ENSMUSG00000040274


Mus musculus

Features
Gene ID: ENSMUSG00000040274
  
Biological name :Cdk6
  
Synonyms : Cdk6 / Cyclin-dependent kinase 6 / Q64261
  
Possible biological names infered from orthology : Q00534
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: A1
Gene start: 3341485
Gene end: 3531008
  
Corresponding Affymetrix probe sets: 10519324 (MoGene1.0st)   1435338_at (Mouse Genome 430 2.0 Array)   1455287_at (Mouse Genome 430 2.0 Array)   1460291_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000126024
Ensembl peptide - ENSMUSP00000143564
Ensembl peptide - ENSMUSP00000143492
Ensembl peptide - ENSMUSP00000142796
Ensembl peptide - ENSMUSP00000037925
NCBI entrez gene - 12571     See in Manteia.
MGI - MGI:1277162
RefSeq - NM_009873
RefSeq Peptide - NP_034003
swissprot - Q0VBK8
swissprot - A0A0G2JGH2
swissprot - Q64261
swissprot - A0A0G2JGA8
swissprot - A0A0G2JEJ6
Ensembl - ENSMUSG00000040274
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdk6ENSDARG00000070228Danio rerio
 CDK6ENSGALG00000009476Gallus gallus
 CDK6ENSG00000105810Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cdk4 / P30285 / Cyclin-dependent kinase 4 / P11802*ENSMUSG0000000672863
Cdk2 / P97377 / Cyclin-dependent kinase 2 / P24941*ENSMUSG0000002535844
Cdk3-ps / cyclin dependent kinase 3 / CDK3* / Q00526*ENSMUSG0000009230042
Cdk5 / P49615 / Cyclin-dependent-like kinase 5 / Q00535* / cyclin dependent kinase 5*ENSMUSG0000002896941
Cdk1 / P11440 / Cyclin-dependent kinase 1 / P06493*ENSMUSG0000001994241
Cdk11b / P24788 / Mus musculus cyclin-dependent kinase 11B (Cdk11b), transcript variant 3, mRNA. / Q9UQ88* / CDK11A* / cyclin dependent kinase 11A* / cyclin dependent kinase 11B*ENSMUSG0000002906239
Cdk10 / Q3UMM4 / Cyclin-dependent kinase 10 / Q15131*ENSMUSG0000003386234
E030030I06RikENSMUSG0000009732713


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR028788  Cyclin-dependent kinase 6


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IBA
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0001954 positive regulation of cell-matrix adhesion ISO
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IMP
 biological_processGO:0003323 type B pancreatic cell development ISO
 biological_processGO:0006468 protein phosphorylation IBA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007219 Notch signaling pathway IGI
 biological_processGO:0008284 positive regulation of cell proliferation IBA
 biological_processGO:0010389 regulation of G2/M transition of mitotic cell cycle IBA
 biological_processGO:0010468 regulation of gene expression ISO
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0033077 T cell differentiation in thymus IMP
 biological_processGO:0042063 gliogenesis ISO
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0043697 cell dedifferentiation ISO
 biological_processGO:0045638 negative regulation of myeloid cell differentiation ISO
 biological_processGO:0045646 regulation of erythrocyte differentiation ISO
 biological_processGO:0045656 negative regulation of monocyte differentiation ISO
 biological_processGO:0045668 negative regulation of osteoblast differentiation ISO
 biological_processGO:0045786 negative regulation of cell cycle ISO
 biological_processGO:0048146 positive regulation of fibroblast proliferation ISO
 biological_processGO:0050680 negative regulation of epithelial cell proliferation ISO
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0060218 hematopoietic stem cell differentiation IMP
 biological_processGO:1902036 regulation of hematopoietic stem cell differentiation IMP
 biological_processGO:1904628 cellular response to phorbol 13-acetate 12-myristate ISO
 biological_processGO:2000773 negative regulation of cellular senescence ISO
 cellular_componentGO:0000307 cyclin-dependent protein kinase holoenzyme complex ISO
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005813 centrosome ISS
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0097132 cyclin D2-CDK6 complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004693 cyclin-dependent protein serine/threonine kinase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0016301 kinase activity IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030332 cyclin binding IBA
 molecular_functionGO:0098770 FBXO family protein binding ISO


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Cyclin D associated events in G1
Regulation of RUNX1 Expression and Activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 * ICR

