Manteia - Molecule gene

ENSMUSG00000028551

Mus musculus

Features

Gene ID:	ENSMUSG00000028551

Biological name :	Cdkn2c

Synonyms :	Cdkn2c / Cyclin-dependent kinase 4 inhibitor C / Q60772

Possible biological names infered from orthology :	cyclin dependent kinase inhibitor 2C / P42773

Species:	Mus musculus

Chr. number:	4
Strand:	-1
Band:	C7
Gene start:	109660876
Gene end:	109667189

Corresponding Affymetrix probe sets:	10515090 (MoGene1.0st) 1416868_at (Mouse Genome 430 2.0 Array) 1439164_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000070313 Ensembl peptide - ENSMUSP00000095534 NCBI entrez gene - 12580 See in Manteia. MGI - MGI:105388 RefSeq - NM_001301368 RefSeq - NM_007671 RefSeq Peptide - NP_001288297 RefSeq Peptide - NP_031697 swissprot - Q60772 Ensembl - ENSMUSG00000028551

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
cdkn2c	ENSDARG00000057610	Danio rerio
CDKN2C	ENSGALG00000010537	Gallus gallus
CDKN2C	ENSG00000123080	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Cdkn2d / Q60773 / Cyclin-dependent kinase 4 inhibitor D / P55273* / cyclin dependent kinase inhibitor 2D*	ENSMUSG00000096472	42
Cdkn2b / P55271 / Cyclin-dependent kinase 4 inhibitor B / P42772* / cyclin dependent kinase inhibitor 2B*	ENSMUSG00000073802	31

Protein motifs (from Interpro)

Interpro ID	Name
IPR002110	Ankyrin repeat
IPR020683	Ankyrin repeat-containing domain
IPR036770	Ankyrin repeat-containing domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	ISO
biological_process	GO:0000082	G1/S transition of mitotic cell cycle	ISO
biological_process	GO:0007049	cell cycle	IEA
biological_process	GO:0007050	cell cycle arrest	ISO
biological_process	GO:0008285	negative regulation of cell proliferation	ISO
biological_process	GO:0030308	negative regulation of cell growth	ISO
biological_process	GO:0042326	negative regulation of phosphorylation	ISO
biological_process	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	IDA
biological_process	GO:0048709	oligodendrocyte differentiation	IEA
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005737	cytoplasm	ISO
molecular_function	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	ISO
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0019901	protein kinase binding	ISO

Pathways (from Reactome)

Pathway description

Oxidative Stress Induced Senescence

Senescence-Associated Secretory Phenotype (SASP)

