ENSMUSG00000003031


Mus musculus

Features
Gene ID: ENSMUSG00000003031
  
Biological name :Cdkn1b
  
Synonyms : Cdkn1b / Cyclin-dependent kinase inhibitor 1B / P46414
  
Possible biological names infered from orthology : P46527
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: G1
Gene start: 134920401
Gene end: 134925513
  
Corresponding Affymetrix probe sets: 10542310 (MoGene1.0st)   10542317 (MoGene1.0st)   1419497_at (Mouse Genome 430 2.0 Array)   1434045_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003115
Ensembl peptide - ENSMUSP00000065832
Ensembl peptide - ENSMUSP00000145056
NCBI entrez gene - 12576     See in Manteia.
MGI - MGI:104565
RefSeq - NM_009875
RefSeq Peptide - NP_034005
swissprot - P46414
Ensembl - ENSMUSG00000003031
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdkn1baENSDARG00000029018Danio rerio
 cdkn1bbENSDARG00000054271Danio rerio
 CDKN1BENSGALG00000022980Gallus gallus
 CDKN1BENSG00000111276Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cdkn1c / P49919 / Mus musculus cyclin-dependent kinase inhibitor 1C (P57) (Cdkn1c), mRNA. / P49918* / cyclin dependent kinase inhibitor 1C*ENSMUSG0000003766421
Cdkn1a / P39689 / Cyclin-dependent kinase inhibitor 1 / P38936* / cyclin dependent kinase inhibitor 1A*ENSMUSG0000002306719


Protein motifs (from Interpro)
Interpro ID Name
 IPR003175  Cyclin-dependent kinase inhibitor
 IPR029843  Cyclin-dependent kinase inhibitor 1B


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IDA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001890 placenta development IGI
 biological_processGO:0006813 potassium ion transport IGI
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007050 cell cycle arrest ISO
 biological_processGO:0007096 regulation of exit from mitosis IGI
 biological_processGO:0007219 Notch signaling pathway IDA
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0008219 cell death IEA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0008285 negative regulation of cell proliferation ISO
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010942 positive regulation of cell death ISO
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0030308 negative regulation of cell growth ISO
 biological_processGO:0031116 positive regulation of microtubule polymerization IGI
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0033673 negative regulation of kinase activity ISO
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042326 negative regulation of phosphorylation ISO
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043200 response to amino acid IEA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
 biological_processGO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA
 biological_processGO:0045786 negative regulation of cell cycle ISO
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 biological_processGO:0045930 negative regulation of mitotic cell cycle ISO
 biological_processGO:0046686 response to cadmium ion IEA
 biological_processGO:0048102 autophagic cell death ISO
 biological_processGO:0048839 inner ear development IMP
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IMP
 biological_processGO:0051271 negative regulation of cellular component movement IDA
 biological_processGO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development IMP
 biological_processGO:0071236 cellular response to antibiotic IDA
 biological_processGO:0071285 cellular response to lithium ion ISO
 biological_processGO:0071407 cellular response to organic cyclic compound IDA
 biological_processGO:0071850 mitotic cell cycle arrest ISO
 biological_processGO:1902746 regulation of lens fiber cell differentiation IGI
 biological_processGO:1904030 negative regulation of cyclin-dependent protein kinase activity ISO
 biological_processGO:1904706 negative regulation of vascular smooth muscle cell proliferation ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0031464 Cul4A-RING E3 ubiquitin ligase complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0004693 cyclin-dependent protein serine/threonine kinase activity ISO
 molecular_functionGO:0004860 protein kinase inhibitor activity ISO
 molecular_functionGO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0019903 protein phosphatase binding ISO
 molecular_functionGO:0030332 cyclin binding ISO
 molecular_functionGO:0030544 Hsp70 protein binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0051087 chaperone binding IEA


Pathways (from Reactome)
Pathway description
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
AKT phosphorylates targets in the cytosol
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
PTK6 Regulates Cell Cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000005 increased brown fat amount "increased amount of thermogenic tissue in the body that is composed of cells containing multiple small fat droplets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:14208]
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Allelic Composition: Cdkn2ctm1Yxi/Cdkn2ctm1Yxi,Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0000042 abnormal organ of Corti "abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6NHsd

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako,Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6 * DBA/2

Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * C57BL

 MP:0000275 heart hyperplasia "increased cell number in the heart" [J:18048]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * C57BL

 MP:0000350 abnormal cell proliferation "anomalous growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Terctm1Rdp/Terctm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald,Cdk4tm1Kiyo/Cdk4tm1Kiyo
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cdkn1btm1Jro/Cdkn1btm1Jro
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin,Zfp949tm1Htno/Zfp949tm1Htno
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000635 pituitary gland hyperplasia "increased size of pituitary gland due to increased cell number" [J:63229, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0000636 enlarged pituitary gland "increased size of pituitary gland" [J:50053]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako,Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6 * DBA/2

 MP:0000642 enlarged adrenal glands "increased size of the endocrine gland" [J:40203]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako,Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6 * DBA/2

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn,Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cdkn1btm3Jro/Cdkn1btm3Jro
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako,Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6 * DBA/2

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0000708 thymus hyperplasia "increased cell number in the thymus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn,Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf,Tg(KRT5-CDK4)2303Mlrp/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB * SENCAR * SSIN

 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn,Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cdkn1btm3Jro/Cdkn1btm3Jro
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf,Tg(KRT5-CDK4)2303Mlrp/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB * SENCAR * SSIN

Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako,Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6 * DBA/2

 MP:0000714 increased thymocyte number "greater than expected number of precursors to T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000754 partial paralysis "partial loss of power of voluntary movement in a muscle through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0000840 abnormal epithalamus morphology "any malformation or absence of the small dorsomedial area of the thalamus including the habenular nuclei and associated fiber bundles, the pineal body, and the epithelial roof of the third ventricle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0000889 abnormal cerebellar molecular layer "any malformation or absence of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1b+,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

 MP:0001004 abnormal photoreceptor morphology "structural or developmental anomaly of the receptors sensitive to light " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001120 abnormal uterus morphology "malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001130 abnormal ovarian folliculogenesis "atypical formation or failure to form the spherical ovum in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:35782]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001134 absent corpora lutea "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0001148 enlarged testes "increased size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn,Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako,Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6 * DBA/2

 MP:0001149 testicular hyperplasia "increased cell number in the testes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001163 abnormal coagulating gland "malformed or malfunctioning anterior lobe of the prostate" [J:64981]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn,Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cdkn1btm3Jro/Cdkn1btm3Jro
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv

Allelic Composition: Cdkn1btm1Jro/Cdkn1btm1Jro
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin,Leprdb/Leprdb
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Cdkn1btm1Kin/Cdkn1b+,Leprdb/Leprdb
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako,Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6 * DBA/2

 MP:0001264 increased body size "larger than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cdkn1btm3Jro/Cdkn1btm3Jro
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Cdkn1btm3Jro/Cdkn1b+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Cdkn1btm3Mlf/Cdkn1btm3Mlf
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6NHsd

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf,Myctm1Atp/Myc+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N

Allelic Composition: Cdkn1btm1Mlf/Cdkn1b+,Myctm1Atp/Myc+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N

 MP:0001328 disorganized retinal layers "delaminated or mispositioned sheets of cells comprising the optic part of the retina" [J:33400]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn,Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako,Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6 * DBA/2

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako,Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6 * DBA/2

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin,Leprdb/Leprdb
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Cdkn1btm1Kin/Cdkn1b+,Leprdb/Leprdb
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001548 hyperlipidemia "abnormally high concentration of lipids in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin,Leprdb/Leprdb
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Cdkn1btm1Kin/Cdkn1b+,Leprdb/Leprdb
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1b+,Leprdb/Leprdb
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin,Zfp949tm1Htno/Zfp949tm1Htno
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin,Zfp949tm1Htno/Zfp949tm1Htno
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Ccnd3tm1Pisc/Ccnd3tm1Pisc,Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1b+,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn,Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129S1.Cg-Cdkn1btm1Ako Ptentm2.1Ppp Tg(TPO-cre)1Shk

 MP:0001961 abnormal reflex "anomalies in an involuntary response to a peripheral stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn,Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001999 photosensitivity "alterations in the response to sunlight or UV irradiation, especially sensitivity of the eyes" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002009 preneoplasia "state preceding the pathological process resulting in a neoplasm; does not necessarily imply cancerous development" [J:47225]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf,Nkx3-1tm1.1Saa/Nkx3-1tm1.1Saa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: C57BL/6J * C3H * NIH

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako,Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

Allelic Composition: Cdkn1btm1Mlf/Cdkn1b+,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: C57BL/6J * C3H * NIH

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Cdkn1btm1Mlf/Cdkn1b+,Crebbptm1Jvd/Crebbptm1Jvd,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: 129 * C57BL/6 * CBA * FVB

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv

 MP:0002031 adrenal tumor "tumors of the adrenal gland, including phaeochomocytomas" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako,Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: C57BL/6J * C3H * NIH

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J

 MP:0002036 rhabdomyosarcoma "malignant tumor derived from skeletal (striated) muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1b+,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako,Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6 * DBA/2

 MP:0002041 pituitary adenoma "appearance of benign neoplasms of the pituitary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn,Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako,Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6 * DBA/2

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako,Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1btm3Mlf/Cdkn1btm3Mlf,Tg(Pomc1-cre)1Mlf/0
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Cdkn1btm1Kin/Cdkn1b+,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin,Leprdb/Leprdb
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Cdkn1btm1Kin/Cdkn1b+,Leprdb/Leprdb
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: C57BL/6J * C3H * NIH

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Cdkn1btm2.1Mlf/Cdkn1btm2.1Mlf
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Cdkn1btm2Mlf/Cdkn1btm2Mlf,Tg(Pomc1-cre)1Mlf/0
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Cdkn1btm3Mlf/Cdkn1btm3Mlf
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Cdkn1btm3Mlf/Cdkn1btm3Mlf,Tg(Pomc1-cre)1Mlf/0
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako,Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6 * DBA/2

Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129S1.Cg-Cdkn1btm1Ako Ptentm2.1Ppp Tg(TPO-cre)1Shk

Allelic Composition: Cdkn1btm1Ako/Cdkn1b+,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129S1.Cg-Cdkn1btm1Ako Ptentm2.1Ppp Tg(TPO-cre)1Shk

Allelic Composition: Cdkn1btm1Mlf/Cdkn1b+,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

Allelic Composition: Cdkn1btm1Ako/Cdkn1b+,KitW-v/KitW-v
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: MitfMi/Mitf+,Vsx2tm1.1Eml/Vsx2tm1.1Eml
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002100 abnormal tooth morphology "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn2ctm1Yxi/Cdkn2ctm1Yxi,Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0002176 high brain weight "greater than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0002581 abnormal ileum morphology "malformation of the portion of the small intestine that extends from the jejunum to the colon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:70183]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0002679 abnormal corpora lutea "malformed or absent yellow endocrine body formed in the ovary after follicle rupture" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Ccnd1tm1Dsn/Ccnd1tm1Dsn,Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002780 decreased circulating testosterone level "less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * C57BL

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
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Allelic Composition: Cdkn1btm1Jro/Cdkn1btm1Jro
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Cdkn1btm2Kin/Cdkn1btm2Kin,Rassf5tm1Kina/Rassf5tm1Kina
Genetic Background: involves: C57BL/6 * CBA

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003496 thyroid adenoma "appearance of benign neoplasms in the thyroid gland" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1b+,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129S1.Cg-Cdkn1btm1Ako Ptentm2.1Ppp Tg(TPO-cre)1Shk

 MP:0003498 thyroid hyperplasia 
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129S1.Cg-Cdkn1btm1Ako Ptentm2.1Ppp Tg(TPO-cre)1Shk

 MP:0003507 abnormal ovary physiology "anomaly or loss either the production of female germ cells or the endocrine cells for the production of estrogen and progesterone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Snap91tm1.1Tmar/Snap91+,Vamp2tm1Sud/Vamp2+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * C57BL/6NTac

Allelic Composition: Cdkn1btm1Ako/Cdkn1b+,KitW-v/KitW-v
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0003567 abnormal cardiomyocyte proliferation "anomalous division or replication of cardiac muscle cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * C57BL

 MP:0003607 abnormal prostate physiology "malfunction of the gland in males that secretes part of the seminiferous fluid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv

 MP:0003645 increased number of pancreatic beta cells "greater than normal number of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Cdkn1btm1Kin/Cdkn1b+,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin,Leprdb/Leprdb
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Cdkn1btm1Kin/Cdkn1b+,Leprdb/Leprdb
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0003667 hemangiosarcoma "a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1b+,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0003825 abnormal pillar cell morphology "abnormalities of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6NHsd

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004143 hypertonia "increased muscle tone" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004395 increased cochlear inner hair cell number "increased number (or more than the expected single row) of the flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6NHsd

Allelic Composition: Cdkn1btm1Mlf/Cdkn1b+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6NHsd

 MP:0004401 increased cochlear outer hair cell number "increased number (or more than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6NHsd

 MP:0004407 increased cochlear hair cell number "increased number of the sensory epithelial cells of the cochlea, which are normally in synaptic contact with the auditory nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6NHsd

 MP:0004498 increased supporting cell number "increased number of the highly differentiated epithelial cells with distinctive morphological features which surround the hair cells in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6NHsd

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Cdkn1btm1Mlf/Cdkn1b+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1btm3Jro/Cdkn1b+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0004565 small myocardial fiber "decreased size of the cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * C57BL

 MP:0004760 increased mitotic index "increased number of cells in G2/M phase" [Bertram_Weiss:Bayer_Schering_Pharma_AG]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004832 enlarged ovary "increased size of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004910 decreased seminal gland weight "reduction in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0004955 increased thymus weight "greater than average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0004958 enlarged prostate "increased size of the gland in males that secretes part of the seminiferous fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004962 decreased prostate weight "reduction in the average weight of the gland in males that secretes part of the seminiferous fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ccnd3tm1Pisc/Ccnd3tm1Pisc,Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf,Myctm1Atp/Myc+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N

Allelic Composition: Cdkn1btm1Jro/Cdkn1btm1Jro
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Ccnd3tm1Pisc/Ccnd3tm1Pisc,Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005156 bradykinesia "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin,Leprdb/Leprdb
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Cdkn1btm1Kin/Cdkn1b+,Leprdb/Leprdb
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin,Leprdb/Leprdb
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Cdkn1btm1Kin/Cdkn1b+,Leprdb/Leprdb
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0005547 abnormal Muller cell morphology "anomalous structure of the elongated neuroglial cells that traverse all the layers of the retina and that act as supporting elements" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Cdkn1btm1Kin/Cdkn1b+,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0006262 testis tumor "presence of abnormal rapidly proliferating cells in the testis, usually in the form of a distinct mass" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:60034]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako,Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

 MP:0006283 medulloblastoma "a solid, cancerous tumor originating in the cerebellum of the brain and of primitive neuroectodermal origin " [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1b+,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

 MP:0006321 increased myocardial fiber number "increased number of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * C57BL

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6NHsd

 MP:0008000 ovary tumor "presence of abnormal rapidly proliferating cells in the ovary, usually in the form of a distinct mass" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv

Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako,KitW-v/KitW-v
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Cdkn1btm1Ako/Cdkn1b+,KitW-v/KitW-v
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0008105 increased amacrine cell number "increase in the number of one of the three types of interneurons found in the inner nuclear layer of the mature retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008108 abnormal small intestinal villus morphology "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor

 MP:0008130 abnormal pituitary intermediate lobe "any structural anomaly of the thin boundary between the adenohypophysis and neurohypophysis of the pituitary that produces melanocyte stimulating hormone (MSH); this area is small or absent in mammalian adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008301 adrenal medulla hyperplasia "overdevelopment or increased size of the inner portion of the adrenal gland that consists mainly of chromaffin cells, usually due to an increase in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008371 pituitary intermediate lobe hyperplasia "overdevelopment or increased size, usually due to increased cell number, of the thin boundary between the adenohypophysis and neurohypophysis of the pituitary that produces melanocyte stimulating hormone (MSH); this area is small or absent in mammalian adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako,Cdkn2ctm1Yxi/Cdkn2ctm1Yxi
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6 * DBA/2

 MP:0008868 abnormal granulosa cell morphology "any structural anomaly of a supporting cell for the developing female gamete in the ovary of mammals; granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle" [MESH:A.05.360.319.114.630.535.200]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008883 abnormal enterocyte proliferation "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor

 MP:0008939 increased pituitary gland weight "greater than average weight of the compound gland suspended from the base of the hypothalamus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009006 prolonged estrous cycle "increase in the length of the sexual cycle of female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0009017 prolonged estrus "increase in the length of the estrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0009092 endometrium hyperplasia "overdevelopment or increased size, usually due an increased number of cells, of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009130 increased white fat cell number "increase in the number of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0009153 pancreas tumor "tumors or cancer of the pancreas" [MESH:C04.588.274.761]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako,Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

 MP:0009171 enlarged pancreatic islets "increase in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Cdkn1btm1Kin/Cdkn1b+,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009219 prostate intraepithelial neoplasia "noninvasive prostate duct lesions that affect smaller caliber ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf,Nkx3-1tm1.1Saa/Nkx3-1tm1.1Saa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccnd3tm1Pisc/Ccnd3tm1Pisc,Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor

 MP:0009292 increased inguinal fat pad weight 
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0009300 increased parametrial fat pad weight 
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0009363 abnormal secondary ovarian follicle morphology "any structural abnormality in the ovarian follicle in which the primary oocyte attains its full size and is surrounded by an extracellular glycoprotein layer (zona pellucida) that separates it from a peripheral layer of follicular cells permeated by one or more fluid-filled antra; the primary oocyte occupies the cumulus oophorus while the theca of the follicle develops into internal and external layers" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009380 abnormal ventral prostate morphology 
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0009381 abnormal dorsolateral prostate morphology 
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0009584 decreased keratinocyte proliferation "reduction in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1btm1Jro/Cdkn1btm1Jro
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0010236 abnormal retina outer limiting membrane morphology "any structural anomaly of the row of junctional complexes between the plasma membranes of rod segments and the Muller glia cells; this barrier separates the layer of inner and outer segments of the rods and cones from the outer nuclear layer and forms a blood-retina barrier" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010279 increased gastrointestinal tumor incidence "greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1b+,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

 MP:0010316 increased thyroid tumor incidence "greater than the expected number of neoplams in the thyroid occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako,Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

 MP:0010320 increased pituitary gland tumor incidence "greater than the expected number of neoplams in the pituitary gland occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cdkn1btm2Mlf/Cdkn1btm2Mlf,Tg(Pomc1-cre)1Mlf/0
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Cdkn1btm3Mlf/Cdkn1btm3Mlf
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako,Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

 MP:0010321 increased parathyroid gland tumor incidence "greater than the expected number of neoplams in the parathyroid gland occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako,Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

 MP:0010346 increased thyroid carcinioma incidence "greater than the expected number of a malignant epithelial neoplasms of the thyroid gland, occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1b+,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: 129S1.Cg-Cdkn1btm1Ako Ptentm2.1Ppp Tg(TPO-cre)1Shk

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf,Tg(TG-TPR/NTRK1)#Rstn/0
Genetic Background: involves: 129S4/SvJaeSor * C3H * C57BL/6 * C57BL/6J

Allelic Composition: Cdkn1btm1Mlf/Cdkn1b+,Tg(TG-TPR/NTRK1)#Rstn/0
Genetic Background: involves: 129S4/SvJaeSor * C3H * C57BL/6 * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Cdkn2btm1Bbd/Cdkn2btm1Bbd,Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1b+,Myctm1Atp/Myc+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako,Men1tm1.1Ctre/Men1+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Rbx1Gt(XB674)Byg/Rbx1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin,Zfp949tm1Htno/Zfp949tm1Htno
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Cdk2tm1Kald/Cdk2tm1Kald,Cdk4tm1Kiyo/Cdk4tm1Kiyo,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6NHsd

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1b+,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

 MP:0013539 increased ovary adenoma incidence "greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the ovary, occurring in a specific population in a given time period" [MGI:Anna]
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Allelic Composition: Cdkn1btm1Ako/Cdkn1btm1Ako,KitW-v/KitW-v
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Cdkn1btm1Ako/Cdkn1b+,KitW-v/KitW-v
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0030516 abnormal junctional epithelium morphology "any structural anomaly of the collar-like band of non-keratinized squamous epithelium that attaches the gingival soft tissue to the tooth surface; the term epithelial attachment refers to the attachment apparatus, i.e. the internal basal lamina and hemidesmosomes, that connects the junctional epithelium (JE) to the tooth surface; in the initiation of periodontitis, JE detaches from the tooth surface and converts gradually, by sprouting laterally and migrating apically, to pathological pocket epithelium" [http://dental.pitt.edu/junctional-epithelium, https://books.google.com/books?isbn=0123977630, PMID:25911094]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001729 Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*  / reaction
 ENSMUSG00000028212 Ccne2 / Q9Z238 / G1/S-specific cyclin-E2 / O96020* / cyclin E2*  / complex
 ENSMUSG00000031666 Rbl2 / Q64700 / Retinoblastoma-like protein 2 / Q08999* / RB transcriptional corepressor like 2*  / reaction
 ENSMUSG00000070348 Ccnd1 / P25322 / G1/S-specific cyclin-D1 / P24385* / cyclin D1*  / complex / reaction
 ENSMUSG00000025358 Cdk2 / P97377 / Cyclin-dependent kinase 2 / P24941*  / complex / reaction
 ENSMUSG00000027552 E2f5 / Q61502 / Transcription factor E2F5 / Q15329* / E2F transcription factor 5*  / reaction
 ENSMUSG00000038482 Tfdp1 / Q08639 / transcription factor Dp 1 / TFDP3* / Q14186* / Q5H9I0* / transcription factor Dp family member 3*  / reaction
 ENSMUSG00000002068 Ccne1 / Q61457 / G1/S-specific cyclin-E1 / P24864* / cyclin E1*  / complex
 ENSMUSG00000014859 E2f4 / Q8R0K9 / Transcription factor E2F4 / Q16254* / E2F transcription factor 4*  / reaction
 ENSMUSG00000006728 Cdk4 / P30285 / Cyclin-dependent kinase 4 / P11802*  / complex / reaction
 ENSMUSG00000040274 Cdk6 / Q64261 / Cyclin-dependent kinase 6 / Q00534*  / reaction / complex
 ENSMUSG00000022105 Rb1 / P13405 / Retinoblastoma-associated protein / P06400* / RB transcriptional corepressor 1*  / reaction
 ENSMUSG00000027641 Rbl1 / Q64701 / Retinoblastoma-like protein 1 / P28749* / RB transcriptional corepressor like 1*  / reaction
 ENSMUSG00000038751 Ptk6 / Q64434 / PTK6 protein tyrosine kinase 6 / Q13882* / protein tyrosine kinase 6*  / reaction / complex
 ENSMUSG00000021103 Mnat1 / P51949 / CDK-activating kinase assembly factor MAT1 / P51948* / MNAT1, CDK activating kinase assembly factor*  / reaction
 ENSMUSG00000021548 Ccnh / Q61458 / Cyclin-H / P51946*  / reaction
 ENSMUSG00000029686 Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*  / complex / reaction
 ENSMUSG00000036309 Skp1a / Q9WTX5 / S-phase kinase-associated protein 1A / SKP1* / P63208* / AC104109.3* / S-phase kinase associated protein 1*  / complex / reaction
 ENSMUSG00000062687 Cks1brt / CDC28 protein kinase 1b, retrogene / CKS1B* / P61024* / CDC28 protein kinase regulatory subunit 1B*  / reaction / complex
 ENSMUSG00000054115 Skp2 / Q9Z0Z3 / S-phase kinase-associated protein 2 (p45) / Q13309* / S-phase kinase associated protein 2*  / complex / reaction
 ENSMUSG00000069089 Cdk7 / Q03147 / Cyclin-dependent kinase 7 / P50613*  / reaction






 

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