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
Show

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
Show

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
Show

Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
Show

Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
Show

Allelic Composition: Cdk6tm2.1Phin/Cdk6tm2.1Phin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Cdk6tm4.1Phin/Cdk6tm4.1Phin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
Show

Allelic Composition: Cdk6tm3.1Phin/Cdk6tm3.1Phin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0000714 increased thymocyte number "greater than expected number of precursors to T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdk6tm3.1Phin/Cdk6tm3.1Phin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cdk6tm1Phin/Cdk6tm1Phin
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Cdk6tm2.1Phin/Cdk6tm2.1Phin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Cdk6tm4.1Phin/Cdk6tm4.1Phin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 * ICR

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Cdk6tm1Phin/Cdk6tm1Phin
Genetic Background: involves: 129S4/SvJae

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
Show

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001929 abnormal gametogenesis "defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]
Show

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001931 abnormal oogenesis "atypical formation or failure to form the female germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cdk6tm1Phin/Cdk6tm1Phin,Tg(Lck-Akt1*E40K)E-3Pnt/0
Genetic Background: involves: 129S4/SvJae

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdk6tm1Phin/Cdk6tm1Phin,Tg(Lck-Akt1*E40K)E-3Pnt/0
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Cdk6tm1Bbd/Cdk6tm1Bbd,Krastm1Bbd/Kras+,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdk6tm1Phin/Cdk6tm1Phin
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Cdk6tm1Phin/Cdk6tm1Phin,Tg(Lck-Akt1*E40K)E-3Pnt/0
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Cdk6tm2.1Phin/Cdk6tm2.1Phin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Cdk6tm3.1Phin/Cdk6tm3.1Phin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Cdk6tm4.1Phin/Cdk6tm4.1Phin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0002356 abnormal spleen red pulp morphology "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002396 abnormal hematopoietic system morphology/development "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pold1tm1Uchi/Pold1tm1.1Uchi
Genetic Background: C57BL/6-Pold1tm1Uchi/Pold1tm1.1Uchi

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 * ICR

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002682 reduced number of mature ovarian follicles "fewer than normal numbers of spehroidal cell aggregations in the ovary containing the ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 * ICR

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdk6tm1Phin/Cdk6tm1Phin
Genetic Background: involves: 129S4/SvJae

 MP:0003850 abnormal thymocyte activation/response "anomaly in the process of producing activated thymocytes from naive thymocytes" [mberry:Melissa Berry, Genetics Resources Curator]
Show

Allelic Composition: Cdk6tm1Phin/Cdk6tm1Phin
Genetic Background: involves: 129S4/SvJae

 MP:0004567 decreased myocardial fiber number "decreased number of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdk6tm3.1Phin/Cdk6tm3.1Phin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Cdk6tm4.1Phin/Cdk6tm4.1Phin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Cdk6tm2.1Phin/Cdk6tm2.1Phin,Il2ratm1Dw/Il2ratm1Dw
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 * ICR

Allelic Composition: Cdk6tm1Phin/Cdk6tm1Phin
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdk6tm2.1Phin/Cdk6tm2.1Phin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cdk6tm1Phin/Cdk6tm1Phin
Genetic Background: involves: 129S4/SvJae

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cdk6tm2.1Phin/Cdk6tm2.1Phin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cdk6tm1Phin/Cdk6tm1Phin
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Cdk6tm1Phin/Cdk6tm1Phin
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdk6tm2.1Phin/Cdk6tm2.1Phin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Cdk6tm4.1Phin/Cdk6tm4.1Phin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005641 increased mean corpuscular hemoglobin concentration "greater than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
Show

Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdk6tm3.1Phin/Cdk6tm3.1Phin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdk6tm1Phin/Cdk6tm1Phin
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdk6tm2.1Phin/Cdk6tm2.1Phin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Cdk6tm3.1Phin/Cdk6tm3.1Phin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Cdk6tm4.1Phin/Cdk6tm4.1Phin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Cdk6tm2.1Phin/Cdk6tm2.1Phin,Il2ratm1Dw/Il2ratm1Dw
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdk6tm1Phin/Cdk6tm1Phin
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdk6tm2.1Phin/Cdk6tm2.1Phin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Cdk6tm4.1Phin/Cdk6tm4.1Phin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Cdk6tm2.1Phin/Cdk6tm2.1Phin,Il2ratm1Dw/Il2ratm1Dw
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdk6tm1Phin/Cdk6tm1Phin
Genetic Background: involves: 129S4/SvJae

