Manteia

ID	Phenotype	Definition	Genetic BG
MP:0000157	abnormal sternum morphology	"malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]	Show Allelic Composition: Drd1^tm1Jcd/Drd1^tm1Jcd,Drd2^tm1Ebo/Drd2⁺ Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MP:0000158	absent sternum	"missing long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62577]	Show Allelic Composition: Runx1^tm1.1Stkd/Runx1^tm1.1Stkd,Runx2^tm1Mjo/Runx2^tm1Mjo,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: C57BL/6J * SJL/J
MP:0000159	abnormal xiphoid process	"malformed posterior tip of the sternum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:42932]	Show Allelic Composition: Drd1^tm1Jcd/Drd1^tm1Jcd,Drd2^tm1Ebo/Drd2⁺ Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
MP:0000208	decreased hematocrit	"less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Runx1^tm2.1Gss/Runx1^tm2.1Gss Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000218	increased WBC count	"greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Hip1^tm4Tsr/Hip1⁺,Runx1^tm3Dow/Runx1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0000219	increased neutrophil count	"greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Runx1^tm2Buch/Runx1^tm2Buch,Tg(Mx1-cre)1Cgn/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Hip1^tm4Tsr/Hip1⁺,Runx1^tm3Dow/Runx1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA Allelic Composition: Bcr^{tm1(BCR/ABL)Tsr}/Bcr⁺,Runx1^tm3Dow/Runx1⁺,Tg(Vav1-cre)#Cgp/0 Genetic Background: involves: C57BL/6
MP:0000220	increased monocyte count	"greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Runx1^tm4Spe/Runx1^tm4Spe Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Runx1^tm2Buch/Runx1^tm2Buch,Tg(Mx1-cre)1Cgn/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Runx1^tm3Spe/Runx1^tm3Spe,Tg(Vav1-cre)1Graf/0 Genetic Background: involves: 129S4/SvJae Allelic Composition: Bcr^{tm1(BCR/ABL)Tsr}/Bcr⁺,Runx1^tm3Dow/Runx1⁺,Tg(Vav1-cre)#Cgp/0 Genetic Background: involves: C57BL/6 Allelic Composition: Runx1^tm2.1Gss/Runx1^tm2.1Gss Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000221	decreased WBC count	"fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Runx1^{tm3(Runx3)Toku}/Runx1^{tm3(Runx3)Toku} Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Runx1^{tm4(Runx2)Toku}/Runx1^{tm4(Runx2)Toku} Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Runx1^tm4Spe/Runx1^tm4Spe Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Runx1^tm3Itan/Runx1^tm3Itan Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000229	abnormal megakaryocyte differentiation	"atypical process of formation and development these very large bone marrow cells which release mature platelets" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Runx1^tm1Soga/Runx1^tm1.1Soga,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Runx1^tm2.1Gss/Runx1^tm2.1Gss Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000240	extramedullary hematopoiesis	"formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Hip1^tm4Tsr/Hip1⁺,Runx1^tm3Dow/Runx1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0000245	abnormal erythropoiesis	"atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Alx1^tm1Crm/Alx1^tm1Crm,Alx4^tm1Rwi/Alx4^tm1Rwi Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd Allelic Composition: Runx1^tm1Sata/Runx1^tm1Sata Genetic Background: involves: 129S4/SvJae * C57BL/6J Allelic Composition: Runx1^tm2.1Gss/Runx1^tm2.1Gss Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000260	abnormal angiogenesis	"aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Runx1^tm1Sata/Runx1^tm1Sata Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0000322	increased granulocyte number	"greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Runx1^tm3Spe/Runx1^tm3Spe,Spi1^tm2.1Dgt/Spi1^tm2.1Dgt,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA Allelic Composition: Runx1^tm3Spe/Runx1^tm3Spe,Tg(Vav1-cre)1Graf/0 Genetic Background: involves: 129S4/SvJae Allelic Composition: Hip1^tm4Tsr/Hip1⁺,Runx1^tm3Dow/Runx1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA Allelic Composition: Runx1^tm2.1Gss/Runx1^tm2.1Gss Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000324	increased mast cell number	"greater than expected number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Runx1^tm2Buch/Runx1^tm2Buch,Tg(Mx1-cre)1Cgn/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0000333	decreased bone marrow cell number	"decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]	Show Allelic Composition: Hip1^tm4Tsr/Hip1⁺,Runx1^tm3Dow/Runx1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0000402	abnormal zigzag hairs	"anomalies of truncal hairs that contain one air cell in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Phex^Hyp-Duk/Y Genetic Background: B6.C-Phex^Hyp-Duk/J Allelic Composition: Runx1^tm2Spe/Runx1^tm3Spe,Tg(KRT5-cre)5132Jlj/0 Genetic Background: either: (involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2J) or (involves: 129S4/SvJae * C57BL/6 * DBA/2J)
MP:0000404	reduced curvature of zigzag hairs	"smaller bending arch of the zigzag hairs" [J:62217]	Show Allelic Composition: Phex^Hyp-Duk/Y Genetic Background: B6.C-Phex^Hyp-Duk/J Allelic Composition: Runx1^tm2Spe/Runx1^tm3Spe,Tg(KRT5-cre)5132Jlj/0 Genetic Background: either: (involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2J) or (involves: 129S4/SvJae * C57BL/6 * DBA/2J)
MP:0000406	increased curvature of auchene hairs	"greater bending arch of the auchene hairs" [J:47620]	Show Allelic Composition: Phex^Hyp-Duk/Y Genetic Background: B6.C-Phex^Hyp-Duk/J Allelic Composition: Runx1^tm2Spe/Runx1^tm3Spe,Tg(KRT5-cre)5132Jlj/0 Genetic Background: either: (involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2J) or (involves: 129S4/SvJae * C57BL/6 * DBA/2J)
MP:0000598	abnormal liver morphology	"malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]	Show Allelic Composition: Il2rg^tm1Wjl/Il2rg^tm1Wjl,Tg(CD2-Ccdc86)1Hfuj/? Genetic Background: B6.Cg-Il2rg^tm1Wjl Tg(CD2-Ccdc86)1Hfuj
MP:0000599	enlarged liver	"larger than average size of the liver" [J:65146]	Show Allelic Composition: Hip1^tm4Tsr/Hip1⁺,Runx1^tm3Dow/Runx1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0000603	pale liver	"liver lacking normal coloration, often refers to bloodless condition" [J:18048]	Show Allelic Composition: Apc^Min/Apc⁺ Genetic Background: C57BL/6J-Apc^Min Allelic Composition: Runx1^tm2Dow/Runx1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Runx1^tm3Spe/Runx1^tm3Spe,Tg(Cdh5-cre)1Spe/0 Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6 Allelic Composition: Runx1^tm1.1Gss/Runx1^tm1.1Gss Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Runx1^{tm1.1(RUNX1)Homy}/Runx1^{tm1.1(RUNX1)Homy} Genetic Background: B6.129P2-Runx1^{tm1.1(RUNX1*)Homy}
MP:0000689	abnormal spleen morphology	"atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]	Show Allelic Composition: Hip1^tm4Tsr/Hip1⁺,Runx1^tm3Dow/Runx1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0000691	enlarged spleen	"increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Hip1^tm4Tsr/Hip1⁺,Runx1^tm3Dow/Runx1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA Allelic Composition: Runx1^tm2.1Gss/Runx1^tm2.1Gss Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000692	small spleen	"decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Runx1^{tm3(Runx3)Toku}/Runx1^{tm3(Runx3)Toku} Genetic Background: involves: 129P2/OlaHsd