Oncogene Induced Senescence

Cyclin D associated events in G1

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000240	extramedullary hematopoiesis	"formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Cdkn2b^tm1Bbd/Cdkn2b^tm1Bbd,Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0000274	enlarged heart	"increase over normal size of the heart" [J:29971]	Show Allelic Composition: Cdkn1b^tm1Ako/Cdkn1b^tm1Ako,Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6 * DBA/2
MP:0000321	increased bone marrow cell number	"increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2
MP:0000522	cysts in kidney cortex	"abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL
MP:0000523	cortical glomerulopathies	"any disease of the capillary plexus in the kidney cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL
MP:0000627	abnormal mammary gland morphology	"malformation of the milk-secreting gland that lies within the breast; usually rudimentary in males" [J:70183]	Show Allelic Composition: Cdk5r1^tm1Lht/Cdk5r1^tm1Lht,Cdk5r2^tm1Lht/Cdk5r2^tm1Lht Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: C.129-Cdkn2c^tm1Yxi Allelic Composition: Brca1^tm1Bhk/Brca1⁺,Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: C.129-Cdkn2c^tm1Yxi Brca1^tm1Bhk
MP:0000630	mammary gland hyperplasia	"increased size of mammary gland due to increased cell number" [J:63229]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL
MP:0000635	pituitary gland hyperplasia	"increased size of pituitary gland due to increased cell number" [J:63229, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL Allelic Composition: Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2
MP:0000636	enlarged pituitary gland	"increased size of pituitary gland" [J:50053]	Show Allelic Composition: Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2 Allelic Composition: Cdkn1b^tm1Ako/Cdkn1b^tm1Ako,Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6 * DBA/2
MP:0000642	enlarged adrenal glands	"increased size of the endocrine gland" [J:40203]	Show Allelic Composition: Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2 Allelic Composition: Cdkn1b^tm1Ako/Cdkn1b^tm1Ako,Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6 * DBA/2
MP:0000688	lymphoid hyperplasia	"increased cell number in lymphatic tissues" [J:62478]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL Allelic Composition: Cdkn2b^tm1Bbd/Cdkn2b^tm1Bbd,Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0000691	enlarged spleen	"increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL Allelic Composition: Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2 Allelic Composition: Cdkn2b^tm1Bbd/Cdkn2b^tm1Bbd,Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Cdkn1b^tm1Ako/Cdkn1b^tm1Ako,Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6 * DBA/2
MP:0000693	spleen hyperplasia	"increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]	Show Allelic Composition: Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2
MP:0000702	enlarged lymph nodes	"lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL
MP:0000708	thymus hyperplasia	"increased cell number in the thymus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]	Show Allelic Composition: Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2
MP:0000709	enlarged thymus	"increased size of thymus" [J:50053]	Show Allelic Composition: Cdkn1b^tm1Ako/Cdkn1b^tm1Ako,Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6 * DBA/2
MP:0000889	abnormal cerebellar molecular layer	"any malformation or absence of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL Allelic Composition: Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001146	abnormal testis morphology	"anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cdk5r1^tm1Lht/Cdk5r1^tm1Lht,Cdk5r2^tm1Lht/Cdk5r2^tm1Lht Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0001147	small testis	"reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]	Show Allelic Composition: Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2
MP:0001148	enlarged testes	"increased size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL Allelic Composition: Cdkn2b^tm1Bbd/Cdkn2b^tm1Bbd,Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Cdkn1b^tm1Ako/Cdkn1b^tm1Ako,Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6 * DBA/2
MP:0001152	Leydig cell hyperplasia	"increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL Allelic Composition: Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd,Cdkn2d^tm1Maro/Cdkn2d^tm1Maro Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
MP:0001154	seminiferous tubule degeneration	"a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]	Show Allelic Composition: Cdkn2b^tm1Bbd/Cdkn2b^tm1Bbd,Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd,Cdkn2d^tm1Maro/Cdkn2d^tm1Maro Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
MP:0001156	abnormal spermatogenesis	"incomplete maturation or aberrant formation of the male gametes" [J:58959]	Show Allelic Composition: Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd,Cdkn2d^tm1Maro/Cdkn2d^tm1Maro Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
MP:0001260	increased body weight	"greater than normal average weight " [J:33400]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL Allelic Composition: Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2 Allelic Composition: Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd,Cdkn2d^tm1Maro/Cdkn2d^tm1Maro Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
MP:0001263	weight loss	"progressive reduction of body weight below normal average for age" [J:45400]	Show Allelic Composition: Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2 Allelic Composition: Cdkn1b^tm1Ako/Cdkn1b^tm1Ako,Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6 * DBA/2
MP:0001264	increased body size	"larger than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL Allelic Composition: Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2
MP:0001272	increased metastatic potential		Show Allelic Composition: Brca1^tm1Bhk/Brca1⁺,Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: C.129-Cdkn2c^tm1Yxi Brca1^tm1Bhk
MP:0001393	ataxia	"inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]	Show Allelic Composition: Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2 Allelic Composition: Cdkn1b^tm1Ako/Cdkn1b^tm1Ako,Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6 * DBA/2
MP:0001429	dehydration	"excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]	Show Allelic Composition: Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2 Allelic Composition: Cdkn1b^tm1Ako/Cdkn1b^tm1Ako,Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6 * DBA/2
MP:0001648	abnormal apoptosis	"excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL
MP:0001750	increased circulating follicle stimulating hormone level	"higher than normal levels in the blood stream of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:35782, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd,Cdkn2d^tm1Maro/Cdkn2d^tm1Maro Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
MP:0001883	mammary adenocarcinoma	"higher than normal incidence of malignant tumors of the mammary gland" [J:62919]	Show Allelic Composition: Brca1^tm1Bhk/Brca1⁺,Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: C.129-Cdkn2c^tm1Yxi Brca1^tm1Bhk
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd,Cdkn2d^tm1Maro/Cdkn2d^tm1Maro Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
MP:0002020	increased tumor incidence	"greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]	Show Allelic Composition: Cdkn2b^tm1Bbd/Cdkn2b^tm1Bbd,Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0002023	B cell derived lymphoma	"heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL
MP:0002024	T cell derived lymphoma	"group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL
MP:0002027	lung adenocarcinoma	"malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]	Show Allelic Composition: Men1^tm1.1Ctre/Men1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi,Men1^tm1.1Ctre/Men1⁺ Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6
MP:0002031	adrenal tumor	"tumors of the adrenal gland, including phaeochomocytomas" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]	Show Allelic Composition: Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi,Men1^tm1.1Ctre/Men1⁺ Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6
MP:0002032	sarcoma	"connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]	Show Allelic Composition: Cdkn2b^tm1Bbd/Cdkn2b^tm1Bbd,Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0002038	carcinoma	"malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]	Show Allelic Composition: Cdkn1b^tm1Ako/Cdkn1b^tm1Ako,Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6 * DBA/2
MP:0002041	pituitary adenoma	"appearance of benign neoplasms of the pituitary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL Allelic Composition: Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2 Allelic Composition: Cdkn2b^tm1Bbd/Cdkn2b^tm1Bbd,Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd,Cdkn2d^tm1Maro/Cdkn2d^tm1Maro Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 Allelic Composition: Cdkn1b^tm1Ako/Cdkn1b^tm1Ako,Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6 * DBA/2
MP:0002048	lung adenoma	"benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]	Show Allelic Composition: Men1^tm1.1Ctre/Men1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi,Men1^tm1.1Ctre/Men1⁺ Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6
MP:0002050	pheochromocytoma	"a benign neoplasm derived from adrenal medullary cells; usually associated with hypertension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL Allelic Composition: Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd,Cdkn2d^tm1Maro/Cdkn2d^tm1Maro Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL Allelic Composition: Cdkn1b^tm1Ako/Cdkn1b^tm1Ako,Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6 * DBA/2
MP:0002208	abnormal germ cell morphology	"anomalous structure of the germ cell, that is, any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd,Cdkn2d^tm1Maro/Cdkn2d^tm1Maro Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
MP:0002209	germ cell depletion	"reduced numbers of any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd,Cdkn2d^tm1Maro/Cdkn2d^tm1Maro Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
MP:0002348	abnormal lymph node medulla	"anomaly in the area of the lymph node through which lymph leaves the node; it contains macrophages and antibody-secreting plasma cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL
MP:0002364	abnormal thymus size	"deviation from the normal size of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2
MP:0002444	abnormal T cell physiology	"anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2
MP:0002619	abnormal lymphocyte morphology/development	"anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Cdkn2b^tm1Bbd/Cdkn2b^tm1Bbd,Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0002675	asthenozoospermia	"loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd,Cdkn2d^tm1Maro/Cdkn2d^tm1Maro Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
MP:0002687	oligozoospermia	"reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]	Show Allelic Composition: Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd,Cdkn2d^tm1Maro/Cdkn2d^tm1Maro Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
MP:0002780	decreased circulating testosterone level	"less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL Allelic Composition: Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd,Cdkn2d^tm1Maro/Cdkn2d^tm1Maro Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
MP:0003205	testicular atrophy	"wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]	Show Allelic Composition: Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd,Cdkn2d^tm1Maro/Cdkn2d^tm1Maro Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
MP:0003336	pancreatic cysts	"the appearance of fluid-filled sacs within the pancreas" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Cdkn2b^tm1Bbd/Cdkn2b^tm1Bbd,Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0003667	hemangiosarcoma	"a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL
MP:0003675	kidney cysts	"abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL Allelic Composition: Cdkn2b^tm1Bbd/Cdkn2b^tm1Bbd,Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0005014	increased B cell number	"greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2
MP:0005015	increased T cell number	"greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2
MP:0005169	abnormal male meiosis	"malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd,Cdkn2d^tm1Maro/Cdkn2d^tm1Maro Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
MP:0005621	abnormal cell physiology	"aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Cdkn2b^tm1Bbd/Cdkn2b^tm1Bbd,Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0006009	abnormal neuronal migration	"defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL
MP:0006262	testis tumor	"presence of abnormal rapidly proliferating cells in the testis, usually in the form of a distinct mass" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:60034]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL Allelic Composition: Cdkn2b^tm1Bbd/Cdkn2b^tm1Bbd,Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi,Men1^tm1.1Ctre/Men1⁺ Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6
