ENSDARG00000087554


Danio rerio

Features
Gene ID: ENSDARG00000087554
  
Biological name :cdk1
  
Synonyms : cdk1 / cyclin-dependent kinase 1
  
Possible biological names infered from orthology : P06493 / P11440
  
Species: Danio rerio
  
Chr. number: 17
Strand: 1
Band:
Gene start: 20923691
Gene end: 20929461
  
Corresponding Affymetrix probe sets: Dr.24379.1.S1_at (Zebrafish Array)   NM_212564_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000109027
NCBI entrez gene - 80973     See in Manteia.
RefSeq - NM_212564
RefSeq Peptide - NP_997729
swissprot - Q7T3L7
ZFIN ID - ZDB-GENE-010320-1
Ensembl - ENSDARG00000087554
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CDK1ENSGALG00000003085Gallus gallus
 CDK1ENSG00000170312Homo sapiens
 Cdk1ENSMUSG00000019942Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cdk2 / cyclin-dependent kinase 2 / P24941* / P97377*ENSDARG0000002657764
cdk5 / cyclin-dependent kinase 5 / P49615* / Q00535* / Cyclin-dependent-like kinase 5 *ENSDARG0000005668355
cdk6 / cyclin-dependent kinase 6 / Q00534* / Q64261*ENSDARG0000007022846
cdk11b / cyclin-dependent kinase 11B / CDK11A* / Q9UQ88* / cyclin dependent kinase 11A*ENSDARG0000010254644
cdk4 / cyclin-dependent kinase 4 / P11802*ENSDARG0000008793743
cdk10 / cyclin-dependent kinase 10 / Q15131* / Q3UMM4*ENSDARG0000003425641
cdk21 / cyclin-dependent kinase 21ENSDARG0000003016337


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IBA
 biological_processGO:0006281 DNA repair IBA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0009794 regulation of mitotic cell cycle, embryonic IMP
 biological_processGO:0010468 regulation of gene expression IBA
 biological_processGO:0016572 histone phosphorylation IBA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0044772 mitotic cell cycle phase transition IBA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051445 regulation of meiotic cell cycle IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0072686 mitotic spindle IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004693 cyclin-dependent protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
MAPK3 (ERK1) activation
APC/C:Cdc20 mediated degradation of Cyclin B
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of the APC/C
Phosphorylation of Emi1
Condensation of Prophase Chromosomes
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Nuclear Pore Complex (NPC) Disassembly
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Depolymerisation of the Nuclear Lamina
Anchoring of the basal body to the plasma membrane
MAPK6/MAPK4 signaling
Ovarian tumor domain proteases
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Regulation of TP53 Degradation
Mitotic Prophase
Cyclin A/B1/B2 associated events during G2/M transition
G2/M DNA replication checkpoint
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
AURKA Activation by TPX2
Transcriptional regulation by RUNX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000012 central nervous system central nervous system necrotic , abnormal
Show

 ZFA:0000084 yolk yolk circular , abnormal
yolk quality , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000396 nervous system nervous system quality , abnormal
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 ZFA:0001094 whole organism whole organism viability , abnormal
whole organism shape , abnormal
whole organism bent , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
head edematous , abnormal
Show

 ZFA:0001115 trunk trunk edematous , abnormal
trunk curved dorsal , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000007657 ccnh / cyclin H / P51946* / Q61458*  / reaction
 ENSDARG00000002077 mnat1 / MNAT CDK-activating kinase assembly factor 1 / P51949* / P51948* / CDK-activating kinase assembly factor MAT1 * / MNAT1, CDK activating kinase assembly factor*  / reaction
 ENSDARG00000023323 ywhaqb / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b / SFN* / YWHAQ* / P27348* / P31947* / P68254* / O70456* / stratifin* / tyrosine 3-monoox...  / complex / reaction
 ENSDARG00000010792 cdc25b / cell division cycle 25B / CDC25A* / P30305* / P30306* / P48964* / P30304* / cell division cycle 25A* / M-phase inducer phosphatase 1 * / M-phase inducer phosphatase 2 *  / reaction
 ENSDARG00000051916 cdk7 / cyclin-dependent kinase 7 / P50613* / Q03147*  / reaction
 ENSDARG00000042539 ywhaqa / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a / SFN* / YWHAQ* / P27348* / P31947* / P68254* / O70456* / stratifin* / tyrosine 3-monoox...  / reaction / complex
 ENSDARG00000074927 bub1bb / BUB1 mitotic checkpoint serine/threonine kinase Bb / BUB1B* / O60566* / BUB1 mitotic checkpoint serine/threonine kinase B*  / reaction / complex
 ENSDARG00000013415 lmna / lamin A / P02545* / P48678* / lamin A/C* / Prelamin-A/C Lamin-A/C*  / reaction
 ENSDARG00000100741 cdc20 / cell division cycle 20 homolog / Q12834* / Q9JJ66* / Cell division cycle * / cell division cycle 20*  / reaction / complex
 ENSDARG00000033443 mdm2 / MDM2 oncogene, E3 ubiquitin protein ligase / P23804* / Q00987* / MDM2 proto-oncogene* / E3 ubiquitin-protein ligase Mdm2 *  / reaction
 ENSDARG00000040261 runx2a / runt-related transcription factor 2a / RUNX2* / Q08775* / Q13950* / runt related transcription factor 2*  / reaction
 ENSDARG00000102483 numa1 / wu:fb44b02 / Q14980* / nuclear mitotic apparatus protein 1*  / reaction
 ENSDARG00000044144 wapla / WAPL cohesin release factor a / WAPL* / Q7Z5K2* / Q65Z40* / WAPL cohesin release factor*  / reaction
 ENSDARG00000055022 pds5a / PDS5 cohesin associated factor A / Q29RF7*  / reaction
 ENSDARG00000098897 pds5b / PDS5 cohesin associated factor B / Q4VA53* / Q9NTI5* / Mus musculus PDS5 cohesin associated factor B (Pds5b), transcript variant 2, mRNA.*  / reaction
 ENSDARG00000060177 vcpip1 / valosin containing protein (p97)/p47 complex interacting protein 1 / Q96JH7* / valosin containing protein interacting protein 1*  / reaction
 ENSDARG00000042688 bora / bora, aurora kinase A activator / Q6PGQ7* / Q8BS90* / Protein aurora borealis *  / reaction
 ENSDARG00000032103 mapk6 / mitogen-activated protein kinase 6 / Q16659* / Q61532*  / reaction
 ENSDARG00000015254 fzr1a / fizzy/cell division cycle 20 related 1a / FZR1* / Q9R1K5* / Q9UM11* / Fizzy-related protein homolog * / fizzy and cell division cycle 20 related 1*  / reaction
 ENSDARG00000037174 nek12 / NIMA-related kinase 12 / NEK9* / Q8TD19* / Q8K1R7* / NIMA related kinase 9* / Serine/threonine-protein kinase Nek9 *  / reaction
 ENSDARG00000093864 wee1 / WEE1 G2 checkpoint kinase / P30291* / P47810* / WEE 1 homolog 1 (S. pombe)*  / reaction
 ENSDARG00000074730 pkmyt1 / protein kinase, membrane associated tyrosine/threonine 1 / Q99640* / Q9ESG9* / Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase *  / reaction
 ENSDARG00000075883 bub3 / BUB3 mitotic checkpoint protein / O43684* / Q9WVA3* / Mitotic checkpoint protein BUB3 *  / complex / reaction






 

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