MP:0000693	spleen hyperplasia	"increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]	Show Allelic Composition: Hip1^tm4Tsr/Hip1⁺,Runx1^tm3Dow/Runx1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0000696	abnormal Peyer s patches morphology	"anomalous structure, development, or cellular make-up of the lymphoid tissue located on the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tmem173^tm1Gnb/Tmem173^tm1Gnb Genetic Background: involves: 129P2/OlaHsd
MP:0000701	abnormal lymph node size	"deviation from the normal lymph node size " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Runx1^tm2Buch/Runx1^tm2Buch,Tg(Mx1-cre)1Cgn/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0000706	small thymus	"reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]	Show Allelic Composition: Ripk2^tm1Ghc/Ripk2^tm1Ghc Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Runx1^{tm3(Runx3)Toku}/Runx1^{tm3(Runx3)Toku} Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Runx1^tm1Yg/Runx1^tm1Yg Genetic Background: either: (involves: 129/Sv * 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * ICR) or (involves: 129S1/Sv * 129X1/SvJ * MF1)
MP:0000715	decreased thymocyte number	"fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Runx1^{tm3(Runx3)Toku}/Runx1^{tm3(Runx3)Toku} Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Runx1^tm1Yg/Runx1^tm1Yg Genetic Background: either: (involves: 129/Sv * 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * ICR) or (involves: 129S1/Sv * 129X1/SvJ * MF1) Allelic Composition: Runx1^tm1Tani/Runx1^tm1Tani,Tg(Lck-cre)1Cwi/? Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Runx1^tm3Spe/Runx1^tm3Spe,Tg(Vav1-cre)1Graf/0 Genetic Background: involves: 129S4/SvJae Allelic Composition: Runx1^tm3Itan/Runx1^tm3Itan Genetic Background: involves: 129P2/OlaHsd
MP:0000966	reduced sensory neuron number	"fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]	Show Allelic Composition: Pkd1^tm1.1Fqi/Pkd1^tm1.1Fqi Genetic Background: involves: 129S6/SvEvTac
MP:0000968	abnormal sensory neuron innervation	"defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]	Show Allelic Composition: Pkd1^tm1.1Fqi/Pkd1^tm1.1Fqi Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Mapt^tm2Arbr/?,Runx1^tm3Spe/Runx1^tm3Spe,H2afv^{Tg(Wnt1-cre)11Rth}/? Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J * CBA/J
MP:0000972	abnormal mechanoreceptor morphology	"anomaly in the receptors of the body, usually nerve termini, that respond to mechanical pressure or distortion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:34172]	Show Allelic Composition: Cbfb^tm2.1Ddg/Cbfb^tm2.1Ddg,H2afv^{Tg(Wnt1-cre)11Rth}/? Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J Allelic Composition: Mapt^tm2Arbr/?,Runx1^tm3Spe/Runx1^{tm1(cre/Esr1)Ims} Genetic Background:* involves: 129S4/SvJae * C57BL/6NCrlj * CBA/JNCrlj
MP:0001175	abnormal lung morphology	"malformed organ of respiration" [J:35802]	Show Allelic Composition: Hip1^tm4Tsr/Hip1⁺,Runx1^tm3Dow/Runx1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Bicc1^jcpk/Bicc1⁺ Genetic Background: involves: 101 * C3H * T STOCK
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Bicc1^jcpk/Bicc1⁺ Genetic Background: involves: 101 * C3H * T STOCK Allelic Composition: Runx1^tm1Yg/Runx1^tm1Yg Genetic Background: either: (involves: 129/Sv * 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * ICR) or (involves: 129S1/Sv * 129X1/SvJ * MF1)
MP:0001272	increased metastatic potential		Show Allelic Composition: Runx1^{tm1(RUNX1)Gcg}/Runx1^{tm1(RUNX1)Gcg},Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
MP:0001510	abnormal coat appearance	"coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Phex^Hyp-Duk/Y Genetic Background: B6.C-Phex^Hyp-Duk/J Allelic Composition: Runx1^tm2Spe/Runx1^tm3Spe,Tg(KRT5-cre)5132Jlj/0 Genetic Background: either: (involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA/2J) or (involves: 129S4/SvJae * C57BL/6 * DBA/2J)
MP:0001577	anemia	"less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Runx1^{tm1(RUNX1)Gcg}/Runx1^{tm1(RUNX1)Gcg},Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA Allelic Composition: Runx1^tm1Medv/Runx1^tm1Medv Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Runx1^tm3Spe/Runx1^tm3Spe,Tg(Cdh5-cre)1Spe/0 Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6 Allelic Composition: Etv6^{tm1(RUNX1)Haho}/Etv6⁺,Runx1^tm3Spe/Runx1^tm3Spe,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * CBA Allelic Composition: Runx1^tm1Spe/Runx1^tm1Yg Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 Allelic Composition: Runx1^{tm2.1(cre/Esr1)Ims}/Runx1^tm1Medv Genetic Background:* involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Runx1^{tm2.1(cre/Esr1)Ims}/Runx1^{tm2.1(cre/Esr1)Ims} Genetic Background: involves: C57BL/6 Allelic Composition: Pdgfra^{tm1.1(cre/Esr1)Nshk}/Pdgfra⁺,Runx1^tm1Medv/Runx1^tm1Medv Genetic Background:* involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj Allelic Composition: Runx1^tm2.1Gss/Runx1^tm2.1Gss Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0001601	abnormal myelopoiesis	"atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]	Show Allelic Composition: Slc18a2^tm1Uhl/Slc18a2^tm1Uhl Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Runx1^{tm1(RUNX1/EVI1)Kmit}/Runx1⁺ Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Hip1^tm4Tsr/Hip1⁺,Runx1^tm3Dow/Runx1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0001602	impaired myelopoiesis	"atypical process of bone marrow cell formation and/or the formation of bone marrow-derived blood cells with the result of fewer of these cells being formed" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]	Show Allelic Composition: Alx1^tm1Crm/Alx1^tm1Crm,Alx4^tm1Rwi/Alx4^tm1Rwi Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd Allelic Composition: Runx1^tm2Buch/Runx1^tm2Buch,Tg(Mx1-cre)1Cgn/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0001606	impaired hematopoiesis	"atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]	Show Allelic Composition: Alx1^tm1Crm/Alx1^tm1Crm,Alx4^tm1Rwi/Alx4^tm1Rwi Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd Allelic Composition: Runx1^tm1Dez/Runx1⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Runx1^tm1Medv/Runx1^tm1Medv Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Runx1^{tm1.1(RUNX1)Homy}/Runx1^{tm1.1(RUNX1)Homy} Genetic Background: B6.129P2-Runx1^{tm1.1(RUNX1*)Homy}
MP:0001634	internal hemorrhage	"blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]	Show Allelic Composition: Alx1^tm1Crm/Alx1^tm1Crm,Alx4^tm1Rwi/Alx4^tm1Rwi Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd Allelic Composition: Runx1^tm1Dow/Runx1^tm1Dow Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Runx1^tm1Sata/Runx1^tm1Sata Genetic Background: involves: 129S4/SvJae * C57BL/6J Allelic Composition: Runx1^tm1Yg/Runx1^tm2Spe Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * ICR) or (involves: 129/Sv * MF1) Allelic Composition: Runx1^tm3Spe/Runx1^tm3Spe,Tg(Cdh5-cre)1Spe/0 Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6 Allelic Composition: Runx1^tm1Spe/Runx1^tm1Yg Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Runx1^tm7Spe/Runx1^tm7Spe Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Runx1^tm4Spe/Runx1^tm4Spe Genetic Background: involves: 129/Sv * C57BL/6