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008255 decreased megakaryocyte cell number "reduced number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
Show

Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008716 lung non-small cell carcinoma "a heterogeneous aggregate of at least three distinct histological types of lung cancer" [MESH:C04.557.470.200.300]
Show

Allelic Composition: Cdk6tm1Bbd/Cdk6tm1Bbd,Krastm1Bbd/Kras+,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009542 decreased thymocyte apoptosis "reduction in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdk6tm1Phin/Cdk6tm1Phin
Genetic Background: involves: 129S4/SvJae

 MP:0010129 increased DN1 thymic pro-T cell number "increased number of pro-T cells that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative" [CL:0000894]
Show

Allelic Composition: Cdk6tm3.1Phin/Cdk6tm3.1Phin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0010130 decreased DN1 thymic pro-T cell number "reduced number of pro-T cells that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative" [CL:0000894]
Show

Allelic Composition: Cdk6tm1Phin/Cdk6tm1Phin
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdk6tm2.1Phin/Cdk6tm2.1Phin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Cdk6tm4.1Phin/Cdk6tm4.1Phin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0010132 decreased DN2 thymocyte number "reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive" [CL:0000806]
Show

Allelic Composition: Cdk6tm1Phin/Cdk6tm1Phin
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdk6tm2.1Phin/Cdk6tm2.1Phin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Cdk6tm4.1Phin/Cdk6tm4.1Phin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0010133 increased DN3 thymocyte number "increased number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." [CL:0000807]
Show

Allelic Composition: Cdk6tm1Phin/Cdk6tm1Phin
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdk6tm2.1Phin/Cdk6tm2.1Phin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Cdk6tm4.1Phin/Cdk6tm4.1Phin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0010136 decreased DN4 thymocyte number "reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive." [CL:0000808]
Show

Allelic Composition: Cdk6tm2.1Phin/Cdk6tm2.1Phin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Cdk6tm4.1Phin/Cdk6tm4.1Phin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0010383 increased adenoma incidence "greater than the expected number of a benign epithelial neoplasm with a glandular organization, occurring in a specific population in a given time period; this tumor type usually does not invade or infiltrate surrounding tissue but may remain a benign tumor or progress to malignancy" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:C04.557.470.035]
Show

Allelic Composition: Cdk6tm1Bbd/Cdk6tm1Bbd,Krastm1Bbd/Kras+,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010763 abnormal hematopoietic stem cell physiology "any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdk6tm1Phin/Cdk6tm1Phin
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdk6tm2.1Phin/Cdk6tm2.1Phin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Cdk6tm3.1Phin/Cdk6tm3.1Phin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

Allelic Composition: Cdk6tm4.1Phin/Cdk6tm4.1Phin
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 * ICR

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 * ICR

 MP:0013585 thymus cortex atrophy "acquired diminution of the outer part of a thymus lobule that surrounds the medulla and is composed of closely packed lymphocytes, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:Anna]
Show

Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003031 Cdkn1b / P46414 / Cyclin-dependent kinase inhibitor 1B / P46527*  / complex / reaction
 ENSMUSG00000023067 Cdkn1a / P39689 / Cyclin-dependent kinase inhibitor 1 / P38936* / cyclin dependent kinase inhibitor 1A*  / complex / reaction
 ENSMUSG00000096472 Cdkn2d / Q60773 / Cyclin-dependent kinase 4 inhibitor D / P55273* / cyclin dependent kinase inhibitor 2D*  / reaction / complex
 ENSMUSG00000031885 Cbfb / Q08024 / Core-binding factor subunit beta / Q13951* / core-binding factor beta subunit*  / reaction / complex
 ENSMUSG00000028551 Cdkn2c / Q60772 / Cyclin-dependent kinase 4 inhibitor C / P42773* / cyclin dependent kinase inhibitor 2C*  / complex / reaction
 ENSMUSG00000073802 Cdkn2b / P55271 / Cyclin-dependent kinase 4 inhibitor B / P42772* / cyclin dependent kinase inhibitor 2B*  / reaction / complex
 ENSMUSG00000070348 Ccnd1 / P25322 / G1/S-specific cyclin-D1 / P24385* / cyclin D1*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr