ENSGALG00000016022


Gallus gallus

Features
Gene ID: ENSGALG00000016022
  
Biological name :RUNX1
  
Synonyms : runt related transcription factor 1 / RUNX1
  
Possible biological names infered from orthology : Q01196
  
Species: Gallus gallus
  
Chr. number: 1
Strand: -1
Band:
Gene start: 106016234
Gene end: 106164482
  
Corresponding Affymetrix probe sets: Gga.18911.1.S1_at (Chicken Array)   GgaAffx.20762.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000025762
NCBI entrez gene - 396152     See in Manteia.
RefSeq - XM_015299299
RefSeq - NM_205227
RefSeq - XM_015299305
RefSeq Peptide - NP_990558
swissprot - Q90813
Ensembl - ENSGALG00000016022
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 runx1ENSDARG00000087646Danio rerio
 RUNX1ENSG00000159216Homo sapiens
 Runx1ENSMUSG00000022952Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RUNX2 / runt related transcription factor 2 / Q08775* / Q13950*ENSGALG0000004027667
RUNX3 / runt related transcription factor 3 / Q13761* / Q64131*ENSGALG0000004337260


Protein motifs (from Interpro)
Interpro ID Name
 IPR000040  Acute myeloid leukemia 1 protein (AML1)/Runt
 IPR008967  p53-like transcription factor, DNA-binding
 IPR012346  p53/RUNT-type transcription factor, DNA-binding domain superfamily
 IPR013524  Runt domain
 IPR013711  Runx, C-terminal domain
 IPR027384  Runx, central domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0030097 hemopoiesis IEA
 biological_processGO:0030854 positive regulation of granulocyte differentiation IEA
 biological_processGO:0032743 positive regulation of interleukin-2 production IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0001047 core promoter binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
Organic cation transport
RUNX1 regulates estrogen receptor mediated transcription
Regulation of RUNX1 Expression and Activity
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
RUNX1 regulates transcription of genes involved in BCR signaling
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
RUNX1 regulates transcription of genes involved in interleukin signaling
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000003297 HDAC1 / P56517 / Histone deacetylase 1 / O09106* / Q13547* / Gm10093*  / complex
 ENSGALG00000006818 KMT2A* / P55200* / Q03164* / lysine methyltransferase 2A* / Mus musculus lysine (K)-specific methyltransferase 2A (Kmt2a), transcript variant 1, mRNA.*  / reaction / complex
 ENSGALG00000020078 H3F3C / histone H3.2 / H3.Y* / H3F3B* / H3F3A* / Q6NXT2* / P84243* / P84244* / Histone H3.3 * / H3 histone family member 3B* / H3 histone family member 3A* / H3 histone family member 3C* /...  / complex
 ENSGALG00000001644 SIN3A / SIN3 transcription regulator family member A / Q60520* / Q96ST3* / Mus musculus transcriptional regulator, SIN3A (yeast) (Sin3a), transcript variant 4, mRNA.*  / complex
 ENSGALG00000016431 PAX5 / paired box 5 / Q02548* / Q02650* / Paired box protein Pax-5 *  / reaction / complex
 ENSGALG00000004821 PTPN11 / Q90687 / Tyrosine-protein phosphatase non-receptor type 11 / P35235* / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex / reaction
 ENSGALG00000005983 Q5ZK40 / SMARCB1 / SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 / Q12824* / Q9Z0H3*  / complex / reaction
 ENSGALG00000010164 SMARCA2 / probable global transcription activator SNF2L2 / P51531* / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2*  / complex / reaction
 ENSGALG00000011992 EP300 / E1A binding protein p300 / B2RWS6* / Q09472* / Histone acetyltransferase p300 *  / reaction / complex
 ENSGALG00000003485 CCND3 / cyclin D3 / P30281* / P30282* / G1/S-specific cyclin-D3 *  / reaction / complex
 ENSGALG00000009476 CDK6 / cyclin dependent kinase 6 / Q00534* / Q64261*  / reaction / complex
 ENSGALG00000009774 ELF2 / E74 like ETS transcription factor 2 / Q15723* / Q9JHC9* / ETS-related transcription factor Elf-2 *  / complex / reaction
 ENSGALG00000016947 ELF1 / ETS-related transcription factor Elf-1 / P32519* / Q60775* / E74 like ETS transcription factor 1*  / complex / reaction
 ENSGALG00000043062 P84229 / HIST2H3D / Histone H3.2 / Q71DI3* / histone cluster 2 H3 family member d*  / complex
 ENSGALG00000042491 P62801 / Histone H4   / complex
 ENSGALG00000045534 PML* / P29590* / Q60953* / Protein PML * / promyelocytic leukemia*  / reaction / complex






 

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