ENSGALG00000028318


Gallus gallus

Features
Gene ID: ENSGALG00000028318
  
Biological name :CDKN1A
  
Synonyms : CDKN1A / cyclin-dependent kinase inhibitor 1
  
Possible biological names infered from orthology : cyclin dependent kinase inhibitor 1A / P38936 / P39689
  
Species: Gallus gallus
  
Chr. number: 26
Strand: 1
Band:
Gene start: 1588453
Gene end: 1591609
  
Corresponding Affymetrix probe sets: Gga.1114.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000043020
NCBI entrez gene - 378914     See in Manteia.
RefSeq - NM_204396
RefSeq Peptide - NP_989727
swissprot - R4GLE3
Ensembl - ENSGALG00000028318
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdkn1aENSDARG00000076554Danio rerio
 CDKN1AENSG00000124762Homo sapiens
 Cdkn1aENSMUSG00000023067Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ENSGALG0000002689626
CDKN1B / cyclin dependent kinase inhibitor 1B / P46414* / P46527*ENSGALG0000002298021


Protein motifs (from Interpro)
Interpro ID Name
 IPR003175  Cyclin-dependent kinase inhibitor
 IPR029841  Cyclin-dependent kinase inhibitor 1, vertebrate


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IEA
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IEA
 biological_processGO:0000086 G2/M transition of mitotic cell cycle IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IEA
 biological_processGO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007265 Ras protein signal transduction IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009411 response to UV IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0030890 positive regulation of B cell proliferation IEA
 biological_processGO:0031668 cellular response to extracellular stimulus IEA
 biological_processGO:0033158 regulation of protein import into nucleus, translocation IEA
 biological_processGO:0034198 cellular response to amino acid starvation IEA
 biological_processGO:0042326 negative regulation of phosphorylation IEA
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
 biological_processGO:0043068 positive regulation of programmed cell death IEA
 biological_processGO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0071479 cellular response to ionizing radiation IEA
 biological_processGO:0071480 cellular response to gamma radiation IEA
 biological_processGO:0071493 cellular response to UV-B IEA
 biological_processGO:0071850 mitotic cell cycle arrest IEA
 biological_processGO:0072331 signal transduction by p53 class mediator IEA
 biological_processGO:0090398 cellular senescence IEA
 biological_processGO:0090399 replicative senescence IEA
 biological_processGO:1904030 negative regulation of cyclin-dependent protein kinase activity IEA
 biological_processGO:1904031 positive regulation of cyclin-dependent protein kinase activity IEA
 biological_processGO:2000134 negative regulation of G1/S transition of mitotic cell cycle IEA
 biological_processGO:2000278 regulation of DNA biosynthetic process IEA
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process IEA
 cellular_componentGO:0000307 cyclin-dependent protein kinase holoenzyme complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0070557 PCNA-p21 complex IEA
 molecular_functionGO:0004860 protein kinase inhibitor activity IEA
 molecular_functionGO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019912 cyclin-dependent protein kinase activating kinase activity IEA
 molecular_functionGO:0030332 cyclin binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA


Pathways (from Reactome)
Pathway description
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
AKT phosphorylates targets in the cytosol
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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