ENSDARG00000022350


Danio rerio

Features
Gene ID: ENSDARG00000022350
  
Biological name :nek1
  
Synonyms : nek1 / NIMA-related kinase 1
  
Possible biological names infered from orthology : NIMA (never in mitosis gene a)-related expressed kinase 1 / P51954 / Q96PY6
  
Species: Danio rerio
  
Chr. number: 20
Strand: 1
Band:
Gene start: 23670494
Gene end: 23714017
  
Corresponding Affymetrix probe sets: Dr.3774.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000030937
Ensembl peptide - ENSDARP00000129645
swissprot - F1RC73
swissprot - X1WHD3
ZFIN ID - ZDB-GENE-040730-1
Ensembl - ENSDARG00000022350
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NEK1ENSGALG00000009683Gallus gallus
 NEK1ENSG00000137601Homo sapiens
 Nek1ENSMUSG00000031644Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nek4 / NIMA-related kinase 4 / P51957*ENSDARG000000401528
nek8 / NIMA-related kinase 8 / Q86SG6* / Q91ZR4* / Serine/threonine-protein kinase Nek8 *ENSDARG000000456267
nek12 / NIMA-related kinase 12 / NEK9* / Q8TD19* / Q8K1R7* / NIMA related kinase 9* / Serine/threonine-protein kinase Nek9 *ENSDARG000000371746
nek11 / NIMA-related kinase 11 / Q8C0Q4* / Q8NG66* / Serine/threonine-protein kinase Nek11 *ENSDARG000000875646
NEK3 / NIMA related kinase 3 / P51956*ENSDARG000000588695
nek2 / NIMA-related kinase 2 / O35942* / P51955* / Serine/threonine-protein kinase Nek2 *ENSDARG000000056194
nek7 / NIMA-related kinase 7 / Q8TDX7* / Q9ES74* / Serine/threonine-protein kinase Nek7 *ENSDARG000000569663
nek6 / NIMA-related kinase 6 / Q9ES70* / Q9HC98* / Serine/threonine-protein kinase Nek6 *ENSDARG000000379632


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:1904888 cranial skeletal system development IMP
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain hydrocephalic , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000151 pronephros pronephros cilium decreased length , abnormal
Show

 ZFA:0001094 whole organism whole organism anterior-posterior axis curved ventral , abnormal
Show

 ZFA:0001458 cranial cartilage cranial cartilage morphology , abnormal
Show

 ZFA:0001617 otolith otolith non-functional , abnormal
Show

 ZFA:0009127 photoreceptor cell photoreceptor cell decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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