ENSGALG00000009854


Gallus gallus

Features
Gene ID: ENSGALG00000009854
  
Biological name :NEK2
  
Synonyms : NEK2 / serine/threonine-protein kinase Nek2
  
Possible biological names infered from orthology : NIMA related kinase 2 / O35942 / P51955
  
Species: Gallus gallus
  
Chr. number: 3
Strand: 1
Band:
Gene start: 22192768
Gene end: 22199443
  
Corresponding Affymetrix probe sets: Gga.13420.1.S1_at (Chicken Array)   GgaAffx.11402.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000063588
Ensembl peptide - ENSGALP00000016000
NCBI entrez gene - 421376     See in Manteia.
RefSeq - NM_001031050
RefSeq Peptide - NP_001026221
swissprot - F1NI69
swissprot - A0A1L1RXK7
Ensembl - ENSGALG00000009854
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nek2ENSDARG00000005619Danio rerio
 NEK2ENSG00000117650Homo sapiens
 Nek2ENSMUSG00000026622Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NEK5 / NIMA related kinase 5 / Q6P3R8* / Q7TSC3* / Mus musculus NIMA (never in mitosis a)-related expressed kinase 5 (Nek5), transcript variant 2, mRNA.*ENSGALG0000001702330
NEK4 / NIMA related kinase 4 / P51957*ENSGALG0000004142829
NEK1 / NIMA related kinase 1 / P51954* / Q96PY6* / NIMA (never in mitosis gene a)-related expressed kinase 1*ENSGALG0000000968329
NEK3 / NIMA related kinase 3 / P51956* / Q9R0A5* / Serine/threonine-protein kinase Nek3 *ENSGALG0000001702427
NEK9 / NIMA related kinase 9 / Q8K1R7* / Q8TD19* / Serine/threonine-protein kinase Nek9 *ENSGALG0000001031427
NEK11 / NIMA related kinase 11 / Q8C0Q4* / Q8NG66* / Serine/threonine-protein kinase Nek11 *ENSGALG0000003724225
NEK6ENSGALG0000000111823
NEK7 / NIMA related kinase 7 / Q8TDX7* / Q9ES74* / Serine/threonine-protein kinase Nek7 *ENSGALG0000000221623
NEK6* / Q9ES70* / Q9HC98* / NIMA related kinase 6* / Serine/threonine-protein kinase Nek6 *ENSGALG000000039793


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000070 mitotic sister chromatid segregation IEA
 biological_processGO:0001824 blastocyst development IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007059 chromosome segregation IEA
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase IEA
 biological_processGO:0043392 negative regulation of DNA binding IEA
 biological_processGO:0046602 regulation of mitotic centrosome separation IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0051299 centrosome separation IEA
 biological_processGO:0051973 positive regulation of telomerase activity IEA
 biological_processGO:0051988 regulation of attachment of spindle microtubules to kinetochore IEA
 biological_processGO:0090307 mitotic spindle assembly IEA
 biological_processGO:1903126 negative regulation of centriole-centriole cohesion IEA
 biological_processGO:1904355 positive regulation of telomere capping IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000794 condensed nuclear chromosome IEA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA


Pathways (from Reactome)
Pathway description
APC-Cdc20 mediated degradation of Nek2A
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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