MP:0001786	skin edema	"accumulation of an excessive amount of fluid in the skin" [J:65039]	Show Allelic Composition: Runx1^{tm1.1(RUNX1)Homy}/Runx1^{tm1.1(RUNX1)Homy} Genetic Background: B6.129P2-Runx1^{tm1.1(RUNX1*)Homy}
MP:0001823	thymus hypoplasia	"small size due to reduced cell number in the thymus" [J:23255]	Show Allelic Composition: Ripk2^tm1Ghc/Ripk2^tm1Ghc Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Runx1^{tm3(Runx3)Toku}/Runx1^{tm3(Runx3)Toku} Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Runx1^tm1Yg/Runx1^tm1Yg Genetic Background: either: (involves: 129/Sv * 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * ICR) or (involves: 129S1/Sv * 129X1/SvJ * MF1)
MP:0001825	arrested T cell development	"failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Runx1^tm1Tani/Runx1^tm1Tani,Tg(Lck-cre)1Cwi/? Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Runx1^tm3Spe/Runx1^tm3Spe,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
MP:0001861	lung inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Runx1^tm7Spe/Runx1^tm7Spe Genetic Background: involves: 129/Sv * C57BL/6
MP:0001914	hemorrhage	"loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Alx1^tm1Crm/Alx1^tm1Crm,Alx4^tm1Rwi/Alx4^tm1Rwi Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd Allelic Composition: Runx1^tm1Dez/Runx1⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Runx1^tm1Medv/Runx1^tm1Medv Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Runx1^tm1.1Gss/Runx1^tm1.1Gss Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Runx1^{tm1.1(RUNX1)Homy}/Runx1^{tm1.1(RUNX1)Homy} Genetic Background: B6.129P2-Runx1^{tm1.1(RUNX1)Homy} Allelic Composition:* Runx1^{tm2.1(cre/Esr1)Ims}/Runx1^tm1Medv Genetic Background:* involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Runx1^{tm2.1(cre/Esr1)Ims}/Runx1^{tm2.1(cre/Esr1)Ims} Genetic Background: involves: C57BL/6
MP:0001915	intracranial hemorrhage	"bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Runx1^tm1Yg/Runx1^tm2Spe Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * ICR) or (involves: 129/Sv * MF1)
MP:0001917	intraventricular hemorrhage	"bleeding into the brain ventricles" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Runx1^tm1Dow/Runx1^tm1Dow Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Runx1^tm1Sata/Runx1^tm1Sata Genetic Background: involves: 129S4/SvJae * C57BL/6J Allelic Composition: Runx1^tm2Dow/Runx1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Runx1^{tm1(RUNX1/EVI1)Kmit}/Runx1⁺ Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Runx1^tm5Spe/Runx1^tm5Spe Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Runx1^tm6Spe/Runx1^tm6Spe Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Runx1^tm7Spe/Runx1^tm7Spe Genetic Background: involves: 129/Sv * C57BL/6
MP:0002020	increased tumor incidence	"greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]	Show Allelic Composition: Trp53^tm1Ldo/Trp53⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002024	T cell derived lymphoma	"group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Pafah1b2^tm1Arai/Pafah1b2^tm1Arai,Pafah1b3^tm1Arai/Pafah1b3^tm1Arai Genetic Background: involves: 129X1/SvJ * C57BL/6N Allelic Composition: Runx1^{tm1(RUNX1)Gcg}/Runx1^{tm1(RUNX1)Gcg},Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA Allelic Composition: Runx1^tm2Buch/Runx1^tm2Buch,Tg(Mx1-cre)1Cgn/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Runx1^tm3Dow/Runx1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: C57BL/6 * CBA
MP:0002032	sarcoma	"connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]	Show Allelic Composition: Trp53^tm1Ldo/Trp53⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002058	neonatal lethality	"death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cbln1^tm1Jim/Cbln1^tm1Jim,Bax^tm1Sjk/Bax^tm1Sjk Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ Allelic Composition: Runx1^{tm2.1(cre/Esr1)Ims}/Runx1^tm1Medv Genetic Background:* involves: 129P2/OlaHsd * C57BL/6
MP:0002082	postnatal lethality	"premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Il2rg^tm1Wjl/Il2rg^tm1Wjl,Tg(CD2-Ccdc86)1Hfuj/? Genetic Background: B6.Cg-Il2rg^tm1Wjl Tg(CD2-Ccdc86)1Hfuj
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Trp53^tm1Ldo/Trp53⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Etv6^{tm1(RUNX1)Haho}/Etv6⁺,Runx1^tm3Spe/Runx1^tm3Spe,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * CBA Allelic Composition: Bcr^{tm1(BCR/ABL)Tsr}/Bcr⁺,Runx1^tm3Dow/Runx1⁺,Tg(Vav1-cre)#Cgp/0 Genetic Background: involves: C57BL/6
MP:0002113	abnormal skeleton development	"anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Drd1^tm1Jcd/Drd1^tm1Jcd,Drd2^tm1Ebo/Drd2⁺ Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 Allelic Composition: Runx1^tm1.1Stkd/Runx1^tm1.1Stkd,Runx2^tm1Mjo/Runx2^tm1Mjo,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: C57BL/6J * SJL/J
MP:0002123	abnormal hematopoiesis	"abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Blnk^tm1Dkit/Blnk^tm1Dkit Genetic Background: involves: C57BL/6 Allelic Composition: Runx1^tm1Soga/Runx1^tm1.1Soga,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Runx1^tm1Yg/Runx1^tm1Yg Genetic Background: either: (involves: 129/Sv * 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * ICR) or (involves: 129S1/Sv * 129X1/SvJ * MF1) Allelic Composition: Hip1^tm4Tsr/Hip1⁺,Runx1^tm3Dow/Runx1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA Allelic Composition: Runx1^tm1.1Gss/Runx1^tm1.1Gss Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Runx1^tm2.1Gss/Runx1^tm2.1Gss Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0002144	abnormal B lymphocyte development	"atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Runx1^tm1Soga/Runx1^tm1.1Soga,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: C57BL/6 * CBA
MP:0002145	abnormal T lymphocyte development	"atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Runx1^tm1Soga/Runx1^tm1.1Soga,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Runx1^{tm1(RUNX1)Gcg}/Runx1^{tm1(RUNX1)Gcg},Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA Allelic Composition: Runx1^tm1Yg/Runx1^tm1Yg Genetic Background: either: (involves: 129/Sv * 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * ICR) or (involves: 129S1/Sv * 129X1/SvJ * MF1)
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Runx1^tm1Dow/Runx1^tm1Dow Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Runx1^tm1Buch/Runx1^tm1Buch Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Runx1t1^tm1Buch/Runx1t1⁺,Runx1^tm1Buch/Runx1⁺,Tg(Nes-cre)1Atp/0 Genetic Background: involves: FVB/N Allelic Composition: Runx1^tm4Dow/Runx1^tm4Dow Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Runx1^tm3Spe/Runx1^tm3Spe Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Runx1^tm1.1Medv/Runx1^tm1.1Medv Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Runx1^tm2Buch/Runx1^tm2Buch Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Runx1^tm3.1Spe/Runx1^tm3.1Spe Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Runx1^{tm2.1(Runx1/Mecom)Homy}/Runx1⁺ Genetic Background: B6.129P2-Runx1^{tm2.1(Runx1/Mecom)Homy}
MP:0002340	abnormal axillary lymph node morphology	"anomalous structure, development, or number of the lymph nodes located in the upper body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tmem173^tm1Gnb/Tmem173^tm1Gnb Genetic Background: involves: 129P2/OlaHsd
MP:0002353	abnormal inguinal lymph node morphology	"anomalous structure, development, or number of the lymph nodes located in the groin area" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Tmem173^tm1Gnb/Tmem173^tm1Gnb Genetic Background: involves: 129P2/OlaHsd
MP:0002357	abnormal spleen white pulp morphology	"anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Runx1^tm2.1Gss/Runx1^tm2.1Gss Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0002367	abnormal thymus lobule morphology	"anomalous structure or development of the basic structural unit of the thymus" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Runx1^tm1Yg/Runx1^tm1Yg Genetic Background: either: (involves: 129/Sv * 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * ICR) or (involves: 129S1/Sv * 129X1/SvJ * MF1) Allelic Composition: Runx1^tm2Buch/Runx1^tm2Buch,Tg(Mx1-cre)1Cgn/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0002375	abnormal thymus medulla morphology	"anomalous structure or development of the inner area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Runx1^{tm3(Runx3)Toku}/Runx1^{tm3(Runx3)Toku} Genetic Background: involves: 129P2/OlaHsd
MP:0002396	abnormal hematopoietic system morphology/development	"any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Trp53^tm1Ldo/Trp53⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Runx1^tm3Itan/Runx1^tm3Itan,Tg(Runx1-GFP)#Itan/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Runx1^tm1Yg/Runx1^tm1Yg,Tg(Runx1-GFP)#Itan/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA Allelic Composition: Runx1^tm1Yg/Runx1⁺,Tg(Runx1-GFP)#Itan/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA Allelic Composition: Runx1^{tm2.1(cre/Esr1)Ims}/Runx1^tm1Medv Genetic Background:* involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺,Runx1^{tm2.1(cre/Esr1)Ims}/Runx1^tm1Medv Genetic Background:* B6.Cg-Gt(ROSA)26Sor^tm1(EYFP)Cos Runx1^{tm2.1(cre/Esr1*)Ims}
MP:0002398	abnormal bone marrow cell morphology/development	"anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Hip1^tm4Tsr/Hip1⁺,Runx1^tm3Dow/Runx1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA Allelic Composition: Runx1^tm3Itan/Runx1^tm3Itan Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Runx1^tm1Yg/Runx1^tm1Yg Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002408	abnormal double-positive T cell	"anomalous development or number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Runx1^tm1Tani/Runx1^tm1Tani,Tg(Lck-cre)1Cwi/? Genetic Background: involves: 129P2/OlaHsd
MP:0002413	abnormal megakaryoblast morphology/development	"anomalous structure or development of the progenitor cells of the thrombocytic (platelet) line of cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Runx1^tm1Soga/Runx1^tm1.1Soga,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Runx1^{tm1.1(RUNX1)Homy}/Runx1^{tm1.1(RUNX1)Homy} Genetic Background: B6.129P2-Runx1^{tm1.1(RUNX1*)Homy}
MP:0002414	abnormal myeloblast morphology/development	"anomalous structure, formation, or numbers of the cells found in the bone marrow that give rise to the granulocyte line of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Runx1^tm3Spe/Runx1^tm3Spe,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
MP:0002417	abnormal megakaryocyte morphology/development	"anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Runx1^tm1Soga/Runx1^tm1.1Soga,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Runx1^{tm1(RUNX1/EVI1)Kmit}/Runx1⁺ Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Runx1^tm2Buch/Runx1^tm2Buch,Tg(Mx1-cre)1Cgn/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Runx1^tm2.1Gss/Runx1^tm2.1Gss Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0002447	abnormal erythrocyte morphology	"structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Runx1^tm2.1Gss/Runx1^tm2.1Gss Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0002450	abnormal lymph organ development	"anomaly in the process of morphological maturation of the organs of the lymph system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tmem173^tm1Gnb/Tmem173^tm1Gnb Genetic Background: involves: 129P2/OlaHsd
MP:0002591	decreased mean corpuscular volume	"less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Runx1^tm2.1Gss/Runx1^tm2.1Gss Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0002599	increased mean platelet volume	"increased content of platelet cells over the norm" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]	Show Allelic Composition: Runx1^tm2.1Gss/Runx1^tm2.1Gss Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0002722	abnormal immune system organ morphology	"anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Runx1^tm2Buch/Runx1^tm2Buch,Tg(Mx1-cre)1Cgn/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0002875	decreased erythrocyte count	"reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Runx1^{tm1(RUNX1/EVI1)Kmit}/Runx1⁺ Genetic Background: involves: C57BL/6 * CBA
MP:0002896	abnormal bone mineralization	"defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Drd1^tm1Jcd/Drd1^tm1Jcd,Drd2^tm1Ebo/Drd2⁺ Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 Allelic Composition: Runx1^tm1.1Stkd/Runx1^tm1.1Stkd,Runx2^tm1Mjo/Runx2^tm1Mjo,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: C57BL/6J * SJL/J
MP:0002981	increased liver weight	"a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]	Show Allelic Composition: Hip1^tm4Tsr/Hip1⁺,Runx1^tm3Dow/Runx1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0003043	hypoalgesia	"decreased sensation to painful stimuli that may follow damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Pkd1^tm1.1Fqi/Pkd1^tm1.1Fqi Genetic Background: involves: 129S6/SvEvTac
MP:0003131	increased erythrocyte count	"greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Runx1^tm2.1Gss/Runx1^tm2.1Gss Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0003179	decreased platelet count	"fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]	Show Allelic Composition: Runx1^tm1Soga/Runx1^tm1.1Soga,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Runx1^tm4Spe/Runx1^tm4Spe Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Runx1^tm3Spe/Runx1^tm3Spe,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA Allelic Composition: Runx1^tm2Buch/Runx1^tm2Buch,Tg(Mx1-cre)1Cgn/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Runx1^tm3Itan/Runx1^tm3Itan Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Bcr^{tm1(BCR/ABL)Tsr}/Bcr⁺,Runx1^tm3Dow/Runx1⁺,Tg(Vav1-cre)#Cgp/0 Genetic Background: involves: C57BL/6
