ENSGALG00000022980


Gallus gallus

Features
Gene ID: ENSGALG00000022980
  
Biological name :CDKN1B
  
Synonyms : CDKN1B / cyclin dependent kinase inhibitor 1B
  
Possible biological names infered from orthology : P46414 / P46527
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 72191984
Gene end: 72195253
  
Corresponding Affymetrix probe sets: Gga.17250.1.S1_at (Chicken Array)   Gga.4588.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000036494
NCBI entrez gene - 374106     See in Manteia.
RefSeq - NM_204256
RefSeq Peptide - NP_989587
swissprot - Q8JIV2
Ensembl - ENSGALG00000022980
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdkn1baENSDARG00000029018Danio rerio
 cdkn1bbENSDARG00000054271Danio rerio
 CDKN1BENSG00000111276Homo sapiens
 Cdkn1bENSMUSG00000003031Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ENSGALG0000002689617
CDKN1A / cyclin-dependent kinase inhibitor 1 / P38936* / P39689* / cyclin dependent kinase inhibitor 1A*ENSGALG0000002831816


Protein motifs (from Interpro)
Interpro ID Name
 IPR003175  Cyclin-dependent kinase inhibitor
 IPR029843  Cyclin-dependent kinase inhibitor 1B


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IEA
 biological_processGO:0001890 placenta development IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007096 regulation of exit from mitosis IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0031116 positive regulation of microtubule polymerization IEA
 biological_processGO:0033673 negative regulation of kinase activity IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042326 negative regulation of phosphorylation IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity IEA
 biological_processGO:0045786 negative regulation of cell cycle IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045930 negative regulation of mitotic cell cycle IEA
 biological_processGO:0048102 autophagic cell death IEA
 biological_processGO:0048839 inner ear development IEA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 biological_processGO:0051271 negative regulation of cellular component movement IEA
 biological_processGO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development IEA
 biological_processGO:0071236 cellular response to antibiotic IEA
 biological_processGO:0071285 cellular response to lithium ion IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0071850 mitotic cell cycle arrest IEA
 biological_processGO:1902746 regulation of lens fiber cell differentiation IEA
 biological_processGO:1904030 negative regulation of cyclin-dependent protein kinase activity IEA
 biological_processGO:1904706 negative regulation of vascular smooth muscle cell proliferation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0031464 Cul4A-RING E3 ubiquitin ligase complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004860 protein kinase inhibitor activity IEA
 molecular_functionGO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0030332 cyclin binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA


Pathways (from Reactome)
Pathway description
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
AKT phosphorylates targets in the cytosol
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000006474 SKP1 / Q5ZKF5 / S-phase kinase-associated protein 1 / Skp1a* / Q9WTX5* / P63208* / AC104109.3* / S-phase kinase-associated protein 1A*  / reaction / complex
 ENSGALG00000009476 CDK6 / cyclin dependent kinase 6 / Q00534* / Q64261*  / complex / reaction
 ENSGALG00000028664 CKS1B / CDC28 protein kinase regulatory subunit 1B / P61024* / P61025* / Cks1brt* / CDC28 protein kinase 1b, retrogene* / Cyclin-dependent kinases regulatory subunit 1 *  / reaction / complex
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction / complex
 ENSGALG00000040794 CCNE2 / cyclin E2 / O96020* / Q9Z238* / G1/S-specific cyclin-E2 *  / complex
 ENSGALG00000036941 CUL1 / cullin 1 / Q13616* / Q9WTX6* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*  / reaction / complex
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction / complex






 

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