ENSDARG00000087937


Danio rerio

Features
Gene ID: ENSDARG00000087937
  
Biological name :cdk4
  
Synonyms : cdk4 / cyclin-dependent kinase 4
  
Possible biological names infered from orthology : P11802 / P30285
  
Species: Danio rerio
  
Chr. number: 11
Strand: -1
Band:
Gene start: 135249
Gene end: 141592
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000087219
swissprot - A0A0R4IKV4
swissprot - F1RDQ7
ZFIN ID - ZDB-GENE-060929-974
Ensembl - ENSDARG00000087937
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CDK4ENSG00000135446Homo sapiens
 Cdk4ENSMUSG00000006728Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cdk6 / cyclin-dependent kinase 6 / Q00534* / Q64261*ENSDARG0000007022867
cdk21 / cyclin-dependent kinase 21ENSDARG0000003016351
cdk2 / cyclin-dependent kinase 2 / P24941* / P97377*ENSDARG0000002657746
cdk1 / cyclin-dependent kinase 1 / P06493* / P11440*ENSDARG0000008755444
cdk5 / cyclin-dependent kinase 5 / P49615* / Q00535* / Cyclin-dependent-like kinase 5 *ENSDARG0000005668343
cdk10 / cyclin-dependent kinase 10 / Q15131* / Q3UMM4*ENSDARG0000003425640
cdk11b / cyclin-dependent kinase 11B / CDK11A* / Q9UQ88* / cyclin dependent kinase 11A*ENSDARG0000010254639


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IBA
 biological_processGO:0006468 protein phosphorylation IBA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0008284 positive regulation of cell proliferation IBA
 biological_processGO:0010033 response to organic substance IBA
 biological_processGO:0010389 regulation of G2/M transition of mitotic cell cycle IBA
 biological_processGO:0010468 regulation of gene expression IBA
 cellular_componentGO:0000307 cyclin-dependent protein kinase holoenzyme complex IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004693 cyclin-dependent protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0030332 cyclin binding IBA


Pathways (from Reactome)
Pathway description
SCF(Skp2)-mediated degradation of p27/p21
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
RMTs methylate histone arginines
Ubiquitin-dependent degradation of Cyclin D1
Cyclin D associated events in G1
PTK6 Regulates Cell Cycle
Transcriptional regulation by RUNX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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