ENSG00000141867


Homo sapiens

Features
Gene ID: ENSG00000141867
  
Biological name :BRD4
  
Synonyms : BRD4 / bromodomain containing 4 / O60885
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.12
Gene start: 15235519
Gene end: 15332545
  
Corresponding Affymetrix probe sets: 202102_s_at (Human Genome U133 Plus 2.0 Array)   202103_at (Human Genome U133 Plus 2.0 Array)   226052_at (Human Genome U133 Plus 2.0 Array)   226054_at (Human Genome U133 Plus 2.0 Array)   238612_at (Human Genome U133 Plus 2.0 Array)   239000_at (Human Genome U133 Plus 2.0 Array)   240360_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000471240
Ensembl peptide - ENSP00000470481
Ensembl peptide - ENSP00000486621
Ensembl peptide - ENSP00000263377
Ensembl peptide - ENSP00000353112
Ensembl peptide - ENSP00000360901
Ensembl peptide - ENSP00000470108
NCBI entrez gene - 23476     See in Manteia.
OMIM - 608749
RefSeq - XM_011527856
RefSeq - NM_001330384
RefSeq - NM_014299
RefSeq - NM_058243
RefSeq - XM_011527854
RefSeq - XM_011527855
RefSeq Peptide - NP_001317313
RefSeq Peptide - NP_490597
RefSeq Peptide - NP_055114
swissprot - M0R0H4
swissprot - A0A024R7H8
swissprot - O60885
swissprot - M0QYW0
swissprot - M0QZD9
Ensembl - ENSG00000141867
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 brd4ENSDARG00000078904Danio rerio
 Brd4ENSMUSG00000024002Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BRD3 / Q15059 / bromodomain containing 3ENSG0000016992532
BRD2 / P25440 / bromodomain containing 2ENSG0000020425631
BRDT / Q58F21 / bromodomain testis associatedENSG0000013794829
CREBBP / Q92793 / CREB binding proteinENSG0000000533920
EP300 / Q09472 / E1A binding protein p300ENSG0000010039320
BAZ2A / Q9UIF9 / bromodomain adjacent to zinc finger domain 2AENSG0000007610812
BAZ2B / Q9UIF8 / bromodomain adjacent to zinc finger domain 2BENSG0000012363611
BAZ1A / Q9NRL2 / bromodomain adjacent to zinc finger domain 1AENSG000001986049
BAZ1B / Q9UIG0 / bromodomain adjacent to zinc finger domain 1BENSG000000099548


Protein motifs (from Interpro)
Interpro ID Name
 IPR001487  Bromodomain
 IPR018359  Bromodomain, conserved site
 IPR027353  NET domain
 IPR031354  Bromodomain protein 4, C-terminal
 IPR036427  Bromodomain-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0010971 positive regulation of G2/M transition of mitotic cell cycle IMP
 biological_processGO:0016032 viral process IEA
 biological_processGO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter IMP
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0050727 regulation of inflammatory response IDA
 biological_processGO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain IDA
 cellular_componentGO:0000794 condensed nuclear chromosome IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0000993 RNA polymerase II core binding IDA
 molecular_functionGO:0002039 p53 binding IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0070577 lysine-acetylated histone binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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