ENSDARG00000070228


Danio rerio

Features
Gene ID: ENSDARG00000070228
  
Biological name :cdk6
  
Synonyms : cdk6 / cyclin-dependent kinase 6
  
Possible biological names infered from orthology : Q00534 / Q64261
  
Species: Danio rerio
  
Chr. number: 19
Strand: 1
Band:
Gene start: 40248697
Gene end: 40328549
  
Corresponding Affymetrix probe sets: Dr.17925.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000093662
Ensembl peptide - ENSDARP00000122935
Ensembl peptide - ENSDARP00000126132
NCBI entrez gene - 100034507     See in Manteia.
RefSeq - NM_001144053
RefSeq Peptide - NP_001137525
swissprot - F6NR87
swissprot - E9QFH2
swissprot - I3IT74
ZFIN ID - ZDB-GENE-060503-786
Ensembl - ENSDARG00000070228
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CDK6ENSGALG00000009476Gallus gallus
 CDK6ENSG00000105810Homo sapiens
 Cdk6ENSMUSG00000040274Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cdk4 / cyclin-dependent kinase 4 / P11802*ENSDARG0000008793761
cdk21 / cyclin-dependent kinase 21ENSDARG0000003016348
cdk2 / cyclin-dependent kinase 2 / P24941* / P97377*ENSDARG0000002657743
cdk1 / cyclin-dependent kinase 1 / P06493* / P11440*ENSDARG0000008755443
cdk5 / cyclin-dependent kinase 5 / P49615* / Q00535* / Cyclin-dependent-like kinase 5 *ENSDARG0000005668342
cdk11b / cyclin-dependent kinase 11B / CDK11A* / Q9UQ88* / cyclin dependent kinase 11A*ENSDARG0000010254637
cdk10 / cyclin-dependent kinase 10 / Q15131* / Q3UMM4*ENSDARG0000003425636


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR028788  Cyclin-dependent kinase 6


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IBA
 biological_processGO:0006468 protein phosphorylation IBA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0008284 positive regulation of cell proliferation IBA
 biological_processGO:0010033 response to organic substance IBA
 biological_processGO:0010389 regulation of G2/M transition of mitotic cell cycle IBA
 biological_processGO:0010468 regulation of gene expression IBA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0043697 cell dedifferentiation IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 cellular_componentGO:0000307 cyclin-dependent protein kinase holoenzyme complex IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0030332 cyclin binding IBA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Cyclin D associated events in G1
Regulation of RUNX1 Expression and Activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000054271 cdkn1bb / cyclin-dependent kinase inhibitor 1Bb / CDKN1B* / P46414* / P46527* / cyclin dependent kinase inhibitor 1B*  / reaction / complex
 ENSDARG00000087646 runx1 / runt-related transcription factor 1 / Q01196*  / reaction / complex
 ENSDARG00000029018 cdkn1ba / cyclin-dependent kinase inhibitor 1Ba / CDKN1B* / P46414* / P46527* / cyclin dependent kinase inhibitor 1B*  / complex / reaction
 ENSDARG00000057610 cdkn2c / cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) / P42773* / Q60772* / cyclin dependent kinase inhibitor 2C* / Cyclin-dependent kinase 4 inhibitor C *  / complex / reaction
 ENSDARG00000094176 cdkn2d / cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) / P55273* / Q60773* / cyclin dependent kinase inhibitor 2D* / Cyclin-dependent kinase 4 inhibitor D *  / reaction / complex
 ENSDARG00000037262 cdkn2a/b / cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4) / CDKN2A* / CDKN2B* / P42772* / P55271* / Q8N726* / P42771* / cyclin dependent kinase inhibitor 2A* / cyclin dependent...  / reaction / complex
 ENSDARG00000076554 cdkn1a / cyclin-dependent kinase inhibitor 1A / P38936* / P39689* / Cyclin-dependent kinase inhibitor 1 *  / reaction / complex
 ENSDARG00000101637 ccnd1 / Q90459 / cyclin D1 / P24385* / P25322* / G1/S-specific cyclin-D1 *  / reaction / complex






 

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