ENSMUSG00000096472


Mus musculus

Features
Gene ID: ENSMUSG00000096472
  
Biological name :Cdkn2d
  
Synonyms : Cdkn2d / Cyclin-dependent kinase 4 inhibitor D / Q60773
  
Possible biological names infered from orthology : cyclin dependent kinase inhibitor 2D / P55273
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A3
Gene start: 21288410
Gene end: 21291407
  
Corresponding Affymetrix probe sets: 10591517 (MoGene1.0st)   1416253_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000083561
Ensembl peptide - ENSMUSP00000150701
Ensembl peptide - ENSMUSP00000149499
NCBI entrez gene - 12581     See in Manteia.
MGI - MGI:105387
RefSeq - NM_009878
RefSeq - XM_006509968
RefSeq Peptide - NP_034008
swissprot - A0A1N9MI08
swissprot - Q60773
swissprot - A0A1L1SRJ2
Ensembl - ENSMUSG00000096472
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdkn2dENSDARG00000094176Danio rerio
 CDKN2DENSG00000129355Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cdkn2c / Q60772 / Cyclin-dependent kinase 4 inhibitor C / P42773* / cyclin dependent kinase inhibitor 2C*ENSMUSG0000002855142
Cdkn2b / P55271 / Cyclin-dependent kinase 4 inhibitor B / P42772* / cyclin dependent kinase inhibitor 2B*ENSMUSG0000007380237


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IEA
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IEA
 biological_processGO:0000731 DNA synthesis involved in DNA repair IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009411 response to UV IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0032526 response to retinoic acid IEA
 biological_processGO:0033280 response to vitamin D IEA
 biological_processGO:0042326 negative regulation of phosphorylation IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0048102 autophagic cell death IEA
 biological_processGO:0071901 negative regulation of protein serine/threonine kinase activity IEA
 biological_processGO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IEA
 biological_processGO:1902807 negative regulation of cell cycle G1/S phase transition IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0097129 cyclin D2-CDK4 complex IDA
 molecular_functionGO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Cyclin D associated events in G1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000754 partial paralysis "partial loss of power of voluntary movement in a muscle through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001152 Leydig cell hyperplasia "increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065]
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Allelic Composition: Cdkn2ctm1Bbd/Cdkn2ctm1Bbd,Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Cdkn2ctm1Bbd/Cdkn2ctm1Bbd,Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Cdkn2ctm1Bbd/Cdkn2ctm1Bbd,Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Allelic Composition: Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Ceacam9tm1Wzm/Ceacam9tm1Wzm
Genetic Background: either: (involves: 129/Sv * BALB/cJ) or (involves: BALB/cJ)

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
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Allelic Composition: Apobtm5Sgy/Apobtm5Sgy
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001750 increased circulating follicle stimulating hormone level "higher than normal levels in the blood stream of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:35782, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn2ctm1Bbd/Cdkn2ctm1Bbd,Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Allelic Composition: Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Cdkn2ctm1Bbd/Cdkn2ctm1Bbd,Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001999 photosensitivity "alterations in the response to sunlight or UV irradiation, especially sensitivity of the eyes" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002041 pituitary adenoma "appearance of benign neoplasms of the pituitary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
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Allelic Composition: Cdkn2ctm1Bbd/Cdkn2ctm1Bbd,Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0002050 pheochromocytoma "a benign neoplasm derived from adrenal medullary cells; usually associated with hypertension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229]
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Allelic Composition: Cdkn2ctm1Bbd/Cdkn2ctm1Bbd,Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002208 abnormal germ cell morphology "anomalous structure of the germ cell, that is, any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn2ctm1Bbd/Cdkn2ctm1Bbd,Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0002209 germ cell depletion "reduced numbers of any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn2ctm1Bbd/Cdkn2ctm1Bbd,Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn2ctm1Bbd/Cdkn2ctm1Bbd,Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Cdkn2ctm1Bbd/Cdkn2ctm1Bbd,Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Allelic Composition: Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002780 decreased circulating testosterone level "less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn2ctm1Bbd/Cdkn2ctm1Bbd,Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
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Allelic Composition: Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Cdkn2ctm1Bbd/Cdkn2ctm1Bbd,Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0004025 polyploidy "more than two chromosome sets are present" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: B6.129-Apoetm1Unc Cdkn1atm1Tyj

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004143 hypertonia "increased muscle tone" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004362 cochlear hair cell degeneration "degeneration or loss of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0004393 abnormal cochlear inner hair cell morphology "any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there is a single row of flask-shaped inner hair cells tightly surrounded by supporting interphalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a more or less linear (or shallow) U-shaped pattern extend from the cell s surface through the cuticular plate into the endolymphic space inferior to the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129X1/SvJ * C57BL/6 * CD-1

 MP:0004396 decreased cochlear inner hair cell number "decreased number (or less than the expected single row) of the flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129X1/SvJ * C57BL/6 * CD-1

Allelic Composition: Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CD-1

 MP:0004398 cochlear inner hair cell degeneration "degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0004402 decreased cochlear outer hair cell number "decreased number (or less than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129X1/SvJ * C57BL/6 * CD-1

Allelic Composition: Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CD-1

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0004407 increased cochlear hair cell number "increased number of the sensory epithelial cells of the cochlea, which are normally in synaptic contact with the auditory nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129X1/SvJ * C57BL/6 * CD-1

 MP:0004408 decreased cochlear hair cell number "decreased number of the sensory epithelial cells of the cochlea, which are normally in synaptic contact with the auditory nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129X1/SvJ * C57BL/6 * CD-1

 MP:0004432 abnormal cochlear hair cell physiology "anomalies in processes pertinent to the integrated function of cochlear hair cells i.e. the sensory cells in the spiral organ which are in synaptic contact with sensory as well as efferent fibers of the cochlear (auditory) nerve " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129X1/SvJ * C57BL/6 * CD-1

 MP:0004737 absent distortion product otoacoustic emissions "failure to create mechanical distortions in the inner ear when two primary tones are presented, indicating failure of outer hair cells to amplify basilar membrane motion" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0004740 sensorineural hearing loss "a form of progressive hearing loss due to a lesion of the auditory division of cranial nerve VIII or the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0004749 nonsyndromic hearing loss "a form of progressive hearing loss that is not associated with visible abnormalities of the external ear or other signs and symptoms; the vast majority of hereditary hearing loss is nonsyndromic and can be associated with abnormalities of the middle ear and/or inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0004760 increased mitotic index "increased number of cells in G2/M phase" [Bertram_Weiss:Bayer_Schering_Pharma_AG]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005156 bradykinesia "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn2ctm1Bbd/Cdkn2ctm1Bbd,Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Allelic Composition: Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0013602 abnormal Leydig cell differentiation "atypical formation of or inability to produce the interstitial cells that are found adjacent to the seminiferous tubules in the testicle and produce testosterone in the presence of luteinizing hormone; in most mammals, normal Leydig cell (LC) development comprises two sequential but overlapping cell lineages known as the fetal and adult type LC populations, which display distinct functional characteristics reflected by different morphology, hormonal regulation, and steroidogenic output" [http://press.endocrine.org/doi/full/10.1210/en.2012-2273, MGI:Anna]
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Allelic Composition: Cdkn2ctm1Bbd/Cdkn2ctm1Bbd,Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006728 Cdk4 / P30285 / Cyclin-dependent kinase 4 / P11802*  / complex / reaction
 ENSMUSG00000040274 Cdk6 / Q64261 / Cyclin-dependent kinase 6 / Q00534*  / complex / reaction






 

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