ENSMUSG00000070691


Mus musculus

Features
Gene ID: ENSMUSG00000070691
  
Biological name :Runx3
  
Synonyms : Q64131 / Runt-related transcription factor 3 / Runx3
  
Possible biological names infered from orthology : Q13761
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D3
Gene start: 135120652
Gene end: 135177990
  
Corresponding Affymetrix probe sets: 10509030 (MoGene1.0st)   1421467_at (Mouse Genome 430 2.0 Array)   1440275_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000050353
Ensembl peptide - ENSMUSP00000113159
NCBI entrez gene - 12399     See in Manteia.
MGI - MGI:102672
RefSeq - XM_006538506
RefSeq - NM_019732
RefSeq Peptide - NP_062706
swissprot - Q3U1Q3
swissprot - Q64131
Ensembl - ENSMUSG00000070691
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 runx3ENSDARG00000052826Danio rerio
 RUNX3ENSGALG00000043372Gallus gallus
 RUNX3ENSG00000020633Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Runx2 / Q08775 / runt related transcription factor 2 / Q13950*ENSMUSG0000003915361
Runx1 / runt related transcription factor 1 / Q01196*ENSMUSG0000002295260


Protein motifs (from Interpro)
Interpro ID Name
 IPR000040  Acute myeloid leukemia 1 protein (AML1)/Runt
 IPR008967  p53-like transcription factor, DNA-binding
 IPR012346  p53/RUNT-type transcription factor, DNA-binding domain superfamily
 IPR013524  Runt domain
 IPR013711  Runx, C-terminal domain
 IPR016554  Runt-related transcription factor RUNX
 IPR027384  Runx, central domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001503 ossification IBA
 biological_processGO:0002062 chondrocyte differentiation IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation ISS
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0030097 hemopoiesis IBA
 biological_processGO:0031069 hair follicle morphogenesis IMP
 biological_processGO:0031175 neuron projection development IMP
 biological_processGO:0032609 interferon-gamma production IDA
 biological_processGO:0042789 mRNA transcription by RNA polymerase II IDA
 biological_processGO:0045595 regulation of cell differentiation IBA
 biological_processGO:0045786 negative regulation of cell cycle IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048469 cell maturation IGI
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IMP
 biological_processGO:0071559 response to transforming growth factor beta ISS
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IMP
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0042826 histone deacetylase binding ISO
 molecular_functionGO:0046332 SMAD binding ISO


Pathways (from Reactome)
Pathway description
RUNX3 regulates CDKN1A transcription
RUNX3 regulates NOTCH signaling
Regulation of RUNX3 expression and activity
RUNX3 regulates WNT signaling
RUNX3 regulates YAP1-mediated transcription
RUNX3 regulates p14-ARF


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
Show

Allelic Composition: Runx3tm1Yg/Runx3tm1Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Runx2tm1Mjo/Runx2+,Runx3tm1Yg/Runx3tm1Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Runx3tm3.1Yg/Runx3tm3.1Yg
Genetic Background: Not Specified

Allelic Composition: Runx3tm1Yg/Runx3tm1Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Runx3tm1Yg/Runx3tm1Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
Show

Allelic Composition: Runx3tm1Yg/Runx3tm1Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx3tm1Yg/Runx3tm1Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0000162 lordosis "anteriorly convex curvature of the spine, "saddle back" " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62022]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Runx3tm1Yg/Runx3tm1Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000402 abnormal zigzag hairs "anomalies of truncal hairs that contain one air cell in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0000405 abnormal auchene hairs "anomalies of truncal hairs that contain two or more air cells in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Runx3tm3.1Yg/Runx3tm3.1Yg
Genetic Background: Not Specified

 MP:0000471 abnormal stomach epithelium morphology "malformation of the epithelial layer of the stomach " [tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bcl2tm1Mpin/Bcl2+,Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0000489 abnormal large intestine morphology "structural or developmental anomalies of the intestinum crassum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0000494 abnormal cecum morphology "malformation of the large sac at the ileum and large intestine junction" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0000956 reduced spinal cord size "smaller appearance of the spinal cord" [J:35802]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0000964 small dorsal root ganglia "reduced size of the dorsal root ganglia" [J:17123]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0000965 abnormal sensory neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of sensory impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001255 decreased body height "decreased shoulder to floor distance compared to controls" [dlb:Donna Burkart, Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx3tm3.1Yg/Runx3tm3.1Yg
Genetic Background: Not Specified

Allelic Composition: Runx3tm3Yg/Runx3tm3Yg,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: FVB/N

Allelic Composition: Runx2tm1Mjo/Runx2+,Runx3tm3Yg/Runx3tm3Yg,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: FVB/N

Allelic Composition: Runx3tm3Yg/Runx3tm3Yg,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Runx3tm3.1Yg/Runx3tm3.1Yg
Genetic Background: Not Specified

Allelic Composition: Runx3tm3Yg/Runx3tm3Yg,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: FVB/N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Runx3tm1Yg/Runx3tm1Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Runx3tm1Yg/Runx3tm1Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Runx3tm3Yg/Runx3tm3Yg,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: FVB/N

Allelic Composition: Runx2tm1Mjo/Runx2+,Runx3tm3Yg/Runx3tm3Yg,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: FVB/N

Allelic Composition: Runx3tm3Yg/Runx3tm3Yg,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: CD-1

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Runx3tm1Yg/Runx3tm1Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Runx3tm3.1Yg/Runx3tm3.1Yg
Genetic Background: Not Specified

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Runx3tm1Yg/Runx3tm1Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Runx3tm3.1Yg/Runx3tm3.1Yg
Genetic Background: Not Specified

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Runx3tm3.1Yg/Runx3tm3.1Yg
Genetic Background: Not Specified

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001858 intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Runx3tm3.1Yg/Runx3tm3.1Yg
Genetic Background: Not Specified

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Runx3tm1Itan/Runx3tm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0001873 stomach inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the stomach" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001952 increased airway responsiveness "more easily provoked into bronchoconstriction in bronchial provocation tests" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx3tm1Yg/Runx3tm1Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Runx3tm1Yg/Runx3tm1Yg
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * BALB/c) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx3tm1Yg/Runx3tm1Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002408 abnormal double-positive T cell "anomalous development or number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Shmt1tm1.1Stov/Shmt1tm1.1Stov
Genetic Background: 129S/SvEv-Shmt1tm1.1Stov

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Runx3tm1Itan/Runx3tm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx3tm1Yg/Runx3tm1Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Runx3tm3.1Yg/Runx3tm3.1Yg
Genetic Background: Not Specified

Allelic Composition: Runx3tm1Yg/Runx3tm1Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0003306 small intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0003994 abnormal dorsal spinal root morphology "any anomaly, deformity, or malformation of the posterior bundle of nerves emerging from the spinal cord to join with the anterior/ventral nerve bundle at each spinal cord segment to form one of the 31 paired peripheral nerves" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0004016 decreased bone mass "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx3tm1Yg/Runx3tm1Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0004139 abnormal parietal cell morphology "malformation of the gastric acid producing epithelial cells that are distributed throughout the length of the gastric gland " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0004140 abnormal chief cell morphology "malformation of the pepsinogen producing epithelial cells that are clustered at the base of the gastric gland " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0004142 abnormal muscle tone "anomaly in the resting tautness or laxity of a muscle, normally somewhere in the middle of the range between total contraction and total relaxation" [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Runx3tm1Yg/Runx3tm1Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004351 short humerus "reduced length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Runx3tm1Yg/Runx3tm1Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx3tm1Yg/Runx3tm1Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx3tm3.1Yg/Runx3tm3.1Yg
Genetic Background: Not Specified

 MP:0004989 decreased osteoblast cell number "reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx3tm1Yg/Runx3tm1Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0004991 decreased bone strength "reduced ability of bone to endure the application of force without yielding or breaking" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx3tm1Yg/Runx3tm1Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fli1tm1Ber/Fli1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

