ENSMUSG00000006728


Mus musculus

Features
Gene ID: ENSMUSG00000006728
  
Biological name :Cdk4
  
Synonyms : Cdk4 / Cyclin-dependent kinase 4 / P30285
  
Possible biological names infered from orthology : P11802
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: D3
Gene start: 127063534
Gene end: 127067920
  
Corresponding Affymetrix probe sets: 10366814 (MoGene1.0st)   1422439_a_at (Mouse Genome 430 2.0 Array)   1422440_at (Mouse Genome 430 2.0 Array)   1422441_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006911
Ensembl peptide - ENSMUSP00000122973
Ensembl peptide - ENSMUSP00000117234
Ensembl peptide - ENSMUSP00000116190
Ensembl peptide - ENSMUSP00000112549
NCBI entrez gene - 12567     See in Manteia.
MGI - MGI:88357
RefSeq - XM_006513163
RefSeq - NM_009870
RefSeq Peptide - NP_034000
swissprot - E9PZX7
swissprot - E9Q9E4
swissprot - D3YWB0
swissprot - P30285
swissprot - Q545C3
swissprot - D6RHS5
Ensembl - ENSMUSG00000006728
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdk4ENSDARG00000087937Danio rerio
 CDK4ENSG00000135446Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cdk6 / Q64261 / Cyclin-dependent kinase 6 / Q00534*ENSMUSG0000004027468
Cdk2 / P97377 / Cyclin-dependent kinase 2 / P24941*ENSMUSG0000002535844
Cdk5 / P49615 / Cyclin-dependent-like kinase 5 / Q00535* / cyclin dependent kinase 5*ENSMUSG0000002896943
Cdk1 / P11440 / Cyclin-dependent kinase 1 / P06493*ENSMUSG0000001994242
Cdk3-ps / cyclin dependent kinase 3 / CDK3* / Q00526*ENSMUSG0000009230041
Cdk10 / Q3UMM4 / Cyclin-dependent kinase 10 / Q15131*ENSMUSG0000003386241
Cdk11b / P24788 / Mus musculus cyclin-dependent kinase 11B (Cdk11b), transcript variant 3, mRNA. / Q9UQ88* / CDK11A* / cyclin dependent kinase 11A* / cyclin dependent kinase 11B*ENSMUSG0000002906238
E030030I06RikENSMUSG0000009732713


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IEA
 biological_processGO:0002088 lens development in camera-type eye IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007165 signal transduction IDA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010288 response to lead ion IEA
 biological_processGO:0010389 regulation of G2/M transition of mitotic cell cycle IBA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010971 positive regulation of G2/M transition of mitotic cell cycle IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0032869 cellular response to insulin stimulus IMP
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0040014 regulation of multicellular organism growth IMP
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0045727 positive regulation of translation IEA
 biological_processGO:0045793 positive regulation of cell size IEA
 biological_processGO:0046626 regulation of insulin receptor signaling pathway IMP
 biological_processGO:0046890 regulation of lipid biosynthetic process IMP
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0050994 regulation of lipid catabolic process IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051726 regulation of cell cycle IDA
 biological_processGO:0055093 response to hyperoxia IEA
 biological_processGO:0060612 adipose tissue development IMP
 biological_processGO:0071157 negative regulation of cell cycle arrest IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IDA
 biological_processGO:0071353 cellular response to interleukin-4 IDA
 biological_processGO:1904628 cellular response to phorbol 13-acetate 12-myristate IDA
 biological_processGO:1904637 cellular response to ionomycin IDA
 cellular_componentGO:0000307 cyclin-dependent protein kinase holoenzyme complex IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005923 bicellular tight junction IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0097129 cyclin D2-CDK4 complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004693 cyclin-dependent protein serine/threonine kinase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030332 cyclin binding IEA


Pathways (from Reactome)
Pathway description
SCF(Skp2)-mediated degradation of p27/p21
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
RMTs methylate histone arginines
Ubiquitin-dependent degradation of Cyclin D1
Cyclin D associated events in G1
PTK6 Regulates Cell Cycle
Transcriptional regulation by RUNX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 * ICR

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm2.1Bbd/Cdk4tm2.1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

 MP:0000285 abnormal cardiac valve morphology "malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald,Cdk4tm1Kiyo/Cdk4tm1Kiyo,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cdk4tm2.1Bbd/Cdk4tm2.1Bbd,Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cdk4tm2.2Bbd/Cdk4tm2.1Bbd,Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm2.1Bbd/Cdk4tm2.1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm2.1Bbd/Cdk4tm2.1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

 MP:0001119 abnormal female reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that bears the offspring" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0001145 abnormal male reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001152 Leydig cell hyperplasia "increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065]
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Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Tarbp2tm1.2Dzw/Tarbp2tm1.2Dzw
Genetic Background: involves: 129 * FVB/N

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Cdk4tm1Kiyo/Cdk4tm1Kiyo,Lin9tm1Orc/Lin9tm1Orc
Genetic Background: involves: 129S1/Sv

Allelic Composition: Cdk4tm1Kiyo/Cdk4tm1Kiyo
Genetic Background: involves: 129S1/Sv

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm2.1Bbd/Cdk4tm2.1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Cdk2tm2Sgo/Cdk2tm2Sgo,Cdk4tm2.1Bbd/Cdk4tm2.1Bbd,Polr2atm1(cre/ERT2)Bbd/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Cdk4tm1b(NCOM)Mfgc/Cdk4tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Cdk4tm1b(NCOM)Mfgc/Tcp

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0001426 polydipsia "excessive thirst that is relatively prolonged" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
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Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Catsper3tm1.1(KOMP)Vlcg/Catsper3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Catsper3tm1.1(KOMP)Vlcg/Ucd

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0001627 abnormal cardiac output "anomaly in the blood volume pumped by each ventricle per minute (stroke volume x heart rate)" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm2.1Bbd/Cdk4tm2.1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Cdk4tm1b(NCOM)Mfgc/Cdk4tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Cdk4tm1b(NCOM)Mfgc/Tcp

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 * ICR

Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald,Cdk4tm1Kiyo/Cdk4tm1Kiyo
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001759 increased urine glucose level "a greater level of excretion of glucose in the urine compared to the normal state" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald,Cdk4tm1Kiyo/Cdk4tm1Kiyo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Cdk4tm1Kiyo/Cdk4tm1Kiyo,Lin9tm1Orc/Lin9tm1Orc
Genetic Background: involves: 129S1/Sv

Allelic Composition: Cdk4tm1Kiyo/Cdk4tm1Kiyo
Genetic Background: involves: 129S1/Sv

Allelic Composition: Cdk4tm1b(NCOM)Mfgc/Cdk4tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Cdk4tm1b(NCOM)Mfgc/Tcp

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Cdk4tm1Kiyo/Cdk4tm1Kiyo,Lin9tm1Orc/Lin9tm1Orc
Genetic Background: involves: 129S1/Sv

Allelic Composition: Cdk4tm1Kiyo/Cdk4tm1Kiyo
Genetic Background: involves: 129S1/Sv

Allelic Composition: Cdk4tm1b(NCOM)Mfgc/Cdk4tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Cdk4tm1b(NCOM)Mfgc/Tcp

 MP:0002014 papilloma "benign epithelial tumor" [J:47225]
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Allelic Composition: Cdk4tm1.1Bbd/Cdk4+,Krastm1Bbd/Kras+,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Cdk4tm2.2Bbd/Cdk4tm2.1Bbd,Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Cdk4tm1.1Bbd/Cdk4+,Krastm1Bbd/Kras+,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0002041 pituitary adenoma "appearance of benign neoplasms of the pituitary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
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Allelic Composition: Cdk4tm1.1Bbd/Cdk4+,Krastm1Bbd/Kras+,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
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Allelic Composition: Krastm1Bbd/Kras+,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atoh1tm1(cre)Gan/Atoh1tm1(cre)Gan
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Cdk4tm2.2Bbd/Cdk4tm2.1Bbd,Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Etv2tm1Dlim/Etv2tm2.1Dlim,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

Allelic Composition: Cdk4tm1b(NCOM)Mfgc/Cdk4tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Cdk4tm1b(NCOM)Mfgc/Tcp

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm2.1Bbd/Cdk4tm2.1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm1(tetO-YAP1*)Fcam/Col1a1+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
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Allelic Composition: Faslpr/Faslpr
Genetic Background: MRL/MpJ-Faslpr/J

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdk4tm1b(NCOM)Mfgc/Cdk4tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Cdk4tm1b(NCOM)Mfgc/Tcp

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 * ICR

Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald,Cdk4tm1Kiyo/Cdk4tm1Kiyo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002679 abnormal corpora lutea "malformed or absent yellow endocrine body formed in the ovary after follicle rupture" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0002784 abnormal Sertoli cell morphology "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0002785 absent Leydig cells "lack of the interstitial cells of the seminiferous tubules that secrete testosterone " [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cdk4tm1Kiyo/Cdk4tm1Kiyo
Genetic Background: involves: 129S1/Sv

 MP:0002790 decreased circulating follicle stimulating hormone level "less than expected blood concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 * ICR

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm2.1Bbd/Cdk4tm2.1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

 MP:0002893 ketoaciduria "excretion of urine having an elevated concentration of keto acids" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald,Cdk4tm1Kiyo/Cdk4tm1Kiyo
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cdk4tm1Kiyo/Cdk4tm1Kiyo,Lin9tm1Orc/Lin9tm1Orc
Genetic Background: involves: 129S1/Sv

Allelic Composition: Cdk4tm1Kiyo/Cdk4+,Lin9tm1Orc/Lin9+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm2.1Bbd/Cdk4tm2.1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

 MP:0003356 impaired lutenization "atypical transformation of the mature ovarian follicle and its theca interna into a corpus luteum after ovulation" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:57854, J:43075]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Cdk4tm2.1Bbd/Cdk4tm2.1Bbd,Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cdk4tm2.2Bbd/Cdk4tm2.1Bbd,Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003567 abnormal cardiomyocyte proliferation "anomalous division or replication of cardiac muscle cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald,Cdk4tm1Kiyo/Cdk4tm1Kiyo
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm2.1Bbd/Cdk4tm2.1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

 MP:0003645 increased number of pancreatic beta cells "greater than normal number of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

Allelic Composition: Cdk4tm1.1Bbd/Cdk4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0003667 hemangiosarcoma "a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511]
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Allelic Composition: Cdk4tm1.1Bbd/Cdk4+,Krastm1Bbd/Kras+,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0003698 abnormal male reproductive system physiology "anomaly in the function of the male organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0003699 abnormal female reproductive system physiology "anomaly in the function of the female organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald,Cdk4tm1Kiyo/Cdk4tm1Kiyo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004501 increased incidence of UV-induced tumors "higher than normal frequency of tumor incidence induced by exposure to ultraviolet light" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tarbp2tm1.2Dzw/Tarbp2tm1.2Dzw
Genetic Background: involves: 129 * FVB/N

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm2.1Bbd/Cdk4tm2.1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

 MP:0004567 decreased myocardial fiber number "decreased number of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004803 increased susceptibility to autoimmune diabetes "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdk2tm2Sgo/Cdk2tm2Sgo,Cdk4tm2.1Bbd/Cdk4tm2.1Bbd,Polr2atm1(cre/ERT2)Bbd/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdk4tm1Kiyo/Cdk4+,Lin9tm1Orc/Lin9+
Genetic Background: involves: 129S1/Sv

 MP:0004808 abnormal hematopoietic stem cell morphology "any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald,Cdk4tm1Kiyo/Cdk4tm1Kiyo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 * ICR

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdk4tm1Kiyo/Cdk4tm1Kiyo
Genetic Background: involves: 129S1/Sv

 MP:0005185 decreased circulating progesterone level "less than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]
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Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0005536 Leydig cell hypoplasia "reduced numbers of the interstitial cells of the seminiferous tubules that secrete testosterone" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm2.1Bbd/Cdk4tm2.1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdk4tm2.1Bbd/Cdk4tm2.1Bbd,Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Cdk4tm2.2Bbd/Cdk4tm2.1Bbd,Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008332 decreased lactotroph cell number "reduced number of an acidophilic cell of the anterior pituitary that produces prolactin" [CL:0000439, MESH:A06.407.747.608.812]
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Allelic Composition: Cdk4tm1Kiyo/Cdk4tm1Kiyo
Genetic Background: involves: 129S1/Sv

 MP:0008365 adenohypophysis hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, of the anterior lobe of the pituitary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdk4tm1Kiyo/Cdk4tm1Kiyo,Lin9tm1Orc/Lin9tm1Orc
Genetic Background: involves: 129S1/Sv

Allelic Composition: Cdk4tm1Kiyo/Cdk4tm1Kiyo
Genetic Background: involves: 129S1/Sv

 MP:0008725 enlarged heart atrium "increased size of one or both of the two upper chambers of the heart, to which the blood returns from the circulation" [MESH:A07.541.358]
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Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald,Cdk4tm1Kiyo/Cdk4tm1Kiyo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009008 delayed estrous cycle "onset of the sexual cycle of females occurring at a later than expected day/age" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0009143 abnormal pancreatic duct morphology "any structural anomaly of the excretory duct of the exocrine pancreas that collects fluid containing digestive enzymes and transports it to the duodenum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A03.734.667]
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Allelic Composition: Cdk4tm1.1Bbd/Cdk4+,Krastm1Bbd/Kras+,Tg(CMV-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

 MP:0009308 adenocarcinoma "malignant neoplasm of epithelial cells in a glandular or glandular-like pattern" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cdk4tm2.1Bbd/Cdk4tm2.1Bbd,Krastm1Bbd/Krastm2Bbd,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010322 increased cutaneous melanoma incidence "greater than the expected number of a dark-pigmented, usually malignant tumor arising from a melanocyte in the skin, occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tarbp2tm1.2Dzw/Tarbp2tm1.2Dzw
Genetic Background: involves: 129 * FVB/N

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald,Cdk4tm1Kiyo/Cdk4tm1Kiyo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0010741 abnormal melanocyte proliferation "anomaly in the ability of the a melanocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tarbp2tm1.2Dzw/Tarbp2tm1.2Dzw
Genetic Background: involves: 129 * FVB/N

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 * ICR

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm2.1Bbd/Cdk4tm2.1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald,Cdk4tm1Kiyo/Cdk4tm1Kiyo,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Cdk4tm1Bbd/Cdk4tm1Bbd,Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 * ICR

Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald,Cdk4tm1Kiyo/Cdk4tm1Kiyo
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Cdk4tm1b(NCOM)Mfgc/Cdk4tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Cdk4tm1b(NCOM)Mfgc/Tcp

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Cdk2tm1Sgo/Cdk2tm1Sgo,Cdk4tm2.1Bbd/Cdk4tm2.1Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

 MP:0012022 increased melanocyte number "greater number of the cells that produce pigment" [MGI:llw2]
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Allelic Composition: Tarbp2tm1.2Dzw/Tarbp2tm1.2Dzw
Genetic Background: involves: 129 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003031 Cdkn1b / P46414 / Cyclin-dependent kinase inhibitor 1B / P46527*  / complex / reaction
 ENSMUSG00000023110 Prmt5 / protein arginine N-methyltransferase 5 / O14744* / protein arginine methyltransferase 5*  / complex
 ENSMUSG00000031666 Rbl2 / Q64700 / Retinoblastoma-like protein 2 / Q08999* / RB transcriptional corepressor like 2*  / reaction
 ENSMUSG00000070348 Ccnd1 / P25322 / G1/S-specific cyclin-D1 / P24385* / cyclin D1*  / complex / reaction
 ENSMUSG00000000561 Wdr77 / Q99J09 / WD repeat domain 77 / Q9BQA1*  / complex
 ENSMUSG00000023067 Cdkn1a / P39689 / Cyclin-dependent kinase inhibitor 1 / P38936* / cyclin dependent kinase inhibitor 1A*  / complex / reaction
 ENSMUSG00000028551 Cdkn2c / Q60772 / Cyclin-dependent kinase 4 inhibitor C / P42773* / cyclin dependent kinase inhibitor 2C*  / complex / reaction
 ENSMUSG00000039153 Runx2 / Q08775 / runt related transcription factor 2 / Q13950*  / reaction
 ENSMUSG00000027552 E2f5 / Q61502 / Transcription factor E2F5 / Q15329* / E2F transcription factor 5*  / reaction
 ENSMUSG00000038482 Tfdp1 / Q08639 / transcription factor Dp 1 / TFDP3* / Q14186* / Q5H9I0* / transcription factor Dp family member 3*  / reaction
 ENSMUSG00000014859 E2f4 / Q8R0K9 / Transcription factor E2F4 / Q16254* / E2F transcription factor 4*  / reaction
 ENSMUSG00000096472 Cdkn2d / Q60773 / Cyclin-dependent kinase 4 inhibitor D / P55273* / cyclin dependent kinase inhibitor 2D*  / complex / reaction
 ENSMUSG00000031885 Cbfb / Q08024 / Core-binding factor subunit beta / Q13951* / core-binding factor beta subunit*  / reaction
 ENSMUSG00000027641 Rbl1 / Q64701 / Retinoblastoma-like protein 1 / P28749* / RB transcriptional corepressor like 1*  / reaction
 ENSMUSG00000073802 Cdkn2b / P55271 / Cyclin-dependent kinase 4 inhibitor B / P42772* / cyclin dependent kinase inhibitor 2B*  / reaction / complex
 ENSMUSG00000022105 Rb1 / P13405 / Retinoblastoma-associated protein / P06400* / RB transcriptional corepressor 1*  / reaction
 ENSMUSG00000038751 Ptk6 / Q64434 / PTK6 protein tyrosine kinase 6 / Q13882* / protein tyrosine kinase 6*  / reaction / complex
 ENSMUSG00000022812 Gsk3b / Q9WV60 / glycogen synthase kinase 3 beta / P49841*  / reaction
 ENSMUSG00000021103 Mnat1 / P51949 / CDK-activating kinase assembly factor MAT1 / P51948* / MNAT1, CDK activating kinase assembly factor*  / reaction
 ENSMUSG00000021548 Ccnh / Q61458 / Cyclin-H / P51946*  / reaction
 ENSMUSG00000031458 Coprs / Q9CQ13 / Coordinator of PRMT5 and differentiation stimulator / Q9NQ92*  / complex / reaction
 ENSMUSG00000069089 Cdk7 / Q03147 / Cyclin-dependent kinase 7 / P50613*  / reaction






 

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