ENSDARG00000074927


Danio rerio

Features
Gene ID: ENSDARG00000074927
  
Biological name :bub1bb
  
Synonyms : bub1bb / BUB1 mitotic checkpoint serine/threonine kinase Bb
  
Possible biological names infered from orthology : BUB1B / BUB1 mitotic checkpoint serine/threonine kinase B / Mitotic checkpoint serine/threonine-protein kinase BUB1 beta / O60566 / Q9Z1S0
  
Species: Danio rerio
  
Chr. number: 17
Strand: 1
Band:
Gene start: 2130018
Gene end: 2150984
  
Corresponding Affymetrix probe sets: Dr.16997.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000099195
Ensembl peptide - ENSDARP00000144935
NCBI entrez gene - 567006     See in Manteia.
swissprot - E7F5T9
ZFIN ID - ZDB-GENE-030829-51
Ensembl - ENSDARG00000074927
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BUB1BENSGALG00000036892Gallus gallus
 BUB1BENSG00000156970Homo sapiens
 Bub1bENSMUSG00000040084Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
bub1 / BUB1 mitotic checkpoint serine/threonine kinase / O43683* / mitotic checkpoint serine/threonine-protein kinase BUB1 isoform 2 *ENSDARG0000007702915
bub1ba / BUB1 mitotic checkpoint serine/threonine kinase BaENSDARG000000788256


Protein motifs (from Interpro)
Interpro ID Name
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013212  Mad3/Bub1 homology region 1
 IPR015661  Mitotic spindle checkpoint protein Bub1/Mad3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007094 mitotic spindle assembly checkpoint IBA
 biological_processGO:0051754 meiotic sister chromatid cohesion, centromeric IBA
 cellular_componentGO:0000778 condensed nuclear chromosome kinetochore IBA
 molecular_functionGO:0004672 protein kinase activity IBA


Pathways (from Reactome)
Pathway description
Inactivation of APC/C via direct inhibition of the APC/C complex
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
APC/C:Cdc20 mediated degradation of mitotic proteins
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000005619 nek2 / NIMA-related kinase 2 / O35942* / P51955* / Serine/threonine-protein kinase Nek2 *  / complex / reaction
 ENSDARG00000087554 cdk1 / cyclin-dependent kinase 1 / P06493* / P11440*  / complex / reaction
 ENSDARG00000100741 cdc20 / cell division cycle 20 homolog / Q12834* / Q9JJ66* / Cell division cycle * / cell division cycle 20*  / reaction / complex
 ENSDARG00000075883 bub3 / BUB3 mitotic checkpoint protein / O43684* / Q9WVA3* / Mitotic checkpoint protein BUB3 *  / complex / reaction






 

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