ENSMUSG00000029279
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 brdtENSDARG00000102802Danio rerio
 BRDTENSGALG00000006031Gallus gallus
 BRDTENSG00000137948Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Brd4 / Q9ESU6 / Bromodomain-containing protein 4 / O60885* / bromodomain containing 4*ENSMUSG0000002400242
Brd2 / Q7JJ13 / Bromodomain-containing protein 2 / P25440* / bromodomain containing 2*ENSMUSG0000002433539
Brd3 / Q8K2F0 / Bromodomain-containing protein 3 / Q15059* / bromodomain containing 3*ENSMUSG0000002691837
Crebbp / CREB binding protein / Q92793*ENSMUSG0000002252120
Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*ENSMUSG0000005502418
Baz2b / bromodomain adjacent to zinc finger domain, 2B / Q9UIF8*ENSMUSG0000002698713
Baz2a / bromodomain adjacent to zinc finger domain 2A / Q9UIF9*ENSMUSG0000004005413
Baz1a / O88379 / Bromodomain adjacent to zinc finger domain protein 1A / Q9NRL2* / bromodomain adjacent to zinc finger domain 1A*ENSMUSG0000003502112
Baz1b / Q9Z277 / Tyrosine-protein kinase BAZ1B / Q9UIG0* / bromodomain adjacent to zinc finger domain 1B*ENSMUSG0000000274810


Protein motifs (from Interpro)
Interpro ID Name
 IPR001487  Bromodomain
 IPR018359  Bromodomain, conserved site
 IPR027353  NET domain
 IPR031354  Bromodomain protein 4, C-terminal
 IPR036427  Bromodomain-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001207 histone displacement IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006338 chromatin remodeling IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISO
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0007140 male meiotic nuclear division IMP
 biological_processGO:0007141 male meiosis I IMP
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0043484 regulation of RNA splicing IMP
 biological_processGO:0051039 positive regulation of transcription involved in meiotic cell cycle IMP
 biological_processGO:0051321 meiotic cell cycle IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042393 histone binding ISO
 molecular_functionGO:0070577 lysine-acetylated histone binding IMP


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Trp53tm2.1Umol/Trp53tm2.1Umol
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Ltbp1tm2Veto/Ltbp1tm2Veto
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Brdttm1a(EUCOMM)Wtsi/Brdttm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6-Brdttm1a(EUCOMM)Wtsi

 MP:0001938 delayed sexual maturation "immaturity of the sexual organs at a given age" [J:61190]
Show

Allelic Composition: Trp53tm2.1Umol/Trp53tm2.1Umol
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm2.1Umol/Trp53tm2.1Umol
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

 MP:0002674 abnormal sperm motility "anomalies in the mobility of the spermatozoa" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ltbp1tm2Veto/Ltbp1tm2Veto
Genetic Background: involves: 129 * C57BL/6

 MP:0002780 decreased circulating testosterone level "less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Brdttm1a(EUCOMM)Wtsi/Brdttm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6-Brdttm1a(EUCOMM)Wtsi

 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Asxl1tm1a(EUCOMM)Wtsi/Asxl1+
Genetic Background: C57BL/6N-Asxl1tm1a(EUCOMM)Wtsi/Cnrm

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brdttm1a(EUCOMM)Wtsi/Brdttm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6-Brdttm1a(EUCOMM)Wtsi

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ltbp1tm2Veto/Ltbp1tm2Veto
Genetic Background: involves: 129 * C57BL/6

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Brdttm1a(EUCOMM)Wtsi/Brdttm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6-Brdttm1a(EUCOMM)Wtsi

 MP:0006362 abnormal male germ cell morphology "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ltbp1tm2Veto/Ltbp1tm2Veto
Genetic Background: involves: 129 * C57BL/6

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brdttm1a(EUCOMM)Wtsi/Brdttm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6-Brdttm1a(EUCOMM)Wtsi

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ltbp1tm2Veto/Ltbp1tm2Veto
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Brdttm1a(EUCOMM)Wtsi/Brdttm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6-Brdttm1a(EUCOMM)Wtsi

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: ApcMin/Apc+,Trp53tm1Mlh/Trp53tm1Mlh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SWR

Allelic Composition: Brdttm1a(EUCOMM)Wtsi/Brdttm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6-Brdttm1a(EUCOMM)Wtsi

 MP:0010101 increased sacral vertebrae number "increase of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Asxl1tm1a(EUCOMM)Wtsi/Asxl1+
Genetic Background: C57BL/6N-Asxl1tm1a(EUCOMM)Wtsi/Cnrm

 MP:0013330 abnormal male accessory sex gland morphology "any structural anomaly of any gland, other than the gonad, associated with the genital tract, such as the ampulla of the ductus deferens and the bulbourethral, prostate and seminal vesicles of the male" [MGI:Anna]
Show

Allelic Composition: Brdttm1a(EUCOMM)Wtsi/Brdttm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6-Brdttm1a(EUCOMM)Wtsi

 MP:0014052 increased male germ cell apoptosis "greater number of male germs cells that undergo programmed cell death" [MGI:csmith]
Show

Allelic Composition: Brdttm1a(EUCOMM)Wtsi/Brdttm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6-Brdttm1a(EUCOMM)Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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