MP:0003227	abnormal vascular branching morphogenesis	"increase, decrease or anomaly in the process by which new vessels sprout off pre-existing vessels" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]	Show Allelic Composition: Runx1^tm1Sata/Runx1^tm1Sata Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0003279	aneurysm	"a protruding sac formed by the dilation of the wall of an artery, a vein, or the heart resulting from a weakening of the vessel wall or heart muscle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Runx1^tm1Sata/Runx1^tm1Sata Genetic Background: involves: 129S4/SvJae * C57BL/6J Allelic Composition: Runx1^{tm1.1(RUNX1)Homy}/Runx1^{tm1.1(RUNX1)Homy} Genetic Background: B6.129P2-Runx1^{tm1.1(RUNX1*)Homy}
MP:0003396	abnormal embryonic hematopoiesis	"anomaly in the development of primarily large, nucleated erythroblasts as well as some megakaryocytes and primitive macrophages occuring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans " [J:94136, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Runx1^tm1Dow/Runx1^tm1Dow Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Runx1^tm2Dow/Runx1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Runx1^tm1Spe/Runx1^tm2Spe Genetic Background: either: (involves: 129S4/Jae * BALB/c) or (involves: 129S4/SvJae * C57BL/6) Allelic Composition: Runx1^{tm1(RUNX1/EVI1)Kmit}/Runx1⁺ Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Runx1^tm4Spe/Runx1⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Runx1^tm5Spe/Runx1⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Runx1^tm6Spe/Runx1⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Runx1^tm7Spe/Runx1⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Runx1^tm8Spe/Runx1⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Runx1^tm5Spe/Runx1^tm5Spe Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Runx1^tm6Spe/Runx1^tm6Spe Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Runx1^tm7Spe/Runx1^tm7Spe Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Runx1^tm8Spe/Runx1^tm8Spe Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Runx1^tm4Spe/Runx1^tm4Spe Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Runx1^tm1Spe/Runx1⁺ Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
MP:0003448	altered tumor morphology	"changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Hip1^tm4Tsr/Hip1⁺,Runx1^tm3Dow/Runx1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0003717	pallor	"an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Pdgfra^{tm1.1(cre/Esr1)Nshk}/Pdgfra⁺,Runx1^tm1Medv/Runx1^tm1Medv Genetic Background:* involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj
MP:0003719	abnormal pericyte morphology	"malformation in the connective tissue cells that occurs around capillaries or other small blood vessels " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Runx1^{tm1.1(RUNX1)Homy}/Runx1^{tm1.1(RUNX1)Homy} Genetic Background: B6.129P2-Runx1^{tm1.1(RUNX1*)Homy}
MP:0003944	abnormal T cell subpopulation ratio	"deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]	Show Allelic Composition: Ripk2^tm1Ghc/Ripk2^tm1Ghc Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Runx1^{tm2(Runx1)Toku}/Runx1^{tm2(Runx1)Toku} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004049	acute promyelocytic leukemia	"rapid onset of abnormal leukocyte proliferation, manifesting as a severe bleeding disorder from coagulation abnormalities, and bone marrow infiltration of abnormal promyelocytes and myelocytes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Runx1^tm3Dow/Runx1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: C57BL/6 * CBA
MP:0004076	abnormal vitelline vascular remodelling	"anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Runx1^tm1Sata/Runx1^tm1Sata Genetic Background: involves: 129S4/SvJae * C57BL/6J
MP:0004720	abnormal platelet morphology	"any structural anomaly of blood plasma cells derived from megakaryocytes, which function to promote blood clotting" [MESH:National Library of Medicine_Medical Subject Headings]	Show Allelic Composition: Runx1^tm3Spe/Runx1^tm3Spe,Tg(Vav1-cre)1Graf/0 Genetic Background: involves: 129S4/SvJae
MP:0004787	abnormal dorsal aorta morphology	"any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]	Show Allelic Composition: Runx1^tm3Itan/Runx1^tm3Itan,Tg(Runx1-GFP)#Itan/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Runx1^tm1Yg/Runx1^tm1Yg,Tg(Runx1-GFP)#Itan/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA Allelic Composition: Runx1^tm1Yg/Runx1⁺,Tg(Runx1-GFP)#Itan/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
MP:0004808	abnormal hematopoietic stem cell morphology	"any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Runx1^tm3Spe/Runx1^tm3Spe,Tg(Cdh5-cre)1Spe/0 Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6
MP:0004809	increased hematopoietic stem cell number	"greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Runx1^tm3Spe/Runx1^tm3Spe,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA Allelic Composition: Runx1^tm2Buch/Runx1^tm2Buch,Tg(Mx1-cre)1Cgn/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Runx1^tm3Spe/Runx1^tm3Spe,Tg(Vav1-cre)1Graf/0 Genetic Background: involves: 129S4/SvJae Allelic Composition: Etv6^{tm1(RUNX1)Haho}/Etv6⁺,Runx1^tm3Spe/Runx1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * CBA Allelic Composition: Hip1^tm4Tsr/Hip1⁺,Runx1^tm3Dow/Runx1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA Allelic Composition: Runx1^tm3Itan/Runx1^tm3Itan Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004810	decreased hematopoietic stem cell number	"reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Runx1^tm3Spe/Runx1^tm3Spe,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA Allelic Composition: Runx1^tm3Spe/Runx1^tm3Spe,Tg(Cdh5-cre)1Spe/0 Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6 Allelic Composition: Etv6^{tm1(RUNX1)Haho}/Etv6⁺,Runx1^tm3Spe/Runx1^tm3Spe,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * CBA Allelic Composition: Hip1^tm4Tsr/Hip1⁺,Runx1^tm3Dow/Runx1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA Allelic Composition: Runx1^tm1.1Gss/Runx1^tm1.1Gss Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0004938	dilated vasculature	"stretched or widened aperture of the luminal space of the network of tubes that carries blood through the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Runx1^{tm1.1(RUNX1)Homy}/Runx1^{tm1.1(RUNX1)Homy} Genetic Background: B6.129P2-Runx1^{tm1.1(RUNX1*)Homy}
MP:0004952	increased spleen weight	"greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Runx1^tm3Spe/Runx1^tm3Spe,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA Allelic Composition: Runx1^tm3Spe/Runx1^tm3Spe,Spi1^tm2.1Dgt/Spi1^tm2.1Dgt,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA Allelic Composition: Runx1^tm2Buch/Runx1^tm2Buch,Tg(Mx1-cre)1Cgn/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Hip1^tm4Tsr/Hip1⁺,Runx1^tm3Dow/Runx1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0004956	decreased thymus weight	"reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Runx1^tm3Spe/Runx1^tm3Spe,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA Allelic Composition: Runx1^tm3Spe/Runx1^tm3Spe,Spi1^tm2.1Dgt/Spi1^tm2.1Dgt,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA Allelic Composition: Runx1^tm2Buch/Runx1^tm2Buch,Tg(Mx1-cre)1Cgn/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0005016	decreased lymphocyte number	"fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Runx1^{tm3(Runx3)Toku}/Runx1^{tm3(Runx3)Toku} Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Runx1^tm4Spe/Runx1^tm4Spe Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Runx1^tm2Buch/Runx1^tm2Buch,Tg(Mx1-cre)1Cgn/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Runx1^tm3Spe/Runx1^tm3Spe,Tg(Vav1-cre)1Graf/0 Genetic Background: involves: 129S4/SvJae Allelic Composition: Bcr^{tm1(BCR/ABL)Tsr}/Bcr⁺,Runx1^tm3Dow/Runx1⁺,Tg(Vav1-cre)#Cgp/0 Genetic Background: involves: C57BL/6
