ENSMUSG00000023067


Mus musculus

Features
Gene ID: ENSMUSG00000023067
  
Biological name :Cdkn1a
  
Synonyms : Cdkn1a / Cyclin-dependent kinase inhibitor 1 / P39689
  
Possible biological names infered from orthology : cyclin dependent kinase inhibitor 1A / P38936
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A3.3
Gene start: 29090979
Gene end: 29100722
  
Corresponding Affymetrix probe sets: 10443463 (MoGene1.0st)   1421679_a_at (Mouse Genome 430 2.0 Array)   1424638_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023829
Ensembl peptide - ENSMUSP00000112411
Ensembl peptide - ENSMUSP00000113150
NCBI entrez gene - 12575     See in Manteia.
MGI - MGI:104556
RefSeq - NM_001111099
RefSeq - NM_007669
RefSeq Peptide - NP_001104569
RefSeq Peptide - NP_031695
swissprot - P39689
swissprot - Q564P6
Ensembl - ENSMUSG00000023067
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdkn1aENSDARG00000076554Danio rerio
 CDKN1AENSGALG00000028318Gallus gallus
 CDKN1AENSG00000124762Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cdkn1c / P49919 / Mus musculus cyclin-dependent kinase inhibitor 1C (P57) (Cdkn1c), mRNA. / P49918* / cyclin dependent kinase inhibitor 1C*ENSMUSG0000003766424
Cdkn1b / P46414 / Cyclin-dependent kinase inhibitor 1B / P46527*ENSMUSG0000000303123


Protein motifs (from Interpro)
Interpro ID Name
 IPR003175  Cyclin-dependent kinase inhibitor
 IPR029841  Cyclin-dependent kinase inhibitor 1, vertebrate


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IMP
 biological_processGO:0000082 G1/S transition of mitotic cell cycle ISO
 biological_processGO:0000086 G2/M transition of mitotic cell cycle ISO
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest ISO
 biological_processGO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IDA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007050 cell cycle arrest IMP
 biological_processGO:0007265 Ras protein signal transduction IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IMP
 biological_processGO:0008285 negative regulation of cell proliferation ISO
 biological_processGO:0009411 response to UV IMP
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010165 response to X-ray IEA
 biological_processGO:0010243 response to organonitrogen compound IEA
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030308 negative regulation of cell growth ISO
 biological_processGO:0030890 positive regulation of B cell proliferation IGI
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0031668 cellular response to extracellular stimulus ISO
 biological_processGO:0033158 regulation of protein import into nucleus, translocation IMP
 biological_processGO:0034198 cellular response to amino acid starvation ISO
 biological_processGO:0034605 cellular response to heat IEA
 biological_processGO:0042326 negative regulation of phosphorylation ISO
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043068 positive regulation of programmed cell death IMP
 biological_processGO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
 biological_processGO:0045860 positive regulation of protein kinase activity ISO
 biological_processGO:0046685 response to arsenic-containing substance IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation ISO
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051412 response to corticosterone IEA
 biological_processGO:0051726 regulation of cell cycle IDA
 biological_processGO:0055093 response to hyperoxia IEA
 biological_processGO:0060574 intestinal epithelial cell maturation IEA
 biological_processGO:0071479 cellular response to ionizing radiation IMP
 biological_processGO:0071480 cellular response to gamma radiation IDA
 biological_processGO:0071493 cellular response to UV-B IDA
 biological_processGO:0071850 mitotic cell cycle arrest IDA
 biological_processGO:0071901 negative regulation of protein serine/threonine kinase activity IEA
 biological_processGO:0072331 signal transduction by p53 class mediator IEA
 biological_processGO:0090398 cellular senescence ISO
 biological_processGO:0090399 replicative senescence IMP
 biological_processGO:1904030 negative regulation of cyclin-dependent protein kinase activity ISO
 biological_processGO:1904031 positive regulation of cyclin-dependent protein kinase activity IEA
 biological_processGO:2000134 negative regulation of G1/S transition of mitotic cell cycle ISO
 biological_processGO:2000278 regulation of DNA biosynthetic process IMP
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process IMP
 cellular_componentGO:0000307 cyclin-dependent protein kinase holoenzyme complex ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016604 nuclear body ISO
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070557 PCNA-p21 complex ISO
 molecular_functionGO:0004693 cyclin-dependent protein serine/threonine kinase activity ISO
 molecular_functionGO:0004860 protein kinase inhibitor activity ISO
 molecular_functionGO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0019912 cyclin-dependent protein kinase activating kinase activity ISO
 molecular_functionGO:0030332 cyclin binding IDA
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
AKT phosphorylates targets in the cytosol
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
The role of GTSE1 in G2/M progression after G2 checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000005 increased brown fat amount "increased amount of thermogenic tissue in the body that is composed of cells containing multiple small fat droplets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:14208]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0000061 fragile skeleton "easily damaged or broken bones" [J:14208]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000131 abnormal long bone epiphysis morphology "the head of a developing long bone that is separated from the shaft by the epiphyseal plate" [J:61509]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0000149 abnormal scapula morphology "malformation of either or both of the large, flat bones of the back part of the shoulder" [J:13049]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0000153 rib bifurcation "forking or division of ribs, may be a result of partial rib fusions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0000159 abnormal xiphoid process "malformed posterior tip of the sternum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:42932]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Rb1tm1Tyj/Rb1+,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dlg1tm1Jhm/Dlg1tm1Jhm
Genetic Background: involves: 129 * C57BL/6J

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Guca1a/Guca1btm1Jnc/Guca1a/Guca1btm1Jnc,Rcvrntm1Clma/Rcvrntm1Clma
Genetic Background: involves: 129S1/Sv

 MP:0000400 abnormal awl hair "anomalies of truncal hairs that contain two or more air cells in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnao1tm1Ejne/Gnao1tm1Ejne
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1a+
Genetic Background: involves: 129S6/SvEvTac

 MP:0000405 abnormal auchene hairs "anomalies of truncal hairs that contain two or more air cells in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnao1tm1Ejne/Gnao1tm1Ejne
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1a+
Genetic Background: involves: 129S6/SvEvTac

 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0000526 small inner medullary pyramid "reduced size of pyramidal masses; contain part of the secreting tubules and collecting tubules" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0000540 abnormal urinary bladder epithelium morphology "malformation of the epithelial layer of the urinary bladder" [MGI:tc]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Ptentm1Hwu/Ptentm1Hwu,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * FVB/N

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle,Neurog2tm1Fgu/Neurog2tm1Fgu
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Fahtm1Mgo/Fahtm1Mgo
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0000621 salivary adenocarcinoma "malignant neoplasm of the secreting cells of the salivary gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Agertm1.1Hyam/Agertm1.1Hyam
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

Allelic Composition: Cdkn1atm1.1(KOMP)Vlcg/Cdkn1atm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cdkn1atm1.1(KOMP)Vlcg/Ucd

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Brca1tm2Mak/Brca1tm2Mak,Tg(BCL2)36Wehi/?,Tg(Lck-cre)548Jxm/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000729 abnormal myogenesis "anomaly in embryonic formation of muscle cells or fibers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas

 MP:0000757 herniated abdominal wall "protrusions through and/or into the abdominal wall often resulting in the extrusion of viscera" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0000761 thin diaphragm muscle "reduced thickness of the diaphragm muscle" [MGI:CLS, J:60159]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0001163 abnormal coagulating gland "malformed or malfunctioning anterior lobe of the prostate" [J:64981]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0001204 skin irradiation resistance "decreased incidence of aberrant or damaged cells due to irradiation induced genotoxic damage" [J:65162]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Fahtm1Mgo/Fahtm1Mgo
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0001272 increased metastatic potential 
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * SJL

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Palb2tm1.2Dli/Palb2tm1.2Dli
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * BALB/cJ * C57BL/6

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
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Allelic Composition: Kdm8tm1Tasu/Kdm8tm1Tasu
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Kdm8tm1.2Tasu/Kdm8tm1.2Tasu
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C3H * C57BL/6

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Zbtb17tm1Cksn/Zbtb17tm1Cksn,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: B6.Cg-Zbtb17tm1Cksn Cdkn1atm1Led Commd10Tg(Vav1-icre)A2Kio

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
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Allelic Composition: Agertm1.1Hyam/Agertm1.1Hyam
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002018 malignant tumors "higher than normal incidence of locally invasive, destructive and metastatic tumors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:44427]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Cdkn1atm1Tyj/Cdkn1a+
Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * C57BL/6J

 MP:0002019 abnormal tumor incidence "deviation from the expected number of abnormal growths of a specific tissue in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Crabp1tm1Ipc/Crabp1tm1Ipc
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Csnk1a1tm1.1Ybn/Csnk1a1tm1.1Ybn,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129 * C57BL/6 * CD-1 * DBA/2

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gnao1tm1Ejne/Gnao1tm1Ejne
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Ctnnb1tm1Mmt/Ctnnb1tm1Mmt,Tg(Upk2-cre)6Xrw/0
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * FVB/N

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hgstn/Hgstn
Genetic Background: B6.C3-Hgstn

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0002115 abnormal skeleton extremities morphology "abnormal development of limb, foot or tail bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0002176 high brain weight "greater than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0002264 abnormal bronchus morphology "any structural anomaly of of the upper conducting airways of the lung; these airways arise from the terminus of the trachea " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0002267 abnormal bronchiole morphology "any structural anomaly of the conducting airway of the lungs found terminal to the bronchi. These structures contain neither cartilage nor mucous-secreting glands; the epithelium of the bronchioles becomes thinner with each branching. " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dlg1tm1Jhm/Dlg1tm1Jhm
Genetic Background: involves: 129 * C57BL/6J

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0002427 dwarfism "abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr3tm1Cxd/Fgfr3+
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0002581 abnormal ileum morphology "malformation of the portion of the small intestine that extends from the jejunum to the colon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:70183]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor

 MP:0002607 decreased basophil count "lower than average number of basophils as measured by the percent of the total number of leukocytes" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, MPD:Mouse Phenome Database]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nkx2-5tm1(cre)Rjs/Nkx2-5+,Tbx1tm1Bld/Tbx1tm3Bld
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdkn1atm2(HBx)Xya/Cdkn1atm2(HBx)Xya
Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss)

Allelic Composition: Cdkn1atm1(HBsAg)Xya/Cdkn1a+
Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss)

Allelic Composition: Cdkn1atm2(HBx)Xya/Cdkn1a+
Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss)

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1atm1.1(KOMP)Vlcg/Cdkn1atm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cdkn1atm1.1(KOMP)Vlcg/Ucd

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1atm1.1(KOMP)Vlcg/Cdkn1atm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cdkn1atm1.1(KOMP)Vlcg/Ucd

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002780 decreased circulating testosterone level "less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003010 decreased mortality induced by ionizing radiation "reduced sensitivity to lethal doses of ionizing radiation such as ultraviolet light, X-rays, or gamma rays" [smb:Susan M. Bello , Mouse Genome Informatics Curator, J:88888]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cdkn1atm1Hpw/Cdkn1a+,Trp53tm2Wahl/Trp53tm2Wahl
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0003052 omphalocele "protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Fgfr3tm1Cxd/Fgfr3tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0003075 response to CNS ischemic injury 
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas

 MP:0003237 abnormal lens epithelium morphology "malformation in the one or more of the layers of epithelial cells in the lens" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93301]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Nkx2-5tm1(cre)Rjs/Nkx2-5+,Tbx1tm1Bld/Tbx1tm3Bld
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdkn1atm2(HBx)Xya/Cdkn1atm2(HBx)Xya
Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss)

Allelic Composition: Cdkn1atm1(HBsAg)Xya/Cdkn1a+
Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss)

Allelic Composition: Cdkn1atm2(HBx)Xya/Cdkn1a+
Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss)

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Fahtm1Mgo/Fahtm1Mgo
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
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Allelic Composition: Dlg1tm1Jhm/Dlg1tm1Jhm
Genetic Background: involves: 129 * C57BL/6J

 MP:0003453 abnormal keratinocyte physiology "atypical function of the cells of the epidermis that produce keratin" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94860]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003613 abnormal kidney medulla development 
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: B6.129-Apoetm1Unc Cdkn1atm1Tyj

 MP:0003667 hemangiosarcoma "a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Fahtm1Mgo/Fahtm1Mgo
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Gnao1tm1Ejne/Gnao1tm1Ejne
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0003763 abnormal thymus physiology "anomalous function of the primary lymphoid organ that is required for immune system development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dlg1tm1Jhm/Dlg1tm1Jhm
Genetic Background: involves: 129 * C57BL/6J

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Fahtm1Mgo/Fahtm1Mgo
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0003893 increased hepatocyte proliferation "anomalous growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Fahtm1Mgo/Fahtm1Mgo
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0003941 abnormal skin development "anomaly in the formation of of the membranous protective covering of the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Kdm8tm1.2Tasu/Kdm8tm1.2Tasu
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C3H * C57BL/6

 MP:0004002 abnormal jejunum morphology "malformation of the portion of the small intestine that extends from the duodenum to the ileum" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0004023 abnormal chromosome number "chromosome count is other than the expected diploid chromosome number" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Gnao1tm1Ejne/Gnao1tm1Ejne
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0004025 polyploidy "more than two chromosome sets are present" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129X1/SvJ * C57BL/6 * CD-1

 MP:0004028 chromosome breakage "chromosome instability in the from of increased frequency of spontaneous breakage with or without rearrangements" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Guca1a/Guca1btm1Jnc/Guca1a/Guca1btm1Jnc,Rcvrntm1Clma/Rcvrntm1Clma
Genetic Background: involves: 129S1/Sv

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Hus1tm1Led/Hus1tm1Led
Genetic Background: involves: 129S6/SvEvTac

 MP:0004045 abnormal cell cycle checkpoint function "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gnao1tm1Ejne/Gnao1tm1Ejne
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Hdac2tm1.2Rdp/Hdac2tm1.2Rdp
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0004056 abnormal myocardial compact layer morphology "malformation of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Cep290Gt(CC0582)Wtsi/Cep290Gt(CC0582)Wtsi
Genetic Background: 129P2/OlaHsd-Cep290Gt(CC0582)Wtsi

 MP:0004174 abnormal spine curvature "deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Palb2tm1.2Dli/Palb2tm1.2Dli
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * BALB/cJ * C57BL/6

 MP:0004207 squamous cell carcinoma "a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6

 MP:0004320 split sternum "the appearance of an abnormal division in the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0004321 short sternum "reduced length of the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0004353 abnormal deltoid tuberosity morphology "any structural anomaly of a rough elevation at the middle of the lateral side of the shaft of the humerus to which the deltoid muscle attaches" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas

 MP:0004354 absent deltoid tuberosity "missing the rough elevation at the middle of the lateral side of the shaft of the humerus to which the deltoid muscle attaches" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas

 MP:0004393 abnormal cochlear inner hair cell morphology "any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there is a single row of flask-shaped inner hair cells tightly surrounded by supporting interphalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a more or less linear (or shallow) U-shaped pattern extend from the cell s surface through the cuticular plate into the endolymphic space inferior to the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129X1/SvJ * C57BL/6 * CD-1

 MP:0004396 decreased cochlear inner hair cell number "decreased number (or less than the expected single row) of the flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129X1/SvJ * C57BL/6 * CD-1

 MP:0004402 decreased cochlear outer hair cell number "decreased number (or less than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129X1/SvJ * C57BL/6 * CD-1

 MP:0004407 increased cochlear hair cell number "increased number of the sensory epithelial cells of the cochlea, which are normally in synaptic contact with the auditory nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129X1/SvJ * C57BL/6 * CD-1

 MP:0004408 decreased cochlear hair cell number "decreased number of the sensory epithelial cells of the cochlea, which are normally in synaptic contact with the auditory nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129X1/SvJ * C57BL/6 * CD-1

 MP:0004432 abnormal cochlear hair cell physiology "anomalies in processes pertinent to the integrated function of cochlear hair cells i.e. the sensory cells in the spiral organ which are in synaptic contact with sensory as well as efferent fibers of the cochlear (auditory) nerve " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129X1/SvJ * C57BL/6 * CD-1

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004500 increased incidence of ionizing radiation-induced tumors "higher than normal frequency of tumor incidence induced by radiation in which the individual particle or photon carries sufficient energy to completely remove an electron from its orbit; common types of this radiation include gamma-rays and X-rays" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Cdkn1atm1Tyj/Cdkn1a+
Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * C57BL/6J

 MP:0004503 decreased incidence of ionizing radiation-induced tumors "lower than normal frequency of tumor incidence induced by radiation in which the individual particle or photon carries sufficient energy to completely remove an electron from its orbit; common types of this radiation include gamma-rays and X-rays" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnao1tm1Ejne/Gnao1tm1Ejne
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004771 increased anti-single stranded DNA antibody level "increase in the level of antibodies that recognize single stranded DNA" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnao1tm1Ejne/Gnao1tm1Ejne
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004796 increased anti-histone antibody level "elevated level of antibodies to histones present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnao1tm1Ejne/Gnao1tm1Ejne
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0004910 decreased seminal gland weight "reduction in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0004931 enlarged epididymis "increase in the average size of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1.1(KOMP)Vlcg/Cdkn1atm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cdkn1atm1.1(KOMP)Vlcg/Ucd

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004962 decreased prostate weight "reduction in the average weight of the gland in males that secretes part of the seminiferous fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0004980 increased neuronal precursor cell number "increased number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0005005 abnormal self tolerance "a defect in the normal lack of response to autologous (self) antigens" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0005341 decreased susceptibility to atherosclerosis "less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: B6.129-Apoetm1Unc Cdkn1atm1Tyj

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnao1tm1Ejne/Gnao1tm1Ejne
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Fgfr3tm1Cxd/Fgfr3tm1Cxd
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

 MP:0005545 abnormal lens development "aberrant formation of the transparent structure of the eye responsible for focusing light rays" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0005595 abnormal vascular smooth muscle physiology "anomalous function of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: B6.129-Apoetm1Unc Cdkn1atm1Tyj

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Mir34atm1.1Lhe/Mir34atm1.1Lhe
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J

 MP:0006270 abnormal mammary gland growth during lactation "anomaly in the final stage of mammary growth that occurs during the start of lactation" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Sema4atm1Kik/Sema4atm1Kik
Genetic Background: Not Specified

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Hdac2tm1.2Rdp/Hdac2tm1.2Rdp
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0008009 delayed cellular replicative senescence "slower progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: B6.129-Apoetm1Unc Cdkn1atm1Tyj

 MP:0008049 increased memory T cell number "greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008057 abnormal DNA replication "any anomaly in the process whereby new strands of DNA are synthesized" [GO:0006260]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0008102 lymph node hyperplasia "overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008108 abnormal small intestinal villus morphology "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor

 MP:0008148 abnormal rib-sternum attachment "any anomaly in the in the normal joining of the ribs to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas

 MP:0008277 abnormal sternum ossification "anomaly in the process of the formation of the sternum bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958, MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Rb1tm1Tyj/Rb1tm1Tyj,Tg(Rb1)1Blg/0
Genetic Background: involves: 129S2/SvPas

 MP:0008409 increased cellular sensitivity to hydroxyurea "greater incidence of cell death following exposure to hydroxyurea" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Hus1tm1Led/Hus1tm1Led
Genetic Background: involves: 129S6/SvEvTac

 MP:0008410 increased cellular sensitivity to ultraviolet irradiation "greater incidence of cell death following exposure to ultraviolet irradiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Hus1tm1Led/Hus1tm1Led
Genetic Background: involves: 129S6/SvEvTac

 MP:0008411 decreased cellular sensitivity to ultraviolet irradiation "reduced incidence of cell death following exposure to ultraviolet irradiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008538 decreased zigzag hair amount "reduced number of the truncal hairs that have two or more sharp bends with diameter constrictions at the bends, and contain one air cell in the medulla" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnao1tm1Ejne/Gnao1tm1Ejne
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1a+
Genetic Background: involves: 129S6/SvEvTac

 MP:0008542 enlarged cervical lymph nodes "increased size of the lymph nodes found near the neck and shoulders" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008714 lung carcinoma "a malignant neoplasm of the ling, arising from epithelial cells, usually glandular or squamous" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0008883 abnormal enterocyte proliferation "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Mlf/Cdkn1btm1Mlf
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Csnk1a1tm1.1Ybn/Csnk1a1tm1.1Ybn,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129 * C57BL/6 * CD-1 * DBA/2

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0008947 increased neuron number "greater than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0009050 dilated proximal convoluted tubules "stretched or widened aperture of the luminal space of the convoluted portion of the duct system of the nephron that extends from the renal glomerular capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Fahtm1Mgo/Fahtm1Mgo
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0009130 increased white fat cell number "increase in the number of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0009292 increased inguinal fat pad weight 
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0009300 increased parametrial fat pad weight 
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0009321 histiocytic sarcoma 
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009380 abnormal ventral prostate morphology 
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0009381 abnormal dorsolateral prostate morphology 
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0009399 increased skeletal muscle fiber size "increase in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0009550 urinary bladder carcinoma "a malignant neoplasm of the urinary bladder, arising from epithelial cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Ptentm1Hwu/Ptentm1Hwu,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * FVB/N

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Ctnnb1tm1Mmt/Ctnnb1tm1Mmt,Tg(Upk2-cre)6Xrw/0
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * FVB/N

 MP:0009583 increased keratinocyte proliferation "increase in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

 MP:0009592 Leydig cell tumor "rare testicular tumors of the male gonadal interstitium that are frequently hormonally active, leading to feminizing or virilizing syndromes; Leydig cell tumors comprise 1-3% of all testicular neoplasms, can be pure or mixed with other sex cord-stromal or germ cell tumors, and are usually benign, although malignant variants also occur" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: B6.129-Apoetm1Unc Cdkn1atm1Tyj

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0010268 decreased lymphoma incidence "less than the expected number of neoplasms derived from lymphoid tissue in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1btm1Mlf/Cdkn1btm1Mlf,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J

 MP:0010289 increased urinary system tumor incidence "greater than the expected number of tumors originating in the urinary system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010300 increased skin tumor incidence "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010308 decreased tumor latency "earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

 MP:0010384 increased renal carcinoma incidence "greater than the expected number of malignant neoplasms arising from kidney epithelial tissue, occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Fahtm1Mgo/Fahtm1Mgo
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Zfpm2tm1.1Esv/Zfpm2tm1.1Esv
Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0010403 atrial septal defect "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Zfpm2tm1.1Esv/Zfpm2tm1.1Esv
Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0010763 abnormal hematopoietic stem cell physiology "any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm2.1Kei/Cdkn1c+,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Cdkn1ctm2.1Kei Cdkn1atm1Led Tg(Mx1-cre)1Cgn

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Zfpm2tm1.1Esv/Zfpm2tm1.1Esv
Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Brca1tm2.1Cxd/Brca1tm2.1Cxd,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Kdm8tm1.2Tasu/Kdm8tm1.2Tasu
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C3H * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Nfe2l2tm1Mym/Nfe2l2tm1Mym
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Palb2tm1.2Dli/Palb2tm1.2Dli
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * BALB/cJ * C57BL/6

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm1Sje/Cdkn1c+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0011427 mesangial cell hyperplasia "increased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0011440 increased kidney cell proliferation "increase in the expansion rate of any kidney cell population by cell division" [MGI:anna]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0011453 abnormal glomerular capillary endothelium morphology "any structural anomaly of the thin, extremely flattened layer of cells that line the interior surface of glomerular capillaries and is densely perforated by large transcellular pores (aka fenestrae or fenestrations) that, unlike those of other fenestrated capillaries, are generally thought to lack diaphragms" [MGI:anna]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0011512 mesangial cell interposition "spreading of mesangial cells into the contiguous space between the adjacent glomerular endothelial cells and the glomerular basement membrane (GBM)" [MGI:anna]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0011703 increased fibroblast proliferation "greater the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Gnao1tm1Ejne/Gnao1tm1Ejne
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Guca1a/Guca1btm1Jnc/Guca1a/Guca1btm1Jnc,Rcvrntm1Clma/Rcvrntm1Clma
Genetic Background: involves: 129S1/Sv

 MP:0011925 abnormal heart echocardiography feature "any anomaly in echocardiographic representation of systolic and diastolic function, ventricular compliance, valvular function, or interventricular septum features" [MPD:Molly]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Zfpm2tm1.1Esv/Zfpm2tm1.1Esv
Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0013383 increased sebaceous gland adenoma incidence "greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in any sebaceous gland, occurring in a specific population in a given time period" [MGI:Anna]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0013443 Harderian gland hyperplasia "overdevelopment or increased size, usually due to an increased number of cells, of the sebaceous gland that is located behind the eyeball and excretes fluid that facilitates movement of the nictitating membrane" [MGI:Anna]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

 MP:0013446 enlarged Harderian gland "increased size of the sebaceous gland that is located behind the eyeball and excretes fluid that facilitates movement of the nictitating membrane" [MGI:Anna]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Tg(MMTV-vHaras)SH1Led/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J * CD-1 * FVB/N

 MP:0020135 abnormal heart ventricle wall thickness "anomaly in the depth of the cardiac wall of the heart ventricles" [GOC:NV]
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Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Zfpm2tm1.1Esv/Zfpm2tm1.1Esv
Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0030516 abnormal junctional epithelium morphology "any structural anomaly of the collar-like band of non-keratinized squamous epithelium that attaches the gingival soft tissue to the tooth surface; the term epithelial attachment refers to the attachment apparatus, i.e. the internal basal lamina and hemidesmosomes, that connects the junctional epithelium (JE) to the tooth surface; in the initiation of periodontitis, JE detaches from the tooth surface and converts gradually, by sprouting laterally and migrating apically, to pathological pocket epithelium" [http://dental.pitt.edu/junctional-epithelium, https://books.google.com/books?isbn=0123977630, PMID:25911094]
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Allelic Composition: Pax6132-14Neu/Pax6+
Genetic Background: involves: 101 * C3H

Allelic Composition: Cdkn1atm1Tyj/Cdkn1atm1Tyj,Cdkn1btm1Ako/Cdkn1btm1Ako
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001729 Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*  / reaction
 ENSMUSG00000006728 Cdk4 / P30285 / Cyclin-dependent kinase 4 / P11802*  / complex / reaction
 ENSMUSG00000023944 P11499 / Hsp90ab1 / Heat shock protein HSP 90-beta / P08238* / heat shock protein 90 alpha family class B member 1*  / complex / reaction
 ENSMUSG00000025358 Cdk2 / P97377 / Cyclin-dependent kinase 2 / P24941*  / complex / reaction
 ENSMUSG00000021103 Mnat1 / P51949 / CDK-activating kinase assembly factor MAT1 / P51948* / MNAT1, CDK activating kinase assembly factor*  / reaction
 ENSMUSG00000070348 Ccnd1 / P25322 / G1/S-specific cyclin-D1 / P24385* / cyclin D1*  / complex / reaction
 ENSMUSG00000027552 E2f5 / Q61502 / Transcription factor E2F5 / Q15329* / E2F transcription factor 5*  / reaction
 ENSMUSG00000031666 Rbl2 / Q64700 / Retinoblastoma-like protein 2 / Q08999* / RB transcriptional corepressor like 2*  / reaction
 ENSMUSG00000027641 Rbl1 / Q64701 / Retinoblastoma-like protein 1 / P28749* / RB transcriptional corepressor like 1*  / reaction
 ENSMUSG00000040274 Cdk6 / Q64261 / Cyclin-dependent kinase 6 / Q00534*  / complex / reaction
 ENSMUSG00000028212 Ccne2 / Q9Z238 / G1/S-specific cyclin-E2 / O96020* / cyclin E2*  / complex
 ENSMUSG00000022105 Rb1 / P13405 / Retinoblastoma-associated protein / P06400* / RB transcriptional corepressor 1*  / reaction
 ENSMUSG00000022385 Gtse1 / Q8R080 / G2 and S phase-expressed protein 1 / Q9NYZ3* / G2 and S-phase expressed 1*  / complex / reaction
 ENSMUSG00000033739 Fkbpl / O35450 / FK506-binding protein-like / Q9UIM3*  / complex / reaction
 ENSMUSG00000014859 E2f4 / Q8R0K9 / Transcription factor E2F4 / Q16254* / E2F transcription factor 4*  / reaction
 ENSMUSG00000002068 Ccne1 / Q61457 / G1/S-specific cyclin-E1 / P24864* / cyclin E1*  / complex
 ENSMUSG00000038482 Tfdp1 / Q08639 / transcription factor Dp 1 / TFDP3* / Q14186* / Q5H9I0* / transcription factor Dp family member 3*  / reaction
 ENSMUSG00000021270 P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*  / complex / reaction
 ENSMUSG00000021548 Ccnh / Q61458 / Cyclin-H / P51946*  / reaction
 ENSMUSG00000029686 Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*  / reaction / complex
 ENSMUSG00000036309 Skp1a / Q9WTX5 / S-phase kinase-associated protein 1A / SKP1* / P63208* / AC104109.3* / S-phase kinase associated protein 1*  / reaction / complex
 ENSMUSG00000062687 Cks1brt / CDC28 protein kinase 1b, retrogene / CKS1B* / P61024* / CDC28 protein kinase regulatory subunit 1B*  / reaction / complex
 ENSMUSG00000054115 Skp2 / Q9Z0Z3 / S-phase kinase-associated protein 2 (p45) / Q13309* / S-phase kinase associated protein 2*  / complex / reaction
 ENSMUSG00000069089 Cdk7 / Q03147 / Cyclin-dependent kinase 7 / P50613*  / reaction






 

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