MP:0006283	medulloblastoma	"a solid, cancerous tumor originating in the cerebellum of the brain and of primitive neuroectodermal origin " [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2c^tm1Bbd/Cdkn2c⁺,Trp53^tm1Tyj/Trp53⁺ Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6 Allelic Composition: Cdkn2c^tm1Bbd/Cdkn2c⁺,Trp53^tm1Tyj/Trp53^tm1Tyj Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6 Allelic Composition: Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd,Trp53^tm1Tyj/Trp53^tm1Tyj Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6 Allelic Composition: Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd,Trp53^tm1Brn/Trp53^tm1Tyj,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL Allelic Composition: Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ Allelic Composition: Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0006423	dilated rete testis	"an expansion in the volume or area of the network of canals located at the termination of the straight tubules in the mediastinum testis, usually with an increase in contained fluid" [J:121125, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2b^tm1Bbd/Cdkn2b^tm1Bbd,Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0008014	lung tumor	"presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Men1^tm1.1Ctre/Men1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi,Men1^tm1.1Ctre/Men1⁺ Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6
MP:0008102	lymph node hyperplasia	"overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2b^tm1Bbd/Cdkn2b^tm1Bbd,Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0008117	abnormal Langerhans cell morphology	"any structural anomaly of a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus" [CL:0000453, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2b^tm1Bbd/Cdkn2b^tm1Bbd,Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0008130	abnormal pituitary intermediate lobe	"any structural anomaly of the thin boundary between the adenohypophysis and neurohypophysis of the pituitary that produces melanocyte stimulating hormone (MSH); this area is small or absent in mammalian adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2
MP:0008371	pituitary intermediate lobe hyperplasia	"overdevelopment or increased size, usually due to increased cell number, of the thin boundary between the adenohypophysis and neurohypophysis of the pituitary that produces melanocyte stimulating hormone (MSH); this area is small or absent in mammalian adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn1b^tm1Ako/Cdkn1b^tm1Ako,Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6 * DBA/2
MP:0008478	increased spleen white pulp amount	"increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL
MP:0009153	pancreas tumor	"tumors or cancer of the pancreas" [MESH:C04.588.274.761]	Show Allelic Composition: Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi,Men1^tm1.1Ctre/Men1⁺ Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6
MP:0009308	adenocarcinoma	"malignant neoplasm of epithelial cells in a glandular or glandular-like pattern" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi,Men1^tm1.1Ctre/Men1⁺ Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6
MP:0009504	abnormal mammary gland epithelium morphology	"any structural anomaly of the epithelial layer of the luminal surfaces of the mammary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL
MP:0009592	Leydig cell tumor	"rare testicular tumors of the male gonadal interstitium that are frequently hormonally active, leading to feminizing or virilizing syndromes; Leydig cell tumors comprise 1-3% of all testicular neoplasms, can be pure or mixed with other sex cord-stromal or germ cell tumors, and are usually benign, although malignant variants also occur" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi,Men1^tm1.1Ctre/Men1⁺ Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6
MP:0009937	abnormal neuron differentiation	"abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL Allelic Composition: Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd,Trp53^tm1Tyj/Trp53^tm1Tyj Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6 Allelic Composition: Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd,Ptch1^tm1Mps/Ptch1⁺ Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
MP:0010299	increased mammary gland tumor incidence	"greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: C.129-Cdkn2c^tm1Yxi Allelic Composition: Brca1^tm1Bhk/Brca1⁺,Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: C.129-Cdkn2c^tm1Yxi Brca1^tm1Bhk
MP:0010308	decreased tumor latency	"earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi,Men1^tm1.1Ctre/Men1⁺ Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6
MP:0010316	increased thyroid tumor incidence	"greater than the expected number of neoplams in the thyroid occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi,Men1^tm1.1Ctre/Men1⁺ Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6
MP:0010321	increased parathyroid gland tumor incidence	"greater than the expected number of neoplams in the parathyroid gland occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi,Men1^tm1.1Ctre/Men1⁺ Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6
MP:0010384	increased renal carcinoma incidence	"greater than the expected number of malignant neoplasms arising from kidney epithelial tissue, occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL
MP:0010829	increased bronchioalveolar stem cell number		Show Allelic Composition: Men1^tm1.1Ctre/Men1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0011092	complete embryonic lethality	"death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]	Show Allelic Composition: Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi,Men1^tm1.1Ctre/Men1⁺ Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6
MP:0011099	complete lethality throughout fetal growth and development	"death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Brca1^tm1Bhk/Brca1^tm1Bhk,Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Genetic Background: C.129-Cdkn2c^tm1Yxi Brca1^tm1Bhk
MP:0011703	increased fibroblast proliferation	"greater the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]	Show Allelic Composition: Cdkn2b^tm1Bbd/Cdkn2b^tm1Bbd,Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0012431	increased lymphoma incidence	"greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]	Show Allelic Composition: Cdkn2b^tm1Bbd/Cdkn2b^tm1Bbd,Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0013602	abnormal Leydig cell differentiation	"atypical formation of or inability to produce the interstitial cells that are found adjacent to the seminiferous tubules in the testicle and produce testosterone in the presence of luteinizing hormone; in most mammals, normal Leydig cell (LC) development comprises two sequential but overlapping cell lineages known as the fetal and adult type LC populations, which display distinct functional characteristics reflected by different morphology, hormonal regulation, and steroidogenic output" [http://press.endocrine.org/doi/full/10.1210/en.2012-2273, MGI:Anna]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Genetic Background: involves: 129/Sv * C57BL/6 * SJL Allelic Composition: Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd,Cdkn2d^tm1Maro/Cdkn2d^tm1Maro Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000006728	Cdk4 / P30285 / Cyclin-dependent kinase 4 / P11802*	/ complex / reaction
ENSMUSG00000040274	Cdk6 / Q64261 / Cyclin-dependent kinase 6 / Q00534*	/ complex / reaction

0 s.

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