MP:0005017	decreased B cell number	"fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Runx1^tm3Spe/Runx1^tm3Spe,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA Allelic Composition: Runx1^tm3Spe/Runx1^tm3Spe,Spi1^tm2.1Dgt/Spi1^tm2.1Dgt,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA Allelic Composition: Runx1^tm3Spe/Runx1^tm3Spe,Tg(Vav1-cre)1Graf/0 Genetic Background: involves: 129S4/SvJae
MP:0005018	decreased T cell number	"fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Runx1^tm1Yg/Runx1^tm2Spe Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * ICR) or (involves: 129/Sv * MF1) Allelic Composition: Runx1^tm2Buch/Runx1^tm2Buch,Tg(Mx1-cre)1Cgn/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0005089	decreased double-negative T cell count	"reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Runx1^tm3Spe/Runx1^tm3Spe,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
MP:0005090	increased double-negative T cells count	"greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Runx1^tm1Tani/Runx1^tm1Tani,Tg(Lck-cre)1Cwi/? Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Runx1^tm3Spe/Runx1^tm3Spe,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
MP:0005091	increased double-positive T cell count	"greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Runx1^tm1Yg/Runx1^tm1Yg Genetic Background: either: (involves: 129/Sv * 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * ICR) or (involves: 129S1/Sv * 129X1/SvJ * MF1)
MP:0005092	decreased double-positive T cell count	"less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Runx1^{tm1(RUNX1)Gcg}/Runx1^{tm1(RUNX1)Gcg},Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA Allelic Composition: Runx1^tm1Tani/Runx1^tm1Tani,Tg(Lck-cre)1Cwi/? Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Runx1^tm2Buch/Runx1^tm2Buch,Tg(Mx1-cre)1Cgn/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Runx1^tm3Spe/Runx1^tm3Spe,Tg(Vav1-cre)1Graf/0 Genetic Background: involves: 129S4/SvJae
MP:0005244	hemopericardium	"bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0]	Show Allelic Composition: Alx1^tm1Crm/Alx1^tm1Crm,Alx4^tm1Rwi/Alx4^tm1Rwi Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd Allelic Composition: Runx1^tm1Dow/Runx1^tm1Dow Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Runx1^tm1Sata/Runx1^tm1Sata Genetic Background: involves: 129S4/SvJae * C57BL/6J Allelic Composition: Runx1^tm2Dow/Runx1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Runx1^tm5Spe/Runx1^tm5Spe Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Runx1^tm6Spe/Runx1^tm6Spe Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Runx1^tm7Spe/Runx1^tm7Spe Genetic Background: involves: 129/Sv * C57BL/6
MP:0005404	abnormal axon morphology	"anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Mapt^tm2Arbr/?,Runx1^tm3Spe/Runx1^tm3Spe,H2afv^{Tg(Wnt1-cre)11Rth}/? Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J * CBA/J
MP:0005425	increased macrophage count	"greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]	Show Allelic Composition: Runx1^tm2.1Gss/Runx1^tm2.1Gss Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0005435	hemoperitoneum	"blood in the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87293]	Show Allelic Composition: Runx1^tm1Dow/Runx1^tm1Dow Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Runx1^tm5Spe/Runx1^tm5Spe Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Runx1^tm6Spe/Runx1^tm6Spe Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Runx1^tm7Spe/Runx1^tm7Spe Genetic Background: involves: 129/Sv * C57BL/6
MP:0005460	abnormal leukopoiesis	"anomalous process of generating white blood cells (leukocytes) from the pluripotent hematopoietic stem cells of the bone marrow; two significant pathways generate various types of leukocytes: myelopoiesis, in which leukocytes in the blood are derived from myeloid stem cells, and lymphopoiesis, in which leukocytes of the lymphatic system (lymphocytes) are generated from lymphoid stem cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Runx1^tm1Yg/Runx1^tm1Yg Genetic Background: either: (involves: 129/Sv * 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * ICR) or (involves: 129S1/Sv * 129X1/SvJ * MF1)
MP:0005481	chronic myelocytic leukemia	"a heterogeneous group of myeloproliferative disorders that may evolve into acute leukemia in late stages " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Hip1^tm4Tsr/Hip1⁺,Runx1^tm3Dow/Runx1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0005505	increased platelet count	"greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Runx1^tm2.1Gss/Runx1^tm2.1Gss Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0005508	abnormal skeleton morphology	"malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Runx2^tm1Mjo/Runx2^tm1Mjo Genetic Background: Not Specified
MP:0005564	increased hemoglobin content	"increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]	Show Allelic Composition: Runx1^tm2.1Gss/Runx1^tm2.1Gss Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0005621	abnormal cell physiology	"aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Runx1^tm3Dow/Runx1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: C57BL/6 * CBA
MP:0006054	spinal hemorrhage	"bleeding into the spine" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Runx1^tm1Yg/Runx1^tm2Spe Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * ICR) or (involves: 129/Sv * MF1)
MP:0006410	abnormal common myeloid progenitor cell morphology	"anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Runx1^tm1Soga/Runx1^tm1.1Soga,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Runx1^tm2Buch/Runx1^tm2Buch,Tg(Mx1-cre)1Cgn/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Runx1^tm3Spe/Runx1^tm3Spe,Tg(Vav1-cre)1Graf/0 Genetic Background: involves: 129S4/SvJae Allelic Composition: Runx1^{tm1.1(RUNX1)Homy}/Runx1^{tm1.1(RUNX1)Homy} Genetic Background: B6.129P2-Runx1^{tm1.1(RUNX1*)Homy}
MP:0008074	increased CD4-positive T cell number	"greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ripk2^tm1Ghc/Ripk2^tm1Ghc Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: H2-Ab1^tm1Gru/H2-Ab1^tm1Gru,Runx1^tm1Toku/Runx1^tm1Toku,Runx3^tm1Itan/Runx3^tm1Itan,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2