Allelic Composition: Runx3tm1Yg/Runx3tm1Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Runx3tm1Itan/Runx3tm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0005211 increased thickness of gastric mucosa "greater than the normal depth or width of the epithelial layer of the stomach" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:77398]
Show

Allelic Composition: Bcl2tm1Mpin/Bcl2+,Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0005232 abnormal mesenteric lymph node morphology "anomalous structure, development, or number of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0005298 abnormal clavicle morphology "malformation of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Runx3tm1Yg/Runx3tm1Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0005461 abnormal dendritic cell morphology/development "anomalous structure or atypical formation of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Runx3tm1Yg/Runx3tm1Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bcl2tm1Mpin/Bcl2+,Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0006086 decreased body mass index "less than normal average of a measure of weight for height " [ncbi:NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx3tm3Yg/Runx3tm3Yg,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: FVB/N

 MP:0006282 abnormal posterior horn morphology "any structural anomaly of the dorsal gray matter of the spinal cord" [J:77764, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0006382 abnormal lung epithelium morphology "any structural anomaly of the epithelial layer of the lung" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Runx1tm1Toku/Runx1tm1Toku,Runx3tm1Itan/Runx3tm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx1tm1Toku/Runx1tm1Toku,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Runx1tm1Toku/Runx1tm1Toku,Runx3tm1Itan/Runx3+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx3tm1Itan/Runx3tm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Runx1tm1Tani/Runx1tm1Tani,Runx3tm1Itan/Runx3tm1Itan,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Runx1tm1Toku/Runx1tm1Toku,Runx3tm1Itan/Runx3tm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Runx1tm1Toku/Runx1+,Runx3tm1Itan/Runx3tm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Runx1tm1Toku/Runx1tm1Toku,Runx3tm1Itan/Runx3+,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0008080 abnormal CD8-positive T cell differentiation "atypical production of or inability to produce the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx3tm1Itan/Runx3tm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Runx3tm1Litt/Runx3tm1Litt
Genetic Background: involves: 129P2/OlaHsd

 MP:0008115 abnormal dendritic cell differentiation "atypical production of or inability to produce a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Runx3tm2Yg/Runx3tm2Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * ICR

 MP:0008118 absent Langerhans cell "absence of stellate dendritic cells of myeloid origin, that appear clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Runx3tm3.1Yg/Runx3tm3.1Yg
Genetic Background: Not Specified

 MP:0008126 increased dendritic cell number "greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0008152 decreased diameter of femur "reduced width of the cross-sectional distance that extends from one lateral edge of the femur, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx3tm1Yg/Runx3tm1Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Runx3tm3Yg/Runx3tm3Yg,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: FVB/N

 MP:0008273 abnormal intramembranous bone ossification "anomaly in the process of the formation of bone in which osteoblasts secrete a collage-proteoglycan matrix that binds calcium salts and becomes calcified; intramembranous ossification is the way flat bones are formed" [GO:0001957]
Show

Allelic Composition: Runx3tm1Yg/Runx3tm1Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0008468 absent muscle spindles "absence of the sensory organs in muscle that are involved in the stretch reflex" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0008555 abnormal interferon secretion "anomaly in the production or release of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
Show

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Runx1tm1Toku/Runx1tm1Toku,Runx3tm1Itan/Runx3tm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0008750 abnormal interferon level "deviation from the normal levels of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx3tm3Yg/Runx3tm3Yg,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: CD-1

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx3tm1Yg/Runx3tm1Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0009677 abnormal spinal cord dorsal column morphology "any structural anomaly of the wedge-shaped fiber bundle of white matter in the dorsomedial side of the spinal cord that is made up of the fasciculus gracilis and fasciculus cuneatus; it is part of the ascending posterior column-medial lemniscus pathway that is important for well-localized fine touch and conscious proprioception" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN-10:0940780577 "Goldberg, S, Clinical Neuroanatomy Made Ridiculously Simple, 3rd edition"]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx3tm3.1Yg/Runx3tm3.1Yg
Genetic Background: Not Specified

