ENSGALG00000009476


Gallus gallus

Features
Gene ID: ENSGALG00000009476
  
Biological name :CDK6
  
Synonyms : CDK6 / cyclin dependent kinase 6
  
Possible biological names infered from orthology : Q00534 / Q64261
  
Species: Gallus gallus
  
Chr. number: 2
Strand: -1
Band:
Gene start: 22731404
Gene end: 22863502
  
Corresponding Affymetrix probe sets: Gga.16438.1.S1_at (Chicken Array)   Gga.16938.1.S1_at (Chicken Array)   Gga.19672.1.S1_at (Chicken Array)   Gga.20006.1.S1_at (Chicken Array)   GgaAffx.21475.1.S1_at (Chicken Array)   GgaAffx.5966.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000015412
NCBI entrez gene - 420558     See in Manteia.
RefSeq - NM_001007892
RefSeq Peptide - NP_001007893
swissprot - Q90771
Ensembl - ENSGALG00000009476
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdk6ENSDARG00000070228Danio rerio
 CDK6ENSG00000105810Homo sapiens
 Cdk6ENSMUSG00000040274Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CDK3 / Q00526* / Cdk3-ps* / cyclin dependent kinase 3*ENSGALG0000000846244
CDK2 / cyclin-dependent kinase 2 / P24941* / P97377*ENSGALG0000003269944
CDK3* / Q00526* / Cdk3-ps* / cyclin dependent kinase 3*ENSGALG0000003853543
CDK1 / cyclin-dependent kinase 1 / P06493* / P11440*ENSGALG0000000308541
CDK11A / cell division protein kinase 11 / Q9UQ88* / CDK11B* / P24788* / cyclin dependent kinase 11A* / cyclin dependent kinase 11B* / Mus musculus cyclin-dependent kinase 11B (Cdk11b), tr...ENSGALG0000000138237
CDK10 / cyclin dependent kinase 10 / Q15131* / Q3UMM4*ENSGALG0000000614435


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR028788  Cyclin-dependent kinase 6


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IBA
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001954 positive regulation of cell-matrix adhesion IEA
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IEA
 biological_processGO:0003323 type B pancreatic cell development IEA
 biological_processGO:0006468 protein phosphorylation IBA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0008284 positive regulation of cell proliferation IBA
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0010033 response to organic substance IBA
 biological_processGO:0010389 regulation of G2/M transition of mitotic cell cycle IBA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030097 hemopoiesis IEA
 biological_processGO:0033077 T cell differentiation in thymus IEA
 biological_processGO:0042063 gliogenesis IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0043697 cell dedifferentiation IEA
 biological_processGO:0045638 negative regulation of myeloid cell differentiation IEA
 biological_processGO:0045646 regulation of erythrocyte differentiation IEA
 biological_processGO:0045656 negative regulation of monocyte differentiation IEA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IEA
 biological_processGO:0045786 negative regulation of cell cycle IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 biological_processGO:0060218 hematopoietic stem cell differentiation IEA
 biological_processGO:1902036 regulation of hematopoietic stem cell differentiation IEA
 biological_processGO:2000773 negative regulation of cellular senescence IEA
 cellular_componentGO:0000307 cyclin-dependent protein kinase holoenzyme complex IEA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0097132 cyclin D2-CDK6 complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0030332 cyclin binding IEA
 molecular_functionGO:0098770 FBXO family protein binding IEA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Cyclin D associated events in G1
Regulation of RUNX1 Expression and Activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000016022 RUNX1 / runt related transcription factor 1 / Q01196*  / reaction / complex
 ENSGALG00000010537 CDKN2C / cyclin dependent kinase inhibitor 2C / P42773* / Q60772* / Cyclin-dependent kinase 4 inhibitor C *  / reaction / complex
 ENSGALG00000022980 CDKN1B / cyclin dependent kinase inhibitor 1B / P46414* / P46527*  / complex / reaction
 ENSGALG00000026137 CDKN2B / Q8N726* / P42772* / P55271* / CDKN2A* / P42771* / cyclin dependent kinase inhibitor 2A* / cyclin dependent kinase inhibitor 2B* / Cyclin-dependent kinase 4 inhibitor B *  / complex / reaction






 

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