MP:0008075	decreased CD4-positive T cell number	"reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Runx1^{tm1(RUNX1)Gcg}/Runx1^{tm1(RUNX1)Gcg},Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA Allelic Composition: Runx1^tm4Spe/Runx1⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Runx1^tm5Spe/Runx1⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Runx1^tm6Spe/Runx1⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Runx1^tm7Spe/Runx1⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Runx1^tm8Spe/Runx1⁺ Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Runx1^tm1Spe/Runx1⁺ Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6) Allelic Composition: Runx1^tm1Tani/Runx1^tm1Tani,Tg(Cd4-cre)1Cwi/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Runx1^tm1Toku/Runx1^tm1Toku,Runx3^tm1Itan/Runx3^tm1Itan,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Runx1^tm1Toku/Runx1^tm1Toku,Runx3^tm1Itan/Runx3⁺,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Runx1^tm2Buch/Runx1^tm2Buch,Tg(Mx1-cre)1Cgn/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Runx1^tm3Itan/Runx1^tm3Itan Genetic Background: involves: 129P2/OlaHsd
MP:0008076	abnormal CD4-positive T cell differentiation	"atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Runx1^tm1Tani/Runx1^tm1Tani,Tg(Cd4-cre)1Cwi/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
MP:0008078	increased CD8-positive T cell number	"greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Runx1^{tm1(RUNX1)Gcg}/Runx1^{tm1(RUNX1)Gcg},Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
MP:0008079	decreased CD8-positive T cell number	"reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Runx1^tm1Tani/Runx1^tm1Tani,Tg(Cd4-cre)1Cwi/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Runx1^tm1Toku/Runx1^tm1Toku,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Runx1^tm1Toku/Runx1^tm1Toku,Runx3^tm1Itan/Runx3^tm1Itan,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Runx1^tm1Toku/Runx1⁺,Runx3^tm1Itan/Runx3^tm1Itan,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Runx1^tm1Toku/Runx1^tm1Toku,Runx3^tm1Itan/Runx3⁺,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Runx1^tm2Buch/Runx1^tm2Buch,Tg(Mx1-cre)1Cgn/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Runx1^tm2.1Gss/Runx1^tm2.1Gss Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0008080	abnormal CD8-positive T cell differentiation	"atypical production of or inability to produce the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Runx1^tm1Tani/Runx1^tm1Tani,Tg(Cd4-cre)1Cwi/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
MP:0008083	decreased single-positive T cell number	"reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Runx1^tm1Yg/Runx1^tm1Yg Genetic Background: either: (involves: 129/Sv * 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * ICR) or (involves: 129S1/Sv * 129X1/SvJ * MF1)
MP:0008111	abnormal granulocyte differentiaton	"atypical production of or inability to produce leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Runx1^{tm1(RUNX1)Gcg}/Runx1^{tm1(RUNX1)Gcg},Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
MP:0008133	decreased Peyer s patch number	"reduction in the number of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]	Show Allelic Composition: Runx1^tm3Itan/Runx1^tm3Itan Genetic Background: involves: 129P2/OlaHsd
MP:0008135	small Peyer s patches	"reduced size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]	Show Allelic Composition: Runx1^tm2Buch/Runx1^tm2Buch,Tg(Mx1-cre)1Cgn/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Runx1^tm3Itan/Runx1^tm3Itan Genetic Background: involves: 129P2/OlaHsd
MP:0008186	increased pro-B cell number	"greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Runx1^tm2.1Gss/Runx1^tm2.1Gss Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0008210	increased mature B cell number	"greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]	Show Allelic Composition: Runx1^tm2.1Gss/Runx1^tm2.1Gss Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0008211	decreased mature B cell number	"reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]	Show Allelic Composition: Runx1^tm2Buch/Runx1^tm2Buch,Tg(Mx1-cre)1Cgn/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0008215	decreased immature B cell number	"reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Runx1^tm2.1Gss/Runx1^tm2.1Gss Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0008246	abnormal leukocyte morphology	"any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]	Show Allelic Composition: Runx1^tm2Buch/Runx1^tm2Buch,Tg(Mx1-cre)1Cgn/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Runx1^tm2.1Gss/Runx1^tm2.1Gss Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0008255	decreased megakaryocyte cell number	"reduced number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]	Show Allelic Composition: Runx1^tm2Buch/Runx1^tm2Buch,Tg(Mx1-cre)1Cgn/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0008470	abnormal spleen B cell follicle morphology	"any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]	Show Allelic Composition: Hip1^tm4Tsr/Hip1⁺,Runx1^tm3Dow/Runx1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0008476	increased spleen red pulp amount	"increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Runx1^tm2Buch/Runx1^tm2Buch,Tg(Mx1-cre)1Cgn/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA Allelic Composition: Hip1^tm4Tsr/Hip1⁺,Runx1^tm3Dow/Runx1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0008479	decreased spleen white pulp amount	"reduction in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Runx1^tm2Buch/Runx1^tm2Buch,Tg(Mx1-cre)1Cgn/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0008489	postnatal slow weight gain	"the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Runx1^tm1Yg/Runx1^tm1Yg Genetic Background: either: (involves: 129/Sv * 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * ICR) or (involves: 129S1/Sv * 129X1/SvJ * MF1)
MP:0008555	abnormal interferon secretion	"anomaly in the production or release of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]	Show Allelic Composition: H2-Ab1^tm1Gru/H2-Ab1^tm1Gru,Runx1^tm1Toku/Runx1^tm1Toku,Runx3^tm1Itan/Runx3^tm1Itan,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2
MP:0008762	embryonic lethality	"death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Runx1^tm1Spe/Runx1^tm1Yg Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0008801	abnormal erythroid progenitor cell morphology	"any structural anomaly of a progenitor cell committed to the erythroid lineage" [CL:0000038]	Show Allelic Composition: Runx1^tm2.1Gss/Runx1^tm2.1Gss Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0008813	decreased common myeloid progenitor cell number	"reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hip1^tm4Tsr/Hip1⁺,Runx1^tm3Dow/Runx1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0008973	decreased erythroid progenitor cell number	"reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Runx1^{tm1.1(RUNX1)Homy}/Runx1^{tm1.1(RUNX1)Homy} Genetic Background: B6.129P2-Runx1^{tm1.1(RUNX1*)Homy}
MP:0008986	abnormal liver parenchyma morphology	"any structural anomaly of the functional units of the liver including the lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hip1^tm4Tsr/Hip1⁺,Runx1^tm3Dow/Runx1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0009253	abnormal sympathetic neuron physiology	"any functional anomaly of any of the neurons of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body s response to stressful situations" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pkd1^tm1.1Fqi/Pkd1^tm1.1Fqi Genetic Background: involves: 129S6/SvEvTac
