ENSDARG00000005619


Danio rerio

Features
Gene ID: ENSDARG00000005619
  
Biological name :nek2
  
Synonyms : nek2 / NIMA-related kinase 2
  
Possible biological names infered from orthology : O35942 / P51955 / Serine/threonine-protein kinase Nek2
  
Species: Danio rerio
  
Chr. number: 20
Strand: 1
Band:
Gene start: 13883131
Gene end: 13894916
  
Corresponding Affymetrix probe sets: Dr.10580.1.S1_at (Zebrafish Array)   NM_201050_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000020452
Ensembl peptide - ENSDARP00000126960
Ensembl peptide - ENSDARP00000149828
NCBI entrez gene - 394025     See in Manteia.
RefSeq - NM_201050
RefSeq Peptide - NP_957344
swissprot - Q7ZUN2
swissprot - R4GEP7
ZFIN ID - ZDB-GENE-040426-752
Ensembl - ENSDARG00000005619
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NEK2ENSGALG00000009854Gallus gallus
 NEK2ENSG00000117650Homo sapiens
 Nek2ENSMUSG00000026622Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nek4 / NIMA-related kinase 4 / P51957*ENSDARG0000004015227
nek12 / NIMA-related kinase 12 / NEK9* / Q8TD19* / Q8K1R7* / NIMA related kinase 9* / Serine/threonine-protein kinase Nek9 *ENSDARG0000003717426
nek11 / NIMA-related kinase 11 / Q8C0Q4* / Q8NG66* / Serine/threonine-protein kinase Nek11 *ENSDARG0000008756425
nek8 / NIMA-related kinase 8 / Q86SG6* / Q91ZR4* / Serine/threonine-protein kinase Nek8 *ENSDARG0000004562625
NEK3 / NIMA related kinase 3 / P51956*ENSDARG0000005886925
nek7 / NIMA-related kinase 7 / Q8TDX7* / Q9ES74* / Serine/threonine-protein kinase Nek7 *ENSDARG0000005696623
nek6 / NIMA-related kinase 6 / Q9ES70* / Q9HC98* / Serine/threonine-protein kinase Nek6 *ENSDARG0000003796322
nek1 / NIMA-related kinase 1 / P51954* / Q96PY6* / NIMA (never in mitosis gene a)-related expressed kinase 1*ENSDARG0000002235012


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0046548 retinal rod cell development IMP
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA


Pathways (from Reactome)
Pathway description
APC-Cdc20 mediated degradation of Nek2A
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000046 retinal neural layer retinal neural layer has fewer parts of type retinal rod cell , abnormal
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 ZFA:0000107 eye eye apoptotic , abnormal
eye decreased size , abnormal
Show

 ZFA:0001114 head head apoptotic , abnormal
Show

 ZFA:0009275 retinal rod cell retinal rod cell photoreceptor outer segment malformed , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000074927 bub1bb / BUB1 mitotic checkpoint serine/threonine kinase Bb / BUB1B* / O60566* / BUB1 mitotic checkpoint serine/threonine kinase B*  / complex / reaction
 ENSDARG00000075883 bub3 / BUB3 mitotic checkpoint protein / O43684* / Q9WVA3* / Mitotic checkpoint protein BUB3 *  / reaction / complex
 ENSDARG00000100741 cdc20 / cell division cycle 20 homolog / Q12834* / Q9JJ66* / Cell division cycle * / cell division cycle 20*  / complex / reaction






 

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