Allelic Composition: Runx3tm1Yg/Runx3tm1Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Runx3tm3Yg/Runx3tm3Yg,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: FVB/N

 MP:0010792 abnormal stomach mucosa morphology "any structural anomaly of the mucous layer of the stomach wall which contains the gastric pits and glands, and consists of epithelium, lamina propria, and the muscularis mucosae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0010799 stomach mucosa hyperplasia "overdevelopment or increased size, usually due to an increase in the number of cells, of the mucous layer of the stomach wall which contains the gastric pits and glands, and consists of epithelium, lamina propria, and the muscularis mucosae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl2tm1Mpin/Bcl2+,Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0010876 decreased bone volume "reduced amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx3tm1Yg/Runx3tm1Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0010879 decreased trabecular bone volume "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx3tm1Yg/Runx3tm1Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0010968 decreased compact bone area "reduction in the total amount of cross-sectional area of compact bone tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Runx3tm3.1Yg/Runx3tm3.1Yg
Genetic Background: Not Specified

Allelic Composition: Runx3tm3Yg/Runx3tm3Yg,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: FVB/N

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Bcl2tm1Mpin/Bcl2+,Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Runx2tm1Mjo/Runx2+,Runx3tm1Yg/Runx3tm1Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Bcl2tm1Mpin/Bcl2+,Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0013639 decreased bone stiffness "decrease in material stiffness (N/mm) during elastic deformation" [MGI:jwhite]
Show

Allelic Composition: Runx3tm1Yg/Runx3tm1Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0030315 small neurocranium "decreased size of the bones of the skull enclosing the brain" [MGI:anna]
Show

Allelic Composition: Runx3tm1Yg/Runx3tm1Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0030439 decreased osteoblast proliferation "reduction in the expansion rate of osteoblasts by cell division; osteoblasts are skeletogenic cells that secrete osteoid, are capable of producing mineralized (hydroxyapatite) matrix, are located adjacent to or within osteoid tissue, and arise from the transformation of a preosteoblast cell" [MGI:anna]
Show

Allelic Composition: Runx3tm1Yg/Runx3tm1Yg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026313 Hdac4 / Q6NZM9 / Histone deacetylase 4 / P56524*  / complex / reaction
 ENSMUSG00000038872 Zfhx3 / zinc finger homeobox 3 / Q15911*  / complex
 ENSMUSG00000031885 Cbfb / Q08024 / Core-binding factor subunit beta / Q13951* / core-binding factor beta subunit*  / reaction / complex
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction / complex
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / reaction / complex
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / reaction / complex
 ENSMUSG00000053110 Yap1 / P46938 / yes-associated protein 1 / P46937*  / reaction / complex
 ENSMUSG00000032402 Smad3 / Q8BUN5 / Mothers against decapentaplegic homolog 3 / P84022* / SMAD family member 3*  / complex / reaction
 ENSMUSG00000055024 Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*  / complex / reaction
 ENSMUSG00000070348 Ccnd1 / P25322 / G1/S-specific cyclin-D1 / P24385* / cyclin D1*  / complex / reaction
 ENSMUSG00000024335 Brd2 / Q7JJ13 / Bromodomain-containing protein 2 / P25440* / bromodomain containing 2*  / complex / reaction
 ENSMUSG00000024515 Smad4 / P97471 / Mothers against decapentaplegic homolog 4 / Q13485* / SMAD family member 4*  / reaction / complex
 ENSMUSG00000020184 Mdm2 / P23804 / E3 ubiquitin-protein ligase Mdm2 / Q00987* / MDM2 proto-oncogene*  / complex / reaction
 ENSMUSG00000024985 Q924A0 / Tcf7l2 / transcription factor 7 like 2, T cell specific, HMG box / Q9NQB0* / transcription factor 7 like 2*  / complex / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr