ENSDARG00000076554


Danio rerio

Features
Gene ID: ENSDARG00000076554
  
Biological name :cdkn1a
  
Synonyms : cdkn1a / cyclin-dependent kinase inhibitor 1A
  
Possible biological names infered from orthology : Cyclin-dependent kinase inhibitor 1 / P38936 / P39689
  
Species: Danio rerio
  
Chr. number: 22
Strand: -1
Band:
Gene start: 603382
Gene end: 607812
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000114199
Ensembl peptide - ENSDARP00000117888
NCBI entrez gene - 100151416     See in Manteia.
swissprot - A5WWG2
swissprot - A5WWG3
ZFIN ID - ZDB-GENE-070705-7
Ensembl - ENSDARG00000076554
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CDKN1AENSGALG00000028318Gallus gallus
 CDKN1AENSG00000124762Homo sapiens
 Cdkn1aENSMUSG00000023067Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cdkn1cb / cyclin-dependent kinase inhibitor 1Cb / P49919* / P49918* / CDKN1C* / cyclin dependent kinase inhibitor 1C* / Mus musculus cyclin-dependent kinase inhibitor 1C (P57) (Cdkn1c), mRNA.*ENSDARG0000010490323
cdkn1ca / cyclin-dependent kinase inhibitor 1Ca / P49919* / P49918* / CDKN1C* / cyclin dependent kinase inhibitor 1C* / Mus musculus cyclin-dependent kinase inhibitor 1C (P57) (Cdkn1c), mRNA.*ENSDARG0000001087823
cdkn1bb / cyclin-dependent kinase inhibitor 1Bb / CDKN1B* / P46414* / P46527* / cyclin dependent kinase inhibitor 1B*ENSDARG0000005427120
cdkn1ba / cyclin-dependent kinase inhibitor 1Ba / CDKN1B* / P46414* / P46527* / cyclin dependent kinase inhibitor 1B*ENSDARG0000002901819


Protein motifs (from Interpro)
Interpro ID Name
 IPR003175  Cyclin-dependent kinase inhibitor
 IPR029841  Cyclin-dependent kinase inhibitor 1, vertebrate


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IEA
 biological_processGO:0007519 skeletal muscle tissue development IDA
 biological_processGO:0010165 response to X-ray IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035904 aorta development IGI
 biological_processGO:0035914 skeletal muscle cell differentiation IMP
 biological_processGO:0071901 negative regulation of protein serine/threonine kinase activity IEA
 biological_processGO:0072331 signal transduction by p53 class mediator IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity IEA
 molecular_functionGO:0016301 kinase activity IEA


Pathways (from Reactome)
Pathway description
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
AKT phosphorylates targets in the cytosol
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
The role of GTSE1 in G2/M progression after G2 checkpoint


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0005004 aortic arch aortic arch morphology , ameliorated
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000007657 ccnh / cyclin H / P51946* / Q61458*  / reaction
 ENSDARG00000010478 Q90474 / hsp90aa1.1 / heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1 / P07900* / P07901* / HSP90AA1* / Heat shock protein HSP 90-alpha * / heat shock protein...  / reaction / complex
 ENSDARG00000002077 mnat1 / MNAT CDK-activating kinase assembly factor 1 / P51949* / P51948* / CDK-activating kinase assembly factor MAT1 * / MNAT1, CDK activating kinase assembly factor*  / reaction
 ENSDARG00000013719 gtse1 / G-2 and S-phase expressed 1 / Q8R080* / Q9NYZ3* / G2 and S phase-expressed protein 1 *  / complex / reaction
 ENSDARG00000051916 cdk7 / cyclin-dependent kinase 7 / P50613* / Q03147*  / reaction
 ENSDARG00000070228 cdk6 / cyclin-dependent kinase 6 / Q00534* / Q64261*  / reaction / complex
 ENSDARG00000095322 fkbpl / FK506 binding protein like / O35450* / Q9UIM3*  / reaction / complex
 ENSDARG00000101578 e2f4 / E2F transcription factor 4 / Q16254*  / reaction
 ENSDARG00000007971 cks1b / CDC28 protein kinase regulatory subunit 1B / P61024* / P61025* / Cks1brt* / CDC28 protein kinase 1b, retrogene* / Cyclin-dependent kinases regulatory subunit 1 *  / reaction / complex
 ENSDARG00000004937 skp2 / S-phase kinase-associated protein 2, E3 ubiquitin protein ligase / Q9Z0Z3* / Q13309* / S-phase kinase associated protein 2* / S-phase kinase-associated protein 2 (p45)*  / reaction / complex
 ENSDARG00000026577 cdk2 / cyclin-dependent kinase 2 / P24941* / P97377*  / reaction / complex
 ENSDARG00000045636 rbl2 / retinoblastoma-like 2 (p130) / Q64700* / Q08999* / Retinoblastoma-like protein 2 * / RB transcriptional corepressor like 2*  / reaction
 ENSDARG00000019239 cul1a / cullin 1a / CUL1* / Q13616* / Q9WTX6* / cullin 1* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*  / complex / reaction
 ENSDARG00000003151 skp1 / S-phase kinase-associated protein 1 / Skp1a* / P63208* / Q9WTX5* / AC104109.3* / S-phase kinase-associated protein 1A*  / complex / reaction
 ENSDARG00000038812 e2f5 / E2F transcription factor 5 / Q15329* / Q61502* / Transcription factor E2F5 *  / reaction
 ENSDARG00000101637 ccnd1 / Q90459 / cyclin D1 / P24385* / P25322* / G1/S-specific cyclin-D1 *  / complex / reaction
 ENSDARG00000019293 tfdp1a / transcription factor Dp-1, a / TFDP1* / TFDP3* / Q14186* / Q5H9I0* / Q08639* / transcription factor Dp-1* / transcription factor Dp family member 3*  / reaction






 

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