MP:0009278	abnormal bone marrow cell physiology	"any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hip1^tm4Tsr/Hip1⁺,Runx1^tm3Dow/Runx1⁺,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA
MP:0009395	persistence of primitive erythrocytes	"presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Alx1^tm1Crm/Alx1^tm1Crm,Alx4^tm1Rwi/Alx4^tm1Rwi Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd
MP:0009541	increased thymocyte apoptosis	"increase in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Runx1^tm1Yg/Runx1^tm1Yg Genetic Background: either: (involves: 129/Sv * 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * ICR) or (involves: 129S1/Sv * 129X1/SvJ * MF1)
MP:0009543	abnormal thymus corticomedullary boundary morphology	"any structural anomaly of the dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; site of entry of bone marrow stem cells and exit of mature, functional T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17067941]	Show Allelic Composition: Runx1^tm1Yg/Runx1^tm1Yg Genetic Background: either: (involves: 129/Sv * 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * ICR) or (involves: 129S1/Sv * 129X1/SvJ * MF1)
MP:0010067	increased red blood cell distribution width	"higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"]	Show Allelic Composition: Runx1^tm2.1Gss/Runx1^tm2.1Gss Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0010178	increased number of Howell-Jolly bodies	"abnormal presence of basophilic nuclear remnants of condensed DNA (1 to 2 um in diameter) in circulating erythrocytes, typically seen in severe hemolytic anemias or after splenectomy; these inclusions are normally removed by the spleen but will persist in individuals with functional hyposplenia or asplenia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Runx1^tm2Buch/Runx1^tm2Buch,Tg(Mx1-cre)1Cgn/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0010373	myeloid hyperplasia	"greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Runx1^tm2.1Gss/Runx1^tm2.1Gss Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Runx1^tm8Spe/Runx1^tm8Spe Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Runx1^tm1Yg/Runx1^tm1Yg Genetic Background: either: (involves: 129/Sv * 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * ICR) or (involves: 129S1/Sv * 129X1/SvJ * MF1)
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Runx1^{tm3(Runx3)Toku}/Runx1^{tm3(Runx3)Toku} Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Runx1^tm4Spe/Runx1^tm4Spe Genetic Background: involves: 129/Sv * C57BL/6
MP:0011098	complete embryonic lethality during organogenesis	"death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Alx1^tm1Crm/Alx1^tm1Crm,Alx4^tm1Rwi/Alx4^tm1Rwi Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd Allelic Composition: Runx1^tm1Dow/Runx1^tm1Dow Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Runx1^tm1Dez/Runx1⁺ Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Runx1^tm1Sata/Runx1^tm1Sata Genetic Background: involves: 129S4/SvJae * C57BL/6J Allelic Composition: Runx1^tm2Dow/Runx1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Runx1^tm1Medv/Runx1^tm1Medv Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Runx1^{tm1(RUNX1/EVI1)Kmit}/Runx1⁺ Genetic Background: involves: C57BL/6 * CBA Allelic Composition: Runx1^tm5Spe/Runx1^tm5Spe Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Runx1^tm6Spe/Runx1^tm6Spe Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Runx1^tm7Spe/Runx1^tm7Spe Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Runx1^tm1Yg/Runx1^tm2Spe Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * ICR) or (involves: 129/Sv * MF1) Allelic Composition: Runx1^tm1.1Gss/Runx1^tm1.1Gss Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Runx1^{tm2.1(cre/Esr1)Ims}/Runx1^tm1Medv Genetic Background:* involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Runx1^{tm2.1(cre/Esr1)Ims}/Runx1^{tm2.1(cre/Esr1)Ims} Genetic Background: involves: C57BL/6 Allelic Composition: Pdgfra^{tm1.1(cre/Esr1)Nshk}/Pdgfra⁺,Runx1^tm1Medv/Runx1^tm1Medv Genetic Background:* involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj
MP:0011099	complete lethality throughout fetal growth and development	"death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Runx1^{tm1.1(RUNX1)Homy}/Runx1^{tm1.1(RUNX1)Homy} Genetic Background: B6.129P2-Runx1^{tm1.1(RUNX1*)Homy}
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Runx1^tm1.1Stkd/Runx1^tm1.1Stkd,Runx2^tm1Mjo/Runx2^tm1Mjo,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: C57BL/6J * SJL/J
MP:0011109	partial lethality throughout fetal growth and development	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Runx1^tm3Spe/Runx1^tm3Spe,Tg(Cdh5-cre)1Spe/0 Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6
MP:0011180	abnormal hematopoietic cell number	"any anomaly in the expected number of cells of the hematopoietic lineage" [CL:0000988, MGI:csmith]	Show Allelic Composition: Pdgfra^{tm1.1(cre/Esr1)Nshk}/Pdgfra⁺,Runx1^tm1Medv/Runx1^tm1Medv Genetic Background:* involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj
MP:0011182	decreased hematopoietic cell number	"fewer than expected number of cells of the hematopoietic lineage" [MGI:csmith]	Show Allelic Composition: Runx1^{tm1.1(RUNX1)Homy}/Runx1^{tm1.1(RUNX1)Homy} Genetic Background: B6.129P2-Runx1^{tm1.1(RUNX1*)Homy}
MP:0011816	decreased pre-pro B cell number	"reduced number of pro-B cells that are CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative; this cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive" [CL:0002045, MGI:csmith]	Show Allelic Composition: Runx1^tm2.1Gss/Runx1^tm2.1Gss Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0012431	increased lymphoma incidence	"greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]	Show Allelic Composition: Runx1^tm2Buch/Runx1^tm2Buch,Tg(Mx1-cre)1Cgn/? Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
MP:0013241	embryo tissue necrosis	"morphological changes resulting from pathological death of some or all embryo tissue; usually due to irreversible damage" [MGI:csmith]	Show Allelic Composition: Alx1^tm1Crm/Alx1^tm1Crm,Alx4^tm1Rwi/Alx4^tm1Rwi Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd
MP:0014105	abnormal chondrocyte differentiation	"any anomaly in the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte" [GO:0002062]	Show Allelic Composition: Runx1^tm1.1Stkd/Runx1^tm1.1Stkd,Runx2^tm1Mjo/Runx2^tm1Mjo,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: C57BL/6J * SJL/J
MP:0014130	thymus cysts	"presence of fluid-filled spaces lined by epithelium within the thymus; thymic cysts are rare mediastinal lesions and are thought to result from the congenital persistence of thymopharyngeal tracts and acquired, progressive cystic degeneration of thymic (Hassall) corpuscles and epithelial reticulum of the thymus; congenital cysts are unilocular, whereas acquired cysts are usually multilocular and result as a consequence of inflammatory processes" [http://www.pedsradiology.com/historyanswer.aspx?qid=408&fid=1, PMID:23050117]	Show Allelic Composition: Runx1^tm1Yg/Runx1^tm1Yg Genetic Background: either: (involves: 129/Sv * 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * ICR) or (involves: 129S1/Sv * 129X1/SvJ * MF1)

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